Cask (calcium/calmodulin dependent serine protein kinase) - Rat Genome Database

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Gene: Cask (calcium/calmodulin dependent serine protein kinase) Rattus norvegicus
Analyze
Symbol: Cask
Name: calcium/calmodulin dependent serine protein kinase
RGD ID: 62004
Description: Enables PDZ domain binding activity; neurexin family protein binding activity; and protein kinase C binding activity. Involved in several processes, including positive regulation of dendritic spine morphogenesis; positive regulation of insulin secretion; and protein localization to plasma membrane. Located in several cellular components, including apical dendrite; basolateral plasma membrane; and podocyte foot. Part of protein-containing complex. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); LOC100910506; peripheral plasma membrane protein CASK; peripheral plasma membrane protein CASK-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X11,572,328 - 11,915,831 (+)NCBIGRCr8
mRatBN7.2X8,899,500 - 9,243,014 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX8,899,833 - 9,238,694 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX9,082,098 - 9,422,591 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X12,579,235 - 12,919,741 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X8,846,509 - 9,191,254 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X9,815,652 - 10,156,155 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX9,815,652 - 10,156,155 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX9,436,707 - 9,467,884 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X10,614,514 - 10,954,635 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X20,910,960 - 21,250,869 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X20,964,277 - 21,304,187 (+)NCBI
CeleraX9,439,547 - 9,776,994 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylparaben  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
potassium chromate  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Butz S, etal., Cell 1998 Sep 18;94(6):773-82.
2. SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. Chao HW, etal., J Cell Biol. 2008 Jul 14;182(1):141-55. doi: 10.1083/jcb.200712094. Epub 2008 Jul 7.
3. The location of human CASK at Xp11.4 identifies this gene as a candidate for X-linked optic atrophy. Dimitratos SD, etal., Genomics 1998 Jul 15;51(2):308-9.
4. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. Fallon L, etal., J Biol Chem. 2002 Jan 4;277(1):486-91. Epub 2001 Oct 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. Hata Y, etal., J Neurosci 1996 Apr 15;16(8):2488-94.
8. CASK associates with glutamate receptor interacting protein and signaling molecules. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
9. Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. Hsueh YP, etal., J Cell Biol. 1998 Jul 13;142(1):139-51.
10. Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. Hsueh YP, etal., J Neurosci. 2001 Jun 1;21(11):3764-70.
11. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Hsueh YP, etal., Nature. 2000 Mar 16;404(6775):298-302.
12. Calcium influx and postsynaptic proteins coordinate the dendritic filopodium-spine transition. Hu HT and Hsueh YP, Dev Neurobiol. 2014 Oct;74(10):1011-29. doi: 10.1002/dneu.22181. Epub 2014 Apr 28.
13. CASK point mutation regulates protein-protein interactions and NR2b promoter activity. Huang TN and Hsueh YP, Biochem Biophys Res Commun. 2009 Apr 24;382(1):219-22. doi: 10.1016/j.bbrc.2009.03.015. Epub 2009 Mar 9.
14. X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. Kuo TY, etal., J Neurosci Res. 2010 Aug 15;88(11):2364-73. doi: 10.1002/jnr.22407.
15. Murine CASK is disrupted in a sex-linked cleft palate mouse mutant. Laverty HG and Wilson JB, Genomics. 1998 Oct 1;53(1):29-41.
16. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Lehtonen S, etal., Am J Pathol. 2004 Sep;165(3):923-36.
17. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Lehtonen S, etal., Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9814-9. Epub 2005 Jul 1.
18. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
19. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
20. Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus. Liu L, etal., PLoS One. 2014 Aug 4;9(8):e103948. doi: 10.1371/journal.pone.0103948. eCollection 2014.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. Ohno H, etal., Oncogene. 2003 Nov 20;22(52):8422-31.
24. The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. Ojeh N, etal., J Cell Sci. 2008 Aug 15;121(Pt 16):2705-17. doi: 10.1242/jcs.025643. Epub 2008 Jul 29.
25. Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases. Olsen O and Bredt DS, J Biol Chem 2003 Feb 28;278(9):6873-8.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. A missense mutation in CASK causes FG syndrome in an Italian family. Piluso G, etal., Am J Hum Genet. 2009 Feb;84(2):162-77. doi: 10.1016/j.ajhg.2008.12.018. Epub 2009 Feb 5.
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Scaffolding proteins in highly purified rat olfactory cilia membranes. Saavedra MV, etal., Neuroreport. 2008 Jul 16;19(11):1123-6. doi: 10.1097/WNR.0b013e3283086797.
33. Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. Schuh K, etal., J Biol Chem 2003 Mar 14;278(11):9778-83.
34. mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus. Straight SW, etal., Am J Physiol Renal Physiol. 2000 Mar;278(3):F464-75.
35. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. Tabuchi K, etal., J Neurosci 2002 Jun 1;22(11):4264-73.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Transcriptional modification by a CASK-interacting nucleosome assembly protein. Wang GS, etal., Neuron. 2004 Apr 8;42(1):113-28.
38. CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase. Yap CC, etal., J Neurochem 2003 Apr;85(1):123-34.
39. Calcium/calmodulin-dependent serine protein kinase is involved in exendin-4-induced insulin secretion in INS-1 cells. Zhu ZQ, etal., Metabolism. 2014 Jan;63(1):120-6. doi: 10.1016/j.metabol.2013.09.009. Epub 2013 Oct 17.
Additional References at PubMed
PMID:11036064   PMID:11865057   PMID:12151521   PMID:12202822   PMID:12351654   PMID:14622577   PMID:15048107   PMID:15266631   PMID:15584924   PMID:16105026   PMID:16186258   PMID:17287346  
PMID:18054859   PMID:18423203   PMID:19036990   PMID:19620977   PMID:19781660   PMID:21423176   PMID:22871113   PMID:23542924   PMID:23751498   PMID:24498267   PMID:25796372   PMID:32348748  
PMID:33159991  


Genomics

Comparative Map Data
Cask
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X11,572,328 - 11,915,831 (+)NCBIGRCr8
mRatBN7.2X8,899,500 - 9,243,014 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX8,899,833 - 9,238,694 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX9,082,098 - 9,422,591 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X12,579,235 - 12,919,741 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X8,846,509 - 9,191,254 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X9,815,652 - 10,156,155 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX9,815,652 - 10,156,155 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX9,436,707 - 9,467,884 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X10,614,514 - 10,954,635 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X20,910,960 - 21,250,869 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X20,964,277 - 21,304,187 (+)NCBI
CeleraX9,439,547 - 9,776,994 (+)NCBICelera
Cytogenetic MapXq12NCBI
CASK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X41,514,934 - 41,923,554 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX41,514,934 - 41,923,554 (-)EnsemblGRCh38hg38GRCh38
GRCh37X41,374,187 - 41,782,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X41,264,287 - 41,667,212 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X41,135,596 - 41,538,522NCBI
CeleraX45,516,432 - 45,924,508 (-)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX39,105,639 - 39,513,256 (-)NCBIHuRef
CHM1_1X41,406,782 - 41,814,790 (-)NCBICHM1_1
T2T-CHM13v2.0X40,919,852 - 41,328,508 (-)NCBIT2T-CHM13v2.0
Cask
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X13,383,319 - 13,713,020 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX13,383,319 - 13,717,606 (-)EnsemblGRCm39 Ensembl
GRCm38X13,517,080 - 13,846,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX13,517,080 - 13,851,367 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X13,094,206 - 13,423,667 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X12,678,006 - 13,003,515 (-)NCBIMGSCv36mm8
MGSCv36X10,595,356 - 10,921,350 (-)NCBIMGSCv36mm8
CeleraX11,186,392 - 11,514,710 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.43NCBI
Cask
