Abcb4 (ATP binding cassette subfamily B member 4) - Rat Genome Database

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Gene: Abcb4 (ATP binding cassette subfamily B member 4) Rattus norvegicus
Analyze
Symbol: Abcb4
Name: ATP binding cassette subfamily B member 4
RGD ID: 620248
Description: Predicted to enable ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in response to glucocorticoid and response to xenobiotic stimulus. Located in Golgi membrane and apical plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in cholestasis (multiple) and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4); PARTICIPATES IN multidrug resistance protein mediated transport pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; 1,9-dideoxyforskolin; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2; ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette sub-family B member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette, subfamily B (MDR/TAP), member 4; ATP-binding cassette, subfamily B, member 4; Mdr2; multidrug resistance protein 2; multidrug resistance protein 3; P-glycoprotein 2; P-glycoprotein 3; P-glycoprotein 3/ multidrug resistance 2; Pgy3; phosphatidylcholine translocator ABCB4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,106,895 - 26,164,440 (-)NCBIGRCr8
mRatBN7.2425,150,998 - 25,209,489 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,151,953 - 25,209,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,150,422 - 30,207,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,076,666 - 26,134,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,463,506 - 24,520,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,133,984 - 22,192,687 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,070,806 - 22,128,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,946,274 - 22,004,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1421,946,273 - 22,004,328 (+)NCBI
Celera420,645,103 - 20,702,285 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+/-)-Aegeline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,9-dideoxyforskolin  (EXP)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
AB-Fubinaca  (EXP)
adefovir  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (EXP)
beclomethasone  (ISO)
benzarone  (ISO)
benzatropine  (ISO)
benzbromarone  (ISO)
benziodarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
biperiden  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
bromosulfophthalein  (EXP)
brompheniramine  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (EXP)
Calphostin C  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chlorphenamine  (ISO)
chlorpromazine  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
ciprofibrate  (ISO)
clavulanic acid  (ISO)
clemastine  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dihydroergotamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (EXP)
doxylamine  (ISO)
ebrotidine  (ISO)
emodin  (EXP)
entinostat  (ISO)
esmolol  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
Finrozole  (ISO)
flutamide  (EXP,ISO)
fluvoxamine  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyburide  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
guanethidine  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
herbicide  (ISO)
hydroxyzine  (ISO)
indocyanine green  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (EXP,ISO)
labetalol  (ISO)
lapatinib  (ISO)
leflunomide  (EXP,ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
loratadine  (ISO)
LY-2157299  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methyltestosterone  (ISO)
methysergide  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP,ISO)
nitrofurantoin  (ISO)
nomifensine  (ISO)
nortriptyline  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
omeprazole  (ISO)
oxaliplatin  (EXP)
oxybutynin  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pazopanib  (ISO)
penbutolol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (EXP,ISO)
permethrin  (EXP)
phenazopyridine  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
physcion  (EXP)
pirinixic acid  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
primaquine  (ISO)
procyclidine  (ISO)
procymidone  (EXP)
propiconazole  (ISO)
protriptyline  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
soybean oil  (EXP)
streptozocin  (EXP)
tacrine  (ISO)
tamoxifen  (EXP,ISO)
tamsulosin  (ISO)
tartrazine  (ISO)
tasosartan  (ISO)
taurocholic acid  (EXP)
Technetium tc 99m sestamibi  (ISO)
tenofovir disoproxil fumarate  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP,ISO)
thioacetamide  (EXP)
tipranavir  (ISO)
titanium dioxide  (ISO)
tolterodine tartrate  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
verapamil  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)
yohimbine  (ISO)
zafirlukast  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice. Aronson SJ, etal., J Hepatol. 2019 Jul;71(1):153-162. doi: 10.1016/j.jhep.2019.03.021. Epub 2019 Mar 29.
