Snap29 (synaptosome associated protein 29) - Rat Genome Database

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Gene: Snap29 (synaptosome associated protein 29) Rattus norvegicus
Analyze
Symbol: Snap29
Name: synaptosome associated protein 29
RGD ID: 620225
Description: Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in regulation of synaptic vesicle cycle and regulation of synaptic vesicle exocytosis. Located in terminal bouton. Is active in synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Orthologous to human SNAP29 (synaptosome associated protein 29); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: golgi SNARE of 32 kDa; Gs32; MGC105273; SNAP-29; soluble 29 kDa NSF attachment protein; synaptosomal-associated protein 29; synaptosomal-associated protein 29kD; synaptosomal-associated protein, 29kD; vesicle-membrane fusion protein SNAP-29
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,082,721 - 97,113,195 (-)NCBIGRCr8
mRatBN7.21183,578,479 - 83,608,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,578,489 - 83,608,958 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,306,158 - 92,336,737 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,967,310 - 84,997,887 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,020,918 - 84,051,495 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,827,633 - 87,858,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,827,651 - 87,858,107 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,883,352 - 90,914,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,579,141 - 85,609,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,619,738 - 85,650,439 (-)NCBI
Celera1182,342,398 - 82,372,753 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions. Pabst S, etal., J Biol Chem 2000 Jun 30;275(26):19808-18.
7. SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons. Pan PY, etal., J Biol Chem. 2005 Jul 8;280(27):25769-79. doi: 10.1074/jbc.M502356200. Epub 2005 May 12.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. Rotem-Yehudar R, etal., J Biol Chem. 2001 Aug 31;276(35):33054-60. Epub 2001 Jun 21.
12. SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission. Su Q, etal., Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14038-43. doi: 10.1073/pnas.251532398. Epub 2001 Nov 13.
13. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
14. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
15. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
16. Mutually exclusive interactions of EHD1 with GS32 and syndapin II. Xu Y, etal., Mol Membr Biol. 2004 Jul-Aug;21(4):269-77.
Additional References at PubMed
PMID:9880331   PMID:12477932   PMID:23185475   PMID:23217709   PMID:25468996   PMID:25686250   PMID:25686604   PMID:27628032   PMID:33754017   PMID:34800366  


Genomics

Comparative Map Data
Snap29
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,082,721 - 97,113,195 (-)NCBIGRCr8
mRatBN7.21183,578,479 - 83,608,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,578,489 - 83,608,958 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,306,158 - 92,336,737 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,967,310 - 84,997,887 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,020,918 - 84,051,495 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,827,633 - 87,858,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,827,651 - 87,858,107 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,883,352 - 90,914,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,579,141 - 85,609,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,619,738 - 85,650,439 (-)NCBI
Celera1182,342,398 - 82,372,753 (-)NCBICelera
Cytogenetic Map11q23NCBI
SNAP29
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,859,007 - 20,891,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,859,007 - 20,891,214 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,213,295 - 21,245,502 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,543,292 - 19,574,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,537,845 - 19,568,663NCBI
Celera224,704,631 - 4,736,842 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,481,433 - 4,513,635 (+)NCBIHuRef
CHM1_12221,213,478 - 21,245,708 (+)NCBICHM1_1
T2T-CHM13v2.02221,267,728 - 21,299,920 (+)NCBIT2T-CHM13v2.0
Snap29
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,223,864 - 17,248,690 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,223,850 - 17,248,691 (+)EnsemblGRCm39 Ensembl
GRCm381617,406,000 - 17,430,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,405,986 - 17,430,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,406,093 - 17,430,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,319,614 - 17,344,386 (+)NCBIMGSCv36mm8
Celera1617,978,957 - 18,003,859 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.79NCBI
Snap29
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,419,821 - 19,446,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,419,381 - 19,446,782 (-)NCBIChiLan1.0ChiLan1.0
SNAP29
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,565,341 - 30,598,111 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,114,289 - 33,143,796 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,082,622 - 3,115,325 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12219,572,675 - 19,604,943 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,572,618 - 19,605,931 (+)Ensemblpanpan1.1panPan2
SNAP29
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,606,195 - 30,630,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,609,158 - 30,630,262 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,564,536 - 30,588,777 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,014,732 - 32,038,982 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,014,976 - 32,038,981 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,060,478 - 30,084,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,685,160 - 29,709,411 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,774,254 - 30,798,700 (-)NCBIUU_Cfam_GSD_1.0
Snap29
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,348,833 - 140,376,865 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,376,815 - 2,401,967 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,377,284 - 2,402,049 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNAP29
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,492,187 - 50,511,456 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,492,187 - 50,511,475 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,940,923 - 53,955,920 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNAP29
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,797,690 - 4,827,573 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,797,725 - 4,830,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,177,660 - 2,209,408 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snap29
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945801,833 - 837,564 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945799,831 - 837,720 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Snap29
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:719
Count of miRNA genes:301
Interacting mature miRNAs:400
Transcripts:ENSRNOT00000002550
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

