P2ry6 (pyrimidinergic receptor P2Y6) - Rat Genome Database

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Gene: P2ry6 (pyrimidinergic receptor P2Y6) Rattus norvegicus
Analyze
Symbol: P2ry6
Name: pyrimidinergic receptor P2Y6
RGD ID: 620269
Description: Predicted to enable G protein-coupled ADP receptor activity; G protein-coupled UDP receptor activity; and G protein-coupled UTP receptor activity. Involved in several processes, including cellular response to pyrimidine ribonucleotide; positive regulation of release of sequestered calcium ion into cytosol; and positive regulation of smooth muscle cell migration. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: P2Y ATP receptor 6; P2Y purinoceptor 6; P2y6; pyrimidinergic receptor P2Y, G-protein coupled, 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,707,188 - 164,742,689 (-)NCBIGRCr8
GRCr8 Ensembl1164,706,116 - 164,743,588 (-)EnsemblGRCr8 Ensembl
mRatBN7.21155,295,110 - 155,330,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,295,111 - 155,330,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,280,542 - 163,305,882 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,460,651 - 170,485,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,344,864 - 163,369,750 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,972,439 - 166,008,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,169,438 - 172,204,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,381,127 - 158,406,783 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1153,376,657 - 153,401,528 (-)NCBICelera
RGSC_v3.11158,460,144 - 158,485,800 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
quercitrin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
UDP  (ISO)
urethane  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and functional analysis of a novel P2 nucleotide receptor. Chang K, etal., J Biol Chem 1995 Nov 3;270(44):26152-8.
2. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Koizumi S, etal., Nature. 2007 Apr 26;446(7139):1091-5. doi: 10.1038/nature05704. Epub 2007 Apr 4.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. Pillois X, etal., Circ Res 2002 Apr 5;90(6):678-81.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8670200   PMID:11259526   PMID:14764443   PMID:15489334   PMID:15722352   PMID:18250478   PMID:21317391   PMID:21323829   PMID:21879346   PMID:22728100   PMID:23479225   PMID:23941325  
PMID:24269631   PMID:24886406   PMID:25449358   PMID:28277742   PMID:31106899   PMID:31638262   PMID:35349212  


