Slc17a1 (solute carrier family 17 member 1)

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Gene: Slc17a1 (solute carrier family 17 member 1) Rattus norvegicus

Analyze

Symbol:

Slc17a1 (Ensembl: AABR07027750.1)

Name:

solute carrier family 17 member 1

RGD ID:

620099

Description:

Predicted to enable transmembrane transporter activity. Predicted to be involved in several processes, including sodium-dependent phosphate transport; urate metabolic process; and urate transport. Predicted to be located in apical plasma membrane. Orthologous to human SLC17A1 (solute carrier family 17 member 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

na(+)/PI cotransporter 1; Napi-1; renal Na(+)-dependent phosphate cotransporter 1; renal sodium-dependent phosphate transport protein 1; renal sodium-phosphate transport protein 1; sodium-dependent phosphate transport protein 1; sodium/phosphate cotransporter 1; solute carrier family 17 (organic anion transporter), member 1; solute carrier family 17 (sodium phosphate), member 1; solute carrier family 17 vesicular glutamate transporter), member 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC17A1 (solute carrier family 17 member 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Slc17a1 (solute carrier family 17 (sodium phosphate), member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc17a1 (solute carrier family 17 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC17A1 (solute carrier family 17 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC17A1 (solute carrier family 17 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC17A1 (solute carrier family 17 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC17A1 (solute carrier family 17 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc17a1 (solute carrier family 17 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Slc17a1 (solute carrier family 17 (sodium phosphate), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC17A1 (solute carrier family 17 member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch1073-513e17.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	DAL5	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	SOA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	THI73	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Drosophila melanogaster (fruit fly):	CG2003	Alliance	DIOPT (Ensembl Compara\|OMA)
Saccharomyces cerevisiae (baker's yeast):	FEN2	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Drosophila melanogaster (fruit fly):	CG7881	Alliance	DIOPT (Ensembl Compara\|OMA)
Saccharomyces cerevisiae (baker's yeast):	YCT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Drosophila melanogaster (fruit fly):	CG9254	Alliance	DIOPT (Ensembl Compara\|OMA)
Drosophila melanogaster (fruit fly):	CG3649	Alliance	DIOPT (Ensembl Compara\|OMA)
Drosophila melanogaster (fruit fly):	MFS17	Alliance	DIOPT (Ensembl Compara\|OMA)
Saccharomyces cerevisiae (baker's yeast):	TNA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	SEO1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	VHT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Caenorhabditis elegans (roundworm):	T19D12.10	Alliance	DIOPT (Ensembl Compara\|OMA)
Caenorhabditis elegans (roundworm):	T19D12.9	Alliance	DIOPT (Ensembl Compara\|OMA)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	41,219,461 - 41,255,199 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	41,222,049 - 41,253,304 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	41,289,547 - 41,319,951 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	42,893,593 - 42,923,997 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	41,177,740 - 41,209,009 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	43,473,048 - 43,504,645 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	17	45,328,999 - 45,358,447 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	17	48,343,283 - 48,351,209 (-)	NCBI
Celera	17	40,853,552 - 40,884,798 (-)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

5-azaorotic acid (ISO)

acetamide (EXP)

acyclovir (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

allopurinol (ISO)

alpha-hexachlorocyclohexane (EXP)

arsane (ISO)

arsenic atom (ISO)

atazanavir sulfate (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

bisphenol A (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chenodeoxycholic acid (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

clofibric acid (EXP)

cobalt dichloride (EXP)

coumarin (EXP)

cyclosporin A (ISO)

deoxycholic acid (ISO)

dichlorine (EXP)

flutamide (EXP)

furan (ISO)

glafenine (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

GW 4064 (ISO)

hypoxanthine (ISO)

leflunomide (EXP)

methamphetamine (EXP)

methylmercury(1+) (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

nitrofen (EXP)

ochratoxin A (EXP)

ozone (EXP)

p-toluidine (EXP)

paracetamol (ISO)

paraquat (EXP)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (EXP,ISO)

potassium atom (EXP)

pravastatin (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

pyrazinecarboxamide (EXP)

resveratrol (ISO)

rifampicin (ISO)

silicon dioxide (ISO)

tetrachloromethane (EXP)

toluene (EXP)

Triptolide (EXP,ISO)

valproic acid (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

monoatomic anion transport (IBA)

phosphate ion transmembrane transport (IEA)

sodium ion transmembrane transport (IEA)

sodium ion transport (IEA)

sodium-dependent phosphate transport (IEA,ISO,ISS)

urate metabolic process (IEA,ISO)

urate transport (IEA,ISO,ISS)

Cellular Component

apical plasma membrane (IEA,ISO,ISS)

