Ppfia4 (PTPRF interacting protein alpha 4) - Rat Genome Database

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Gene: Ppfia4 (PTPRF interacting protein alpha 4) Rattus norvegicus
Analyze
Symbol: Ppfia4
Name: PTPRF interacting protein alpha 4
RGD ID: 620055
Description: Predicted to be involved in synapse organization. Predicted to be located in synapse. Predicted to be active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone. Orthologous to human PPFIA4 (PTPRF interacting protein alpha 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC685423; liprin-alpha-4; LOC685423; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; PTPRF-interacting protein alpha-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,305,844 - 48,354,329 (-)NCBIGRCr8
mRatBN7.21345,753,827 - 45,802,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,753,827 - 45,802,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,361,659 - 48,409,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,649,729 - 49,697,621 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,914,476 - 46,962,738 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,134,831 - 51,183,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,134,525 - 51,183,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,191,119 - 56,239,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,252,084 - 47,300,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,266,851 - 47,298,660 (-)NCBI
Celera1346,081,944 - 46,130,233 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
butanal  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
esketamine  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
hypochlorous acid  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
pyrethrins  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Schoch S, etal., Nature 2002 Jan 17;415(6869):321-6.
7. Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Wyszynski M, etal., Neuron 2002 Mar 28;34(1):39-52.
Additional References at PubMed
PMID:12477932   PMID:12522103   PMID:12629171   PMID:14612982   PMID:21618221   PMID:21618222  