Genomics

Comparative Map Data
P2ry6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,707,188 - 164,742,689 (-)NCBIGRCr8
GRCr8 Ensembl1164,706,116 - 164,743,588 (-)EnsemblGRCr8 Ensembl
mRatBN7.21155,295,110 - 155,330,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,295,111 - 155,330,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,280,542 - 163,305,882 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,460,651 - 170,485,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,344,864 - 163,369,750 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,972,439 - 166,008,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,169,438 - 172,204,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,381,127 - 158,406,783 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1153,376,657 - 153,401,528 (-)NCBICelera
RGSC_v3.11158,460,144 - 158,485,800 (-)NCBI
Cytogenetic Map1q32NCBI
P2RY6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,264,506 - 73,298,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,264,498 - 73,305,103 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,975,551 - 73,009,670 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,653,218 - 72,687,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341172,658,586 - 72,686,497NCBI
Celera1170,280,653 - 70,314,752 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBIHuRef
CHM1_11172,859,110 - 72,893,227 (+)NCBICHM1_1
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBIT2T-CHM13v2.0
P2ry6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,586,837 - 100,628,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,586,837 - 100,623,856 (-)EnsemblGRCm39 Ensembl
GRCm387100,937,630 - 100,975,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,937,630 - 100,974,649 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,086,148 - 108,112,880 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,811,721 - 100,838,449 (-)NCBIMGSCv36mm8
Celera7101,288,708 - 101,316,203 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.46NCBI
P2ry6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,177,406 - 18,215,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,177,406 - 18,215,428 (-)NCBIChiLan1.0ChiLan1.0
P2RY6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,210,309 - 74,243,682 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,253,497 - 75,286,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,341,722 - 68,375,923 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11171,562,990 - 71,595,540 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,594,250 - 71,595,236 (+)Ensemblpanpan1.1panPan2
P2RY6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,929,502 - 24,966,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,929,771 - 24,930,757 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,693,846 - 24,731,202 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,136,107 - 25,173,439 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,136,107 - 25,173,442 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,929,647 - 24,967,004 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,130,680 - 25,168,052 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02125,045,964 - 25,083,341 (-)NCBIUU_Cfam_GSD_1.0
P2ry6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,868,422 - 60,901,890 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364982,500,128 - 2,501,114 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364982,468,020 - 2,501,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,749,375 - 7,759,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,708,452 - 7,759,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,538,019 - 8,554,097 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,508,959 - 64,543,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,541,221 - 64,542,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,343,922 - 61,369,829 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,648,829 - 3,671,852 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248173,648,829 - 3,672,051 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2ry6
171 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:511
Count of miRNA genes:265
Interacting mature miRNAs:328
Transcripts:ENSRNOT00000050227
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 89 88 57 25 57 6 216 97 11 93 45 59 31 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC072520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D63665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000050227   ⟹   ENSRNOP00000049439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,707,022 - 164,712,435 (-)Ensembl
mRatBN7.2 Ensembl1155,295,111 - 155,320,042 (-)Ensembl
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107101   ⟹   ENSRNOP00000088558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,708,085 - 164,716,391 (-)Ensembl
mRatBN7.2 Ensembl1155,295,900 - 155,302,013 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108172   ⟹   ENSRNOP00000081429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,707,760 - 164,732,398 (-)Ensembl
mRatBN7.2 Ensembl1155,295,779 - 155,321,998 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111790   ⟹   ENSRNOP00000094637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,707,786 - 164,743,588 (-)Ensembl
mRatBN7.2 Ensembl1155,295,813 - 155,312,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116084   ⟹   ENSRNOP00000087971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,707,978 - 164,713,051 (-)Ensembl
mRatBN7.2 Ensembl1155,295,801 - 155,330,808 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132449   ⟹   ENSRNOP00000104799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,708,114 - 164,723,655 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147128   ⟹   ENSRNOP00000101795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,706,155 - 164,743,202 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157075   ⟹   ENSRNOP00000104762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,706,116 - 164,743,202 (-)Ensembl
RefSeq Acc Id: NM_057124   ⟹   NP_476465
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,188 - 164,732,117 (-)NCBI
mRatBN7.21155,295,110 - 155,320,042 (-)NCBI
Rnor_6.01165,972,439 - 165,997,751 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
RGSC_v3.41158,381,127 - 158,406,783 (-)RGD
Celera1153,376,657 - 153,401,528 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229712   ⟹   XP_006229774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,732,209 (-)NCBI
mRatBN7.21155,295,871 - 155,320,178 (-)NCBI
Rnor_6.01165,973,200 - 165,999,087 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229713   ⟹   XP_006229775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,742,689 (-)NCBI
mRatBN7.21155,295,871 - 155,330,610 (-)NCBI
Rnor_6.01165,973,200 - 166,008,348 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229715   ⟹   XP_006229777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,732,209 (-)NCBI
mRatBN7.21155,295,871 - 155,320,178 (-)NCBI
Rnor_6.01165,973,200 - 165,999,087 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078872   ⟹   XP_038934800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,742,607 (-)NCBI
mRatBN7.21155,295,871 - 155,330,533 (-)NCBI
RefSeq Acc Id: XM_063268010   ⟹   XP_063124080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,717,139 (-)NCBI
RefSeq Acc Id: NP_476465   ⟸   NM_057124
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229775   ⟸   XM_006229713
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229774   ⟸   XM_006229712
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229777   ⟸   XM_006229715
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049439   ⟸   ENSRNOT00000050227
RefSeq Acc Id: XP_038934800   ⟸   XM_039078872
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081429   ⟸   ENSRNOT00000108172
Ensembl Acc Id: ENSRNOP00000088558   ⟸   ENSRNOT00000107101
Ensembl Acc Id: ENSRNOP00000087971   ⟸   ENSRNOT00000116084
Ensembl Acc Id: ENSRNOP00000094637   ⟸   ENSRNOT00000111790
RefSeq Acc Id: XP_063124080   ⟸   XM_063268010
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104799   ⟸   ENSRNOT00000132449
Ensembl Acc Id: ENSRNOP00000104762   ⟸   ENSRNOT00000157075
Ensembl Acc Id: ENSRNOP00000101795   ⟸   ENSRNOT00000147128
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63371-F1-model_v2 AlphaFold Q63371 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690251
Promoter ID:EPDNEW_R776
Type:single initiation site
Name:P2ry6_1
Description:pyrimidinergic receptor P2Y6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,997,727 - 165,997,787EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620269 AgrOrtholog
BioCyc Gene G2FUF-58310 BioCyc
Ensembl Genes ENSRNOG00000019270 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050227 ENTREZGENE
  ENSRNOT00000050227.3 UniProtKB/Swiss-Prot
  ENSRNOT00000107101 ENTREZGENE
  ENSRNOT00000107101.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108172 ENTREZGENE
  ENSRNOT00000108172.1 UniProtKB/Swiss-Prot
  ENSRNOT00000111790.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116084.1 UniProtKB/Swiss-Prot
  ENSRNOT00000147128 ENTREZGENE
  ENSRNOT00000157075 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105972 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  P2Y6_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:117264 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91535 IMAGE-MGC_LOAD
NCBI Gene 117264 ENTREZGENE
PANTHER P2Y PURINOCEPTOR 6 UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen P2ry6 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  P2Y6PRNOCPTR UniProtKB/Swiss-Prot
  P2YPURNOCPTR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019270 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6I6S4 ENTREZGENE, UniProtKB/TrEMBL
  P2RY6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry6  pyrimidinergic receptor P2Y6  P2ry6  pyrimidinergic receptor P2Y, G-protein coupled, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 P2ry6  pyrimidinergic receptor P2Y, G-protein coupled, 6      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_process mediates vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_regulation activated only by UDP 628452