Prdx3 (peroxiredoxin 3) - Rat Genome Database

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Gene: Prdx3 (peroxiredoxin 3) Rattus norvegicus
Analyze
Symbol: Prdx3
Name: peroxiredoxin 3
RGD ID: 620040
Description: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and thioredoxin peroxidase activity. Involved in negative regulation of neuron apoptotic process. Predicted to be located in early endosome. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and mitochondrion. Biomarker of glucose intolerance. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32. Orthologous to human PRDX3 (peroxiredoxin 3); INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: peroxiredoxin-3; PRx III; PRX-3; Prx3; thioredoxin-dependent peroxide reductase, mitochondrial; thioredoxin-dependent peroxiredoxin 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Niddm24
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,987,691 - 270,000,111 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1269,987,685 - 270,000,300 (-)EnsemblGRCr8
mRatBN7.21260,001,642 - 260,014,064 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1260,001,637 - 260,014,111 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1268,208,324 - 268,220,730 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,914,350 - 274,926,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,568,638 - 267,581,056 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,238,774 - 282,251,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,238,773 - 282,251,257 (-)Ensemblrn6Rnor6.0
Rnor_5.01289,577,325 - 289,589,744 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41267,468,371 - 267,481,273 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1255,642,701 - 255,655,171 (-)NCBICelera
RGSC_v3.11267,679,456 - 267,692,358 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4-diaminotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-butoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aminoglutethimide  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
auranofin  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
carbon nanotube  (ISO)
Carnosol  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chromium(6+)  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crystal violet  (ISO)
cyclosporin A  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
eugenol  (ISO)
famotidine  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP,ISO)
geraniol  (ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
kanamycin A  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
miconazole  (EXP)
minocycline  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
nobiletin  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
picloram  (ISO)
potassium dichromate  (EXP)
propiconazole  (ISO)
pyrogallol  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triapine  (ISO)
trichlopyr  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
early endosome  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)
protein-containing complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mitochondrial peroxiredoxin-3 protects hippocampal neurons from excitotoxic injury in vivo. Hattori F, etal., J Neurochem. 2003 Aug;86(4):860-8.
3. Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat. Kotoh J, etal., J Vet Med Sci. 2016 Aug 11.
4. Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member. Matsumoto A, etal., FEBS Lett 1999 Jan 29;443(3):246-50.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2210385   PMID:7733872   PMID:10514471   PMID:10521424   PMID:11591653   PMID:12011429   PMID:12492477   PMID:14651853   PMID:15489334   PMID:15750338   PMID:16585391   PMID:17060495  
PMID:17316558   PMID:17634366   PMID:17707404   PMID:17893648   PMID:18195003   PMID:18205602   PMID:18262354   PMID:18544346   PMID:18614015   PMID:20807727   PMID:20873783   PMID:20929858  
PMID:21385867   PMID:21562855   PMID:21850687   PMID:21988832   PMID:23106098   PMID:23376485   PMID:25914057   PMID:26316108   PMID:26975474   PMID:27393003   PMID:28529127   PMID:28828729  
PMID:29427714   PMID:31829064   PMID:36566946   PMID:36933848  


Genomics

Comparative Map Data
Prdx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,987,691 - 270,000,111 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1269,987,685 - 270,000,300 (-)EnsemblGRCr8
mRatBN7.21260,001,642 - 260,014,064 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1260,001,637 - 260,014,111 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1268,208,324 - 268,220,730 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,914,350 - 274,926,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,568,638 - 267,581,056 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,238,774 - 282,251,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,238,773 - 282,251,257 (-)Ensemblrn6Rnor6.0
Rnor_5.01289,577,325 - 289,589,744 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41267,468,371 - 267,481,273 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1255,642,701 - 255,655,171 (-)NCBICelera
RGSC_v3.11267,679,456 - 267,692,358 (-)NCBI
Cytogenetic Map1q55NCBI
PRDX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,167,720 - 119,178,812 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,167,699 - 119,178,865 (-)Ensemblhg38GRCh38
GRCh3710120,927,232 - 120,938,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,917,205 - 120,928,335 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410120,917,204 - 120,928,335NCBI
Celera10114,656,794 - 114,667,924 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,556,779 - 114,567,810 (-)NCBIHuRef
CHM1_110121,211,591 - 121,222,754 (-)NCBICHM1_1
T2T-CHM13v2.010120,063,136 - 120,074,228 (-)NCBIT2T-CHM13v2.0
Prdx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,852,504 - 60,862,976 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,852,489 - 60,862,994 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381960,864,066 - 60,874,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,864,051 - 60,874,556 (-)Ensemblmm10GRCm38
MGSCv371960,939,969 - 60,950,441 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361960,918,750 - 60,929,177 (-)NCBIMGSCv36mm8
Celera1963,076,194 - 63,086,472 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Prdx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543123,638,765 - 23,652,191 (-)Ensembl
ChiLan1.0NW_00495543123,640,775 - 23,651,738 (-)NCBIChiLan1.0ChiLan1.0
PRDX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28131,026,443 - 131,037,624 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110131,031,795 - 131,042,978 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010115,738,346 - 115,749,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,162,714 - 119,173,845 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,162,714 - 119,173,845 (-)EnsemblpanPan2panpan1.1
PRDX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,395,593 - 29,403,745 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,395,581 - 29,403,745 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2829,537,872 - 29,546,025 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02829,926,539 - 29,934,692 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,926,543 - 29,934,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,480,901 - 29,489,053 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,500,899 - 29,509,052 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,694,965 - 29,703,117 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prdx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,954,513 - 16,963,828 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,597,388 - 8,606,780 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,597,479 - 8,606,727 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,079,051 - 129,090,830 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114129,079,050 - 129,090,790 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,603,648 - 140,614,864 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,957,865 - 111,968,514 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9111,955,952 - 111,968,475 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604873,230,005 - 73,240,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473727,625,120 - 27,635,221 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prdx3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1255,279,010 - 55,291,758 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:259
Count of miRNA genes:172
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000015186
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1269633753270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
737975Bw122Body weight QTL 1229.110.005body mass (VT:0001259)body weight (CMO:0000012)1269158828270108840Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat

Markers in Region
RH127395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21260,001,900 - 260,002,089 (+)MAPPERmRatBN7.2
Rnor_6.01282,239,033 - 282,239,221NCBIRnor6.0
Rnor_5.01289,577,584 - 289,577,772UniSTSRnor5.0
RGSC_v3.41267,468,630 - 267,468,818UniSTSRGSC3.4
Celera1255,642,960 - 255,643,148UniSTS
RH 3.4 Map11710.9UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015186   ⟹   ENSRNOP00000015186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1269,987,691 - 270,000,111 (-)Ensembl
mRatBN7.2 Ensembl1260,001,637 - 260,014,051 (-)Ensembl
Rnor_6.0 Ensembl1282,238,773 - 282,251,257 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115921   ⟹   ENSRNOP00000085033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1269,987,685 - 269,999,109 (-)Ensembl
mRatBN7.2 Ensembl1260,001,639 - 260,013,062 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118773   ⟹   ENSRNOP00000079203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1269,987,685 - 270,000,300 (-)Ensembl
mRatBN7.2 Ensembl1260,002,255 - 260,014,111 (-)Ensembl
RefSeq Acc Id: NM_022540   ⟹   NP_071985
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81269,987,691 - 270,000,111 (-)NCBI
mRatBN7.21260,001,642 - 260,014,064 (-)NCBI
Rnor_6.01282,238,774 - 282,251,193 (-)NCBI
Rnor_5.01289,577,325 - 289,589,744 (-)NCBI
RGSC_v3.41267,468,371 - 267,481,273 (-)RGD
Celera1255,642,701 - 255,655,171 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071985 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD17992 (Get FASTA)   NCBI Sequence Viewer  
  AAH60567 (Get FASTA)   NCBI Sequence Viewer  
  EDL94585 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015186
GenBank Protein Q9Z0V6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071985   ⟸   NM_022540
- Peptide Label: precursor
- UniProtKB: Q9Z0V6 (UniProtKB/Swiss-Prot),   Q6P9W3 (UniProtKB/Swiss-Prot),   A0A8I5ZMG4 (UniProtKB/TrEMBL),   A6JIB1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015186   ⟸   ENSRNOT00000015186
Ensembl Acc Id: ENSRNOP00000085033   ⟸   ENSRNOT00000115921
Ensembl Acc Id: ENSRNOP00000079203   ⟸   ENSRNOT00000118773
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0V6-F1-model_v2 AlphaFold Q9Z0V6 1-257 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691024
Promoter ID:EPDNEW_R1548
Type:initiation region
Name:Prdx3_1
Description:peroxiredoxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,251,237 - 282,251,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620040 AgrOrtholog
BioCyc Gene G2FUF-55220 BioCyc
Ensembl Genes ENSRNOG00000010958 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015186 ENTREZGENE
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922338 IMAGE-MGC_LOAD
InterPro AhpC/TSA UniProtKB/Swiss-Prot
  Peroxiredoxin UniProtKB/Swiss-Prot
  Peroxiredoxin_C UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:64371 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72824 IMAGE-MGC_LOAD
NCBI Gene 64371 ENTREZGENE
PANTHER THIOREDOXIN PEROXIDASE UniProtKB/Swiss-Prot
  THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam 1-cysPrx_C UniProtKB/Swiss-Prot
  AhpC-TSA UniProtKB/Swiss-Prot
PhenoGen Prdx3 PhenoGen
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010958 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I5ZMG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0U2_RAT UniProtKB/TrEMBL
  A6JIB1 ENTREZGENE, UniProtKB/TrEMBL
  G3V7I0_RAT UniProtKB/TrEMBL
  PRDX3_RAT UniProtKB/Swiss-Prot
  Q6P9W3 ENTREZGENE
  Q9Z0V6 ENTREZGENE
UniProt Secondary Q6P9W3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prdx3  peroxiredoxin 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Prdx3  peroxiredoxin 3      Symbol and Name status set to provisional 70820 PROVISIONAL