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955565879,830 - 1,237,692 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955565879,560 - 1,242,727 (+)NCBIChiLan1.0ChiLan1.0
CASK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X43,166,165 - 43,573,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X43,173,793 - 43,576,833 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X33,967,329 - 34,374,385 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X41,659,295 - 42,066,570 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX41,659,295 - 42,066,570 (-)Ensemblpanpan1.1panPan2
CASK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X35,939,117 - 36,296,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX35,940,647 - 36,297,014 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX23,287,445 - 23,579,098 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X35,992,809 - 36,371,502 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX35,990,986 - 36,371,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X36,067,274 - 36,417,597 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X36,039,464 - 36,395,455 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X36,082,753 - 36,433,406 (-)NCBIUU_Cfam_GSD_1.0
Cask
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X28,092,601 - 28,440,781 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365027,937,146 - 8,281,492 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365027,933,312 - 8,281,492 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX37,167,577 - 37,536,160 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X37,166,973 - 37,535,723 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X41,385,026 - 41,762,853 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X38,704,623 - 39,121,309 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660763,886,383 - 4,287,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cask
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476213,722,691 - 14,106,844 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476213,723,347 - 14,106,844 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cask
941 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:106
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000004187
Prediction methods:Microtar, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat

Markers in Region
DXRat48  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X11,847,045 - 11,847,182 (+)Marker Load Pipeline
mRatBN7.2X9,174,224 - 9,174,361 (+)MAPPERmRatBN7.2
Rnor_6.0X10,092,596 - 10,092,732NCBIRnor6.0
Rnor_6.0X9,404,154 - 9,404,290NCBIRnor6.0
Rnor_5.0X10,891,076 - 10,891,212UniSTSRnor5.0
Rnor_5.0X10,208,459 - 10,208,595UniSTSRnor5.0
RGSC_v3.4X21,186,403 - 21,186,539UniSTSRGSC3.4
RGSC_v3.4X21,186,402 - 21,186,539RGDRGSC3.4
RGSC_v3.1X21,239,720 - 21,239,857RGD
CeleraX9,713,555 - 9,713,691UniSTS
SHRSP x BN MapX0.0UniSTS
SHRSP x BN MapX0.0RGD
Cytogenetic MapXq12UniSTS
DXGot4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,024,962 - 9,025,175 (+)MAPPERmRatBN7.2
Rnor_6.0X9,942,299 - 9,942,511NCBIRnor6.0
Rnor_5.0X10,740,760 - 10,740,972UniSTSRnor5.0
RGSC_v3.4X21,037,438 - 21,037,650RGDRGSC3.4
RGSC_v3.4X21,037,439 - 21,037,651UniSTSRGSC3.4
RGSC_v3.1X21,090,756 - 21,090,968RGD
CeleraX9,564,724 - 9,564,926UniSTS
Cytogenetic MapXq12UniSTS
RH144070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,083,660 - 9,083,808 (+)MAPPERmRatBN7.2
Rnor_6.0X10,001,822 - 10,001,969NCBIRnor6.0
Rnor_5.0X10,799,719 - 10,799,866UniSTSRnor5.0
RGSC_v3.4X21,095,558 - 21,095,705UniSTSRGSC3.4
CeleraX9,623,139 - 9,623,286UniSTS
RH 3.4 MapX8.8UniSTS
Cytogenetic MapXq12UniSTS
BF404609  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X8,926,400 - 8,926,647 (+)MAPPERmRatBN7.2
Rnor_6.0X9,842,690 - 9,842,936NCBIRnor6.0
Rnor_5.0X10,641,552 - 10,641,798UniSTSRnor5.0
RGSC_v3.4X20,937,567 - 20,937,813UniSTSRGSC3.4
CeleraX9,466,100 - 9,466,346UniSTS
Cytogenetic MapXq12UniSTS
AU049649  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,024,960 - 9,025,171 (+)MAPPERmRatBN7.2
Rnor_6.0X9,942,297 - 9,942,507NCBIRnor6.0
Rnor_5.0X10,740,758 - 10,740,968UniSTSRnor5.0
RGSC_v3.4X21,037,437 - 21,037,647UniSTSRGSC3.4
CeleraX9,564,722 - 9,564,922UniSTS
Cytogenetic MapXq12UniSTS
