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Gene: Slc5a2 (solute carrier family 5 member 2) Rattus norvegicus
Symbol: Slc5a2
Name: solute carrier family 5 member 2
Description: Exhibits glucose:sodium symporter activity. Involved in glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Localizes to brush border membrane and integral component of membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2); PARTICIPATES IN sodium-glucose cotransporter mediated glucose transport pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: low affinity Na-dependent glucose transporter (SGLT2); low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 2; Sglt2; sodium/glucose cotransporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 2
Homo sapiens (human) : SLC5A2 (solute carrier family 5 member 2)  HGNC  Alliance
Mus musculus (house mouse) : Slc5a2 (solute carrier family 5 (sodium/glucose cotransporter), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc5a2 (solute carrier family 5 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC5A2 (solute carrier family 5 member 2)
Canis lupus familiaris (dog) : SLC5A2 (solute carrier family 5 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc5a2 (solute carrier family 5 member 2)
Sus scrofa (pig) : SLC5A2 (solute carrier family 5 member 2)
Chlorocebus sabaeus (African green monkey) : SLC5A2 (solute carrier family 5 member 2)
Heterocephalus glaber (naked mole-rat) : Slc5a2 (solute carrier family 5 member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01199,682,688 - 199,688,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,682,688 - 199,688,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,728,635 - 206,734,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,523,230 - 187,529,351 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,673,110 - 187,679,232 (+)NCBI
Celera1180,493,106 - 180,499,226 (+)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc5a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620217
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.