Clock Rat (+)-epicatechin-3-O-gallate multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the more ... CTD PMID:29061316 Clock Rat (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the more ... CTD PMID:22079256|PMID:29061316 Clock Rat (1->4)-beta-D-glucan multiple interactions ISO RGD:1552430 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CLOCK mRNA CTD PMID:36331819 Clock Rat 1,2-dimethylhydrazine decreases expression ISO RGD:1552430 6480464 1,2-Dimethylhydrazine results in decreased expression of CLOCK mRNA CTD PMID:22206623 Clock Rat 1,2-dimethylhydrazine multiple interactions ISO RGD:1552430 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CLOCK mRNA CTD PMID:22206623 Clock Rat 1,3-dichloropropan-2-ol decreases expression ISO RGD:1552430 6480464 1,3-dichloro-2-propanol results in decreased expression of CLOCK protein CTD PMID:36805544 Clock Rat 17alpha-ethynylestradiol affects expression ISO RGD:1552430 6480464 Ethinyl Estradiol affects the expression of CLOCK mRNA CTD PMID:17555576 Clock Rat 17alpha-ethynylestradiol increases expression ISO RGD:1552430 6480464 Ethinyl Estradiol results in increased expression of CLOCK mRNA CTD PMID:17942748 Clock Rat 17alpha-ethynylestradiol multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLOCK mRNA CTD PMID:17942748 Clock Rat 17beta-estradiol increases expression ISO RGD:1552430 6480464 Estradiol results in increased expression of CLOCK mRNA CTD PMID:39298647 Clock Rat 2,2',4,4',5,5'-hexachlorobiphenyl increases activity ISO RGD:1348034 6480464 2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of CLOCK protein CTD PMID:27589886 Clock Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased more ... CTD PMID:28433925 Clock Rat 2,2',5,5'-tetrachlorobiphenyl increases expression ISO RGD:1348034 6480464 2,5,2',5'-tetrachlorobiphenyl results in increased expression of CLOCK mRNA CTD PMID:21703328 Clock Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1552430 6480464 Tetrachlorodibenzodioxin results in increased expression of CLOCK mRNA CTD PMID:17942748|PMID:24058054 Clock Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1552430 6480464 Tetrachlorodibenzodioxin results in decreased expression of CLOCK mRNA CTD PMID:18295293|PMID:28213091 Clock Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased more ... CTD PMID:17942748|PMID:28433925 Clock Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552430 6480464 Tetrachlorodibenzodioxin affects the expression of CLOCK mRNA CTD PMID:21570461|PMID:28922406|PMID:36222588 Clock Rat 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:1552430 6480464 Glucosamine results in decreased expression of CLOCK mRNA; Glucosamine results in decreased expression of CLOCK more ... CTD PMID:24442997 Clock Rat 20-HETE affects abundance ISO RGD:1552430 6480464 CLOCK protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid CTD PMID:22440902 Clock Rat 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1552430 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CLOCK mRNA CTD PMID:26251327 Clock Rat 4,4'-diaminodiphenylmethane increases expression ISO RGD:1552430 6480464 4,4'-diaminodiphenylmethane results in increased expression of CLOCK mRNA CTD PMID:18648102 Clock Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4,4'-diaminodiphenylmethane results in decreased expression of CLOCK mRNA CTD PMID:30723492 Clock Rat 4,4'-sulfonyldiphenol increases expression ISO RGD:1552430 6480464 bisphenol S results in increased expression of CLOCK mRNA CTD PMID:33297965|PMID:39298647 Clock Rat 4-nitro-m-cresol affects expression ISO RGD:1552430 6480464 4-nitro-3-cresol affects the expression of CLOCK mRNA CTD PMID:35654127 Clock Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of CLOCK mRNA CTD PMID:30047161 Clock Rat acrolein multiple interactions ISO RGD:1348034 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... CTD PMID:32699268 Clock Rat aflatoxin B1 increases expression ISO RGD:1552430 6480464 Aflatoxin B1 results in increased expression of CLOCK mRNA CTD PMID:19770486 Clock Rat aldehydo-D-glucosamine decreases expression ISO RGD:1552430 6480464 Glucosamine results in decreased expression of CLOCK mRNA; Glucosamine results in decreased expression of CLOCK more ... CTD PMID:24442997 Clock Rat all-trans-retinoic acid multiple interactions ISO RGD:1552430 6480464 RARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to more ... CTD PMID:17069763 Clock Rat alpha-pinene multiple interactions ISO RGD:1348034 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... CTD PMID:32699268 Clock Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of CLOCK mRNA CTD PMID:30047161 Clock Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CLOCK mRNA