2. Cloning and regulation of the rat mdr2 gene. Brown PC, etal., Nucleic Acids Res 1993 Aug 11;21(16):3885-91.
3. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. de Vree JM, etal., Proc Natl Acad Sci U S A 1998 Jan 6;95(1):282-7.
4. ABCB4 mutations in adult patients with cholestatic liver disease: impact and phenotypic expression. Degiorgio D, etal., J Gastroenterol. 2016 Mar;51(3):271-80. doi: 10.1007/s00535-015-1110-z. Epub 2015 Sep 1.
5. Identification of distinct P-glycoprotein gene sequences in rat. Deuchars KL, etal., Biochim Biophys Acta 1992 Mar 24;1130(2):157-65.
6. Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Fickert P, etal., Gastroenterology. 2004 Jul;127(1):261-74.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults. Gotthardt D, etal., Hepatology. 2008 Oct;48(4):1157-66. doi: 10.1002/hep.22485.
9. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
10. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats. Hooiveld GJ, etal., Gastroenterology. 1999 Sep;117(3):678-87.
11. Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model. Hyogo H, etal., Dig Dis Sci. 2001 Oct;46(10):2089-97.
12. ABCB4 mutations underlie hormonal cholestasis but not pediatric idiopathic gallstones. Jirsa M, etal., World J Gastroenterol. 2014 May 21;20(19):5867-74. doi: 10.3748/wjg.v20.i19.5867.
13. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. Kipp H and Arias IM, J Biol Chem. 2000 May 26;275(21):15917-25.
14. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
15. Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes. Luttringer O, etal., Biochem Pharmacol. 2002 Dec 1;64(11):1637-50.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis. Nakken KE, etal., Scand J Gastroenterol. 2007 Oct;42(10):1245-55. doi: 10.1080/00365520701320521.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Single-nucleotide polymorphism analysis of the multidrug resistance protein 3 gene for the detection of clinical progression in Japanese patients with primary biliary cirrhosis. Ohishi Y, etal., Hepatology. 2008 Sep;48(3):853-62. doi: 10.1002/hep.22382.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
22. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Paulusma CC, etal., Science 1996 Feb 23;271(5252):1126-8.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Smit JJ, etal., Cell 1993 Nov 5;75(3):451-62.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. An MBL2 haplotype and ABCB4 variants modulate the risk of liver disease in cystic fibrosis patients: a multicentre study. Tomaiuolo R, etal., Dig Liver Dis. 2009 Nov;41(11):817-22. Epub 2009 May 20.
30. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
31. Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. van Waarde WM, etal., Gastroenterology. 2002 Jun;122(7):1842-52.
32. ABCB4 heterozygous gene mutations associated with fibrosing cholestatic liver disease in adults. Ziol M, etal., Gastroenterology. 2008 Jul;135(1):131-41. doi: 10.1053/j.gastro.2008.03.044. Epub 2008 Mar 26.
