Ocln (occludin) - Rat Genome Database

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Gene: Ocln (occludin) Rattus norvegicus
Analyze
Symbol: Ocln
Name: occludin
RGD ID: 620089
Description: Predicted to enable protein domain specific binding activity. Involved in cellular response to tumor necrosis factor; response to Gram-positive bacterium; and response to interleukin-18. Located in apical plasma membrane and lateral plasma membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; hepatitis C pathway; INTERACTS WITH (R)-carnitine; 17beta-estradiol; 17beta-estradiol 17-glucosiduronic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,391,303 - 33,442,207 (-)NCBIGRCr8
mRatBN7.2231,657,217 - 31,707,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,657,220 - 31,764,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,791,782 - 38,841,944 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,819,361 - 36,869,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,690,347 - 31,739,905 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,527,327 - 30,577,218 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,686,707 - 49,737,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,317,090 - 31,367,485 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,237,461 - 31,287,854 (-)NCBI
Celera227,670,881 - 27,719,967 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-carnitine  (EXP)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-benzoate  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
4-tert-Octylphenol  (EXP)
5-azacytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-dihydroxycoumarin  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acrylonitrile  (ISO)
actinidine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
Alpinetin  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
ampicillin  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
chlorogenic acid  (EXP)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
Dictamnine  (ISO)
diethyl phthalate  (ISO)
diiodine  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol  (EXP)
excitatory amino acid agonist  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
galactose  (ISO)
gamma-linolenic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgolide A  (ISO)
ginsenoside Re  (ISO)
glabridin  (ISO)
glucose  (ISO)
glycine  (ISO)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
hydroxychloroquine  (ISO)
hydroxysafflor yellow A  (ISO)
indometacin  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprene  (ISO)
isovitexin  (EXP)
kaempferol  (EXP,ISO)
ketamine  (ISO)
kynurenic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
malaoxon  (EXP)
malathion  (EXP)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (EXP)
metronidazole  (ISO)
microcystin-LR  (EXP,ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP,ISO)
mycophenolic acid  (ISO)
myricetin  (EXP)
N(6),N(6)-dimethyladenine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
papaverine  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phoxim  (EXP)
pirinixic acid  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
probenecid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
Salidroside  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium propionate  (ISO)
sodium sulfide (anhydrous)  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfasalazine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
tioguanine  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
zafirlukast  (ISO)
zileuton  (ISO)
zinc sulfate  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression. Chehade JM, etal., Neurochem Res 2002 Mar;27(3):249-52.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. Hori S, etal., J Neurochem 2004 Apr;89(2):503-13.
5. The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosa. Hussar P, etal., Chem Senses 2002 Jan;27(1):7-11.
6. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Khailova L, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug 27.
7. S-methylation of 2-mercaptopyrazine in rat liver microsomes and cytosol. Lee DH and Kim DH, Xenobiotica 1999 Sep;29(9):909-16.
8. Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Li X, etal., Biochim Biophys Acta. 2012 Feb;1822(2):196-203. doi: 10.1016/j.bbadis.2011.09.019. Epub 2011 Oct 7.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Increase in the tight junction protein claudin-1 in intestinal inflammation. Poritz LS, etal., Dig Dis Sci. 2011 Oct;56(10):2802-9. doi: 10.1007/s10620-011-1688-9. Epub 2011 Jul 12.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Focal adhesion kinase is a blood-testis barrier regulator. Siu ER, etal., Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9298-303. doi: 10.1073/pnas.0813113106. Epub 2009 May 21.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK). Su L, etal., Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19623-8. doi: 10.1073/pnas.1111414108. Epub 2011 Nov 21.
20. Bile canalicular barrier function and expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation. Takakuwa Y, etal., Cell Tissue Res 2002 Feb;307(2):181-9.
21. Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury. Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24.
22. Dendrobium chrysotoxum Lindl. alleviates diabetic retinopathy by preventing retinal inflammation and tight junction protein decrease. Yu Z, etal., J Diabetes Res. 2015;2015:518317. doi: 10.1155/2015/518317. Epub 2015 Jan 1.
Additional References at PubMed
PMID:9647647   PMID:11025210   PMID:11090614   PMID:11782481   PMID:11810420   PMID:12060405   PMID:12498716   PMID:12507281   PMID:12734665   PMID:14685273   PMID:15052661   PMID:15489334  
PMID:15528189   PMID:15605377   PMID:15775979   PMID:16365161   PMID:16510873   PMID:16520537   PMID:16651389   PMID:17000770   PMID:17065217   PMID:17130295   PMID:17245419   PMID:17666436  
PMID:17825302   PMID:18183615   PMID:18279593   PMID:18647175   PMID:18706176   PMID:18855986   PMID:19017651   PMID:19129494   PMID:19213829   PMID:19319148   PMID:19332538   PMID:19457074  
PMID:19507189   PMID:19555995   PMID:20028514   PMID:20089884   PMID:20152177   PMID:20164257   PMID:20170644   PMID:20180397   PMID:20473716   PMID:20970449   PMID:21192956   PMID:21257729  
PMID:21318404   PMID:21334421   PMID:21336719   PMID:21415414   PMID:22378877   PMID:22559818   PMID:22946046   PMID:23018187   PMID:23171401   PMID:23288152   PMID:23297502   PMID:23345400  
PMID:23417864   PMID:23708107   PMID:24008412   PMID:24081143   PMID:24398936   PMID:24567356   PMID:24854121   PMID:24889144   PMID:25278303   PMID:25304966   PMID:25617501   PMID:25649016  
PMID:26585695   PMID:26607202   PMID:28079139   PMID:28718701   PMID:29179201   PMID:29258088   PMID:29845266   PMID:30452951   PMID:30734065   PMID:31506421   PMID:32716860   PMID:32807750  
PMID:33343804   PMID:34359845   PMID:35908134  


