Mutyh (mutY DNA glycosylase) - Rat Genome Database

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Gene: Mutyh (mutY DNA glycosylase) Rattus norvegicus
Analyze
Symbol: Mutyh
Name: mutY DNA glycosylase
RGD ID: 620045
Description: Enables DNA N-glycosylase activity. Involved in response to oxidative stress. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; stomach cancer; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase); PARTICIPATES IN base excision repair pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: a/G-specific adenine DNA glycosylase; adenine DNA glycosylase; MGC156598; mutY homolog; mutY homolog (E. coli); Myh; rMYH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,510,666 - 135,522,777 (+)NCBIGRCr8
mRatBN7.25130,274,034 - 130,286,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,274,122 - 130,286,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,900,056 - 132,916,846 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,654,658 - 134,671,449 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,677,060 - 134,693,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,663,328 - 135,675,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,663,371 - 135,675,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,459,628 - 139,471,467 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45137,103,958 - 137,115,897 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15137,109,183 - 137,121,122 (+)NCBI
Celera5128,800,792 - 128,812,815 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
caffeine  (EXP)
ceric oxide  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
FR900359  (ISO)
furan  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
Monobutylphthalate  (EXP)
myristicin  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. Al-Tassan N, etal., Nat Genet. 2002 Feb;30(2):227-32. Epub 2002 Jan 30.
2. Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria. Englander EW, etal., J Neurochem 2002 Dec;83(6):1471-80.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Genetic alterations of the MYH gene in gastric cancer. Kim CJ, etal., Oncogene. 2004 Sep 2;23(40):6820-2.
6. Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain. Lee HM, etal., J Neurochem 2002 Mar;80(5):928-37.
7. Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain. Lee HM, etal., J Neurochem. 2004 Jan;88(2):394-400.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11801590   PMID:12477932   PMID:18614015   PMID:20848659   PMID:28059467  


Genomics

Comparative Map Data
Mutyh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,510,666 - 135,522,777 (+)NCBIGRCr8
mRatBN7.25130,274,034 - 130,286,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,274,122 - 130,286,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,900,056 - 132,916,846 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,654,658 - 134,671,449 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,677,060 - 134,693,850 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,663,328 - 135,675,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,663,371 - 135,675,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,459,628 - 139,471,467 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45137,103,958 - 137,115,897 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15137,109,183 - 137,121,122 (+)NCBI
Celera5128,800,792 - 128,812,815 (+)NCBICelera
Cytogenetic Map5q35NCBI
MUTYH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,329,242 - 45,340,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,329,163 - 45,340,893 (-)EnsemblGRCh38hg38GRCh38
GRCh37145,794,914 - 45,806,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,567,501 - 45,578,729 (-)NCBINCBI36Build 36hg18NCBI36
Build 34145,464,007 - 45,475,153NCBI
Celera144,078,292 - 44,089,518 (-)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef143,906,571 - 43,917,689 (-)NCBIHuRef
CHM1_1145,911,718 - 45,922,945 (-)NCBICHM1_1
T2T-CHM13v2.0145,200,799 - 45,211,997 (-)NCBIT2T-CHM13v2.0
Mutyh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,664,846 - 116,676,641 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,664,920 - 116,676,637 (+)EnsemblGRCm39 Ensembl
GRCm384116,807,636 - 116,819,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,807,723 - 116,819,440 (+)EnsemblGRCm38mm10GRCm38
MGSCv374116,480,339 - 116,492,036 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,312,257 - 116,317,312 (+)NCBIMGSCv36mm8
Celera4115,542,682 - 115,558,847 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.34NCBI
Mutyh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,933,497 - 12,938,468 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,927,669 - 12,936,894 (+)NCBIChiLan1.0ChiLan1.0