CTD PMID:16483693 Clock Rat amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of CLOCK mRNA CTD PMID:30779732 Clock Rat aristolochic acid A decreases expression ISO RGD:1348034 6480464 aristolochic acid I results in decreased expression of CLOCK mRNA CTD PMID:33212167 Clock Rat Aroclor 1254 decreases expression ISO RGD:1552430 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CLOCK mRNA CTD PMID:23650126 Clock Rat benzo[a]pyrene increases expression ISO RGD:1348034 6480464 Benzo(a)pyrene results in increased expression of CLOCK mRNA CTD PMID:17879257 Clock Rat benzo[a]pyrene increases expression ISO RGD:1552430 6480464 Benzo(a)pyrene results in increased expression of CLOCK mRNA CTD PMID:20127859|PMID:22228805 Clock Rat benzo[a]pyrene multiple interactions ISO RGD:1552430 6480464 CLOCK gene mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:21978865 Clock Rat benzo[b]fluoranthene decreases expression ISO RGD:1552430 6480464 benzo(b)fluoranthene results in decreased expression of CLOCK mRNA CTD PMID:26377693 Clock Rat beta-D-glucosamine decreases expression ISO RGD:1552430 6480464 Glucosamine results in decreased expression of CLOCK mRNA; Glucosamine results in decreased expression of CLOCK more ... CTD PMID:24442997 Clock Rat beta-naphthoflavone multiple interactions ISO RGD:1552430 6480464 beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to BMAL1 protein]; beta-Naphthoflavone inhibits the reaction [CLOCK more ... CTD PMID:20106950 Clock Rat bezafibrate multiple interactions ISO RGD:1552430 6480464 [CLOCK protein binds to BMAL1 protein] promotes the reaction [Bezafibrate results in increased expression of more ... CTD PMID:20400680 Clock Rat bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of CLOCK mRNA CTD PMID:28871463 Clock Rat bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased more ... CTD PMID:28433925 Clock Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CLOCK mRNA CTD PMID:25181051 Clock Rat bisphenol A increases expression ISO RGD:1552430 6480464 bisphenol A results in increased expression of CLOCK mRNA CTD PMID:33221593 Clock Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CLOCK mRNA CTD PMID:30816183 Clock Rat bisphenol A affects methylation ISO RGD:1552430 6480464 bisphenol A affects the methylation of CLOCK promoter CTD PMID:27334623 Clock Rat bisphenol A multiple interactions ISO RGD:1552430 6480464 [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased more ... CTD PMID:28433925 Clock Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of CLOCK gene CTD PMID:28505145 Clock Rat bisphenol F increases expression ISO RGD:1552430 6480464 bisphenol F results in increased expression of CLOCK mRNA CTD PMID:38685157 Clock Rat bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of CLOCK mRNA CTD PMID:32479839 Clock Rat butanal decreases expression ISO RGD:1348034 6480464 butyraldehyde results in decreased expression of CLOCK mRNA CTD PMID:26079696 Clock Rat cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of CLOCK; Cadmium Chloride affects the expression of CLOCK mRNA CTD PMID:21442002|PMID:23085516 Clock Rat cadmium dichloride multiple interactions EXP 6480464 Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 Clock Rat cadmium dichloride affects methylation EXP 6480464 Cadmium Chloride affects the methylation of CLOCK promoter CTD PMID:22457795 Clock Rat cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of CLOCK mRNA CTD PMID:20107868 Clock Rat caffeine decreases phosphorylation ISO RGD:1348034 6480464 Caffeine results in decreased phosphorylation of CLOCK protein CTD PMID:35688186 Clock Rat cannabidiol decreases expression ISO RGD:1552430 6480464 Cannabidiol results in decreased expression of CLOCK mRNA CTD PMID:30307084|PMID:33019509 Clock Rat cannabigerol decreases expression ISO RGD:1552430 6480464 cannabigerol results in decreased expression of CLOCK mRNA CTD PMID:33019509 Clock Rat carbon nanotube increases expression ISO RGD:1552430 6480464 Nanotubes, Carbon results in increased expression of CLOCK mRNA CTD PMID:25554681|PMID:25620056 Clock Rat CGS-21680 increases expression ISO RGD:1348034 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of CLOCK mRNA CTD PMID:22923002 Clock Rat cisplatin decreases expression ISO RGD:1348034 6480464 Cisplatin results in decreased expression of CLOCK protein CTD PMID:21157427 Clock Rat clozapine affects response to substance ISO RGD:1348034 6480464 CLOCK gene SNP affects the susceptibility to Clozapine CTD PMID:15331141 Clock Rat cocaine increases expression ISO RGD:1552430 6480464 Cocaine results in increased expression of CLOCK mRNA CTD PMID:15994025 Clock Rat cocaine hydrochloride increases expression ISO RGD:1552430 405866348 cocaine