Ryr2 (ryanodine receptor 2) - Rat Genome Database

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Gene: Ryr2 (ryanodine receptor 2) Rattus norvegicus
Analyze
Symbol: Ryr2
Name: ryanodine receptor 2
RGD ID: 620314
Description: Enables ryanodine-sensitive calcium-release channel activity and scaffold protein binding activity. Involved in several processes, including metal ion transport; regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study congestive heart failure. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cardiac muscle ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; cardiac-type ryaodine receptor; LOC689560; ryanodine receptor 2, cardiac; ryanodine receptor type 2; ryanodine receptor type II; RyR; RYR-2; similar to ryanodine receptor 2, cardiac; type 2 ryanodine receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cm15
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81763,081,527 - 63,667,141 (+)NCBIGRCr8
mRatBN7.21758,389,925 - 58,975,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,577,482 - 62,170,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,580,613 - 66,173,955 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,734,794 - 60,328,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01765,533,998 - 65,955,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01767,285,205 - 67,704,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,959,042 - 69,544,816 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11769,519,966 - 69,552,036 (+)NCBI
Celera1761,573,393 - 61,976,022 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
autism spectrum disorder  (ISO)
Brugada syndrome  (ISO)
cardiac arrest  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Defect  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO,ISS)
catecholaminergic polymorphic ventricular tachycardia 2  (ISO)
Childhood Schizophrenia  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (IDA,ISO)
coronary artery disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diastolic Dysfunction  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1AA  (ISO)
dilated cardiomyopathy 1B  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Experimental Diabetes Mellitus  (IDA)
familial hypertrophic cardiomyopathy  (ISO)
Familial Sudden Death  (ISO)
Familial Ventricular Tachycardia  (ISO)
gastrointestinal stromal tumor  (ISO)
gestational diabetes  (ISO)
Heart Block  (ISO)
heart disease  (ISO,ISS)
Hereditary Leiomyomatosis and Renal Cell Cancer  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
Infant Death  (ISO)
Leber congenital amaurosis  (ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
malignant mesothelioma  (ISO)
Myocardial Ischemia  (ISO)
parathyroid carcinoma  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
pre-eclampsia  (ISO)
pulmonary hypertension  (IEP)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Syncope  (ISO)
Tachycardia  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
17beta-estradiol  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
antimony trichloride  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atenolol  (ISO)
baclofen  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bicuculline  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP)
cantharidin  (ISO)
carvedilol  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
cyclic ADP-beta-D-ribose  (EXP)
dantrolene  (EXP)
daunorubicin  (EXP,ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
etoposide  (ISO)
fenvalerate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
linsidomine  (EXP)
maraviroc  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP,ISO)
metoprolol  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
nicotine  (EXP,ISO)
O-methyleugenol  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP)
phenytoin  (EXP)
picrotoxin  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP)
razoxane  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
ryanodine  (EXP,ISO)
SCH 23390  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
terbufos  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transmembrane import into cytosol  (ISO)
calcium ion transmembrane transport  (IEA,IMP,ISO)
calcium ion transport  (ISO,ISS)
calcium ion transport into cytosol  (IEA,ISO)
calcium-mediated signaling  (IEA,ISO,ISS)
cardiac muscle contraction  (ISO)
cardiac muscle hypertrophy  (IEA,ISO)
cellular response to caffeine  (IEA,ISO,ISS)
cellular response to epinephrine stimulus  (IEA,ISO)
detection of calcium ion  (IEA,ISO)
embryonic heart tube morphogenesis  (IEA,ISO,ISS)
establishment of localization in cell  (IEA,ISO)
establishment of protein localization to endoplasmic reticulum  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO,ISS)
left ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)
manganese ion transmembrane transport  (IMP)
monoatomic ion transmembrane transport  (IMP)
negative regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of heart rate  (IEA,ISO)
positive regulation of sequestering of calcium ion  (IEA,ISO)
positive regulation of the force of heart contraction  (IEA,ISO)
Purkinje myocyte to ventricular cardiac muscle cell signaling  (IEA,ISO)
regulation of atrial cardiac muscle cell action potential  (IEA,ISO)
regulation of AV node cell action potential  (IEA,ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IEA,ISO)
regulation of cytosolic calcium ion concentration  (IMP)
regulation of heart rate  (ISO)
regulation of SA node cell action potential  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
release of sequestered calcium ion into cytosol  (ISO)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IBA,IEA,ISO,ISS)
response to caffeine  (ISO)
response to calcium ion  (IDA)
response to hypoxia  (IEA,IEP,ISO)
response to magnesium ion  (IDA)
response to muscle activity  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
response to nutrient  (IEP)
response to redox state  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
sarcoplasmic reticulum calcium ion transport  (IMP)
striated muscle contraction  (IBA)
type B pancreatic cell apoptotic process  (IEA,ISO)
ventricular cardiac muscle cell action potential  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
arrhythmogenic right ventricular cardiomyopathy pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway   (IEA,ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Ryanodine receptor dysfunction in hearts of streptozotocin-induced diabetic rats. Bidasee KR, etal., Mol Pharmacol 2001 Dec;60(6):1356-64.
2. Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex. Bull R, etal., J Neurosci. 2008 Sep 17;28(38):9463-72.
3. Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Cavallaro S, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9669-73.
4. Mg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrations. Chugun A, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C535-44. Epub 2006 Sep 13.
5. Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle. Clark JH, etal., J Biol Chem. 2010 Apr 30;285(18):13542-9. doi: 10.1074/jbc.M110.101485. Epub 2010 Feb 21.
6. Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. Dahan D, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1;303(9):L824-33. doi: 10.1152/ajplung.00244.2011. Epub 2012 Sep 7.
7. Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytes. Fritz N, etal., J Cell Sci. 2005 May 15;118(Pt 10):2261-70. Epub 2005 May 3.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. Ho HT, etal., J Physiol. 2011 Oct 1;589(Pt 19):4697-708. Epub 2011 Aug 1.
10. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. Kapiloff MS, etal., J Cell Sci. 2001 Sep;114(Pt 17):3167-76.
11. Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy. Kraner SD, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1384-91. Epub 2011 Apr 6.
12. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Lanner JT, etal., Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003996. doi: 10.1101/cshperspect.a003996. Epub 2010 Oct 20.
13. Functional groups of ryanodine receptors in rat ventricular cells. Lukyanenko V, etal., J Physiol. 2007 Aug 15;583(Pt 1):251-69. Epub 2007 Jul 12.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Oda T, etal., Circ Res. 2013 Feb 1;112(3):487-97. doi: 10.1161/CIRCRESAHA.111.300290. Epub 2012 Dec 11.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. Pare GC, etal., J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
24. Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. Rosker C, etal., J Biol Chem. 2009 Feb 20;284(8):5186-94. doi: 10.1074/jbc.M805587200. Epub 2008 Dec 30.
25. Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes. Scriven DR, etal., Biophys J. 2000 Nov;79(5):2682-91.
26. Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Scriven DR, etal., Biophys J. 2005 Sep;89(3):1893-901. Epub 2005 Jun 24.
27. Formation of molecular complexes by N-methyl-D-aspartate receptor subunit NR2B and ryanodine receptor 2 in neonatal rat myocard. Seeber S, etal., J Biol Chem. 2004 May 14;279(20):21062-8. Epub 2004 Mar 9.
28. Dyssynchronous (non-uniform) Ca(2+) release in myocytes from streptozotocin-induced diabetic rats. Shao CH, etal., J Mol Cell Cardiol. 2007 Jan;42(1):234-46. Epub 2006 Oct 6.
29. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Tiso N, etal., Hum Mol Genet. 2001 Feb 1;10(3):189-94.
30. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
31. Down-regulation of the cardiac sarcoplasmic reticulum ryanodine channel in severely food-restricted rats. Vizotto VA, etal., Braz J Med Biol Res. 2007 Jan;40(1):27-31.
32. Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts. Xiao B, etal., Biochem J. 2006 May 15;396(1):7-16.
33. Effects of simvastatin on cardiac performance and expression of sarcoplasmic reticular calcium regulatory proteins in rat heart. Zheng X and Hu SJ, Acta Pharmacol Sin. 2005 Jun;26(6):696-704.
34. Ryanodine receptor interaction with the SNARE-associated protein snapin. Zissimopoulos S, etal., J Cell Sci. 2006 Jun 1;119(Pt 11):2386-97.
