Pafah1b2 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pafah1b2 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 2) Rattus norvegicus
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Symbol: Pafah1b2
Name: platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
RGD ID: 620332
Description: Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity; identical protein binding activity; and platelet-activating factor acetyltransferase activity. Predicted to be involved in positive regulation of macroautophagy and spermatogenesis. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; ether lipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93124; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH alpha 2; PAF-AH subunit beta; PAFAH subunit beta; platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2); platelet-activating factor acetylhydrolase IB subunit alpha2; platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit; platelet-activating factor acetylhydrolase, isoform 1b, subunit 2; platelet-activating factor acetylhydrolase, isoform Ib, beta subunit; platelet-activating factor acetylhydrolase, isoform Ib, subunit 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,156,778 - 55,208,800 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl855,156,779 - 55,176,836 (-)EnsemblGRCr8
mRatBN7.2846,260,069 - 46,312,073 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,261,064 - 46,279,833 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx851,761,686 - 51,780,128 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,040,454 - 50,058,896 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,904,724 - 47,923,167 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,256,969 - 50,310,043 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,259,248 - 50,277,797 (-)Ensemblrn6Rnor6.0
Rnor_5.0848,883,712 - 48,934,692 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4848,938,556 - 48,957,109 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera845,843,851 - 45,862,380 (-)NCBICelera
RGSC_v3.1848,947,322 - 48,965,875 (-)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Platelet-activating factor acetylhydrolase (PAF-AH). Arai H, etal., J Biochem. 2002 May;131(5):635-40.
2. Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. Bonin F, etal., J Biol Chem 2004 Dec 10;279(50):52425-36. Epub 2004 Sep 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE. Kitagawa M, etal., FEBS Lett 2000 Aug 11;479(1-2):57-62.
5. Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. Manya H, etal., J Biol Chem. 1998 Jul 17;273(29):18567-72.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures. Shmueli O, etal., J Neurosci Res. 1999 Jul 15;57(2):176-84.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase. Watanabe M, etal., Biochim Biophys Acta 1998 Jan 2;1401(1):73-9.
15. The Pafah1b complex interacts with the reelin receptor VLDLR. Zhang G, etal., PLoS One. 2007 Feb 28;2(2):e252.
Additional References at PubMed
PMID:12551946   PMID:15489334   PMID:19056867   PMID:22354037   PMID:23376485   PMID:33760887  


Genomics

Comparative Map Data
Pafah1b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,156,778 - 55,208,800 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl855,156,779 - 55,176,836 (-)EnsemblGRCr8
mRatBN7.2846,260,069 - 46,312,073 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,261,064 - 46,279,833 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx851,761,686 - 51,780,128 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,040,454 - 50,058,896 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,904,724 - 47,923,167 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,256,969 - 50,310,043 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,259,248 - 50,277,797 (-)Ensemblrn6Rnor6.0
Rnor_5.0848,883,712 - 48,934,692 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4848,938,556 - 48,957,109 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera845,843,851 - 45,862,380 (-)NCBICelera
RGSC_v3.1848,947,322 - 48,965,875 (-)NCBI
Cytogenetic Map8q22NCBI
PAFAH1B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,144,287 - 117,178,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11117,144,284 - 117,176,894 (+)Ensemblhg38GRCh38
GRCh3711117,015,003 - 117,048,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,520,250 - 116,544,024 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411116,520,249 - 116,544,024NCBI
Celera11114,172,757 - 114,205,230 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,947,322 - 112,980,405 (+)NCBIHuRef
CHM1_111116,899,903 - 116,932,472 (+)NCBICHM1_1
T2T-CHM13v2.011117,159,595 - 117,193,468 (+)NCBIT2T-CHM13v2.0
Pafah1b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,876,609 - 45,923,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,874,157 - 45,923,988 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38945,965,311 - 46,012,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,962,859 - 46,012,690 (-)Ensemblmm10GRCm38