hydrochloride increases expression of Clock mRNA in caudate-putamen RGD Clock Rat crocidolite asbestos decreases expression ISO RGD:1348034 6480464 Asbestos, Crocidolite results in decreased expression of CLOCK mRNA CTD PMID:29523930 Clock Rat DDE increases activity ISO RGD:1348034 6480464 Dichlorodiphenyl Dichloroethylene results in increased activity of CLOCK protein CTD PMID:27589886 Clock Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of CLOCK mRNA CTD PMID:23640034 Clock Rat deoxynivalenol decreases expression ISO RGD:1552430 6480464 deoxynivalenol results in decreased expression of CLOCK protein CTD PMID:36602574 Clock Rat deoxynivalenol multiple interactions ISO RGD:1552430 6480464 BMAL1 protein promotes the reaction [deoxynivalenol results in decreased expression of CLOCK protein]; deoxynivalenol inhibits more ... CTD PMID:36602574 Clock Rat dexamethasone affects expression ISO RGD:1348034 6480464 Dexamethasone affects the expression of CLOCK mRNA CTD PMID:23251369 Clock Rat dibenz[a,h]anthracene decreases expression ISO RGD:1552430 6480464 1,2,5,6-dibenzanthracene results in decreased expression of CLOCK mRNA CTD PMID:26377693 Clock Rat Dibutyl phosphate affects expression ISO RGD:1348034 6480464 di-n-butylphosphoric acid affects the expression of CLOCK mRNA CTD PMID:37042841 Clock Rat dichloromethane decreases expression ISO RGD:1552430 6480464 Methylene Chloride results in decreased expression of CLOCK mRNA CTD PMID:28392392 Clock Rat doxorubicin decreases expression ISO RGD:1348034 6480464 Doxorubicin results in decreased expression of CLOCK mRNA CTD PMID:29803840 Clock Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of CLOCK mRNA CTD PMID:29391264 Clock Rat epoxiconazole affects expression ISO RGD:1552430 6480464 epoxiconazole affects the expression of CLOCK mRNA CTD PMID:35436446 Clock Rat ethanol increases expression ISO RGD:1348034 405866372 ethanol increases expression of CLOCK protein in intestinal cells RGD Clock Rat ethanol multiple interactions ISO RGD:1348034 405866372 N-acetylcysteamine inhibits the reaction [ethanol increases expression of CLOCK protein in intestinal cells] RGD Clock Rat fluoxetine increases expression ISO RGD:1552430 6480464 Fluoxetine results in increased expression of CLOCK mRNA CTD PMID:15994025 Clock Rat fluoxetine increases expression ISO RGD:1552430 405866348 fluoxetine increases expression of Clock mRNA in hippocampal formation RGD Clock Rat folic acid multiple interactions ISO RGD:1552430 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CLOCK mRNA CTD PMID:22206623 Clock Rat furan increases expression ISO RGD:1552430 6480464 furan results in increased expression of CLOCK mRNA CTD PMID:24183702 Clock Rat gallic acid multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the more ... CTD PMID:29061316 Clock Rat gallocatechin multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the more ... CTD PMID:29061316 Clock Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of CLOCK mRNA CTD PMID:33387578 Clock Rat glyphosate decreases expression ISO RGD:1552430 6480464 Glyphosate results in decreased expression of CLOCK mRNA CTD PMID:36572786 Clock Rat hexadecanoic acid decreases expression ISO RGD:1552430 6480464 Palmitic Acid results in decreased expression of CLOCK mRNA; Palmitic Acid results in decreased expression more ... CTD PMID:24442997 Clock Rat hydrogen peroxide multiple interactions ISO RGD:1348034 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the more ... CTD PMID:29061316|PMID:30316844 Clock Rat hydrogen peroxide affects expression ISO RGD:1348034 6480464 Hydrogen Peroxide affects the expression of CLOCK mRNA; Hydrogen Peroxide affects the expression of CLOCK more ... CTD PMID:29061316|PMID:30316844 Clock Rat lead(0) decreases expression ISO RGD:1348034 6480464 Lead results in decreased expression of CLOCK mRNA CTD PMID:19921347 Clock Rat manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of CLOCK mRNA CTD PMID:28511934 Clock Rat melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 Clock Rat methidathion decreases expression ISO RGD:1552430 6480464 methidathion results in decreased expression of CLOCK mRNA CTD PMID:34813904 Clock Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of CLOCK mRNA CTD PMID:30047161 Clock Rat methylmercury chloride decreases expression ISO RGD:1348034 6480464 methylmercuric chloride results in decreased expression of CLOCK mRNA CTD PMID:28001369 Clock Rat N-nitrosodiethylamine multiple interactions ISO RGD:1552430 6480464 CLOCK protein promotes the reaction [Diethylnitrosamine results in increased activity of CASP3 protein]; CLOCK protein more ... CTD PMID:17942915|PMID:21167249 Clock Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNA CTD PMID:20360939 Clock Rat N-nitrosodiethylamine increases response to substance ISO RGD:1552430 6480464 CLOCK protein results in increased susceptibility to Diethylnitrosamine CTD PMID:21167249 Clock Rat N-nitrosodiethylamine increases expression ISO RGD:1552430 6480464 Diethylnitrosamine results in increased expression of CLOCK mRNA CTD PMID:17942915 Clock Rat ozone multiple interactions ISO RGD:1348034 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... CTD PMID:32699268 Clock Rat parathion decreases expression ISO RGD:1552430 6480464 Parathion results in decreased expression of CLOCK mRNA CTD PMID:34813904 Clock Rat pentanal decreases expression ISO RGD:1348034 6480464 pentanal results in decreased expression of CLOCK mRNA CTD PMID:26079696 Clock Rat perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:1552430 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CLOCK mRNA CTD PMID:36331819 Clock Rat perfluorooctanoic acid increases expression ISO RGD:1348034 6480464 perfluorooctanoic acid results in increased expression of CLOCK mRNA CTD PMID:23146750 Clock Rat phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNA CTD PMID:20360939 Clock Rat phenobarbital decreases expression ISO RGD:1552430 6480464 Phenobarbital results in decreased expression of CLOCK mRNA CTD PMID:19270015 Clock Rat pirinixic acid increases expression ISO RGD:1552430 6480464 pirinixic acid results in increased expression of CLOCK mRNA CTD PMID:23811191 Clock Rat pirinixic acid multiple interactions ISO RGD:1552430 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... CTD PMID:19710929 Clock Rat potassium chromate decreases expression ISO RGD:1348034 6480464 potassium chromate(VI) results in decreased expression of CLOCK mRNA CTD PMID:22079256 Clock Rat potassium chromate multiple interactions ISO RGD:1348034 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CLOCK mRNA CTD PMID:22079256 Clock Rat resveratrol multiple interactions ISO RGD:1552430 6480464 Resveratrol inhibits the reaction [Sodium Fluoride results in decreased expression of CLOCK protein] CTD PMID:36063856 Clock Rat rotenone multiple interactions EXP 6480464 [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Rotenone] results in decreased expression of CLOCK mRNA; more ... CTD PMID:30328585 Clock Rat sodium arsenate increases expression ISO RGD:1552430 6480464 sodium arsenate results in increased expression of CLOCK mRNA CTD PMID:21795629 Clock Rat sodium arsenite decreases expression ISO RGD:1552430 6480464 sodium arsenite results in decreased expression of CLOCK mRNA CTD PMID:30130555 Clock Rat sodium fluoride multiple interactions ISO RGD:1552430 6480464 Resveratrol inhibits the reaction [Sodium Fluoride results in decreased expression of CLOCK protein] CTD PMID:36063856 Clock Rat sodium fluoride decreases expression ISO RGD:1552430 6480464 Sodium Fluoride results in decreased expression of CLOCK mRNA; Sodium Fluoride results in decreased expression more ... CTD PMID:36063856 Clock Rat styrene decreases expression ISO RGD:1552430 6480464 Styrene results in decreased expression of CLOCK mRNA CTD PMID:28951217 Clock Rat sunitinib increases expression ISO RGD:1348034 6480464 Sunitinib results in increased expression of CLOCK mRNA CTD PMID:31533062 Clock Rat tamoxifen affects expression ISO RGD:1552430 6480464 Tamoxifen affects the expression of CLOCK mRNA CTD PMID:17555576 Clock Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CLOCK mRNA CTD PMID:31150632 Clock Rat tetraphene decreases expression ISO RGD:1552430 6480464 benz(a)anthracene results in decreased expression of CLOCK mRNA CTD PMID:26377693 Clock Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of CLOCK mRNA CTD PMID:34492290 Clock Rat titanium dioxide decreases methylation ISO RGD:1552430 6480464 titanium dioxide results in decreased methylation of CLOCK promoter CTD PMID:35295148 Clock Rat trichloroethene decreases methylation EXP 6480464 Trichloroethylene results in decreased methylation of CLOCK gene CTD PMID:27618143 Clock Rat triphenyl phosphate decreases expression EXP 6480464 triphenyl phosphate results in decreased expression of CLOCK mRNA CTD PMID:30589522 Clock Rat triphenyl phosphate affects expression ISO RGD:1348034 6480464 triphenyl phosphate affects the expression of CLOCK mRNA CTD PMID:37042841 Clock Rat valproic acid decreases expression ISO RGD:1348034 6480464 Valproic Acid results in decreased expression of CLOCK mRNA CTD PMID:23179753|PMID:28001369 Clock Rat valproic acid decreases methylation ISO RGD:1348034 6480464 Valproic Acid results in decreased methylation of CLOCK gene CTD PMID:29154799 Clock Rat vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CLOCK mRNA CTD PMID:23034163