Additional References at PubMed
PMID:9287354   PMID:9628868   PMID:10444400   PMID:10473538   PMID:10830164   PMID:11576544   PMID:11934703   PMID:12089338   PMID:12324472   PMID:12401811   PMID:12443530   PMID:12477932  
PMID:12606683   PMID:12676814   PMID:12829653   PMID:12837242   PMID:12919952   PMID:14592808   PMID:14593104   PMID:15041652   PMID:15044459   PMID:15105296   PMID:15197150   PMID:15626694  
PMID:15731460   PMID:16204356   PMID:16213210   PMID:16249429   PMID:16481613   PMID:16931553   PMID:17234969   PMID:17237229   PMID:17267548   PMID:17313373   PMID:17360443   PMID:17431507  
PMID:17516033   PMID:17569730   PMID:17630346   PMID:17652368   PMID:17693412   PMID:17823125   PMID:17872467   PMID:17875969   PMID:17921453   PMID:18468998   PMID:18718444   PMID:18755143  
PMID:18979913   PMID:19120137   PMID:19131648   PMID:19220289   PMID:19226252   PMID:19284993   PMID:19383796   PMID:20008518   PMID:20018773   PMID:20080623   PMID:20226167   PMID:20336285  
PMID:20427316   PMID:20431056   PMID:20445169   PMID:20471962   PMID:21156134   PMID:21282625   PMID:21372126   PMID:21421556   PMID:21612318   PMID:21649588   PMID:21673970   PMID:21788490  
PMID:22067155   PMID:22073362   PMID:22363773   PMID:22404946   PMID:22406107   PMID:22867515   PMID:22890710   PMID:23040497   PMID:23177664   PMID:23354458   PMID:23376485   PMID:23454728  
PMID:23499836   PMID:23943510   PMID:24186966   PMID:24417961   PMID:24631538   PMID:24693334   PMID:24786399   PMID:25263335   PMID:26046640   PMID:26071359   PMID:26092277   PMID:26164367  
PMID:26316108   PMID:26963898   PMID:27013634   PMID:27422983   PMID:27516456   PMID:28630041   PMID:29162778   PMID:29357673   PMID:30123252   PMID:30885011   PMID:31505169   PMID:31916935  
PMID:33689540   PMID:33753579   PMID:33812310   PMID:35134547   PMID:35562179   PMID:36344175   PMID:38266577   PMID:38652413  


Genomics

Comparative Map Data
Ryr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81763,081,527 - 63,667,141 (+)NCBIGRCr8
mRatBN7.21758,389,925 - 58,975,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1761,577,482 - 62,170,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01765,580,613 - 66,173,955 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01759,734,794 - 60,328,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01765,533,998 - 65,955,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01767,285,205 - 67,704,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,959,042 - 69,544,816 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11769,519,966 - 69,552,036 (+)NCBI
Celera1761,573,393 - 61,976,022 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
RYR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381237,042,184 - 237,833,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1237,042,184 - 237,833,988 (+)EnsemblGRCh38hg38GRCh38
GRCh371237,205,484 - 237,997,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361235,272,325 - 236,063,911 (+)NCBINCBI36Build 36hg18NCBI36
Build 341233,531,742 - 234,322,694NCBI
Celera1210,455,038 - 211,246,790 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1207,662,133 - 208,453,675 (+)NCBIHuRef
CHM1_11238,478,098 - 239,269,604 (+)NCBICHM1_1
T2T-CHM13v2.01236,453,199 - 237,245,297 (+)NCBIT2T-CHM13v2.0
Ryr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391311,567,985 - 12,121,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1311,567,988 - 12,121,831 (-)EnsemblGRCm39 Ensembl
GRCm381311,553,099 - 12,106,945 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1311,553,102 - 12,106,945 (-)EnsemblGRCm38mm10GRCm38
MGSCv371311,645,370 - 12,199,212 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361311,608,677 - 12,160,499 (-)NCBIMGSCv36mm8
Celera1311,467,020 - 12,025,871 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.38NCBI
Ryr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554922,648,956 - 3,076,509 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554922,647,597 - 3,275,512 (-)NCBIChiLan1.0ChiLan1.0
RYR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,327,556 - 12,116,058 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,544,360 - 12,334,567 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,600,198 - 213,387,312 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,598,069 - 218,384,849 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,815,676 - 218,383,509 (+)Ensemblpanpan1.1panPan2
RYR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.142,371,868 - 2,908,132 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl42,373,114 - 2,907,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha42,419,733 - 3,146,551 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.042,390,864 - 3,118,926 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl42,391,241 - 3,118,902 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.142,386,589 - 3,119,270 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.042,522,518 - 3,249,453 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.042,743,722 - 3,470,663 (-)NCBIUU_Cfam_GSD_1.0