Cask  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,237,902 - 9,238,879 (+)MAPPERmRatBN7.2
Rnor_6.0X10,155,364 - 10,156,340NCBIRnor6.0
Rnor_6.0X9,467,825 - 9,468,801NCBIRnor6.0
Rnor_5.0X10,272,130 - 10,273,106UniSTSRnor5.0
Rnor_5.0X10,953,844 - 10,954,820UniSTSRnor5.0
RGSC_v3.4X21,250,078 - 21,251,054UniSTSRGSC3.4
CeleraX9,776,203 - 9,777,179UniSTS
Cytogenetic MapXq12UniSTS
UniSTS:256965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,137,554 - 9,137,634 (+)MAPPERmRatBN7.2
Rnor_6.0X10,055,710 - 10,055,789NCBIRnor6.0
Rnor_5.0X10,853,607 - 10,853,686UniSTSRnor5.0
RGSC_v3.4X21,149,446 - 21,149,525UniSTSRGSC3.4
CeleraX9,677,000 - 9,677,079UniSTS
Cytogenetic MapXq12UniSTS
Cask  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,145,989 - 9,146,087 (+)MAPPERmRatBN7.2
Rnor_6.0X10,064,145 - 10,064,242NCBIRnor6.0
Rnor_5.0X10,862,042 - 10,862,139UniSTSRnor5.0
RGSC_v3.4X21,157,881 - 21,157,978UniSTSRGSC3.4
CeleraX9,685,435 - 9,685,532UniSTS
Cytogenetic MapXq12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004187   ⟹   ENSRNOP00000004187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX8,899,833 - 9,238,694 (+)Ensembl
Rnor_6.0 EnsemblX9,436,707 - 9,467,884 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082316   ⟹   ENSRNOP00000074587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX8,899,833 - 9,238,694 (+)Ensembl
Rnor_6.0 EnsemblX9,956,370 - 10,155,420 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084218   ⟹   ENSRNOP00000069498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX9,125,058 - 9,238,694 (+)Ensembl
Rnor_6.0 EnsemblX10,042,893 - 10,155,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091382   ⟹   ENSRNOP00000072295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX8,899,833 - 9,238,694 (+)Ensembl
Rnor_6.0 EnsemblX9,815,652 - 10,156,155 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097626   ⟹   ENSRNOP00000096945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX8,899,833 - 9,238,694 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099608   ⟹   ENSRNOP00000095774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX8,899,833 - 9,238,694 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116121   ⟹   ENSRNOP00000083135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX9,233,294 - 9,238,694 (+)Ensembl
RefSeq Acc Id: NM_022184   ⟹   NP_071520
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,636 - 11,911,511 (+)NCBI
mRatBN7.2X8,899,833 - 9,238,694 (+)NCBI
Rnor_6.0X9,815,652 - 10,156,155 (+)NCBI
Rnor_5.0X10,614,514 - 10,954,635 (+)NCBI
RGSC_v3.4X20,910,960 - 21,250,869 (+)RGD
CeleraX9,439,547 - 9,776,994 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099558   ⟹   XP_038955486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,329 - 11,915,831 (+)NCBI
mRatBN7.2X8,899,503 - 9,243,014 (+)NCBI
RefSeq Acc Id: XM_039099559   ⟹   XP_038955487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,332 - 11,915,831 (+)NCBI
mRatBN7.2X8,900,190 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_039099560   ⟹   XP_038955488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,331 - 11,915,831 (+)NCBI
mRatBN7.2X8,899,503 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_039099561   ⟹   XP_038955489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,331 - 11,915,831 (+)NCBI
mRatBN7.2X8,900,190 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_039099562   ⟹   XP_038955490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,333 - 11,915,831 (+)NCBI
mRatBN7.2X8,900,190 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_039099563   ⟹   XP_038955491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,329 - 11,915,831 (+)NCBI
mRatBN7.2X8,899,503 - 9,243,014 (+)NCBI
RefSeq Acc Id: XM_039099564   ⟹   XP_038955492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,332 - 11,915,831 (+)NCBI
mRatBN7.2X8,899,503 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_039099565   ⟹   XP_038955493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,333 - 11,915,831 (+)NCBI
mRatBN7.2X8,900,190 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_039099566   ⟹   XP_038955494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,336 - 11,915,831 (+)NCBI