Genomics

Comparative Map Data
Ocln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,391,303 - 33,442,207 (-)NCBIGRCr8
mRatBN7.2231,657,217 - 31,707,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,657,220 - 31,764,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,791,782 - 38,841,944 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,819,361 - 36,869,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,690,347 - 31,739,905 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,527,327 - 30,577,218 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,686,707 - 49,737,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,317,090 - 31,367,485 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,237,461 - 31,287,854 (-)NCBI
Celera227,670,881 - 27,719,967 (-)NCBICelera
Cytogenetic Map2q12NCBI
OCLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,492,547 - 69,558,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,492,292 - 69,558,104 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,788,374 - 68,853,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,823,875 - 68,885,889 (+)NCBINCBI36Build 36hg18NCBI36
Build 34568,823,874 - 68,885,887NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,744,381 - 65,800,380 (+)NCBIHuRef
HuRef565,800,577 - 65,803,347 (+)NCBIHuRef
CHM1_1568,787,783 - 68,853,763 (+)NCBICHM1_1
T2T-CHM13v2.0570,316,240 - 70,383,882 (+)NCBIT2T-CHM13v2.0
Ocln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,633,012 - 100,689,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,633,015 - 100,689,226 (-)EnsemblGRCm39 Ensembl
GRCm3813100,496,504 - 100,552,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,496,507 - 100,552,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,267,322 - 101,322,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,597,624 - 101,652,755 (-)NCBIMGSCv36mm8
Celera13104,112,684 - 104,167,697 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ocln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955575163,646 - 210,379 (+)NCBIChiLan1.0ChiLan1.0
OCLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,366,263 - 44,428,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,519,888 - 42,582,278 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,447,230 - 44,509,637 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,022,538 - 46,080,549 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,023,437 - 46,069,342 (-)Ensemblpanpan1.1panPan2
OCLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,500,299 - 54,545,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,500,299 - 54,545,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,466,637 - 51,511,781 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,004,936 - 55,058,838 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,005,004 - 55,058,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,076,201 - 52,121,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,843,313 - 52,888,432 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,733,721 - 53,779,092 (+)NCBIUU_Cfam_GSD_1.0
Ocln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,162,311 - 191,216,242 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648098,371 - 152,413 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648099,516 - 152,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OCLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,600,212 - 47,654,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,547,473 - 51,598,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OCLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,581,943 - 65,641,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,582,460 - 65,644,787 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,326,566 - 14,386,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ocln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905333,864 - 388,880 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905333,853 - 388,990 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ocln
636 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:819
Count of miRNA genes:316
Interacting mature miRNAs:410
Transcripts:ENSRNOT00000024674
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat

Markers in Region
D2Rat193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,685,805 - 31,685,914 (+)MAPPERmRatBN7.2
Rnor_6.0230,555,907 - 30,556,013NCBIRnor6.0
Rnor_5.0249,715,234 - 49,715,340UniSTSRnor5.0
RGSC_v3.4231,346,066 - 31,346,173RGDRGSC3.4
RGSC_v3.4231,346,067 - 31,346,173UniSTSRGSC3.4
RGSC_v3.1231,266,436 - 31,266,542RGD
Celera227,699,448 - 27,699,554UniSTS
RH 3.4 Map277.5UniSTS
RH 3.4 Map277.5RGD
SHRSP x BN Map210.5399UniSTS
SHRSP x BN Map210.5399RGD
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 16 16 10 16 2 35 22 11
Low 34 41 25 9 25 3 3 72 19 3
Below cutoff 9 5 7 5