Ryr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934439,237,258 - 39,734,210 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648415,403,819 - 15,824,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648415,402,488 - 15,825,410 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RYR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1453,652,485 - 54,192,063 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11453,652,140 - 54,406,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21457,571,491 - 58,014,914 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q22-q23NCBI
RYR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12574,169,024 - 74,951,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2574,389,122 - 74,953,451 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605576,267,928 - 77,050,853 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ryr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477512,956,042 - 13,419,381 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477512,954,653 - 13,650,449 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ryr2
3840 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:5
Interacting mature miRNAs:6
Transcripts:ENSRNOT00000023601, ENSRNOT00000067949
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)175402992960463637Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)175639647763640182Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
D17Rat123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,768,794 - 58,768,965 (-)MAPPERmRatBN7.2
Rnor_6.01765,739,231 - 65,739,401NCBIRnor6.0
Rnor_5.01767,489,835 - 67,490,005UniSTSRnor5.0
RGSC_v3.41769,337,501 - 69,337,672RGDRGSC3.4
RGSC_v3.41769,337,502 - 69,337,672UniSTSRGSC3.4
RGSC_v3.11769,348,334 - 69,348,505RGD
Celera1761,772,098 - 61,772,268UniSTS
SHRSP x BN Map1732.6999RGD
SHRSP x BN Map1732.6999UniSTS
Cytogenetic Map17q12.1UniSTS
D17Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,691,835 - 58,691,962 (-)MAPPERmRatBN7.2
Rnor_6.01765,830,897 - 65,831,023NCBIRnor6.0
Rnor_5.01767,580,807 - 67,580,933UniSTSRnor5.0
RGSC_v3.41769,257,315 - 69,257,442RGDRGSC3.4
RGSC_v3.41769,257,316 - 69,257,442UniSTSRGSC3.4
RGSC_v3.11769,268,149 - 69,268,275RGD
Celera1761,848,039 - 61,848,165UniSTS
RH 3.4 Map17617.3RGD
RH 3.4 Map17617.3UniSTS
SHRSP x BN Map1732.6999RGD
SHRSP x BN Map1732.6999UniSTS
FHH x ACI Map1742.1599RGD
Cytogenetic Map17q12.1UniSTS
D17Rat68  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,632,929 - 58,633,100 (-)MAPPERmRatBN7.2
Rnor_6.01765,888,732 - 65,888,902NCBIRnor6.0
Rnor_5.01767,638,898 - 67,639,068UniSTSRnor5.0
RGSC_v3.41769,196,751 - 69,196,921UniSTSRGSC3.4
RGSC_v3.41769,196,750 - 69,196,921RGDRGSC3.4
Celera1761,906,744 - 61,906,915UniSTS
FHH x ACI Map1742.19RGD
FHH x ACI Map1742.19UniSTS
Cytogenetic Map17q12.1UniSTS
D17Got79  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,816,258 - 58,816,366 (-)MAPPERmRatBN7.2
Rnor_6.01765,691,658 - 65,691,765NCBIRnor6.0
Rnor_5.01767,442,262 - 67,442,369UniSTSRnor5.0
RGSC_v3.41769,384,961 - 69,385,068UniSTSRGSC3.4
RGSC_v3.41769,384,960 - 69,385,068RGDRGSC3.4
RGSC_v3.11769,395,794 - 69,395,901RGD
Celera1761,725,590 - 61,725,697UniSTS
RH 3.4 Map17619.1UniSTS
RH 3.4 Map17619.1RGD
RH 2.0 Map17479.8RGD
Cytogenetic Map17q12.1UniSTS
D17Got77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,541,482 - 58,541,590 (-)MAPPERmRatBN7.2
Rnor_6.01765,977,518 - 65,977,625NCBIRnor6.0
Rnor_5.01767,726,678 - 67,726,785UniSTSRnor5.0
RGSC_v3.41769,105,679 - 69,105,786UniSTSRGSC3.4
RGSC_v3.41769,105,678 - 69,105,786RGDRGSC3.4
RGSC_v3.11769,116,512 - 69,116,619RGD
Celera1761,997,939 - 61,998,046UniSTS
RH 3.4 Map17614.8UniSTS
RH 3.4 Map17614.8RGD
RH 2.0 Map17488.8RGD
Cytogenetic Map17q12.1UniSTS
RH131486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,975,330 - 58,975,547 (-)MAPPERmRatBN7.2
Rnor_6.01765,534,089 - 65,534,305NCBIRnor6.0
Rnor_5.01767,285,296 - 67,285,512UniSTSRnor5.0
RGSC_v3.41769,545,842 - 69,546,058UniSTSRGSC3.4
Celera1761,573,484 - 61,573,700UniSTS
RH 3.4 Map17615.9UniSTS
Cytogenetic Map17q12.1UniSTS
AU049096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,116,089 - 85,117,213 (+)MAPPERmRatBN7.2
Rnor_6.01088,096,096 - 88,097,217NCBIRnor6.0
Rnor_5.01087,888,771 - 87,889,892UniSTSRnor5.0
RGSC_v3.41769,029,828 - 69,030,313UniSTSRGSC3.4
RGSC_v3.41089,121,733 - 89,122,854UniSTSRGSC3.4
Celera1762,083,834 - 62,084,319UniSTS
Celera1083,835,564 - 83,836,678UniSTS
Cytogenetic Map17q12.1UniSTS
Cytogenetic Map10q32.1UniSTS
AU049552  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,768,778 - 58,769,026 (-)MAPPERmRatBN7.2
Rnor_6.01765,739,170 - 65,739,417NCBIRnor6.0
Rnor_5.01767,489,774 - 67,490,021UniSTSRnor5.0
RGSC_v3.41769,337,486 - 69,337,733UniSTSRGSC3.4
Celera1761,772,037 - 61,772,284UniSTS
Cytogenetic Map17q12.1UniSTS
PMC21940P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21758,975,120 - 58,975,366 (-)MAPPERmRatBN7.2