mRatBN7.2X8,900,190 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_039099567   ⟹   XP_038955495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,333 - 11,915,831 (+)NCBI
mRatBN7.2X8,900,190 - 9,237,962 (+)NCBI
RefSeq Acc Id: XM_063279864   ⟹   XP_063135934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,328 - 11,915,831 (+)NCBI
RefSeq Acc Id: XM_063279865   ⟹   XP_063135935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,331 - 11,915,831 (+)NCBI
RefSeq Acc Id: XM_063279867   ⟹   XP_063135937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,331 - 11,915,831 (+)NCBI
RefSeq Acc Id: XM_063279868   ⟹   XP_063135938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,333 - 11,915,831 (+)NCBI
RefSeq Acc Id: XM_063279869   ⟹   XP_063135939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,330 - 11,915,831 (+)NCBI
RefSeq Acc Id: XM_063279870   ⟹   XP_063135940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,334 - 11,915,831 (+)NCBI
RefSeq Acc Id: XM_063279871   ⟹   XP_063135941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X11,572,334 - 11,915,831 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001418507 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418508 (Get FASTA)   NCBI Sequence Viewer  
  NP_071520 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955486 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955487 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955488 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955489 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955490 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955491 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955492 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955493 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955494 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955495 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135934 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135935 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135937 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135938 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135939 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135940 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135941 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB19127 (Get FASTA)   NCBI Sequence Viewer  
  CAA70022 (Get FASTA)   NCBI Sequence Viewer  
  EDL97656 (Get FASTA)   NCBI Sequence Viewer  
  EDL97657 (Get FASTA)   NCBI Sequence Viewer  
  EDL97658 (Get FASTA)   NCBI Sequence Viewer  
  EDL97659 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004187
  ENSRNOP00000072295
  ENSRNOP00000074587
  ENSRNOP00000095774
  ENSRNOP00000096945
GenBank Protein Q62915 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071520   ⟸   NM_022184
- UniProtKB: Q62915 (UniProtKB/Swiss-Prot),   A0A0G2K2L8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038955486   ⟸   XM_039099558
- Peptide Label: isoform X1
- UniProtKB: A6JZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955491   ⟸   XM_039099563
- Peptide Label: isoform X7
- UniProtKB: A6JZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955492   ⟸   XM_039099564
- Peptide Label: isoform X9
- UniProtKB: A0A8I6APQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955488   ⟸   XM_039099560
- Peptide Label: isoform X4
- UniProtKB: A6JZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955487   ⟸   XM_039099559
- Peptide Label: isoform X3
- UniProtKB: A6JZX4 (UniProtKB/TrEMBL),   A6JZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955489   ⟸   XM_039099561
- Peptide Label: isoform X5
- UniProtKB: Q62915 (UniProtKB/Swiss-Prot),   A0A8I6GLU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955493   ⟸   XM_039099565
- Peptide Label: isoform X12
- UniProtKB: A0A8I6APQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955490   ⟸   XM_039099562
- Peptide Label: isoform X6
- UniProtKB: D4A8M2 (UniProtKB/TrEMBL),   A6JZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955494   ⟸   XM_039099566
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038955495   ⟸   XM_039099567
- Peptide Label: isoform X17