Markers in Region
BI274180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,578,852 - 83,579,015 (+)MAPPERmRatBN7.2
Rnor_6.01187,828,007 - 87,828,169NCBIRnor6.0
Rnor_5.01190,883,731 - 90,883,893UniSTSRnor5.0
RGSC_v3.41185,579,515 - 85,579,677UniSTSRGSC3.4
Celera1182,342,747 - 82,342,909UniSTS
RH 3.4 Map11714.3UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002550   ⟹   ENSRNOP00000002550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,578,489 - 83,608,958 (-)Ensembl
Rnor_6.0 Ensembl1187,827,651 - 87,858,107 (-)Ensembl
RefSeq Acc Id: NM_053810   ⟹   NP_446262
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,082,721 - 97,113,195 (-)NCBI
mRatBN7.21183,578,479 - 83,608,953 (-)NCBI
Rnor_6.01187,827,633 - 87,858,107 (-)NCBI
Rnor_5.01190,883,352 - 90,914,051 (-)NCBI
RGSC_v3.41185,579,141 - 85,609,842 (-)RGD
Celera1182,342,398 - 82,372,753 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446262 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC72291 (Get FASTA)   NCBI Sequence Viewer  
  AAF69517 (Get FASTA)   NCBI Sequence Viewer  
  AAH91693 (Get FASTA)   NCBI Sequence Viewer  
  EDL77889 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002550.5
GenBank Protein Q9Z2P6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446262   ⟸   NM_053810
- UniProtKB: Q9JI56 (UniProtKB/TrEMBL),   Q5BIZ8 (UniProtKB/TrEMBL),   F7FPA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002550   ⟸   ENSRNOT00000002550
Protein Domains
t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2P6-F1-model_v2 AlphaFold Q9Z2P6 1-257 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698328
Promoter ID:EPDNEW_R8853
Type:initiation region
Name:Snap29_1
Description:synaptosome associated protein 29
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,858,148 - 87,858,208EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620225 AgrOrtholog
BioCyc Gene G2FUF-20587 BioCyc
Ensembl Genes ENSRNOG00000001867 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002550.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134635 IMAGE-MGC_LOAD
InterPro T_SNARE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116500 UniProtKB/TrEMBL
MGC_CLONE MGC:105273 IMAGE-MGC_LOAD
NCBI Gene 116500 ENTREZGENE
PANTHER SYNAPTOSOMAL ASSOCIATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTOSOMAL-ASSOCIATED PROTEIN 29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Snap29 PhenoGen
PROSITE T_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001867 RatGTEx
SMART t_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7FPA1 ENTREZGENE, UniProtKB/TrEMBL
  Q5BIZ8 ENTREZGENE, UniProtKB/TrEMBL
  Q9JI56 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z2P6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Snap29  synaptosome associated protein 29  Snap29  synaptosomal-associated protein 29  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Snap29  synaptosomal-associated protein 29  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Snap29  synaptosomal-associated protein 29    synaptosomal-associated protein, 29kD  Name updated 1299863 APPROVED
2002-08-07 Snap29  synaptosomal-associated protein, 29kD      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process controls membrane fusion by interacting with other members of the family