Additional References at PubMed
PMID:1990275   PMID:7948020   PMID:8615769   PMID:8898203   PMID:11279518   PMID:12068294   PMID:17065236   PMID:17523162   PMID:19674157   PMID:20107068   PMID:22324395   PMID:23486593  
PMID:23533145   PMID:24045840   PMID:24806754  


Genomics

Comparative Map Data
Abcb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,106,895 - 26,164,440 (-)NCBIGRCr8
mRatBN7.2425,150,998 - 25,209,489 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,151,953 - 25,209,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,150,422 - 30,207,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,076,666 - 26,134,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,463,506 - 24,520,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,133,984 - 22,192,687 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,070,806 - 22,128,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,946,274 - 22,004,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1421,946,273 - 22,004,328 (+)NCBI
Celera420,645,103 - 20,702,285 (-)NCBICelera
Cytogenetic Map4q12NCBI
ABCB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38787,365,896 - 87,476,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl787,401,696 - 87,480,435 (-)EnsemblGRCh38hg38GRCh38
GRCh37787,031,012 - 87,104,996 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,869,297 - 86,942,955 (-)NCBINCBI36Build 36hg18NCBI36
Build 34786,676,016 - 86,754,402NCBI
Celera781,736,239 - 81,809,903 (-)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef781,642,357 - 81,716,022 (-)NCBIHuRef
CHM1_1786,961,467 - 87,035,121 (-)NCBICHM1_1
T2T-CHM13v2.0788,615,509 - 88,726,299 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2786,362,871 - 86,436,531 (-)NCBI
Abcb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,943,614 - 9,009,226 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,943,717 - 9,009,231 (+)EnsemblGRCm39 Ensembl
GRCm3858,893,614 - 8,959,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,893,717 - 8,959,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,893,721 - 8,959,226 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,899,723 - 8,965,232 (+)NCBIMGSCv36mm8
Celera58,813,446 - 8,878,635 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
ABCB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26105,280,962 - 105,354,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17153,545,250 - 153,619,385 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0779,395,924 - 79,469,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1793,046,085 - 93,119,439 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,046,085 - 93,119,439 (-)Ensemblpanpan1.1panPan2
ABCB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,542,610 - 13,614,334 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,548,462 - 13,614,571 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,114,115 - 13,185,936 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01413,307,604 - 13,379,530 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1413,307,601 - 13,379,692 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11413,510,779 - 13,582,706 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,236,739 - 13,308,588 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01413,520,259 - 13,592,210 (-)NCBIUU_Cfam_GSD_1.0
Abcb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,585,866 - 26,661,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367631,339,824 - 1,415,586 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367631,339,849 - 1,415,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1993,171,371 - 93,262,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,651,665 - 102,741,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,459,344 - 61,529,017 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604242,535,591 - 42,605,958 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Abcb4
222 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:104
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000043822
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19

Sequence


Ensembl Acc Id: ENSRNOT00000043822   ⟹   ENSRNOP00000042556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,151,956 - 25,209,202 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094965   ⟹   ENSRNOP00000097106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,151,953 - 25,209,202 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095305   ⟹   ENSRNOP00000090279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,151,956 - 25,208,984 (-)Ensembl
RefSeq Acc Id: NM_012690   ⟹   NP_036822
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,106,903 - 26,164,145 (-)NCBI
mRatBN7.2425,151,956 - 25,209,200 (-)NCBI
Rnor_6.0422,134,805 - 22,192,472 (-)NCBI
Rnor_5.0422,070,806 - 22,128,781 (-)NCBI
RGSC_v3.4421,946,274 - 22,004,328 (+)RGD