- UniProtKB: A6JZX6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000004187   ⟸   ENSRNOT00000004187
Ensembl Acc Id: ENSRNOP00000072295   ⟸   ENSRNOT00000091382
Ensembl Acc Id: ENSRNOP00000074587   ⟸   ENSRNOT00000082316
Ensembl Acc Id: ENSRNOP00000069498   ⟸   ENSRNOT00000084218
Ensembl Acc Id: ENSRNOP00000083135   ⟸   ENSRNOT00000116121
Ensembl Acc Id: ENSRNOP00000095774   ⟸   ENSRNOT00000099608
Ensembl Acc Id: ENSRNOP00000096945   ⟸   ENSRNOT00000097626
RefSeq Acc Id: XP_063135934   ⟸   XM_063279864
- Peptide Label: isoform X2
- UniProtKB: Q62915 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063135939   ⟸   XM_063279869
- Peptide Label: isoform X14
- UniProtKB: A6JZX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135937   ⟸   XM_063279867
- Peptide Label: isoform X10
- UniProtKB: A0A8I6APQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135935   ⟸   XM_063279865
- Peptide Label: isoform X8
- UniProtKB: A6JZX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135938   ⟸   XM_063279868
- Peptide Label: isoform X11
- UniProtKB: A0A8I6APQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135940   ⟸   XM_063279870
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063135941   ⟸   XM_063279871
- Peptide Label: isoform X16
- UniProtKB: A6JZX6 (UniProtKB/TrEMBL),   A0A0G2K8F4 (UniProtKB/TrEMBL)
Protein Domains
Guanylate kinase-like   L27   PDZ   Protein kinase   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8M2-F1-model_v2 AlphaFold D4A8M2 1-356 view protein structure
AF-Q62915-F1-model_v2 AlphaFold Q62915 1-909 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62004 AgrOrtholog
BioCyc Gene G2FUF-3096 BioCyc
Ensembl Genes ENSRNOG00000003054 Ensembl
  ENSRNOG00000060946 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000004187 ENTREZGENE
  ENSRNOT00000082316 ENTREZGENE
  ENSRNOT00000091382 ENTREZGENE
  ENSRNOT00000097626 ENTREZGENE
  ENSRNOT00000099608 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  6.10.140.620 UniProtKB/Swiss-Prot
  L27 domain UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CASK_SH3 UniProtKB/Swiss-Prot
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot
  Guanylate_kinase_CS UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  L27_C UniProtKB/Swiss-Prot
  L27_dom UniProtKB/Swiss-Prot
  L27_dom_sf UniProtKB/Swiss-Prot
  MAGUK UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:29647 UniProtKB/Swiss-Prot
NCBI Gene 29647 ENTREZGENE
PANTHER MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Cask PhenoGen
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot
  L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003054 RatGTEx
  ENSRNOG00000060946 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot
  L27 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC218599
UniProt A0A0G2JVI6_RAT UniProtKB/TrEMBL
  A0A0G2K2L8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K8F4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APQ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8I0_RAT UniProtKB/TrEMBL
  A0A8I6GLU3 ENTREZGENE, UniProtKB/TrEMBL
  A6JZX4 ENTREZGENE, UniProtKB/TrEMBL
  A6JZX5 ENTREZGENE, UniProtKB/TrEMBL
  A6JZX6 ENTREZGENE, UniProtKB/TrEMBL
  A6JZX7_RAT UniProtKB/TrEMBL
  CSKP_RAT UniProtKB/Swiss-Prot
  D4A8M2 ENTREZGENE, UniProtKB/TrEMBL
  Q62915 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cask  calcium/calmodulin dependent serine protein kinase  LOC100910506  peripheral plasma membrane protein CASK-like  Data merged from RGD:6498449 737654 PROVISIONAL
2016-06-01 Cask  calcium/calmodulin dependent serine protein kinase  Cask  calcium/calmodulin-dependent serine protein kinase (MAGUK family)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910506  peripheral plasma membrane protein CASK-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Cask  calcium/calmodulin-dependent serine protein kinase (MAGUK family)    calcium/calmodulin-dependent serine protein kinase  Name updated 1299863 APPROVED
2002-06-10 Cask  calcium/calmodulin-dependent serine protein kinase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a calmodulin-dependent protein kinase-like domain, PDZ, SH3, and guanylate kinase-like domains 728219