(+)-dihydromyricetin decreases expression ISO RGD:1346404 6480464 ampelopsin results in decreased expression of SPHK1 protein CTD PMID:22251058 (+)-dihydromyricetin decreases activity ISO RGD:1346404 6480464 ampelopsin results in decreased activity of SPHK1 protein CTD PMID:22251058 1,2-dimethylhydrazine increases expression EXP 6480464 1, 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:27840820 1,2-dimethylhydrazine multiple interactions ISO RGD:733320 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SPHK1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine increases expression ISO RGD:733320 6480464 1, 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of SPHK1 mRNA CTD PMID:17351261 17beta-estradiol affects expression ISO RGD:1346404 6480464 Estradiol affects the expression of SPHK1 mRNA CTD PMID:22574217 17beta-estradiol multiple interactions ISO RGD:1346404 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SPHK1 mRNA CTD PMID:30165855 17beta-estradiol increases expression ISO RGD:1346404 6480464 Estradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 , PMID:31614463 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:27318803 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733320 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733320 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:16960034 , PMID:21964420 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:733320 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 4-(ethoxymethylene)-2-phenyloxazol-5-one increases activity EXP 6480464 Oxazolone results in increased activity of SPHK1 protein CTD PMID:24055189 4-(ethoxymethylene)-2-phenyloxazol-5-one multiple interactions EXP 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 4-hydroxy-17beta-estradiol increases expression ISO RGD:1346404 6480464 4-hydroxyestradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 4-hydroxyphenyl retinamide increases expression ISO RGD:733320 6480464 Fenretinide results in increased expression of SPHK1 mRNA CTD PMID:28973697 4-nitrophenol increases expression ISO RGD:733320 6480464 4-nitrophenol results in increased expression of SPHK1 mRNA CTD PMID:34673133 5-aza-2'-deoxycytidine increases expression ISO RGD:1346404 6480464 Decitabine results in increased expression of SPHK1 mRNA CTD PMID:19194470 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of SPHK1 mRNA CTD PMID:24780913 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of SPHK1 mRNA CTD PMID:28959563 afimoxifene decreases response to substance ISO RGD:1346404 6480464 SPHK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 aflatoxin B1 increases expression ISO RGD:1346404 6480464 Aflatoxin B1 results in increased expression of SPHK1 mRNA CTD PMID:22100608 , PMID:27153756 albendazole multiple interactions ISO RGD:1346404 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 aldehydo-D-glucose multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:20488242 all-trans-retinoic acid decreases expression ISO RGD:1346404 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:23830798 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SPHK1 mRNA CTD PMID:16483693 apigenin multiple interactions EXP 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:25557508 aristolochic acid A increases expression ISO RGD:1346404 6480464 aristolochic acid I results in increased expression of SPHK1 mRNA CTD PMID:33212167 arsane multiple interactions ISO RGD:1346404 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 arsane affects methylation ISO RGD:1346404 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 arsenic atom multiple interactions ISO RGD:1346404 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 arsenic atom affects methylation ISO RGD:1346404 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 arsenite(3-) increases expression ISO RGD:1346404 6480464 arsenite metabolite results in increased expression of SPHK1 mRNA CTD PMID:33129825 benzo[a]pyrene increases expression ISO RGD:733320 6480464 Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:21569818 , PMID:22228805 benzo[a]pyrene increases expression ISO RGD:1346404 6480464 Benzo(a)pyrene metabolite results in increased expression of SPHK1 mRNA, Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:26314263 , PMID:32234424 benzo[a]pyrene diol epoxide I affects expression ISO RGD:1346404 6480464 7 more ... CTD PMID:20382639 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:25181051 more ... bisphenol A decreases expression ISO RGD:1346404 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:29275510 bortezomib decreases expression ISO RGD:1346404 6480464 Bortezomib results in decreased expression of SPHK1 protein CTD PMID:21195056 butan-1-ol multiple interactions ISO RGD:1346404 6480464 1-Butanol inhibits the reaction [C5 protein results in increased activity of SPHK1 protein], [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:19284563 , PMID:29432896 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of SPHK1 mRNA CTD PMID:19167457 cadmium atom increases expression ISO RGD:1346404 6480464 Cadmium results in increased expression of SPHK1 mRNA CTD PMID:21120746 , PMID:24376830 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:33453195 cadmium dichloride increases expression ISO RGD:733320 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:34666113 calcium atom multiple interactions ISO RGD:1346404 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium, resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 , PMID:19346296 calcium atom multiple interactions ISO RGD:733320 