MUTYH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,468,228 - 181,479,312 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,609,692 - 180,620,766 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,632,102 - 44,643,292 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1145,990,588 - 46,001,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl145,990,588 - 46,002,645 (-)Ensemblpanpan1.1panPan2
MUTYH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11515,018,345 - 15,026,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,906,543 - 15,026,539 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1515,139,709 - 15,147,883 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01515,173,687 - 15,181,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1515,173,511 - 15,197,084 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,970,797 - 14,978,950 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01515,038,669 - 15,046,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01515,110,779 - 15,118,951 (+)NCBIUU_Cfam_GSD_1.0
Mutyh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,651,552 - 60,667,885 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,481,211 - 26,493,019 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,484,316 - 26,492,652 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUTYH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6166,003,351 - 166,012,190 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16166,002,853 - 166,012,191 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,412,000 - 153,420,253 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MUTYH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,449,480 - 87,462,329 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,448,986 - 87,462,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,499,732 - 29,512,629 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mutyh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,236,998 - 1,247,914 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,238,332 - 1,252,408 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mutyh
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000024375
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH141630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25130,285,035 - 130,286,093 (+)MAPPERmRatBN7.2
Rnor_6.05135,674,235 - 135,675,292NCBIRnor6.0
Rnor_5.05139,470,354 - 139,471,411UniSTSRnor5.0
RGSC_v3.45137,114,787 - 137,115,844UniSTSRGSC3.4
Celera5128,811,705 - 128,812,762UniSTS
RH 3.4 Map5837.3UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010066340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF478683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024375   ⟹   ENSRNOP00000024375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,274,122 - 130,286,145 (+)Ensembl
Rnor_6.0 Ensembl5135,663,371 - 135,675,344 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098673   ⟹   ENSRNOP00000084180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,274,133 - 130,286,140 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118511   ⟹   ENSRNOP00000083752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,281,062 - 130,286,146 (+)Ensembl
RefSeq Acc Id: NM_133316   ⟹   NP_579850
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,510,754 - 135,522,777 (+)NCBI
mRatBN7.25130,274,122 - 130,286,146 (+)NCBI
Rnor_6.05135,663,371 - 135,675,345 (+)NCBI
Rnor_5.05139,459,628 - 139,471,467 (+)NCBI
RGSC_v3.45137,103,958 - 137,115,897 (+)RGD
Celera5128,800,792 - 128,812,815 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109200   ⟹   XP_038965128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,510,666 - 135,522,766 (+)NCBI
mRatBN7.25130,274,034 - 130,286,146 (+)NCBI
RefSeq Acc Id: XM_039109201   ⟹   XP_038965129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,511,744 - 135,522,766 (+)NCBI
mRatBN7.25130,275,018 - 130,286,149 (+)NCBI
RefSeq Acc Id: XM_039109202   ⟹   XP_038965130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,510,666 - 135,522,766 (+)NCBI
mRatBN7.25130,274,034 - 130,286,146 (+)NCBI
RefSeq Acc Id: XM_039109203   ⟹   XP_038965131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,519,063 - 135,522,766 (+)NCBI
mRatBN7.25130,274,153 - 130,286,146 (+)NCBI
RefSeq Acc Id: XM_039109204   ⟹   XP_038965132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,519,063 - 135,522,766 (+)NCBI
mRatBN7.25130,281,149 - 130,286,149 (+)NCBI
RefSeq Acc Id: XM_039109205   ⟹   XP_038965133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,519,127 - 135,522,766 (+)NCBI
mRatBN7.25130,282,485 - 130,286,149 (+)NCBI
RefSeq Acc Id: XM_039109207   ⟹   XP_038965135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,510,666 - 135,520,941 (+)NCBI
mRatBN7.25130,274,034 - 130,284,313 (+)NCBI
RefSeq Acc Id: XM_039109208   ⟹   XP_038965136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,510,666 - 135,520,953 (+)NCBI