Rnor_6.01765,534,270 - 65,534,515NCBIRnor6.0
Rnor_5.01767,285,477 - 67,285,722UniSTSRnor5.0
RGSC_v3.41769,545,632 - 69,545,877UniSTSRGSC3.4
Celera1761,573,665 - 61,573,910UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 68 67 36 24 36 6 193 95 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB204523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF011789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF130880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF363960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU346200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023601   ⟹   ENSRNOP00000023601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)Ensembl
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067949   ⟹   ENSRNOP00000059019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)Ensembl
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111439   ⟹   ENSRNOP00000087428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1758,562,590 - 58,975,142 (+)Ensembl
RefSeq Acc Id: NM_001191043   ⟹   NP_001177972
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,527 - 63,667,138 (+)NCBI
mRatBN7.21758,389,925 - 58,975,638 (+)NCBI
Rnor_6.01765,533,998 - 65,955,606 (-)NCBI
Rnor_5.01767,285,205 - 67,704,766 (-)NCBI
Celera1761,573,393 - 61,976,022 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032078   ⟹   NP_114467
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,527 - 63,667,138 (+)NCBI
mRatBN7.21758,389,925 - 58,975,638 (+)NCBI
Rnor_6.01765,535,403 - 65,955,606 (-)NCBI
Rnor_5.01767,285,205 - 67,704,766 (-)NCBI
RGSC_v3.41768,959,042 - 69,544,816 (+)RGD
Celera1761,574,873 - 61,976,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276749   ⟹   XP_063132819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276750   ⟹   XP_063132820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276751   ⟹   XP_063132821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276752   ⟹   XP_063132822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276753   ⟹   XP_063132823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276754   ⟹   XP_063132824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276755   ⟹   XP_063132825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276756   ⟹   XP_063132826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276757   ⟹   XP_063132827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276758   ⟹   XP_063132828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276759   ⟹   XP_063132829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276760   ⟹   XP_063132830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276761   ⟹   XP_063132831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,514,922 (+)NCBI
RefSeq Acc Id: XM_063276762   ⟹   XP_063132832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276763   ⟹   XP_063132833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XM_063276764   ⟹   XP_063132834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,667,141 (+)NCBI
RefSeq Acc Id: XR_005495333
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,549,913 (+)NCBI
mRatBN7.21758,390,217 - 58,858,418 (+)NCBI
RefSeq Acc Id: XR_010058952
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81763,081,803 - 63,523,042 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001177972 (Get FASTA)   NCBI Sequence Viewer  
  NP_114467 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132819 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132820 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132821 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132822 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132823 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132824 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132825 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132826 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132827 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132828 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132829 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132830 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132831 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132832 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132833 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132834 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB65757 (Get FASTA)   NCBI Sequence Viewer  
  AAB70011 (Get FASTA)   NCBI Sequence Viewer  
  AAB70013 (Get FASTA)   NCBI Sequence Viewer  
  AAD31271 (Get FASTA)   NCBI Sequence Viewer  
  AAD48900 (Get FASTA)   NCBI Sequence Viewer  
  AAI67757 (Get FASTA)   NCBI Sequence Viewer  
  AAK37569 (Get FASTA)   NCBI Sequence Viewer  
  ABY79796 (Get FASTA)   NCBI Sequence Viewer  