MGSCv37945,773,394 - 45,792,954 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36945,716,306 - 45,735,866 (-)NCBIMGSCv36mm8
Celera943,249,530 - 43,269,004 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
Pafah1b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,474,199 - 18,494,082 (+)Ensembl
ChiLan1.0NW_00495541218,471,621 - 18,494,082 (+)NCBIChiLan1.0ChiLan1.0
PAFAH1B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,844,005 - 117,870,689 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,950,015 - 118,976,715 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,978,368 - 112,005,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,911,803 - 115,944,358 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,911,803 - 115,944,351 (+)EnsemblpanPan2panpan1.1
PAFAH1B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.0516,361,852 - 16,392,824 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,358,906 - 16,392,810 (-)EnsemblROS_Cfam_1.0 Ensembl
Pafah1b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,469,237 - 99,496,440 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,390,513 - 2,414,882 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,390,904 - 2,417,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAFAH1B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,513,461 - 44,536,432 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1944,513,114 - 44,534,312 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,590,686 - 49,603,905 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAFAH1B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,514,443 - 108,542,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,514,172 - 108,544,049 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604317,512,255 - 17,540,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pafah1b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478412,583,430 - 12,619,816 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Pafah1b2
452 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:76
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000024828
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
D8Got71  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,272,970 - 46,273,149 (+)MAPPERmRatBN7.2
Rnor_6.0850,270,925 - 50,271,103NCBIRnor6.0
Rnor_5.0848,895,573 - 48,895,751UniSTSRnor5.0
RGSC_v3.4848,950,236 - 48,950,415RGDRGSC3.4
RGSC_v3.4848,950,237 - 48,950,415UniSTSRGSC3.4
Celera845,855,508 - 45,855,686UniSTS
RGSC_v3.1848,959,002 - 48,959,181RGD
RH 3.4 Map8473.2UniSTS
RH 3.4 Map8473.2RGD
RH 2.0 Map8366.4RGD
Cytogenetic Map8q22UniSTS
AI747451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,262,304 - 46,262,434 (+)MAPPERmRatBN7.2
Rnor_6.0850,260,261 - 50,260,390NCBIRnor6.0
Rnor_5.0848,884,909 - 48,885,038UniSTSRnor5.0
RGSC_v3.4848,939,573 - 48,939,702UniSTSRGSC3.4
Celera845,844,868 - 45,844,997UniSTS
Cytogenetic Map8q22UniSTS
Pafah1b2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,262,314 - 46,262,438 (+)MAPPERmRatBN7.2
Rnor_6.0850,260,271 - 50,260,394NCBIRnor6.0
Rnor_5.0848,884,919 - 48,885,042UniSTSRnor5.0
RGSC_v3.4848,939,583 - 48,939,706UniSTSRGSC3.4
Celera845,844,878 - 45,845,001UniSTS
Cytogenetic Map8q22UniSTS
RH128517  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,260,110 - 46,260,316 (+)MAPPERmRatBN7.2
mRatBN7.2884,125,219 - 84,125,411 (+)MAPPERmRatBN7.2
Rnor_6.0890,729,494 - 90,729,685NCBIRnor6.0
Rnor_6.0850,258,067 - 50,258,272NCBIRnor6.0
Rnor_5.0890,252,738 - 90,252,929UniSTSRnor5.0
Rnor_5.0848,882,535 - 48,882,740UniSTSRnor5.0
RGSC_v3.4848,937,379 - 48,937,584UniSTSRGSC3.4
RGSC_v3.4888,271,539 - 88,271,730UniSTSRGSC3.4
Celera883,781,455 - 83,781,646UniSTS
Celera845,842,674 - 45,842,879UniSTS
Cytogenetic Map8q22UniSTS
RH143765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,275,231 - 46,275,474 (+)MAPPERmRatBN7.2
Rnor_6.0850,273,200 - 50,273,442NCBIRnor6.0
Rnor_5.0848,897,848 - 48,898,090UniSTSRnor5.0
RGSC_v3.4848,952,512 - 48,952,754UniSTSRGSC3.4
Celera845,857,783 - 45,858,025UniSTS
RH 3.4 Map8476.2UniSTS
Cytogenetic Map8q22UniSTS
RH141413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2884,123,804 - 84,124,002 (+)MAPPERmRatBN7.2
mRatBN7.2846,261,553 - 46,261,751 (+)MAPPERmRatBN7.2
Rnor_6.0850,259,510 - 50,259,707NCBIRnor6.0
Rnor_6.0890,728,079 - 90,728,276NCBIRnor6.0
Rnor_5.0890,251,323 - 90,251,520UniSTSRnor5.0
Rnor_5.0848,883,978 - 48,884,175UniSTSRnor5.0
RGSC_v3.4848,938,822 - 48,939,019UniSTSRGSC3.4
RGSC_v3.4888,270,124 - 88,270,321UniSTSRGSC3.4
Celera883,780,040 - 83,780,237UniSTS
Celera845,844,117 - 45,844,314UniSTS
Cytogenetic Map8q22UniSTS
AI228182  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map8896.49UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000082508   ⟹   ENSRNOP00000068672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl855,156,779 - 55,176,836 (-)Ensembl
mRatBN7.2 Ensembl846,261,064 - 46,279,833 (-)Ensembl
