Nfe2l2 (NFE2 like bZIP transcription factor 2)

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Gene: Nfe2l2 (NFE2 like bZIP transcription factor 2) Rattus norvegicus

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Symbol:

Nfe2l2

Name:

NFE2 like bZIP transcription factor 2

RGD ID:

620360

Description:

Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule biosynthetic process; and regulation of cell migration. Located in nucleus. Used to study several diseases, including diabetic retinopathy; middle cerebral artery infarction; non-alcoholic fatty liver disease; pulmonary fibrosis; and visual epilepsy. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); neurodegenerative disease (multiple); non-alcoholic steatohepatitis; and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2); PARTICIPATES IN oxidative stress response pathway; nuclear factor, erythroid 2 like 2 signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-taxifolin; (-)-selegiline; (R)-lipoic acid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

NF-E2-related factor 2; NFE2-related factor 2; nrf2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

Nfe2l2^em1Mcwi Nfe2l2^em1Kyo Nfe2l2^em2Kyo

Genetic Models:

SD-Nfe2l2^em1Mcwi SD-Nfe2l2^em1Mcwi-/- F344-Nfe2l2^em2Kyo F344-Nfe2l2^em1Kyo

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	60,594,239 - 60,621,712 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	60,594,242 - 60,621,737 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	63,968,507 - 63,995,961 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	72,552,163 - 72,579,616 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	70,318,419 - 70,345,871 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	62,497,568 - 62,525,146 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	62,497,571 - 62,524,996 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	69,041,641 - 69,069,190 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	58,366,693 - 58,394,116 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	58,263,064 - 58,290,488 (-)	NCBI
Celera	3	60,095,041 - 60,122,464 (-)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

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Model

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Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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