Eif4ebp1 (eukaryotic translation initiation factor 4E binding protein 1) - Rat Genome Database

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Gene: Eif4ebp1 (eukaryotic translation initiation factor 4E binding protein 1) Rattus norvegicus
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
RGD ID: 620259
Description: Enables eukaryotic initiation factor 4E binding activity and protein phosphatase 2A binding activity. Involved in several processes, including cellular response to hypoxia; response to amino acid starvation; and response to ischemia. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study tuberous sclerosis. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1); PARTICIPATES IN insulin signaling pathway; mTOR signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-octadec-9-enoylglycero-3-phosphate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4E-BP1; eIF4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; phosphorylated heat- and acid-stable protein regulated by insulin 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81671,495,457 - 71,508,845 (-)NCBIGRCr8
mRatBN7.21664,792,595 - 64,805,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,790,226 - 64,805,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,075,417 - 70,089,698 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,481,763 - 73,496,043 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,727,984 - 68,741,372 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01668,954,860 - 68,968,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1668,954,875 - 68,968,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,580,263 - 68,593,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,110,522 - 69,123,895 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,110,729 - 69,124,101 (-)NCBI
Celera1662,716,014 - 62,729,409 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-methyl-GTP  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP)
AICA ribonucleotide  (EXP,ISO)
alachlor  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amino acid  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
antroquinonol  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (EXP)
Bardoxolone methyl  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
berberine  (ISO)
betulin  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butan-1-ol  (EXP)
butan-2-ol  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calyculin a  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (EXP)
chloroquine  (EXP)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
Corynoxine B  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanamide  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucitol  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP,ISO)
Dictamnine  (ISO)
diethylstilbestrol  (EXP)
digitoxin  (ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
everolimus  (ISO)
fenamidone  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
frenolicin B  (ISO)
furan  (EXP)
glucose  (EXP,ISO)
glycidyl methacrylate  (ISO)
gossypol  (ISO)
GSK690693  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
KN-93  (EXP)
Ku-0063794  (ISO)
L-cysteine  (EXP)
L-ethionine  (EXP)
L-methionine  (EXP)
lamivudine  (ISO)
lead nitrate  (EXP)
letrozole  (ISO)
LY294002  (EXP,ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
melatonin  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
MK-2206  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodimethylamine  (EXP)
N-succinylsulfathiazole  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nimesulide  (EXP)
ochratoxin A  (EXP)
omeprazole  (EXP)
omipalisib  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
picoxystrobin  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
pomalidomide  (ISO)
progesterone  (EXP)
prothioconazole  (ISO)
puerarin  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
SB 431542  (ISO)
selumetinib  (ISO)
Shikonin  (ISO)
simvastatin  (ISO)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sorafenib  (EXP,ISO)
stilbenoid  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
swainsonine  (ISO)
tacrolimus hydrate  (ISO)
tebufenpyrad  (ISO)
Temsirolimus  (ISO)
teriflunomide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thioridazine  (ISO)
Thiorphan  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
torin 1  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
vandetanib  (ISO)
wortmannin  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats. Anthony TG, etal., Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E430-9.
2. New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress. Ayuso MI, etal., J Biol Chem. 2010 Nov 5;285(45):34355-63. doi: 10.1074/jbc.M110.135103. Epub 2010 Aug 24.
3. Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells. Bishop JD, etal., J Endocrinol. 2006 Aug;190(2):307-12.
4. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Brunn GJ, etal., Science. 1997 Jul 4;277(5322):99-101.
5. Inhibition of Cap-initiation complexes linked to a novel mechanism of eIF4G depletion in acute myocardial ischemia. Connolly EP, etal., Cell Death Differ. 2006 Sep;13(9):1586-94. Epub 2006 Jan 27.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Gingras AC, etal., Genes Dev. 1999 Jun 1;13(11):1422-37.
8. Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors. Hu C, etal., Proc Natl Acad Sci U S A 1994 Apr 26;91(9):3730-4.
9. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Kenerson HL, etal., Cancer Res 2002 Oct 15;62(20):5645-50.
10. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation. Kim JE and Chen J, Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14340-5.
11. Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. Lin TA, etal., J Biol Chem 1995 Aug 4;270(31):18531-8.
12. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
13. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Global and gene-specific translational regulation in rat lung development. Otulakowski G, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):555-67. Epub 2008 Oct 23.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
22. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Tang SJ, etal., Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72. doi: 10.1073/pnas.012605299. Epub 2001 Dec 26.
23. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Tee AR and Proud CG, Mol Cell Biol. 2002 Mar;22(6):1674-83.
24. Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes. Tinton SA and Buc-Calderon PM, FEBS Lett. 1999 Mar 5;446(1):55-9.
25. Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling. Vary TC, etal., Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H121-8. Epub 2004 Sep 23.
26. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Yang DQ and Kastan MB, Nat Cell Biol 2000 Dec;2(12):893-8.
Additional References at PubMed
PMID:7939721   PMID:8083223   PMID:8889548   PMID:9092573   PMID:10471835   PMID:11319880   PMID:12150926   PMID:14607835   PMID:14673156   PMID:15010853   PMID:15351722   PMID:15389631  
PMID:15494402   PMID:15767663   PMID:15907373   PMID:16010989   PMID:16142217   PMID:16236269   PMID:16306159   PMID:17556672   PMID:17588536   PMID:18097751   PMID:18187610   PMID:18215131  
PMID:20399760   PMID:21228503   PMID:22021677   PMID:22578813   PMID:23814182   PMID:23934994   PMID:24403073   PMID:24553947   PMID:25200811   PMID:25304210   PMID:26706460   PMID:27313212  
PMID:28041982   PMID:29761560   PMID:32208000   PMID:34874016  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81671,495,457 - 71,508,845 (-)NCBIGRCr8
mRatBN7.21664,792,595 - 64,805,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,790,226 - 64,805,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,075,417 - 70,089,698 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,481,763 - 73,496,043 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,727,984 - 68,741,372 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01668,954,860 - 68,968,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1668,954,875 - 68,968,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,580,263 - 68,593,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,110,522 - 69,123,895 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,110,729 - 69,124,101 (-)NCBI
Celera1662,716,014 - 62,729,409 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38838,030,534 - 38,060,365 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,030,534 - 38,060,365 (+)EnsemblGRCh38hg38GRCh38
GRCh37837,888,052 - 37,917,883 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,007,177 - 38,037,040 (+)NCBINCBI36Build 36hg18NCBI36
Build 34838,007,184 - 38,037,033NCBI
Celera836,839,744 - 36,869,730 (+)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,422,762 - 36,452,631 (+)NCBIHuRef
CHM1_1838,089,511 - 38,119,376 (+)NCBICHM1_1
T2T-CHM13v2.0838,306,935 - 38,336,767 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39827,750,355 - 27,765,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl827,750,357 - 27,766,702 (+)EnsemblGRCm39 Ensembl
GRCm38827,260,327 - 27,275,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl827,260,329 - 27,276,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv37828,370,799 - 28,386,128 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36828,726,338 - 28,742,604 (+)NCBIMGSCv36mm8
Celera828,750,731 - 28,766,068 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map815.95NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495546313,702,434 - 13,720,875 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,702,434 - 13,720,875 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2756,597,290 - 56,623,385 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,314,289 - 32,340,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,336,698 - 37,362,768 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,513,276 - 34,539,170 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,513,359 - 34,538,936 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11627,389,850 - 27,410,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,390,181 - 27,410,110 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,907,070 - 27,927,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,288,782 - 29,309,298 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,289,113 - 29,309,320 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,511,040 - 27,531,340 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,088,513 - 28,108,833 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,127,776 - 28,148,089 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494349,999,266 - 50,015,195 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367101,446,030 - 1,461,945 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1548,422,816 - 48,443,399 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,423,001 - 48,443,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,557,800 - 55,560,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1836,063,311 - 36,092,439 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660525,902,191 - 5,931,737 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247805,543,117 - 5,561,261 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,543,117 - 5,561,285 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Eif4ebp1
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:47
Interacting mature miRNAs:51
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 48 24 36 11 8
Low 26 11 5
Below cutoff