Molecular Function

phosphate ion transmembrane transporter activity (IEA)

sodium:phosphate symporter activity (TAS)

transmembrane transporter activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes.	Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
4.	Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex.	Hioki H, etal., Neuroscience 2003;117(1):1-6.
5.	Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts.	Li H and Xie Z, Cell Mol Biol Res 1995;41(5):451-60.
6.	Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to coexpression.	Li JL, etal., J Comp Neurol 2003 Aug 18;463(2):212-20.
7.	Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat.	Li JL, etal., J Comp Neurol 2003 Mar 10;457(3):236-49.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12586437	PMID:14667459	PMID:14681932	PMID:15065123	PMID:19503597	PMID:27906618

Genomics

Comparative Map Data

Slc17a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	41,219,461 - 41,255,199 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	41,222,049 - 41,253,304 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	41,289,547 - 41,319,951 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	42,893,593 - 42,923,997 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	41,177,740 - 41,209,009 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	43,473,048 - 43,504,645 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	17	45,328,999 - 45,358,447 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	17	48,343,283 - 48,351,209 (-)	NCBI
Celera	17	40,853,552 - 40,884,798 (-)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

SLC17A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	25,723,743 - 25,832,052 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	25,782,915 - 25,832,052 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	25,783,143 - 25,832,280 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	25,891,104 - 25,940,266 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	25,891,295 - 25,938,776	NCBI
Celera	6	27,010,324 - 27,059,480 (-)	NCBI		Celera
Cytogenetic Map	6	p22.2	ENTREZGENE
HuRef	6	25,726,038 - 25,775,499 (-)	NCBI		HuRef
CHM1_1	6	25,785,355 - 25,834,494 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	25,589,510 - 25,697,845 (-)	NCBI		T2T-CHM13v2.0

Slc17a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	24,051,607 - 24,079,713 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	24,051,733 - 24,079,713 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	23,867,624 - 23,895,730 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	23,867,750 - 23,895,730 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	23,962,142 - 23,987,599 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	23,877,797 - 23,903,195 (+)	NCBI		MGSCv36	mm8
Celera	13	24,101,937 - 24,127,396 (+)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	9.97	NCBI

Slc17a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955483	1,268,516 - 1,298,456 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955483	1,269,153 - 1,296,329 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC17A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	36,430,402 - 36,478,024 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	25,616,393 - 25,665,603 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	26,274,658 - 26,323,658 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	26,289,651 - 26,323,698 (-)	Ensembl	panpan1.1		panPan2

SLC17A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	23,732,632 - 23,785,296 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	23,738,537 - 23,783,959 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	23,610,821 - 23,687,809 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	23,823,930 - 23,900,871 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	23,854,234 - 23,901,092 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	23,633,634 - 23,717,078 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	23,684,268 - 23,767,995 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	25,121,999 - 25,200,843 (-)	NCBI		UU_Cfam_GSD_1.0

SLC17A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	20,523,022 - 20,574,460 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	20,522,650 - 20,589,037 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	21,858,431 - 21,899,396 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC17A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	46,416,337 - 46,501,367 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	46,417,019 - 46,447,307 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	25,718,590 - 25,771,921 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc17a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	1,196,891 - 1,249,390 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	1,195,037 - 1,261,771 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc17a1
131 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	52
Count of miRNA genes:	46
Interacting mature miRNAs:	49
Transcripts:	ENSRNOT00000066313
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
2313854	Bp343	Blood pressure QTL 343	3.9		life span trait (VT:0005372)	age at time of death (CMO:0001193)	17	31990784	50909196	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY102171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U28504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U28643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000066313 ⟹ ENSRNOP00000061056

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	41,222,049 - 41,253,304 (-)	Ensembl

RefSeq Acc Id:

NM_133554 ⟹ NP_598238

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	41,222,045 - 41,253,304 (-)	NCBI
Rnor_6.0	17	43,473,048 - 43,504,645 (-)	NCBI
Rnor_5.0	17	45,328,999 - 45,358,447 (-)	NCBI
Celera	17	40,853,552 - 40,884,798 (-)	RGD