Genomics

Comparative Map Data
Ppfia4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,305,844 - 48,354,329 (-)NCBIGRCr8
mRatBN7.21345,753,827 - 45,802,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,753,827 - 45,802,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,361,659 - 48,409,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,649,729 - 49,697,621 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,914,476 - 46,962,738 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,134,831 - 51,183,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,134,525 - 51,183,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,191,119 - 56,239,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,252,084 - 47,300,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,266,851 - 47,298,660 (-)NCBI
Celera1346,081,944 - 46,130,233 (-)NCBICelera
Cytogenetic Map13q13NCBI
PPFIA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,026,491 - 203,078,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,026,491 - 203,078,740 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,995,619 - 203,047,864 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,286,934 - 201,314,487 (+)NCBINCBI36Build 36hg18NCBI36
Build 341199,751,967 - 199,779,520NCBI
Celera1176,149,565 - 176,177,122 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,185,942 - 174,213,472 (+)NCBIHuRef
CHM1_11204,442,625 - 204,470,214 (+)NCBICHM1_1
T2T-CHM13v2.01202,289,215 - 202,341,489 (+)NCBIT2T-CHM13v2.0
Ppfia4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,224,521 - 134,272,493 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,224,521 - 134,260,666 (-)EnsemblGRCm39 Ensembl
GRCm381134,296,783 - 134,344,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,296,783 - 134,332,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv371136,193,360 - 136,229,505 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,113,190 - 136,148,934 (-)NCBIMGSCv36mm8
Celera1136,907,323 - 136,945,050 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.18NCBI
Ppfia4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,047,019 - 39,092,597 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,047,069 - 39,094,663 (+)NCBIChiLan1.0ChiLan1.0
PPFIA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2146,299,230 - 46,351,777 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,266,286 - 46,318,804 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,628,003 - 178,680,528 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,922,756 - 182,975,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,922,758 - 182,975,300 (+)Ensemblpanpan1.1panPan2
PPFIA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17118,795 - 164,937 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7120,908 - 164,964 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7174,541 - 221,262 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07129,327 - 176,049 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7129,334 - 174,840 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17117,584 - 164,287 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07227,086 - 273,816 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07249,627 - 296,320 (-)NCBIUU_Cfam_GSD_1.0
Ppfia4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,280,151 - 72,330,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,517,038 - 1,553,736 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,514,831 - 1,565,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPFIA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,727,855 - 113,777,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,727,857 - 113,777,772 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,188,699 - 125,238,345 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPFIA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,274,388 - 26,327,507 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,276,014 - 26,305,025 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605527,050,300 - 27,104,334 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppfia4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,759,616 - 7,793,560 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,757,385 - 7,807,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppfia4
211 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:194
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000039540
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134522835847841255Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
D13Hmgc23  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01351,181,922 - 51,182,122NCBIRnor6.0
Rnor_5.01356,238,270 - 56,238,470UniSTSRnor5.0
RGSC_v3.41347,299,404 - 47,299,604UniSTSRGSC3.4
Celera1346,128,882 - 46,129,093UniSTS
Cytogenetic Map13q13UniSTS
AI448359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,755,446 - 45,755,663 (+)MAPPERmRatBN7.2
Rnor_6.01351,136,451 - 51,136,667NCBIRnor6.0
Rnor_5.01356,192,739 - 56,192,955UniSTSRnor5.0
RGSC_v3.41347,253,704 - 47,253,920UniSTSRGSC3.4
Celera1346,083,564 - 46,083,780UniSTS
Cytogenetic Map13q13UniSTS
RH127096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,755,504 - 45,755,747 (+)MAPPERmRatBN7.2
Rnor_6.01351,136,509 - 51,136,751NCBIRnor6.0
Rnor_5.01356,192,797 - 56,193,039UniSTSRnor5.0
RGSC_v3.41347,253,762 - 47,254,004UniSTSRGSC3.4
Celera1346,083,622 - 46,083,864UniSTS
Cytogenetic Map13q13UniSTS
BF405092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,801,304 - 45,801,471 (+)MAPPERmRatBN7.2
Rnor_6.01351,182,306 - 51,182,472NCBIRnor6.0
Rnor_5.01356,238,654 - 56,238,820UniSTSRnor5.0
RGSC_v3.41347,299,788 - 47,299,954UniSTSRGSC3.4
Celera1346,129,277 - 46,129,443UniSTS
RH 3.4 Map13170.8UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY057064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF285985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB584337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000039540   ⟹   ENSRNOP00000033209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,753,827 - 45,802,261 (-)Ensembl
Rnor_6.0 Ensembl1351,134,525 - 51,183,269 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098935   ⟹   ENSRNOP00000094172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,758,384 - 45,802,261 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108350   ⟹   ENSRNOP00000081918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,753,827 - 45,757,268 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115473   ⟹   ENSRNOP00000080414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,755,421 - 45,802,261 (-)Ensembl
RefSeq Acc Id: NM_080409   ⟹   NP_536334
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,305,848 - 48,354,279 (-)NCBI
mRatBN7.21345,753,827 - 45,802,261 (-)NCBI
Rnor_6.01351,134,831 - 51,183,262 (-)NCBI
Rnor_5.01356,191,119 - 56,239,610 (-)NCBI
RGSC_v3.41347,252,084 - 47,300,744 (-)RGD
Celera1346,081,944 - 46,130,233 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090289   ⟹   XP_038946217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,323,535 - 48,354,323 (-)NCBI
mRatBN7.21345,771,520 - 45,789,743 (-)NCBI
RefSeq Acc Id: XM_039090290   ⟹   XP_038946218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,323,535 - 48,354,323 (-)NCBI
mRatBN7.21345,771,519 - 45,802,305 (-)NCBI
RefSeq Acc Id: XM_063271975   ⟹   XP_063128045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,308,103 - 48,354,329 (-)NCBI
RefSeq Acc Id: XM_063271976   ⟹   XP_063128046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,305,844 - 48,354,323 (-)NCBI
RefSeq Acc Id: XM_063271977   ⟹   XP_063128047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,308,103 - 48,354,323 (-)NCBI
RefSeq Acc Id: XM_063271978   ⟹   XP_063128048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,305,844 - 48,354,323 (-)NCBI
RefSeq Acc Id: XR_005492195
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,323,000 - 48,354,323 (-)NCBI
mRatBN7.21345,770,980 - 45,802,305 (-)NCBI
RefSeq Acc Id: NP_536334   ⟸   NM_080409
- UniProtKB: A0A8I6AIZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033209   ⟸   ENSRNOT00000039540
RefSeq Acc Id: XP_038946218   ⟸   XM_039090290
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946217   ⟸   XM_039090289
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000081918   ⟸   ENSRNOT00000108350
Ensembl Acc Id: ENSRNOP00000080414   ⟸   ENSRNOT00000115473
Ensembl Acc Id: ENSRNOP00000094172   ⟸   ENSRNOT00000098935
RefSeq Acc Id: XP_063128048   ⟸   XM_063271978
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128046   ⟸   XM_063271976
- Peptide Label: isoform X2
- UniProtKB: A6ICB3 (UniProtKB/TrEMBL),   F1M863 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128045   ⟸   XM_063271975
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128047   ⟸   XM_063271977
- Peptide Label: isoform X3
Protein Domains
SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91Z80-F1-model_v2 AlphaFold Q91Z80 1-1043 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620055 AgrOrtholog
BioCyc Gene G2FUF-18245 BioCyc
Ensembl Genes ENSRNOG00000003494 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039540.7 UniProtKB/TrEMBL
  ENSRNOT00000098935.1 UniProtKB/TrEMBL
  ENSRNOT00000108350.1 UniProtKB/TrEMBL
  ENSRNOT00000115473.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7316820 IMAGE-MGC_LOAD
InterPro Liprin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Liprin-alpha_SAM_rpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Liprin-alpha_SAM_rpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Liprin-alpha_SAM_rpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140592 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109376 IMAGE-MGC_LOAD
NCBI Gene 140592 ENTREZGENE
PANTHER PTHR12587 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12587:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppfia4 PhenoGen
PROSITE SAM_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003494 RatGTEx
SMART SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUF7_RAT UniProtKB/TrEMBL
  A0A8I6AIZ8 ENTREZGENE, UniProtKB/TrEMBL
  A6ICB3 ENTREZGENE, UniProtKB/TrEMBL
  F1M863 ENTREZGENE, UniProtKB/TrEMBL
  LIPA4_RAT UniProtKB/Swiss-Prot
  Q562A3_RAT UniProtKB/TrEMBL
  Q91Z80 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppfia4  PTPRF interacting protein alpha 4  Ppfia4  protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Ppfia4  protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4  LOC685423  hypothetical protein LOC685423  Data merged from RGD:1593833 737654 PROVISIONAL
2006-11-20 LOC685423  hypothetical protein LOC685423      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Ppfia4  protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ppfia4  protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to RIM-BPs, cyclic-AMP-GEFII, and Munc13-1 633666