mRatBN7.25130,274,034 - 130,284,325 (+)NCBI
RefSeq Acc Id: XM_063287109   ⟹   XP_063143179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,510,666 - 135,522,766 (+)NCBI
RefSeq Acc Id: XM_063287110   ⟹   XP_063143180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,519,118 - 135,522,766 (+)NCBI
RefSeq Acc Id: XR_010066340
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,510,666 - 135,520,831 (+)NCBI
RefSeq Acc Id: NP_579850   ⟸   NM_133316
- UniProtKB: Q8R5G2 (UniProtKB/Swiss-Prot),   G3V8C1 (UniProtKB/TrEMBL),   A6JZA6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024375   ⟸   ENSRNOT00000024375
RefSeq Acc Id: XP_038965128   ⟸   XM_039109200
- Peptide Label: isoform X1
- UniProtKB: Q8R5G2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038965130   ⟸   XM_039109202
- Peptide Label: isoform X2
- UniProtKB: Q8R5G2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038965136   ⟸   XM_039109208
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038965135   ⟸   XM_039109207
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038965131   ⟸   XM_039109203
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038965129   ⟸   XM_039109201
- Peptide Label: isoform X1
- UniProtKB: Q8R5G2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038965132   ⟸   XM_039109204
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038965133   ⟸   XM_039109205
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000084180   ⟸   ENSRNOT00000098673
Ensembl Acc Id: ENSRNOP00000083752   ⟸   ENSRNOT00000118511
RefSeq Acc Id: XP_063143179   ⟸   XM_063287109
- Peptide Label: isoform X3
- UniProtKB: Q8R5G2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063143180   ⟸   XM_063287110
- Peptide Label: isoform X6
Protein Domains
HhH-GPD   Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5G2-F1-model_v2 AlphaFold Q8R5G2 1-516 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693943
Promoter ID:EPDNEW_R4468
Type:multiple initiation site
Name:Mutyh_1
Description:mutY DNA glycosylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,663,386 - 135,663,446EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620045 AgrOrtholog
BioCyc Gene G2FUF-40236 BioCyc
Ensembl Genes ENSRNOG00000017887 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000118511 ENTREZGENE
Gene3D-CATH 1.10.1670.10 UniProtKB/Swiss-Prot
  Hypothetical protein, domain 2 UniProtKB/Swiss-Prot
  Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/Swiss-Prot
InterPro A/G_AdeGlyc_MutY UniProtKB/Swiss-Prot
  DNA_glycosylase UniProtKB/Swiss-Prot
  Endonuclease-III-like_CS2 UniProtKB/Swiss-Prot
  Endonuclease3_FeS-loop_motif UniProtKB/Swiss-Prot
  Endouclease-III_FeS-bd_BS UniProtKB/Swiss-Prot
  HhH-GPD_domain UniProtKB/Swiss-Prot
  HhH_motif UniProtKB/Swiss-Prot
  HTH_base_excis_C UniProtKB/Swiss-Prot
  MIG/MutY UniProtKB/Swiss-Prot
  MutY_C UniProtKB/Swiss-Prot
  NUDIX_hydrolase-like_dom_sf UniProtKB/Swiss-Prot
  NUDIX_hydrolase_dom UniProtKB/Swiss-Prot
KEGG Report rno:170841 UniProtKB/Swiss-Prot
NCBI Gene 170841 ENTREZGENE
PANTHER ADENINE DNA GLYCOSYLASE UniProtKB/Swiss-Prot
  PTHR42944 UniProtKB/Swiss-Prot
Pfam HHH UniProtKB/Swiss-Prot
  HhH-GPD UniProtKB/Swiss-Prot
  NUDIX_4 UniProtKB/Swiss-Prot
PhenoGen Mutyh PhenoGen
PROSITE ENDONUCLEASE_III_1 UniProtKB/Swiss-Prot
  ENDONUCLEASE_III_2 UniProtKB/Swiss-Prot
  NUDIX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017887 RatGTEx
SMART ENDO3c UniProtKB/Swiss-Prot
  FES UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48150 UniProtKB/Swiss-Prot
  SSF55811 UniProtKB/Swiss-Prot
UniProt A0A8I5ZWL4_RAT UniProtKB/TrEMBL
  A0A8I6A1E8_RAT UniProtKB/TrEMBL
  A1A5M6_RAT UniProtKB/TrEMBL
  A6JZA6 ENTREZGENE, UniProtKB/TrEMBL
  A6JZA7_RAT UniProtKB/TrEMBL
  A6JZA8_RAT UniProtKB/TrEMBL
  A6JZA9_RAT UniProtKB/TrEMBL
  G3V8C1 ENTREZGENE, UniProtKB/TrEMBL
  MUTYH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Mutyh  mutY DNA glycosylase  Mutyh  mutY homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-19 Mutyh  mutY homolog  Mutyh  mutY homolog (E. coli)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Mutyh  mutY homolog (E. coli)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mutyh  mutY homolog (E. coli)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to neuronal mitochondria 628413
gene_expression expressed in hippocampal, cortical and cerebellar regions of the brain 633415
gene_expression expressed in high levels in brain 628413
gene_process may protect mitochondrial genome from damage caused by reative oxygen species(ROS) 628413
gene_process may be involved in the repair of oxidative DNA damage 628413
gene_protein 516 amino acids 633415
gene_protein three forms of protein (~52 kDa,~60 kDa and ~ 49kDa) identified in brain tissue 628413
gene_regulation expression of 60 kDa isoform is induced in response to respiratory hypoxia 628413