RefSeq Acc Id: ENSRNOT00000016885   ⟹   ENSRNOP00000016885
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1664,793,676 - 64,805,984 (-)Ensembl
Rnor_6.0 Ensembl1668,954,875 - 68,968,248 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096679   ⟹   ENSRNOP00000087155
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1664,790,226 - 64,805,937 (-)Ensembl
RefSeq Acc Id: NM_053857   ⟹   NP_446309
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81671,495,457 - 71,508,845 (-)NCBI
mRatBN7.21664,792,595 - 64,805,984 (-)NCBI
Rnor_6.01668,954,860 - 68,968,248 (-)NCBI
Rnor_5.01668,580,263 - 68,593,651 (-)NCBI
RGSC_v3.41669,110,522 - 69,123,895 (-)RGD
Celera1662,716,014 - 62,729,409 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446309 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA86938 (Get FASTA)   NCBI Sequence Viewer  
  EDM09101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016885.4
GenBank Protein Q62622 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446309   ⟸   NM_053857
- UniProtKB: Q62622 (UniProtKB/Swiss-Prot),   A0A8L2Q998 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016885   ⟸   ENSRNOT00000016885
RefSeq Acc Id: ENSRNOP00000087155   ⟸   ENSRNOT00000096679

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62622-F1-model_v2 AlphaFold Q62622 1-117 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700151
Promoter ID:EPDNEW_R10675
Type:initiation region
Description:eukaryotic translation initiation factor 4E binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01668,968,227 - 68,968,287EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620259 AgrOrtholog
BioCyc Gene G2FUF-11037 BioCyc
Ensembl Genes ENSRNOG00000012582 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007988 UniProtKB/Swiss-Prot
  ENSRNOG00060012306 UniProtKB/Swiss-Prot
  ENSRNOG00065002728 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016885.6 UniProtKB/TrEMBL
  ENSRNOT00000096679.1 UniProtKB/Swiss-Prot
  ENSRNOT00055013467 UniProtKB/Swiss-Prot
  ENSRNOT00060020858 UniProtKB/Swiss-Prot
  ENSRNOT00065003710 UniProtKB/Swiss-Prot
InterPro EIF4EBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116636 UniProtKB/Swiss-Prot
  PTHR12669:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam eIF_4EBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif4ebp1 PhenoGen
RatGTEx ENSRNOG00000012582 RatGTEx
  ENSRNOG00055007988 RatGTEx
  ENSRNOG00060012306 RatGTEx
  ENSRNOG00065002728 RatGTEx
UniProt 4EBP1_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Eif4ebp1  eukaryotic translation initiation factor 4E binding protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Eif4ebp1  eukaryotic translation initiation factor 4E binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in fat and skeletal muscle 632512