Celera420,645,103 - 20,702,285 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235999   ⟹   XP_006236061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,106,895 - 26,158,332 (-)NCBI
mRatBN7.2425,150,998 - 25,203,388 (-)NCBI
Rnor_6.0422,133,984 - 22,186,777 (-)NCBI
Rnor_5.0422,070,806 - 22,128,781 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762697   ⟹   XP_008760919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,106,895 - 26,164,326 (-)NCBI
mRatBN7.2425,150,998 - 25,209,392 (-)NCBI
Rnor_6.0422,133,984 - 22,192,659 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592474   ⟹   XP_017447963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,106,895 - 26,164,440 (-)NCBI
mRatBN7.2425,150,998 - 25,209,489 (-)NCBI
Rnor_6.0422,133,984 - 22,192,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107075   ⟹   XP_038963003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,106,895 - 26,151,251 (-)NCBI
mRatBN7.2425,150,998 - 25,203,551 (-)NCBI
RefSeq Acc Id: NP_036822   ⟸   NM_012690
- UniProtKB: Q78E07 (UniProtKB/Swiss-Prot),   Q08201 (UniProtKB/Swiss-Prot),   A6K233 (UniProtKB/TrEMBL),   G3V9C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236061   ⟸   XM_006235999
- Peptide Label: isoform X2
- UniProtKB: A6K233 (UniProtKB/TrEMBL),   G3V9C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760919   ⟸   XM_008762697
- Peptide Label: isoform X1
- UniProtKB: A6K233 (UniProtKB/TrEMBL),   G3V9C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447963   ⟸   XM_017592474
- Peptide Label: isoform X3
- UniProtKB: A6K233 (UniProtKB/TrEMBL),   G3V9C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038963003   ⟸   XM_039107075
- Peptide Label: isoform X4
- UniProtKB: A6K233 (UniProtKB/TrEMBL),   G3V9C8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097106   ⟸   ENSRNOT00000094965
Ensembl Acc Id: ENSRNOP00000042556   ⟸   ENSRNOT00000043822
Ensembl Acc Id: ENSRNOP00000090279   ⟸   ENSRNOT00000095305
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08201-F1-model_v2 AlphaFold Q08201 1-1278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692827
Promoter ID:EPDNEW_R3352
Type:initiation region
Name:Abcb1b_2
Description:ATP-binding cassette, subfamily B (MDR/TAP), member 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3353  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0422,192,467 - 22,192,527EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620248 AgrOrtholog
BioCyc Gene G2FUF-45832 BioCyc
Ensembl Genes ENSRNOG00000008012 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000068001 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011166.6 UniProtKB/TrEMBL
  ENSRNOT00000043822.2 UniProtKB/TrEMBL
  ENSRNOT00000094965.1 UniProtKB/TrEMBL
  ENSRNOT00000095305.1 UniProtKB/TrEMBL
  ENSRNOT00000096021.1 UniProtKB/TrEMBL
  ENSRNOT00000100110.1 UniProtKB/TrEMBL
  ENSRNOT00000101034.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24891 UniProtKB/Swiss-Prot
NCBI Gene 24891 ENTREZGENE
PANTHER ABC TRANSPORTER B FAMILY UniProtKB/TrEMBL
  ALPHA-FACTOR-TRANSPORTING ATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYCOBACTIN IMPORT ATP-BINDING/PERMEASE PROTEIN IRTB UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCB4 RGD
PhenoGen Abcb4 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008012 RatGTEx
  ENSRNOG00000068001 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC210446
UniProt A0A8I5Y6F1_RAT UniProtKB/TrEMBL
  A0A8I5ZY39_RAT UniProtKB/TrEMBL
  A0A8I6AMR4_RAT UniProtKB/TrEMBL
  A0A8I6ATW0_RAT UniProtKB/TrEMBL
  A0A8I6GMN6_RAT UniProtKB/TrEMBL
  A6K233 ENTREZGENE, UniProtKB/TrEMBL
  F7FKA8_RAT UniProtKB/TrEMBL
  G3V9C8 ENTREZGENE, UniProtKB/TrEMBL
  MDR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q78E07 ENTREZGENE
UniProt Secondary Q78E07 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Abcb4  ATP binding cassette subfamily B member 4  Abcb4  ATP-binding cassette, subfamily B (MDR/TAP), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcb4  ATP-binding cassette, subfamily B (MDR/TAP), member 4  Abcb4  ATP-binding cassette, sub-family B (MDR/TAP), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Abcb4  ATP-binding cassette, sub-family B (MDR/TAP), member 4      Symbol and Name updated 629477 APPROVED
2003-03-06 Abcb4  ATP-binding cassette, sub-family B (MDR/TAP), member 4  Pgy3  P-glycoprotein 3/ multidrug resistance 2  Data merged from RGD:3320 628472 PROVISIONAL
2002-08-07 Abcb4        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pgy3  P-glycoprotein 3/ multidrug resistance 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease increased hepatic expression occurs in streptozotocin induced diabetic rats 724707
gene_expression expression reduced in response to certain types of liver damage 70249
gene_process responsible for decreased drug accumulation in multidrug-resistant cells 724707