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium, resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 calcium(0) multiple interactions ISO RGD:1346404 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium, resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 , PMID:19346296 calcium(0) multiple interactions ISO RGD:733320 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium, resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 cannabidiol multiple interactions ISO RGD:733320 6480464 Cannabidiol inhibits the reaction [MOG protein modified form results in increased expression of SPHK1 mRNA] CTD PMID:27256343 carbon nanotube increases expression ISO RGD:1346404 6480464 Nanotubes, Carbon results in increased expression of SPHK1 mRNA CTD PMID:25511174 carbon nanotube affects expression ISO RGD:733320 6480464 Nanotubes more ... CTD PMID:23845593 , PMID:25554681 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of SPHK1 mRNA CTD PMID:18500788 chlorpyrifos decreases methylation EXP 6480464 Chlorpyrifos results in decreased methylation of SPHK1 gene CTD PMID:32905263 choline multiple interactions ISO RGD:733320 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:22023808 cisplatin multiple interactions ISO RGD:1346404 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SPHK1 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:1346404 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:1346404 6480464 cobaltous chloride results in decreased expression of SPHK1 mRNA CTD PMID:19320972 , PMID:26314263 copper(II) sulfate decreases expression ISO RGD:1346404 6480464 Copper Sulfate results in decreased expression of SPHK1 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:1346404 6480464 Asbestos, Crocidolite results in increased expression of SPHK1 mRNA CTD PMID:18687144 crocidolite asbestos affects expression ISO RGD:1346404 6480464 Asbestos, Crocidolite affects the expression of SPHK1 mRNA CTD PMID:25757056 cyclosporin A increases expression ISO RGD:733320 6480464 Cyclosporine results in increased expression of SPHK1 mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:1346404 6480464 Cyclosporine results in decreased expression of SPHK1 mRNA CTD PMID:25562108 , PMID:27989131 D-glucose multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 D-glucose increases expression EXP 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 dexamethasone multiple interactions ISO RGD:733320 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 dexamethasone increases expression ISO RGD:733320 6480464 Dexamethasone results in increased expression of SPHK1 mRNA CTD PMID:22733784 dextran sulfate increases expression EXP 6480464 Dextran Sulfate results in increased expression of SPHK1 protein CTD PMID:30811821 dextran sulfate multiple interactions ISO RGD:733320 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 dextran sulfate multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 diazinon increases methylation ISO RGD:1346404 6480464 Diazinon results in increased methylation of SPHK1 gene CTD PMID:22964155 dibutyl phthalate increases expression ISO RGD:733320 6480464 Dibutyl Phthalate results in increased expression of SPHK1 mRNA CTD PMID:17361019 , PMID:21266533 dioxygen multiple interactions ISO RGD:733320 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SPHK1 mRNA CTD PMID:30529165 divanadium pentaoxide affects expression ISO RGD:733320 6480464 vanadium pentoxide affects the expression of SPHK1 mRNA CTD PMID:26210822 dorsomorphin multiple interactions ISO RGD:1346404 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:1346404 6480464 Doxorubicin results in increased expression of SPHK1 mRNA CTD PMID:29803840 ethanol multiple interactions ISO RGD:1346404 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 folic acid multiple interactions ISO RGD:733320 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 fumonisin B1 multiple interactions ISO RGD:733320 6480464 fumonisin B1 inhibits the reaction [Particulate Matter results in increased expression of SPHK1 mRNA], fumonisin B1 inhibits the reaction [Vehicle Emissions results in increased expression of SPHK1 mRNA] CTD PMID:27376354 furan increases expression EXP 6480464 furan results in increased expression of SPHK1 mRNA CTD PMID:27387713 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of SPHK1 mRNA CTD PMID:33387578 glucose multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 glucose increases expression EXP 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 hesperidin multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 irinotecan affects expression EXP 6480464 Irinotecan affects the expression of SPHK1 mRNA CTD PMID:20097248 isobutanol multiple interactions ISO RGD:1346404 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 isoprenaline increases expression ISO RGD:733320 6480464 Isoproterenol results in increased expression of SPHK1 mRNA CTD PMID:20003209 ivermectin multiple interactions ISO RGD:1346404 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 kaempferol multiple interactions ISO RGD:1346404 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 kaempferol multiple interactions ISO RGD:733320 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein], kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of SPHK1 mRNA CTD PMID:25787151 L-methionine multiple interactions ISO RGD:733320 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 Licochalcone B increases expression ISO RGD:1346404 6480464 licochalcone B results in increased expression of SPHK1 mRNA CTD PMID:33647349 lipopolysaccharide multiple interactions EXP 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein], Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 , PMID:25557508 lipopolysaccharide multiple interactions ISO RGD:733320 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein], kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 lipopolysaccharide decreases expression ISO RGD:1346404 6480464 Lipopolysaccharides results in decreased expression of SPHK1 protein CTD PMID:36243145 lipopolysaccharide increases expression ISO RGD:733320 6480464 Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:36243145 lipopolysaccharide multiple interactions ISO RGD:1346404 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 lipopolysaccharide affects expression ISO RGD:733320 6480464 Lipopolysaccharides affects the expression of SPHK1 protein CTD PMID:36243145 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of SPHK1 mRNA, Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:16415329 , PMID:25557508 menadione affects expression ISO RGD:1346404 6480464 Vitamin K 3 affects the expression of SPHK1 mRNA CTD PMID:20044591 methotrexate decreases expression ISO RGD:1346404 6480464 Methotrexate results in decreased expression of SPHK1 mRNA CTD PMID:17400583 methylmercury(1+) decreases expression ISO RGD:1346404 6480464 methylmercury II results in decreased expression of SPHK1 mRNA CTD PMID:26314263 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 N,N-dimethylsphingosine decreases activity ISO RGD:1346404 6480464 N, N-dimethylsphingosine results in decreased activity of SPHK1 protein CTD PMID:17065523 , PMID:19284563 N,N-dimethylsphingosine decreases expression ISO RGD:1346404 6480464 N, N-dimethylsphingosine results in decreased expression of SPHK1 protein CTD PMID:21195056 N,N-dimethylsphingosine multiple interactions EXP 6480464 N, N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein] CTD PMID:21998146 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 N-methyl-4-phenylpyridinium decreases expression ISO RGD:1346404 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA, 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein CTD PMID:24399507 , PMID:33414358 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1346404 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SPHK1 protein more ... CTD PMID:24399507 , PMID:33414358 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of SPHK1 mRNA CTD PMID:17412507 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 N-Nitrosopyrrolidine increases expression ISO RGD:1346404 6480464 N-Nitrosopyrrolidine results in increased expression of SPHK1 mRNA CTD PMID:32234424 N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions EXP 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 NAD zwitterion decreases activity ISO RGD:1346404 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 NAD(+) decreases activity ISO RGD:1346404 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 naphthalene increases expression ISO RGD:733320 6480464 naphthalene results in increased expression of SPHK1 mRNA CTD PMID:18978301 nickel atom increases expression ISO RGD:733320 6480464 Nickel results in increased expression of SPHK1 mRNA CTD PMID:12540486 nickel sulfate multiple interactions ISO RGD:1346404 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of SPHK1 mRNA CTD PMID:18832182 nickel sulfate increases expression ISO RGD:1346404 6480464 nickel sulfate results in increased expression of SPHK1 mRNA CTD PMID:18832182 ochratoxin A decreases expression ISO RGD:1346404 6480464 ochratoxin A metabolite results in decreased expression of SPHK1 mRNA, ochratoxin A results in decreased expression of SPHK1 mRNA CTD PMID:26314263 ouabain decreases expression ISO RGD:1346404 6480464 Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of SPHK1 mRNA CTD PMID:25729387 ozone increases expression EXP 6480464 Ozone results in increased expression of SPHK1 mRNA CTD PMID:28623178 ozone multiple interactions ISO RGD:733320 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which affects the expression of SPHK1 mRNA, [Air Pollutants results in increased abundance of Ozone] which affects the expression of SPHK1 mRNA CTD PMID:34911549 p-chloromercuribenzoic acid increases expression ISO RGD:1346404 6480464 p-Chloromercuribenzoic Acid results in increased expression of SPHK1 mRNA CTD PMID:26272509 panobinostat multiple interactions ISO RGD:1346404 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:1346404 6480464 panobinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509 paracetamol affects expression ISO RGD:733320 6480464 Acetaminophen affects the expression of SPHK1 mRNA CTD PMID:17562736 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:33387578 paracetamol increases expression ISO RGD:1346404 6480464 Acetaminophen results in increased expression of SPHK1 mRNA CTD PMID:29067470 paracetamol decreases expression ISO RGD:1346404 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:22230336 paraquat increases expression EXP 6480464 Paraquat results in increased expression of SPHK1 mRNA CTD PMID:32680482 perfluorooctanoic acid decreases expression ISO RGD:1346404 6480464 perfluorooctanoic acid results in decreased expression of SPHK1 mRNA CTD PMID:36326898 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 phenobarbital affects expression ISO RGD:1346404 6480464 Phenobarbital affects the expression of SPHK1 mRNA CTD PMID:19159669 phenylmercury acetate increases expression ISO RGD:1346404 6480464 Phenylmercuric Acetate results in increased expression of SPHK1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1346404 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 phosgene affects expression ISO RGD:733320 6480464 Phosgene affects the