Sequence


RefSeq Acc Id: ENSRNOT00000024674   ⟹   ENSRNOP00000024674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,657,220 - 31,707,120 (-)Ensembl
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077537   ⟹   ENSRNOP00000070680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,742,653 - 31,759,468 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084667   ⟹   ENSRNOP00000068691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,657,220 - 31,760,321 (-)Ensembl
Rnor_6.0 Ensembl230,528,242 - 30,576,591 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085488   ⟹   ENSRNOP00000073691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,725,984 - 31,764,150 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106737   ⟹   ENSRNOP00000078336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,742,653 - 31,764,002 (-)Ensembl
RefSeq Acc Id: NM_031329   ⟹   NP_112619
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,391,303 - 33,441,198 (-)NCBI
mRatBN7.2231,657,217 - 31,707,120 (-)NCBI
Rnor_6.0230,527,327 - 30,577,218 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
RGSC_v3.4231,317,090 - 31,367,485 (-)RGD
Celera227,670,881 - 27,719,967 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231853   ⟹   XP_006231915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,441,117 (-)NCBI
mRatBN7.2231,658,558 - 31,707,019 (-)NCBI
Rnor_6.0230,528,283 - 30,577,084 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231854   ⟹   XP_006231916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,441,043 (-)NCBI
mRatBN7.2231,658,558 - 31,706,965 (-)NCBI
Rnor_6.0230,528,283 - 30,577,061 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231855   ⟹   XP_006231917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,440,628 (-)NCBI
mRatBN7.2231,658,558 - 31,706,508 (-)NCBI
Rnor_6.0230,528,283 - 30,576,129 (-)NCBI
Rnor_5.0249,686,707 - 49,737,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103242   ⟹   XP_038959170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,442,207 (-)NCBI
mRatBN7.2231,658,558 - 31,707,466 (-)NCBI
RefSeq Acc Id: XM_039103244   ⟹   XP_038959172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,440,628 (-)NCBI
mRatBN7.2231,658,558 - 31,706,508 (-)NCBI
RefSeq Acc Id: XM_039103245   ⟹   XP_038959173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,441,058 (-)NCBI
mRatBN7.2231,658,558 - 31,707,019 (-)NCBI
RefSeq Acc Id: XM_063282636   ⟹   XP_063138706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,437,874 (-)NCBI
RefSeq Acc Id: XM_063282637   ⟹   XP_063138707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,392,647 - 33,442,207 (-)NCBI
RefSeq Acc Id: NP_112619   ⟸   NM_031329
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231915   ⟸   XM_006231853
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231916   ⟸   XM_006231854
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231917   ⟸   XM_006231855
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068691   ⟸   ENSRNOT00000084667
RefSeq Acc Id: ENSRNOP00000024674   ⟸   ENSRNOT00000024674
RefSeq Acc Id: XP_038959170   ⟸   XM_039103242
- Peptide Label: isoform X1
- UniProtKB: Q6P6T5 (UniProtKB/Swiss-Prot),   Q9Z303 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959173   ⟸   XM_039103245
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QZI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959172   ⟸   XM_039103244
- Peptide Label: isoform X1
- UniProtKB: Q6P6T5 (UniProtKB/Swiss-Prot),   Q9Z303 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL),   A0A8L2QZI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000070680   ⟸   ENSRNOT00000077537
RefSeq Acc Id: ENSRNOP00000078336   ⟸   ENSRNOT00000106737
RefSeq Acc Id: ENSRNOP00000073691   ⟸   ENSRNOT00000085488
RefSeq Acc Id: XP_063138707   ⟸   XM_063282637
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063138706   ⟸   XM_063282636
- Peptide Label: isoform X1
- UniProtKB: Q9Z303 (UniProtKB/Swiss-Prot),   Q6P6T5 (UniProtKB/Swiss-Prot),   A6I594 (UniProtKB/TrEMBL)
Protein Domains
MARVEL   OCEL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T5-F1-model_v2 AlphaFold Q6P6T5 1-523 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620089 AgrOrtholog
BioCyc Gene G2FUF-54668 BioCyc
Ensembl Genes ENSRNOG00000018297 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055028978 UniProtKB/Swiss-Prot
  ENSRNOG00065023023 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024674 ENTREZGENE
  ENSRNOT00000024674.6 UniProtKB/Swiss-Prot
  ENSRNOT00000084667.2 UniProtKB/TrEMBL
  ENSRNOT00000106737.1 UniProtKB/TrEMBL
  ENSRNOT00055050200 UniProtKB/Swiss-Prot
  ENSRNOT00065039377 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623744 IMAGE-MGC_LOAD
InterPro ELL/occludin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Marvel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83497 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72407 IMAGE-MGC_LOAD
NCBI Gene 83497 ENTREZGENE
PANTHER PTHR23288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23288:SF3 UniProtKB/TrEMBL
  PTHR23288:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MARVEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ocln PhenoGen
PIRSF Occludin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS OCCLUDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MARVEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OCEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018297 RatGTEx
  ENSRNOG00055028978 RatGTEx
  ENSRNOG00065023023 RatGTEx
Superfamily-SCOP occludin/ELL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZKQ0_RAT UniProtKB/TrEMBL
  A0A8L2QZI9 ENTREZGENE, UniProtKB/TrEMBL
  A6I594 ENTREZGENE, UniProtKB/TrEMBL
  OCLN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z303 ENTREZGENE
UniProt Secondary Q9Z303 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-09-11 Ocln  occludin  Tpmt  thiopurine methyltransferase  Symbol and Name updated 1299863 APPROVED
2005-01-20 Tpmt  thiopurine methyltransferase  Ocln  occludin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ocln  occludin      Symbol and Name status set to provisional 70820 PROVISIONAL