Cx3cr1 (C-X3-C motif chemokine receptor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cx3cr1 (C-X3-C motif chemokine receptor 1) Rattus norvegicus
Analyze
Symbol: Cx3cr1
Name: C-X3-C motif chemokine receptor 1
RGD ID: 620137
Description: Enables C-X3-C chemokine receptor activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of cell migration; and regulation of signal transduction. Located in several cellular components, including cell surface; neuronal cell body membrane; and perinuclear region of cytoplasm. Used to study Parkinsonism; glomerulonephritis; hepatopulmonary syndrome; and status epilepticus. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); borna disease; portal hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-X3-C CKR-1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CX3C chemokine receptor 1; fractalkine receptor; Rbs11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,661,294 - 128,679,048 (-)NCBIGRCr8
mRatBN7.28119,785,726 - 119,799,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,782,595 - 119,800,014 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8125,366,943 - 125,380,623 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,565,979 - 123,579,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,406,569 - 121,420,231 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,740,756 - 128,754,514 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,740,756 - 128,754,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,941,653 - 127,955,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,033,630 - 125,047,335 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,053,366 - 125,067,072 (-)NCBI
Celera8118,932,179 - 118,945,873 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 12  (ISO,ISS)
anti-basement membrane glomerulonephritis  (IEP)
arteriosclerosis  (ISO)
arthus reaction  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
borna disease  (IEP)
Chloracne  (ISO)
Chronic Mesangial Proliferative Glomerulonephritis  (IEP)
congestive heart failure  (IEP)
conjunctivitis  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (ISO)
cystitis  (IEP)
diabetes mellitus  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP,IMP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Autoimmune Uveitis  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (IEP,IMP)
graft-versus-host disease  (ISO)
Hearing Loss  (ISO)
hepatopulmonary syndrome  (IMP)
Herpes Simplex Encephalitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
Inflammation  (IEP,ISO)
Intervertebral Disc Displacement  (IEP)
Intimal Hyperplasia  (ISO)
macular degeneration  (ISO)
Memory Disorders  (IMP)
Microscopic Polyangiitis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (IEP)
obesity  (ISO)
optic nerve glioma  (ISO)
otitis media  (ISO)
Pain  (IMP)
Parkinsonism  (IMP)
portal hypertension  (IEP)
prion disease  (IEP)
psoriasis  (ISO)
pulmonary embolism  (IEP)
pulmonary hypertension  (IEP,ISO)
respiratory syncytial virus infectious disease  (ISO)
retinal degeneration  (ISO)
retinal vasculitis  (ISO)
retinitis  (ISO)
sciatic neuropathy  (IEP,ISO)
Sepsis  (ISO)
status epilepticus  (IMP)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IEP)
uveitis  (IEP)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
choline  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
dextran sulfate  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
glycidol  (EXP)
GW 501516  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
mechlorethamine  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentane-2,3-dione  (EXP)
phenobarbital  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO,ISS)
antifungal innate immune response  (ISO,ISS)
autocrine signaling  (IGI)
brain development  (ISO,ISS)
calcium-mediated signaling  (IBA)
cell adhesion  (ISO)
cell chemotaxis  (IBA,IMP)
cell-cell adhesion  (IMP)
cellular response to lipopolysaccharide  (IEP,ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IMP)
central nervous system maturation  (ISO)
chemokine-mediated signaling pathway  (IGI,IMP)
chemotaxis  (ISO)
G protein-coupled receptor signaling pathway  (IMP)
host-mediated regulation of intestinal microbiota composition  (ISO,ISS)
immune response  (IBA,ISO,ISS)
leukocyte chemotaxis  (ISO,ISS)
leukocyte tethering or rolling  (ISO)
memory  (IMP)
microglial cell activation  (IMP)
microglial cell activation involved in immune response  (ISS)
modulation of chemical synaptic transmission  (ISO)
multiple spine synapse organization, single dendrite  (ISO)
negative regulation of apoptotic signaling pathway  (IGI)
negative regulation of cell migration  (IMP)
negative regulation of chronic inflammatory response to non-antigenic stimulus  (IMP)
negative regulation of hippocampal neuron apoptotic process  (IGI)
negative regulation of interleukin-1 beta production  (IMP)
negative regulation of long-term synaptic potentiation  (IMP)
negative regulation of microglial cell mediated cytotoxicity  (ISO,ISS)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (IGI)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of I-kappaB phosphorylation  (IGI)
positive regulation of microglial cell migration  (IMP)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuroblast proliferation  (IMP)
positive regulation of neurogenesis  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IGI)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of tumor necrosis factor production  (ISO)
response to ischemia  (IGI)
social behavior  (ISO)
synapse maturation  (ISO)
synapse pruning  (ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Amanatidou V, etal., Pediatr Infect Dis J. 2006 May;25(5):410-4.
2. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. An JL, etal., Forensic Sci Int. 2009 Nov 20;192(1-3):e21-5. Epub 2009 Sep 4.
3. Association of sequence variation in the CX3CR1 gene with geographic atrophy age-related macular degeneration in a Greek population. Anastasopoulos E, etal., Curr Eye Res. 2012 Dec;37(12):1148-55. doi: 10.3109/02713683.2012.705413. Epub 2012 Jul 20.
4. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Andre F, etal., Ann Oncol. 2006 Jun;17(6):945-51. Epub 2006 Apr 20.
5. Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. Arai M, etal., J Dermatol Sci. 2013 Mar;69(3):250-8. doi: 10.1016/j.jdermsci.2012.10.010. Epub 2012 Oct 24.
6. Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. Bachstetter AD, etal., Neurobiol Aging. 2011 Nov;32(11):2030-44. doi: 10.1016/j.neurobiolaging.2009.11.022. Epub 2009 Dec 16.
7. Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia. Boddeke EW, etal., Eur J Pharmacol. 1999 Jun 18;374(2):309-13.
8. Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. Boivin N, etal., J Gen Virol. 2012 Jun;93(Pt 6):1294-304. doi: 10.1099/vir.0.041046-0. Epub 2012 Feb 29.
9. Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling. Briones TL, etal., J Neuroinflammation. 2014 Jan 22;11:13. doi: 10.1186/1742-2094-11-13.
10. Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis. Cepika AM, etal., Pediatr Allergy Immunol. 2008 Mar;19(2):148-56. doi: 10.1111/j.1399-3038.2007.00611.x.
11. Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Chan CC, etal., Histol Histopathol. 2005 Jul;20(3):857-63.
12. Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. Chandrasekar B, etal., Biochem J. 2003 Jul 15;373(Pt 2):547-58. doi: 10.1042/BJ20030207.
13. Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation. Chen M, etal., Invest Ophthalmol Vis Sci. 2013 Jan 23;54(1):682-90. doi: 10.1167/iovs.12-10888.
14. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. Chen S, etal., J Neuroimmunol. 2002 Dec;133(1-2):46-55.
15. Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats. Chen YM, etal., Nephrol Dial Transplant. 2003 Dec;18(12):2505-14.
16. Expression of fractalkine (CX3CL1) and its receptor in endotoxin-induced uveitis. Chu L, etal., Ophthalmic Res. 2009;42(3):160-6. Epub 2009 Jul 31.
17. Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Combadiere C, etal., Circulation. 2003 Feb 25;107(7):1009-16.
18. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Dagkalis A, etal., Immunology. 2009 Sep;128(1):25-33. doi: 10.1111/j.1365-2567.2009.03046.x.
19. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Denoyer A, etal., Mucosal Immunol. 2012 Nov;5(6):702-11. doi: 10.1038/mi.2012.43. Epub 2012 Jun 13.
20. CX3CR1 polymorphisms are associated with atopy but not asthma in German children. Depner M, etal., Int Arch Allergy Immunol. 2007;144(1):91-4. Epub 2007 May 15.
21. Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation. Echigo T, etal., J Allergy Clin Immunol. 2004 May;113(5):940-8.
22. Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis. Fang IM, etal., Mol Vis. 2005 Jul 1;11:443-51.
23. Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication. Feng L, etal., Kidney Int. 1999 Aug;56(2):612-20.
24. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. Study of Polymorphisms in CX3CR1, PLEKHA1 and VEGF Genes as Risk Factors for Age-related Macular Degeneration in Indian Patients. Gupta D, etal., Arch Med Res. 2014 Jul 19. pii: S0188-4409(14)00161-1. doi: 10.1016/j.arcmed.2014.07.005.
27. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. Harcourt J, etal., J Immunol. 2006 Feb 1;176(3):1600-8.
28. Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. Harrison JK, etal., J Biol Chem. 2001 Jun 15;276(24):21632-41. Epub 2001 Mar 8.
29. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Harrison JK, etal., Neurosci Lett 1994 Mar 14;169(1-2):85-9.
30. Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis. Hasegawa M, etal., Ann Rheum Dis. 2005 Jan;64(1):21-8.
31. Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P. Haynes LM, etal., J Virol. 2003 Sep;77(18):9831-44.
32. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Heinisch S and Kirby LG, Neuroscience. 2009 Dec 15;164(3):1210-23. Epub 2009 Sep 10.
33. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Hughes PM, etal., Glia. 2002 Mar 15;37(4):314-27.
34. Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. Ito Y, etal., Kidney Int. 2002 Jun;61(6):2044-57.
35. Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation. Jerath MR, etal., Thromb J. 2010 Sep 13;8:14. doi: 10.1186/1477-9560-8-14.
36. Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus. Katsuyama K, etal., Nephron Exp Nephrol. 2009;113(2):e45-56. Epub 2009 Jul 10.
37. The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse. Kezic JM, etal., Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):854-63. doi: 10.1167/iovs.12-10876.
38. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Kikuchi Y, etal., Nephron Exp Nephrol. 2004;97(1):e17-25.
39. The chemokine CX3CL1 reduces migration and increases adhesion of neurons with mechanisms dependent on the beta1 integrin subunit. Lauro C, etal., J Immunol. 2006 Dec 1;177(11):7599-606.
40. Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK. Lee KM, etal., Eur J Pain. 2010 Aug;14(7):682.e1-12. Epub 2009 Dec 2.
41. mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
42. Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. Lu P, etal., J Immunol. 2008 Mar 15;180(6):4283-91.
43. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. Luhmann UF, etal., PLoS One. 2012;7(4):e35551. doi: 10.1371/journal.pone.0035551. Epub 2012 Apr 24.
44. Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barre syndrome. Luongo L, etal., Neurosci Lett. 2008 May 30;437(2):98-102. Epub 2008 Apr 10.
45. Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. Maciejewski-Lenoir D, etal., J Immunol. 1999 Aug 1;163(3):1628-35.
46. Polymorphism of the fractalkine receptor CX3CR1 and systemic sclerosis-associated pulmonary arterial hypertension. Marasini B, etal., Clin Dev Immunol. 2005 Dec;12(4):275-9.
47. Elevated serum levels of soluble CX3CL1 in patients with microscopic polyangiitis. Matsunawa M, etal., Clin Exp Rheumatol. 2009 Jan-Feb;27(1):72-8.
48. Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis. McDermott DH, etal., Circ Res. 2001 Aug 31;89(5):401-7.
49. Gut-brain chemokine changes in portal hypertensive rats. Merino J, etal., Dig Dis Sci. 2011 Aug;56(8):2309-17. doi: 10.1007/s10620-011-1625-y. Epub 2011 Feb 24.
50. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Meucci O, etal., Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8075-80.
51. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
52. An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Milligan E, etal., Eur J Neurosci. 2005 Dec;22(11):2775-82.
53. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Mionnet C, etal., Nat Med. 2010 Nov;16(11):1305-12. Epub 2010 Oct 31.
54. Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition. Morimura S, etal., Am J Pathol. 2013 May;182(5):1640-7. doi: 10.1016/j.ajpath.2013.01.023. Epub 2013 Mar 5.
55. Predominant infiltration of monocytes in chronic graft-versus-host disease. Namba N, etal., Transplantation. 2007 Jan 27;83(2):220-4.
56. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
57. Polymorphisms of immunity genes and susceptibility to otitis media in children. Nokso-Koivisto J, etal., PLoS One. 2014 Apr 9;9(4):e93930. doi: 10.1371/journal.pone.0093930. eCollection 2014.
58. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
59. Intrathecal infusion of pyrrolidine dithiocarbamate for the prevention and reversal of neuropathic pain in rats using a sciatic chronic constriction injury model. Pan YD, etal., Reg Anesth Pain Med. 2010 May-Jun;35(3):231-7. doi: 10.1097/AAP.0b013e3181df245b.
60. Changes in spinal cord expression of fractalkine and its receptor in a rat model of disc herniation by autologous nucleus pulposus. Park HW, etal., Spine (Phila Pa 1976). 2011 Jan 8.
61. Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Perros F, etal., Eur Respir J. 2007 May;29(5):937-43. Epub 2006 Dec 20.
62. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
63. The CX3CL1-CX3CR1 system and psoriasis. Plant D, etal., Exp Dermatol. 2006 Nov;15(11):900-3.
64. Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. Pong WW, etal., Ann Neurol. 2013 Feb;73(2):303-8. doi: 10.1002/ana.23813. Epub 2013 Feb 19.
65. Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice. Poupel L, etal., Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2297-305. doi: 10.1161/ATVBAHA.112.300930. Epub 2013 Jul 25.
66. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. Rauer M, etal., J Neurovirol. 2002 Jan;8(3):168-79.
67. GOA pipeline RGD automated data pipeline
68. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
69. Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis. Ridderstad Wollberg A, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5409-14. doi: 10.1073/pnas.1316510111. Epub 2014 Mar 25.
70. The cardiovascular actions of fractalkine/CX3CL1 in the hypothalamic paraventricular nucleus are attenuated in rats with heart failure. Ruchaya PJ, etal., Exp Physiol. 2014 Jan;99(1):111-22. doi: 10.1113/expphysiol.2013.075432. Epub 2013 Sep 13.
71. Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. Ruth JH, etal., Arthritis Rheum. 2001 Jul;44(7):1568-81.
72. Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia. Ryu J, etal., Cardiovasc Res. 2008 May 1;78(2):333-40. Epub 2007 Nov 11.
73. Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation. Sbrana S, etal., Cytometry B Clin Cytom. 2005 May;65(1):14-21.
74. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
75. NEW evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. Shan S, etal., Neurobiol Aging. 2009 Apr 14.
76. Association of common polymorphisms in the fractalkine receptor (CX3CR1) with obesity. Sirois-Gagnon D, etal., Obesity (Silver Spring). 2011 Jan;19(1):222-7. Epub 2010 Jun 3.
77. Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice. Staniland AA, etal., J Neurochem. 2010 Aug;114(4):1143-57. doi: 10.1111/j.1471-4159.2010.06837.x. Epub 2010 May 28.
78. CX(3)CL1 (fractalkine) and its receptor CX(3)CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. Staumont-Salle D, etal., J Exp Med. 2014 Jun 2;211(6):1185-96. doi: 10.1084/jem.20121350. Epub 2014 May 12.
79. [Effects of aspirin on CX3CL1 and CX3CR1 in acute pulmonary embolism rats]. Sun C, etal., Zhonghua Yi Xue Za Zhi. 2013 Jan 1;93(1):69-72.
80. Inhibition of the Activation and Recruitment of Microglia-Like Cells Protects Against Neomycin-Induced Ototoxicity. Sun S, etal., Mol Neurobiol. 2014 May 1.
81. New evidence for the involvement of spinal fractalkine receptor in pain facilitation and spinal glial activation in rat model of monoarthritis. Sun S, etal., Pain. 2007 May;129(1-2):64-75. Epub 2006 Nov 22.
82. CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin. Sunnemark D, etal., J Neuroinflammation. 2005 Jul 29;2:17.
83. Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat. Tarozzo G, etal., Eur J Neurosci. 2002 May;15(10):1663-8.
84. Association study between the CX3CR1 gene and asthma. Tremblay K, etal., Genes Immun. 2006 Dec;7(8):632-9. Epub 2006 Nov 2.
85. The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. Tuo J, etal., FASEB J. 2004 Aug;18(11):1297-9. Epub 2004 Jun 18.
86. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Tuo J, etal., Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36.
87. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Verge GM, etal., Eur J Neurosci 2004 Sep;20(5):1150-60.
88. A CX3CR1 genotype associated with retinal vasculitis in patients in the United Kingdom. Wallace GR, etal., Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2966-70.
89. Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model. Wang K, etal., Glia. 2014 Jul 2. doi: 10.1002/glia.22715.
90. A functional relationship between trigeminal astroglial activation and NR1 expression in a rat model of temporomandibular joint inflammation. Wang S, etal., Pain Med. 2012 Dec;13(12):1590-600. doi: 10.1111/j.1526-4637.2012.01511.x. Epub 2012 Oct 30.
91. Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Willemen HL, etal., Pain. 2010 Sep;150(3):550-60. Epub 2010 Jul 6.
92. Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency. Wu J, etal., Neurobiol Aging. 2013 Dec;34(12):2843-52. doi: 10.1016/j.neurobiolaging.2013.06.003. Epub 2013 Jul 12.
93. Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. Yang JL, etal., Mol Brain. 2012 May 30;5:18. doi: 10.1186/1756-6606-5-18.
94. The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus. Yeo SI, etal., J Neuroimmunol. 2011 May;234(1-2):93-102. doi: 10.1016/j.jneuroim.2011.03.005. Epub 2011 Apr 8.
95. Intrathecal injection of anti-CX3CR1 neutralizing antibody delayed and attenuated pain facilitation in rat tibial bone cancer pain model. Yin Q, etal., Behav Pharmacol. 2010 Oct;21(7):595-601.
96. Expression of fractalkine and fractalkine receptor in urinary bladder after cyclophosphamide (CYP)-induced cystitis. Yuridullah R, etal., Auton Neurosci. 2006 Jun 30;126-127:380-9. Epub 2006 May 2.
97. The role of CX(3)CL1/CX(3)CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental hepatopulmonary syndrome. Zhang J, etal., J Hepatol. 2012 Oct;57(4):752-8. doi: 10.1016/j.jhep.2012.05.014. Epub 2012 May 29.
Additional References at PubMed
PMID:10187784   PMID:15993821   PMID:16019082   PMID:16732273   PMID:16980051   PMID:17174525   PMID:18292196   PMID:18971423   PMID:20364328   PMID:21131739   PMID:22213034   PMID:22387113  
PMID:22536384   PMID:22613229   PMID:23125415   PMID:23499256   PMID:24175290   PMID:24487234   PMID:24681877   PMID:25461978   PMID:25768734   PMID:26386845   PMID:28612319   PMID:28791023  
PMID:29082919   PMID:30598122   PMID:31726181   PMID:32152663   PMID:32323731   PMID:32423102   PMID:32664639   PMID:32664984   PMID:32819407   PMID:34339824   PMID:34629047   PMID:35382731  
PMID:37868978  


Genomics

Comparative Map Data
Cx3cr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,661,294 - 128,679,048 (-)NCBIGRCr8
mRatBN7.28119,785,726 - 119,799,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,782,595 - 119,800,014 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8125,366,943 - 125,380,623 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,565,979 - 123,579,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,406,569 - 121,420,231 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,740,756 - 128,754,514 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,740,756 - 128,754,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,941,653 - 127,955,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,033,630 - 125,047,335 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,053,366 - 125,067,072 (-)NCBI
Celera8118,932,179 - 118,945,873 (-)NCBICelera
Cytogenetic Map8q32NCBI
CX3CR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38339,263,494 - 39,292,966 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl339,263,495 - 39,281,735 (-)EnsemblGRCh38hg38GRCh38
GRCh37339,304,985 - 39,323,226 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,279,989 - 39,296,531 (-)NCBINCBI36Build 36hg18NCBI36
Build 34339,279,990 - 39,296,526NCBI
Celera339,246,596 - 39,264,836 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef339,347,466 - 39,365,706 (-)NCBIHuRef
CHM1_1339,256,125 - 39,274,344 (-)NCBICHM1_1
T2T-CHM13v2.0339,276,418 - 39,305,868 (-)NCBIT2T-CHM13v2.0
Cx3cr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,877,749 - 119,897,362 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,877,749 - 119,898,945 (-)EnsemblGRCm39 Ensembl
GRCm389120,048,683 - 120,068,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,901,616 - 120,069,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,957,811 - 119,977,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,897,391 - 119,916,980 (-)NCBIMGSCv36mm8
Celera9120,518,248 - 120,537,939 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.37NCBI
Cx3cr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,701,073 - 24,707,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,691,206 - 24,705,599 (+)NCBIChiLan1.0ChiLan1.0
CX3CR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2239,213,724 - 39,231,983 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1339,218,486 - 39,235,054 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0339,158,346 - 39,176,604 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,439,009 - 39,456,797 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,440,955 - 39,457,219 (-)Ensemblpanpan1.1panPan2
CX3CR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,937,069 - 8,954,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,938,906 - 8,952,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,974,330 - 8,988,240 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0239,221,526 - 9,239,150 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl239,221,526 - 9,237,271 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,036,770 - 9,050,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,179,594 - 9,193,497 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,172,979 - 9,186,888 (-)NCBIUU_Cfam_GSD_1.0
Cx3cr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118195,370,137 - 195,397,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,510,523 - 28,535,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,508,726 - 28,535,640 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CX3CR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,944,369 - 23,957,486 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,944,386 - 23,957,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,204,842 - 26,218,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CX3CR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115136,757 - 153,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15150,718 - 151,785 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660638,861,161 - 8,878,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cx3cr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,706,043 - 1,719,452 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,705,953 - 1,719,452 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cx3cr1
125 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000025019
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
D8Wox28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,785,749 - 119,785,910 (+)MAPPERmRatBN7.2
Rnor_6.08128,740,780 - 128,740,940NCBIRnor6.0
Rnor_5.08127,941,677 - 127,941,837UniSTSRnor5.0
RGSC_v3.48125,033,654 - 125,033,814UniSTSRGSC3.4
Celera8118,932,203 - 118,932,351UniSTS
Cytogenetic Map8q32UniSTS
PMC209384P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,786,211 - 119,786,825 (+)MAPPERmRatBN7.2
Rnor_6.08128,741,242 - 128,741,855NCBIRnor6.0
Rnor_5.08127,942,139 - 127,942,752UniSTSRnor5.0
RGSC_v3.48125,034,116 - 125,034,729UniSTSRGSC3.4
Celera8118,932,653 - 118,933,266UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 25 3
Low 3 33 37 21 18 21 2 2 49 35 38 11 2
Below cutoff 10 20 20 20 6 9 6

Sequence


RefSeq Acc Id: ENSRNOT00000025019   ⟹   ENSRNOP00000025019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,783,208 - 119,800,014 (-)Ensembl
Rnor_6.0 Ensembl8128,740,756 - 128,754,514 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093935   ⟹   ENSRNOP00000097085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,782,595 - 119,799,470 (-)Ensembl
RefSeq Acc Id: NM_133534   ⟹   NP_598218
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,663,361 - 128,677,066 (-)NCBI
mRatBN7.28119,785,726 - 119,799,431 (-)NCBI
Rnor_6.08128,740,756 - 128,754,514 (-)NCBI
Rnor_5.08127,941,653 - 127,955,411 (-)NCBI
RGSC_v3.48125,033,630 - 125,047,335 (-)RGD
Celera8118,932,179 - 118,945,873 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264812   ⟹   XP_063120882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,661,294 - 128,679,048 (-)NCBI
RefSeq Acc Id: NP_598218   ⟸   NM_133534
- UniProtKB: P35411 (UniProtKB/Swiss-Prot),   A6I3Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025019   ⟸   ENSRNOT00000025019
RefSeq Acc Id: ENSRNOP00000097085   ⟸   ENSRNOT00000093935
RefSeq Acc Id: XP_063120882   ⟸   XM_063264812
- Peptide Label: isoform X1
- UniProtKB: P35411 (UniProtKB/Swiss-Prot),   A6I3Y8 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35411-F1-model_v2 AlphaFold P35411 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696381
Promoter ID:EPDNEW_R6904
Type:single initiation site
Name:Cx3cr1_1
Description:C-X3-C motif chemokine receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,754,532 - 128,754,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620137 AgrOrtholog
BioCyc Gene G2FUF-28762 BioCyc
Ensembl Genes ENSRNOG00000018509 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055002443 UniProtKB/Swiss-Prot
  ENSRNOG00060023023 UniProtKB/Swiss-Prot
  ENSRNOG00065003671 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025019.3 UniProtKB/Swiss-Prot
  ENSRNOT00000093935 ENTREZGENE
  ENSRNOT00000093935.1 UniProtKB/Swiss-Prot
  ENSRNOT00055003883 UniProtKB/Swiss-Prot
  ENSRNOT00055003886 UniProtKB/Swiss-Prot
  ENSRNOT00060039829 UniProtKB/Swiss-Prot
  ENSRNOT00060039855 UniProtKB/Swiss-Prot
  ENSRNOT00065005336 UniProtKB/Swiss-Prot
  ENSRNOT00065005339 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CX3CR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171056 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171056 ENTREZGENE
PANTHER CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CX3C CHEMOKINE RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cx3cr1 PhenoGen
PRINTS FRACTALKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018509 RatGTEx
  ENSRNOG00055002443 RatGTEx
  ENSRNOG00060023023 RatGTEx
  ENSRNOG00065003671 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I3Y8 ENTREZGENE, UniProtKB/TrEMBL
  CX3C1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Cx3cr1  C-X3-C motif chemokine receptor 1  Cx3cr1  chemokine (C-X3-C motif) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cx3cr1  chemokine (C-X3-C motif) receptor 1  Cx3cr1  chemokine (C-X3-C) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cx3cr1  chemokine (C-X3-C) receptor 1  Rbs11  Rbs11 protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Rbs11  Rbs11 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in spinal cord, brainstem, pituitary, brain, kidney, gut, uterus, and testis 633846