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Gene: Polg (DNA polymerase gamma, catalytic subunit) Rattus norvegicus
Symbol: Polg
Name: DNA polymerase gamma, catalytic subunit
Description: Exhibits DNA-directed DNA polymerase activity. Involved in several processes, including cellular response to glucose stimulus; response to gamma radiation; and response to hyperoxia. Localizes to gamma DNA polymerase complex and terminal bouton. Used to study hepatocellular carcinoma and mitochondrial DNA depletion syndrome 4a. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit); INTERACTS WITH (+)-pilocarpine; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
Also known as: DNA polymerase gamma; DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; mitochondrial DNA polymerase catalytic subunit; polG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit
Homo sapiens (human) : POLG (DNA polymerase gamma, catalytic subunit)  HGNC  Alliance
Mus musculus (house mouse) : Polg (polymerase (DNA directed), gamma)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Polg (DNA polymerase gamma, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLG (DNA polymerase gamma, catalytic subunit)
Canis lupus familiaris (dog) : POLG (DNA polymerase gamma, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Polg (DNA polymerase gamma, catalytic subunit)
Sus scrofa (pig) : POLG (DNA polymerase gamma, catalytic subunit)
Chlorocebus sabaeus (African green monkey) : POLG (DNA polymerase gamma, catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Polg (DNA polymerase gamma, catalytic subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01141,172,117 - 141,188,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,133,892 - 142,150,597 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,197,075 - 135,212,178 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,275,417 - 135,290,521 (-)NCBI
Celera1125,446,563 - 125,461,666 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Polg
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620057
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.