  B0LPN4 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10276 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10277 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10278 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10279 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10280 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10281 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10282 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10283 (Get FASTA)   NCBI Sequence Viewer  
  BAJ10284 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023601.7
  ENSRNOP00000059019.4
  ENSRNOP00000087428.1
RefSeq Acc Id: NP_114467   ⟸   NM_032078
- Peptide Label: isoform 1
- UniProtKB: D7UNT3 (UniProtKB/Swiss-Prot),   B0LPN4 (UniProtKB/Swiss-Prot),   F1LS89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177972   ⟸   NM_001191043
- Peptide Label: isoform 2
- UniProtKB: D7UNT3 (UniProtKB/Swiss-Prot),   B0LPN4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023601   ⟸   ENSRNOT00000023601
Ensembl Acc Id: ENSRNOP00000059019   ⟸   ENSRNOT00000067949
Ensembl Acc Id: ENSRNOP00000087428   ⟸   ENSRNOT00000111439
RefSeq Acc Id: XP_063132819   ⟸   XM_063276749
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132821   ⟸   XM_063276751
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132826   ⟸   XM_063276756
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063132822   ⟸   XM_063276752
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132827   ⟸   XM_063276757
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063132824   ⟸   XM_063276754
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063132828   ⟸   XM_063276758
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063132823   ⟸   XM_063276753
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132832   ⟸   XM_063276762
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063132833   ⟸   XM_063276763
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063132829   ⟸   XM_063276759
- Peptide Label: isoform X11
- UniProtKB: F1LRZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132830   ⟸   XM_063276760
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063132820   ⟸   XM_063276750
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132825   ⟸   XM_063276755
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063132834   ⟸   XM_063276764
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063132831   ⟸   XM_063276761
- Peptide Label: isoform X13
Protein Domains
B30.2/SPRY   EF-hand   Ion transport   MIR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620314 AgrOrtholog
BioCyc Gene G2FUF-8929 BioCyc
Ensembl Genes ENSRNOG00000017060 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023601.8 UniProtKB/TrEMBL
  ENSRNOT00000067949.4 UniProtKB/TrEMBL
  ENSRNOT00000111439.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.490.160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.350.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IP3 receptor type 1 binding core, RIH domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryan_recept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanodine_IP3_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanodine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanrecept_TM4-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_Jsol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY1_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY2_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY3_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:689560 UniProtKB/Swiss-Prot
NCBI Gene Ryr2 ENTREZGENE
PANTHER B30.2/SPRY DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYANODINE RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ins145_P3_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RR_TM4-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_Jsol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ryr2 PhenoGen
PRINTS RYANODINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017060 RatGTEx
SMART MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7R2_RAT UniProtKB/TrEMBL
  A6KN28_RAT UniProtKB/TrEMBL
  B0LPN4 ENTREZGENE
  B3DM99_RAT UniProtKB/TrEMBL
  D7UNT3 ENTREZGENE
  F1LRZ1 ENTREZGENE, UniProtKB/TrEMBL
  F1LS89 ENTREZGENE, UniProtKB/TrEMBL
  O08660_RAT UniProtKB/TrEMBL
  Q9WUE2_RAT UniProtKB/TrEMBL
  RYR2_RAT UniProtKB/Swiss-Prot
UniProt Secondary D7UNT3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ryr2  ryanodine receptor 2  Ryr2  ryanodine receptor 2, cardiac  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-12 Ryr2  ryanodine receptor 2, cardiac  LOC689560  similar to ryanodine receptor 2, cardiac  Data merged from RGD:1591067 737654 APPROVED
2006-11-20 LOC689560  similar to ryanodine receptor 2, cardiac      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Ryr2  ryanodine receptor 2, cardiac    ryanodine receptor type II  Name updated 1299863 APPROVED
2002-08-07 Ryr2  ryanodine receptor type II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process ryanodine binding to receptor is decreased in diabetic rats 634031