expression of SPHK1 mRNA CTD PMID:16300373 pirinixic acid multiple interactions ISO RGD:733320 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPHK1 mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:733320 6480464 pirinixic acid results in increased expression of SPHK1 mRNA CTD PMID:16985257 potassium dichromate decreases expression ISO RGD:733320 6480464 Potassium Dichromate results in decreased expression of SPHK1 mRNA CTD PMID:23608068 progesterone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA], onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 progesterone increases expression EXP 6480464 Progesterone results in increased expression of SPHK1 mRNA CTD PMID:17164439 prothioconazole decreases expression ISO RGD:1346404 6480464 prothioconazole results in decreased expression of SPHK1 mRNA CTD PMID:35048155 pyridoxamine multiple interactions EXP 6480464 Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 ranitidine multiple interactions EXP 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 resveratrol increases expression ISO RGD:1346404 6480464 resveratrol results in increased expression of SPHK1 mRNA CTD PMID:16624241 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 resveratrol multiple interactions ISO RGD:733320 6480464 resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 resveratrol multiple interactions ISO RGD:1346404 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:19284563 more ... resveratrol decreases expression ISO RGD:1346404 6480464 resveratrol metabolite results in decreased expression of SPHK1 protein more ... CTD PMID:20401667 more ... resveratrol decreases activity ISO RGD:1346404 6480464 resveratrol metabolite results in decreased activity of SPHK1 protein, resveratrol results in decreased activity of SPHK1 protein CTD PMID:22251058 SB 431542 multiple interactions ISO RGD:1346404 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos increases expression ISO RGD:1346404 6480464 Asbestos, Serpentine results in increased expression of SPHK1 mRNA CTD PMID:29523930 silicon dioxide increases expression ISO RGD:1346404 6480464 Silicon Dioxide results in increased expression of SPHK1 mRNA CTD PMID:22300531 , PMID:25351596 sodium arsenate multiple interactions ISO RGD:1346404 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 sodium arsenite increases expression ISO RGD:1346404 6480464 sodium arsenite results in increased expression of SPHK1 mRNA CTD PMID:22714537 , PMID:34032870 sodium fluoride increases expression ISO RGD:733320 6480464 Sodium Fluoride results in increased expression of SPHK1 mRNA CTD PMID:27862939 Soman increases expression EXP 6480464 Soman results in increased expression of SPHK1 mRNA CTD PMID:19281266 sphingosine 1-phosphate increases chemical synthesis ISO RGD:1346404 6480464 SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate CTD PMID:22251058 sphingosine 1-phosphate multiple interactions ISO RGD:1346404 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:24399507 , PMID:26045781 streptozocin increases expression ISO RGD:733320 6480464 Streptozocin results in increased expression of SPHK1 CTD PMID:19657322 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of SPHK1 mRNA, Streptozocin results in increased expression of SPHK1 protein CTD PMID:21998146 T-2 toxin increases expression ISO RGD:1346404 6480464 T-2 Toxin results in increased expression of SPHK1 mRNA CTD PMID:34581912 tamoxifen increases expression ISO RGD:1346404 6480464 Tamoxifen results in increased expression of SPHK1 mRNA CTD PMID:15604281 tert-butyl hydroperoxide increases expression ISO RGD:1346404 6480464 tert-Butylhydroperoxide results in increased expression of SPHK1 mRNA CTD PMID:15336504 tetrachloromethane increases expression ISO RGD:733320 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:17341687 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:31150632 titanium dioxide decreases expression ISO RGD:733320 6480464 titanium dioxide results in decreased expression of SPHK1 mRNA CTD PMID:23557971 titanium dioxide multiple interactions ISO RGD:733320 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 titanium dioxide increases expression ISO RGD:733320 6480464 titanium dioxide results in increased expression of SPHK1 mRNA CTD PMID:27760801 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of SPHK1 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 tributylstannane decreases expression ISO RGD:1346404 6480464 tributyltin results in decreased expression of SPHK1 mRNA CTD PMID:26314263 trichostatin A increases expression ISO RGD:1346404 6480464 trichostatin A results in increased expression of SPHK1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:1346404 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 triclosan decreases expression ISO RGD:1346404 6480464 Triclosan results in decreased expression of SPHK1 mRNA CTD PMID:30510588 triptonide affects expression ISO RGD:733320 6480464 triptonide affects the expression of SPHK1 mRNA CTD PMID:33045310 valproic acid increases methylation ISO RGD:1346404 6480464 Valproic Acid results in increased methylation of SPHK1 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:1346404 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1346404 6480464 Valproic Acid results in increased expression of SPHK1 mRNA CTD PMID:23179753 more ... vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SPHK1 mRNA CTD PMID:22570695 vorinostat multiple interactions ISO RGD:1346404 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 vorinostat increases expression ISO RGD:1346404 6480464 vorinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509