Sequence:

show sequence

GAGCCCGGAGCTGAACCAGGAGAAGCCACAGGACATGTCACGGCTTTGAGAGGCAGGCCCTAAG
AAAAGGTGCAGCTTTCTGAGCACATCAAATGTCAAAGAGTGGATGGAGACCAAGTCCATCAATT
AGAAGATAAGTCTCAAATGGAGAACCGGTGCCTCCCCAAGAAAGTTCCAGGTTTCTGTTCCTTT
CGGTATGGACTGGCTATCCTTTTGCACTTCTGTAACATTGTCATCATGGCTCAGCGAGTGTGCC
TGAACCTCACAATGGTAGCCATGGTGAATAAAACAGAGCCACCCCATTTATCTAACAAGTCTGT
AGCAGAGATGCTGGATAATGTAAAGAACCCTGTGCATTCCTGGAGTCTTGATATTCAAGGGCTT
ATTCTCAGTTCTGTCTTCTTGGGTATGGTTGTGATTCAAGTTCCTGTTGGGTACCTATCTGGAG
CATACCCAATGAAGAAAATAATTGGGTCTTCATTGTTCCTCAGCTCTGTGCTGTCCCTGCTCAT
CCCACCAGCTGCACAAGTCGGAGCAGCTTTGGTCATTGTATGCCGAGTACTCCAAGGAATAGCC
CAGGGAGCAGTGTCAACAGGCCAGCATGGAATATGGGTCAAATGGGCACCTCCCTTGGAACGAG
GCAGACTTACCTCTATGACTCTATCAGGGTTTGTAATGGGACCATTTATTGCCCTGCTTGTGAG
TGGCTTCATCTGTGATCTTCTGGGTTGGCCCATGGTTTTCTACATCTTTGGTATTGTTGGGTGT
GTTCTGAGTCTTTTCTGGTTCATCCTTTTCTTTGATGACCCCAACAACCACCCATATATGAGCA
GCAGTGAGAAGGATTACATCACATCCTCTCTCATGCAACAGGTGCACTCGGGCAGACAATCTCT
GCCAATCAAAGCTATGCTTAAGTCTCTTCCACTCTGGGCCATTATCCTCAATAGCTTTGCTTTC
ATATGGTCGAACAATCTTCTGGTTACATACACGCCAACATTTATTAGCACCACGCTTCATGTTA
ATGTTAGAGAGAATGGGCTGCTGTCCAGCCTCCCCTATCTGCTTGCCTACATCTGTGGTATCGT
AGCAGGTCAGATGTCAGACTTCCTCCTGTCAAGGAAGATTTTCAGCGTAGTTGCTGTCCGGAAA
CTCTTCACCACACTAGGGATTTTCTGTCCTGTGATTTTTGTCGTGTGCCTGCTCTACCTGAGCT
ACAACTTCTACAGCACCGTCATTTTCCTTACACTTGCCAACTCGACACTTAGCTTTTCCTTCTG
TGGACAACTTATCAATGCCTTGGATATTGCTCCCAGATATTATGGATTTCTAAAGGCAGTCACA
GCTTTAATTGGAATATTTGGGGGCCTAATTTCTTCAACTCTTGCTGGGTTGATCCTTAATCAGG
ATCCAGAATATGCTTGGCATAAAAACTTCTTCTTGATGGCAGGCATTAACGTGACATGCCTGGC
TTTCTACCTTCTGTTTGCAAAAGGAGATATTCAGGACTGGGCTAAAGAAACAAAAACCACACGG
CTGTGAAGTTAGTAGAAGAGTGAGCACCTGAGAAGCATGAGGTCAGCATCCATATTGAAAGGAA
GAGGATTCTGTGTGGGACTGCAGTCATGGGAGTCATGAACACCTGAAGACCGGTAGCCTGAAGC
TTTTAAGGGAGTCATTGCCTCCCACTTTAGTCTGAGTGATTCTTTTGCACTGTGTATTGTGTGT
AACAAGTTATACTTCTGACTTTAAAGAGGAATCTGTCTGTCTTCCTATGATCCAATAAACAAAC
ATAAGCCAAAACTTTACTCCACTACTTTATGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039095318 ⟹ XP_038951246

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	41,222,338 - 41,255,199 (-)	NCBI

RefSeq Acc Id:

XR_005495230

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	41,219,461 - 41,255,199 (-)	NCBI

RefSeq Acc Id:

XR_005495231

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	41,219,461 - 41,253,075 (-)	NCBI

RefSeq Acc Id:

XR_005495232

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	41,219,461 - 41,255,199 (-)	NCBI

RefSeq Acc Id:

XR_005495233

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	41,219,461 - 41,248,105 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_598238	(Get FASTA)	NCBI Sequence Viewer
	XP_038951246	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52487	(Get FASTA)	NCBI Sequence Viewer
	AAH78748	(Get FASTA)	NCBI Sequence Viewer
	AAM52218	(Get FASTA)	NCBI Sequence Viewer
	EDL86536	(Get FASTA)	NCBI Sequence Viewer
	EDL86537	(Get FASTA)	NCBI Sequence Viewer
	EDL86538	(Get FASTA)	NCBI Sequence Viewer
	EDL86539	(Get FASTA)	NCBI Sequence Viewer
	EDL86540	(Get FASTA)	NCBI Sequence Viewer
	EDL86541	(Get FASTA)	NCBI Sequence Viewer
	EDL86542	(Get FASTA)	NCBI Sequence Viewer
	EDL86543	(Get FASTA)	NCBI Sequence Viewer
	EDL86544	(Get FASTA)	NCBI Sequence Viewer
	EDL86545	(Get FASTA)	NCBI Sequence Viewer
	EDL86546	(Get FASTA)	NCBI Sequence Viewer
	EDL86547	(Get FASTA)	NCBI Sequence Viewer
	EDL86548	(Get FASTA)	NCBI Sequence Viewer
	EDL86549	(Get FASTA)	NCBI Sequence Viewer
	EDL86550	(Get FASTA)	NCBI Sequence Viewer
	EDL86551	(Get FASTA)	NCBI Sequence Viewer
	EDL86552	(Get FASTA)	NCBI Sequence Viewer
	EDL86553	(Get FASTA)	NCBI Sequence Viewer
	Q62795	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_598238 ⟸ NM_133554

- UniProtKB:

Q6AZ46 (UniProtKB/TrEMBL), F1M6S8 (UniProtKB/TrEMBL), A0A9K3Y819 (UniProtKB/TrEMBL), Q8K3H3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MENRCLPKKVPGFCSFRYGLAILLHFCNIVIMAQRVCLNLTMVAMVNKTEPPHLSNKSVAEMLD
NVKNPVHSWSLDIQGLILSSVFLGMVVIQVPVGYLSGAYPMKKIIGSSLFLSSVLSLLIPPAAQ
VGAALVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICD
LLGWPMVFYIFGIVGCVLSLFWFILFFDDPNNHPYMSSSEKDYITSSLMQQVHSGRQSLPIKAM
LKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQMS
DFLLSRKIFSVVAVRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLIN
ALDIAPRYYGFLKAVTALIGIFGGLISSTLAGLILNQDPEYAWHKNFFLMAGINVTCLAFYLLF
AKGDIQDWAKETKTTRL

hide sequence

RefSeq Acc Id:	XP_038951246 ⟸ XM_039095318
- Peptide Label:	isoform X1
- UniProtKB:	F1M6S8 (UniProtKB/TrEMBL), Q6AZ46 (UniProtKB/TrEMBL), A0A9K3Y819 (UniProtKB/TrEMBL), Q8K3H3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000061056 ⟸ ENSRNOT00000066313

Protein Domains

Major facilitator superfamily (MFS) profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62795-F1-model_v2	AlphaFold	Q62795	1-465	view protein structure
AF-A0A0G2K6H6-F1-model_v2	AlphaFold	A0A0G2K6H6	1-466	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620099	AgrOrtholog
BioCyc Gene	G2FUF-9391	BioCyc
Ensembl Genes	ENSRNOG00000042692	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000061056	ENTREZGENE
	ENSRNOP00000061056.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066313	ENTREZGENE
	ENSRNOT00000066313.4	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7109368	IMAGE-MGC_LOAD
InterPro	MFS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pi_cotranspt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171080	UniProtKB/TrEMBL
MGC_CLONE	MGC:93217	IMAGE-MGC_LOAD
NCBI Gene	171080	ENTREZGENE
PANTHER	SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 17	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MFS_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc17a1	PhenoGen
PROSITE	MFS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A9K3Y819	ENTREZGENE, UniProtKB/TrEMBL
	A6KLJ1_RAT	UniProtKB/TrEMBL
	A6KLJ3_RAT	UniProtKB/TrEMBL
	A6KLJ4_RAT	UniProtKB/TrEMBL
	A6KLK6_RAT	UniProtKB/TrEMBL
	F1M6S8	ENTREZGENE
	NPT1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6AZ46	ENTREZGENE, UniProtKB/TrEMBL
	Q8K3H3	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1M6S8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc17a1	solute carrier family 17 member 1	Slc17a1	solute carrier family 17 (organic anion transporter), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc17a1	solute carrier family 17 (organic anion transporter), member 1	Slc17a1	solute carrier family 17 (sodium phosphate), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-14	Slc17a1	solute carrier family 17 (sodium phosphate), member 1			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-06-18		solute carrier family 17 (sodium phosphate), member 1	Slc17a1	solute carrier family 17 vesicular glutamate transporter), member 1	Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2002-08-07	Slc17a1	solute carrier family 17 vesicular glutamate transporter), member 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression is decreased 1.5 fold in SHR compared with WKY rats	1357414

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD