Cited2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) - Rat Genome Database

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Gene: Cited2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) Rattus norvegicus
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Symbol: Cited2
Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
RGD ID: 620112
Description: Predicted to enable several functions, including LBD domain binding activity; histone acetyltransferase binding activity; and transcription coactivator activity. Involved in several processes, including cellular senescence; negative regulation of cardiac muscle cell proliferation; and regulation of gene expression. Predicted to be located in chromatin; cytoplasm; and nucleus. Predicted to be part of protein-containing complex. Used to study osteosarcoma. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cbp/p300-interacting transactivator 2; MGC93288; Mrg1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2112,312,426 - 12,314,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,312,160 - 12,314,897 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx112,084,290 - 12,086,734 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0118,086,206 - 18,088,650 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0112,292,779 - 12,295,222 (+)NCBIRnor_WKY
Rnor_6.0112,823,363 - 12,825,806 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,823,363 - 12,825,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0114,515,629 - 14,518,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,721,500 - 12,723,943 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,721,561 - 12,724,003 (+)NCBI
Celera110,778,037 - 10,780,480 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
kainic acid  (EXP)
kenpaullone  (EXP)
leflunomide  (EXP,ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal cortex formation  (ISO)
adrenal gland development  (ISO)
blood vessel development  (ISO)
bone morphogenesis  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cardiac neural crest cell development involved in heart development  (ISO)
cardiac septum morphogenesis  (ISO)
cell population proliferation  (ISO,ISS)
cellular response to growth factor stimulus  (IEP)
cellular senescence  (IEP)
central nervous system development  (ISO)
cranial nerve morphogenesis  (ISO)
decidualization  (ISO)
determination of heart left/right asymmetry  (ISO)
determination of left/right symmetry  (ISO,ISS)
DNA-templated transcription  (ISO)
DNA-templated transcription elongation  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
embryonic heart tube left/right pattern formation  (ISO)
embryonic placenta development  (ISO)
embryonic process involved in female pregnancy  (ISO)
endocardial cushion development  (ISO)
erythrocyte development  (ISO)
granulocyte differentiation  (ISO)
heart development  (ISO,ISS)
heart looping  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
in utero embryonic development  (ISO)
kidney development  (ISO)
left/right axis specification  (ISO)
left/right pattern formation  (IBA)
lens morphogenesis in camera-type eye  (ISO)
leukocyte differentiation  (ISO)
liver development  (ISO)
male gonad development  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cell migration  (ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of gene expression  (IMP,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
neural tube closure  (ISO)
neural tube formation  (ISO)
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  (ISO)
outflow tract morphogenesis  (ISO)
peripheral nervous system development  (ISO)
positive regulation of cell cycle  (ISO,ISS)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gene expression  (IMP,ISO,ISS)
positive regulation of male gonad development  (ISO)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO,ISS)
pulmonary artery morphogenesis  (ISO)
regulation of animal organ formation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to estrogen  (ISO)
response to fluid shear stress  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (IEP)
sex determination  (IBA,ISO)
skeletal muscle cell differentiation  (ISO)
spleen development  (ISO)
thymus development  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
trophectodermal cell differentiation  (ISO)
vasculature development  (ISO)
vasculogenesis  (ISO)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Folic acid prevents exencephaly in Cited2 deficient mice. Barbera JP, etal., Hum Mol Genet 2002 Feb 1;11(3):283-93.
2. MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2. Clark AL and Naya FJ, J Biol Chem. 2015 Sep 18;290(38):23162-72. doi: 10.1074/jbc.M115.672659. Epub 2015 Aug 3.
3. Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas. Daino K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):654-8. Epub 2009 Oct 13.
4. Identification of new Nerve Growth Factor-responsive immediate-early genes. Dijkmans TF, etal., Brain Res. 2009 Jan 16;1249:19-33. Epub 2008 Oct 31.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identification of CITED2 as a negative regulator of fracture healing. Lee JY, etal., Biochem Biophys Res Commun. 2009 Oct 2;387(4):641-5. Epub 2009 Jul 14.
8. Physiological loading of joints prevents cartilage degradation through CITED2. Leong DJ, etal., FASEB J. 2011 Jan;25(1):182-91. Epub 2010 Sep 8.
9. Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1. Leung MK, etal., Genomics 1999 Nov 1;61(3):307-13.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Induction of CITED2 expression in the rat hippocampus following transient global ischemia. Sun W, etal., Brain Res. 2006 Feb 9;1072(1):15-8. Epub 2006 Jan 24.
19. Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate. Zhou Z, etal., Aging Cell. 2010 Oct;9(5):911-5.
Additional References at PubMed
PMID:9434189   PMID:9811838   PMID:9887100   PMID:10593900   PMID:11581164   PMID:11694877   PMID:12149478   PMID:12477932   PMID:12586840   PMID:12960175   PMID:14594809   PMID:15051727  
PMID:15475956   PMID:15615595   PMID:15750185   PMID:16287139   PMID:16579983   PMID:16619037   PMID:17537799   PMID:17615577   PMID:17644732   PMID:17906695   PMID:17932483   PMID:18054336  
PMID:18653562   PMID:19035510   PMID:19457926   PMID:20549734   PMID:22147266   PMID:22735262   PMID:27680315   PMID:36626551  