Rnor_6.0 Ensembl850,259,248 - 50,277,797 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111151   ⟹   ENSRNOP00000091075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl846,261,954 - 46,279,806 (-)Ensembl
RefSeq Acc Id: NM_022387   ⟹   NP_071782
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,157,995 - 55,176,548 (-)NCBI
mRatBN7.2846,261,288 - 46,279,829 (-)NCBI
Rnor_6.0850,259,244 - 50,277,797 (-)NCBI
Rnor_5.0848,883,712 - 48,934,692 (-)NCBI
RGSC_v3.4848,938,556 - 48,957,109 (-)RGD
Celera845,843,851 - 45,862,380 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242958   ⟹   XP_006243020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,156,778 - 55,208,800 (-)NCBI
mRatBN7.2846,260,069 - 46,312,073 (-)NCBI
Rnor_6.0850,256,969 - 50,310,043 (-)NCBI
Rnor_5.0848,883,712 - 48,934,692 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082081   ⟹   XP_038938009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,156,778 - 55,175,722 (-)NCBI
mRatBN7.2846,260,069 - 46,279,862 (-)NCBI
RefSeq Acc Id: XM_039082082   ⟹   XP_038938010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,156,778 - 55,176,302 (-)NCBI
mRatBN7.2846,260,069 - 46,279,529 (-)NCBI
RefSeq Acc Id: XM_063266074   ⟹   XP_063122144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,156,778 - 55,172,984 (-)NCBI
RefSeq Acc Id: XM_063266075   ⟹   XP_063122145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,156,778 - 55,176,267 (-)NCBI
RefSeq Acc Id: NP_071782   ⟸   NM_022387
- UniProtKB: O35264 (UniProtKB/Swiss-Prot),   A6J468 (UniProtKB/TrEMBL),   A0A8L2R003 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243020   ⟸   XM_006242958
- Peptide Label: isoform X1
- UniProtKB: O35264 (UniProtKB/Swiss-Prot),   A6J468 (UniProtKB/TrEMBL),   A0A8L2R003 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068672   ⟸   ENSRNOT00000082508
RefSeq Acc Id: XP_038938009   ⟸   XM_039082081
- Peptide Label: isoform X1
- UniProtKB: O35264 (UniProtKB/Swiss-Prot),   A6J468 (UniProtKB/TrEMBL),   A0A8L2R003 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938010   ⟸   XM_039082082
- Peptide Label: isoform X1
- UniProtKB: O35264 (UniProtKB/Swiss-Prot),   A6J468 (UniProtKB/TrEMBL),   A0A8L2R003 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091075   ⟸   ENSRNOT00000111151
RefSeq Acc Id: XP_063122145   ⟸   XM_063266075
- Peptide Label: isoform X1
- UniProtKB: O35264 (UniProtKB/Swiss-Prot),   A6J468 (UniProtKB/TrEMBL),   A0A8L2R003 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122144   ⟸   XM_063266074
- Peptide Label: isoform X1
- UniProtKB: O35264 (UniProtKB/Swiss-Prot),   A6J468 (UniProtKB/TrEMBL),   A0A8L2R003 (UniProtKB/TrEMBL)
Protein Domains
SGNH hydrolase-type esterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35264-F1-model_v2 AlphaFold O35264 1-229 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695924
Promoter ID:EPDNEW_R6449
Type:multiple initiation site
Name:Pafah1b2_1
Description:platelet-activating factor acetylhydrolase 1b, catalytic subunit2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0850,277,802 - 50,277,862EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620332 AgrOrtholog
BioCyc Gene G2FUF-30658 BioCyc
Ensembl Genes ENSRNOG00000057102 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082508 ENTREZGENE
  ENSRNOT00000111151.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1110 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108923 IMAGE-MGC_LOAD
InterPro SGNH_hydro UniProtKB/Swiss-Prot
  SGNH_hydro_sf UniProtKB/Swiss-Prot
KEGG Report rno:64189 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93124 IMAGE-MGC_LOAD
NCBI Gene 64189 ENTREZGENE
PANTHER PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE UniProtKB/Swiss-Prot
  PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA2 UniProtKB/Swiss-Prot
Pfam Lipase_GDSL_2 UniProtKB/Swiss-Prot
PhenoGen Pafah1b2 PhenoGen
RatGTEx ENSRNOG00000057102 RatGTEx
Superfamily-SCOP SGNH hydrolase UniProtKB/Swiss-Prot
UniProt A0A8L2R003 ENTREZGENE, UniProtKB/TrEMBL
  A6J468 ENTREZGENE, UniProtKB/TrEMBL
  O35264 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Pafah1b2  platelet-activating factor acetylhydrolase 1b, catalytic subunit 2  Pafah1b2  platelet-activating factor acetylhydrolase, isoform 1b, subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-04-21 Pafah1b2  platelet-activating factor acetylhydrolase, isoform 1b, subunit 2  Pafah1b2  platelet-activating factor acetylhydrolase, isoform Ib, beta subunit   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Pafah1b2  platelet-activating factor acetylhydrolase, isoform Ib, beta subunit   Pafah1b2  platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pafah1b2  platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit    platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2)  Name updated 1299863 APPROVED
2002-08-07 Pafah1b2  platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2)      Symbol and Name status set to provisional 70820 PROVISIONAL