Genomics

Comparative Map Data
Cited2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2112,312,426 - 12,314,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,312,160 - 12,314,897 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx112,084,290 - 12,086,734 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0118,086,206 - 18,088,650 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0112,292,779 - 12,295,222 (+)NCBIRnor_WKY
Rnor_6.0112,823,363 - 12,825,806 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,823,363 - 12,825,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0114,515,629 - 14,518,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,721,500 - 12,723,943 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,721,561 - 12,724,003 (+)NCBI
Celera110,778,037 - 10,780,480 (+)NCBICelera
Cytogenetic Map1p12NCBI
CITED2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386139,371,807 - 139,374,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6139,371,807 - 139,374,648 (-)EnsemblGRCh38hg38GRCh38
GRCh376139,692,944 - 139,695,785 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366139,735,089 - 139,737,478 (-)NCBINCBI36Build 36hg18NCBI36
Build 346139,735,088 - 139,737,478NCBI
Celera6140,433,459 - 140,435,848 (-)NCBICelera
Cytogenetic Map6q24.1NCBI
HuRef6137,254,618 - 137,257,015 (-)NCBIHuRef
CHM1_16139,956,432 - 139,958,827 (-)NCBICHM1_1
T2T-CHM13v2.06140,555,711 - 140,558,549 (-)NCBIT2T-CHM13v2.0
Cited2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,598,452 - 17,601,422 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,598,966 - 17,601,422 (+)EnsemblGRCm39 Ensembl
GRCm381017,723,228 - 17,725,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,723,218 - 17,725,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv371017,443,034 - 17,445,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361017,412,662 - 17,415,072 (+)NCBIMGSCv36mm8
Celera1017,602,360 - 17,604,805 (+)NCBICelera
Cytogenetic Map10A2NCBI
Cited2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543620,370,950 - 20,372,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543620,370,950 - 20,372,677 (+)NCBIChiLan1.0ChiLan1.0
CITED2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16141,213,671 - 141,215,919 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v06137,134,142 - 137,136,550 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CITED2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,522,911 - 31,525,342 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,523,799 - 31,524,995 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,396,275 - 32,398,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0131,684,411 - 31,686,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl131,685,298 - 31,686,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1131,559,687 - 31,562,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0131,442,285 - 31,444,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0131,753,743 - 31,756,214 (-)NCBIUU_Cfam_GSD_1.0
Cited2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946126,574,685 - 126,577,867 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365606,354,338 - 6,356,735 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365606,353,901 - 6,356,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CITED2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,155,664 - 25,160,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,155,652 - 25,158,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,295,042 - 28,297,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CITED2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11334,009,527 - 34,011,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1334,010,228 - 34,011,046 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660406,152,738 - 6,155,148 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cited2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475314,630,827 - 14,632,536 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475314,630,842 - 14,633,245 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cited2
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:486
Count of miRNA genes:244
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000016244
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat

Markers in Region
RH12860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,314,585 - 12,314,716 (+)MAPPERmRatBN7.2
Rnor_6.0112,825,523 - 12,825,653NCBIRnor6.0
Rnor_5.0114,517,789 - 14,517,919UniSTSRnor5.0
RGSC_v3.4112,723,660 - 12,723,790UniSTSRGSC3.4
Celera110,780,197 - 10,780,327UniSTS
Cytogenetic Map1p12UniSTS
RH128281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,313,796 - 12,313,983 (+)MAPPERmRatBN7.2
Rnor_6.0112,824,734 - 12,824,920NCBIRnor6.0
Rnor_5.0114,517,000 - 14,517,186UniSTSRnor5.0
RGSC_v3.4112,722,871 - 12,723,057UniSTSRGSC3.4
Celera110,779,408 - 10,779,594UniSTS
RH 3.4 Map1130.04UniSTS
Cytogenetic Map1p12UniSTS
AI835299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,314,555 - 12,314,664 (+)MAPPERmRatBN7.2
Rnor_6.0112,825,493 - 12,825,601NCBIRnor6.0
Rnor_5.0114,517,759 - 14,517,867UniSTSRnor5.0
RGSC_v3.4112,723,630 - 12,723,738UniSTSRGSC3.4
Celera110,780,167 - 10,780,275UniSTS
Cytogenetic Map1p12UniSTS
Meis2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,313,403 - 12,313,589 (+)MAPPERmRatBN7.2
Rnor_6.0112,824,341 - 12,824,526NCBIRnor6.0
Rnor_5.0114,516,607 - 14,516,792UniSTSRnor5.0
Celera110,779,015 - 10,779,200UniSTS
Cytogenetic Map1p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 51 35 19 35 8 11 74 35 39 11 8
Low 2 6 6 6 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086790   ⟹   ENSRNOP00000074276
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl112,312,160 - 12,314,897 (+)Ensembl
Rnor_6.0 Ensembl112,823,363 - 12,825,786 (+)Ensembl
RefSeq Acc Id: NM_053698   ⟹   NP_446150
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2112,312,426 - 12,314,869 (+)NCBI
Rnor_6.0112,823,363 - 12,825,806 (+)NCBI
Rnor_5.0114,515,629 - 14,518,072 (+)NCBI
RGSC_v3.4112,721,500 - 12,723,943 (+)RGD
Celera110,778,037 - 10,780,480 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446150 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87005 (Get FASTA)   NCBI Sequence Viewer  
  AAK30621 (Get FASTA)   NCBI Sequence Viewer  
  EDL93758 (Get FASTA)   NCBI Sequence Viewer  
  EDL93759 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446150   ⟸   NM_053698
- UniProtKB: Q99MA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074276   ⟸   ENSRNOT00000086790

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MA1-F1-model_v2 AlphaFold Q99MA1 1-269 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689502
Promoter ID:EPDNEW_R27
Type:single initiation site
Name:Cited2_1
Description:Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminaldomain, 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0112,823,355 - 12,823,415EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620112 AgrOrtholog
BioCyc Gene G2FUF-62285 BioCyc
Ensembl Genes ENSRNOG00000056940 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074276 ENTREZGENE
  ENSRNOP00000074276.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086790 ENTREZGENE
  ENSRNOT00000086790.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191504 IMAGE-MGC_LOAD
InterPro CITED UniProtKB/TrEMBL
KEGG Report rno:114490 UniProtKB/TrEMBL
MGC_CLONE MGC:93288 IMAGE-MGC_LOAD
NCBI Gene 114490 ENTREZGENE
PANTHER CITED UniProtKB/TrEMBL
Pfam CITED UniProtKB/TrEMBL
PhenoGen Cited2 PhenoGen
UniProt Q99MA1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cited2  Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cited2  Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus 634741