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Gene: Rgs14 (regulator of G-protein signaling 14) Rattus norvegicus

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Symbol:

Rgs14

Name:

regulator of G-protein signaling 14

RGD ID:

620003

Description:

Enables several functions, including G-protein alpha-subunit binding activity; GTPase regulator activity; and signaling receptor complex adaptor activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; regulation of signal transduction; and visual learning. Located in several cellular components, including dendrite; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC108631

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	9,254,112 - 9,268,233 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	9,254,149 - 9,268,233 (-)	Ensembl				GRCr8
mRatBN7.2	17	9,248,982 - 9,263,104 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	9,249,019 - 9,263,104 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	9,265,278 - 9,279,405 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,795,224 - 10,809,305 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	9,261,669 - 9,275,796 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,777,925 - 9,792,007 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,777,842 - 9,792,007 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	11,887,270 - 11,901,352 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	15,293,100 - 15,307,162 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	9,327,534 - 9,341,623 (-)	NCBI		Celera
RGSC_v3.1	17	15,293,099 - 15,307,162 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

nephrolithiasis (ISO)

Silver-Russell syndrome (ISO)

Sotos syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

alpha-Zearalanol (EXP)

amitrole (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

buta-1,3-diene (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

dioxygen (EXP)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

niclosamide (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

testosterone (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IBA,IEA,ISO,ISS)

chromosome segregation (IEA,ISO,ISS)

learning (IEA,ISO,ISS)

long-term memory (IBA,IEA,ISO,ISS)

long-term synaptic potentiation (IBA,IEA,ISO,ISS)

mitotic cell cycle (IEA,ISO)

modulation of chemical synaptic transmission (IEA,ISO)

negative regulation of ERK1 and ERK2 cascade (IDA)

negative regulation of G protein-coupled receptor signaling pathway (IEA,ISO,ISS)

negative regulation of MAP kinase activity (ISO,ISS)

negative regulation of MAPK cascade (IEA)

negative regulation of signal transduction (IEA)

negative regulation of synaptic plasticity (IEA,ISO,ISS)

nucleocytoplasmic transport (IDA,IEA,ISO)

platelet-derived growth factor receptor signaling pathway (IDA)

positive regulation of GTPase activity (ISO)

positive regulation of neurogenesis (IMP)

regulation of G protein-coupled receptor signaling pathway (IBA,IDA,IEA)

response to oxidative stress (IMP)

signal transduction (IEA)

spindle organization (IBA,IEA,ISO,ISS)

visual learning (IMP)

zygote asymmetric cell division (IEA,ISO,ISS)

Cellular Component

cell projection (IEA)

centrosome (IDA,IEA,ISO)

cytoplasm (IBA,IDA,IEA,ISO)

cytoskeleton (IEA)

dendrite (IDA,IEA,ISO,ISS)

dendritic spine (IEA,ISO,ISS)

glutamatergic synapse (IEA,ISO)

membrane (IEA)

microtubule (IEA)

nuclear body (IEA,ISO,ISS)

nucleus (IBA,IDA,IEA,ISO)

plasma membrane (IBA,IDA,IEA,ISO)

PML body (IEA)

postsynaptic density (IEA,ISO,ISS)

spindle (IEA,ISO,ISS)

spindle pole (IDA,IEA)

synapse (IEA)

Molecular Function

G-protein alpha-subunit binding (IEA,IPI)

GDP-dissociation inhibitor activity (IDA,IEA,ISO)

GTPase activating protein binding (IEA,ISO)

GTPase activator activity (IBA,IDA,IEA,ISO,TAS)

GTPase regulator activity (IEA)

microtubule binding (IEA,ISO,ISS)

protein binding (IPI,ISO)

protein kinase binding (IPI)

signaling receptor complex adaptor activity (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.	Kimple RJ, etal., J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.
4.	Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.	Kimple RJ, etal., Nature 2002 Apr 25;416(6883):878-81.
5.	Regulation of longevity by regulator of G-protein signaling protein, Loco.	Lin YR, etal., Aging Cell. 2011 Jun;10(3):438-47. doi: 10.1111/j.1474-9726.2011.00678.x. Epub 2011 Mar 22.
6.	Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain.	Lopez-Aranda MF, etal., Eur J Neurosci. 2006 Jun;23(11):2971-82.
7.	Role of layer 6 of V2 visual cortex in object-recognition memory.	Lopez-Aranda MF, etal., Science. 2009 Jul 3;325(5936):87-9. doi: 10.1126/science.1170869.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	The RGS14 GoLoco domain discriminates among Galphai isoforms.	Mittal V and Linder ME, J Biol Chem. 2004 Nov 5;279(45):46772-8. Epub 2004 Aug 26.
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization.	Shu FJ, etal., Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25.
14.	RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.	Shu FJ, etal., Cell Signal. 2010 Mar;22(3):366-76. doi: 10.1016/j.cellsig.2009.10.005. Epub .
15.	Molecular cloning and expression analysis of rat Rgs12 and Rgs14.	Snow BE, etal., Biochem Biophys Res Commun 1997 Apr 28;233(3):770-7.
16.	A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.	Urabe Y, etal., PLoS Genet. 2012;8(3):e1002541. doi: 10.1371/journal.pgen.1002541. Epub 2012 Mar 1.
17.	Activation of the regulator of G protein signaling 14-Galphai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.	Vellano CP, etal., Biochemistry. 2011 Feb 8;50(5):752-62. doi: 10.1021/bi101910n. Epub 2011 Jan 11.
18.	Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.	Willard FS, etal., PLoS One. 2009;4(3):e4884. doi: 10.1371/journal.pone.0004884. Epub 2009 Mar 25.

Additional References at PubMed

PMID:10926822	PMID:12477932	PMID:12534294	PMID:15520006	PMID:15525537	PMID:15917656	PMID:17635935	PMID:20837545	PMID:21880739	PMID:23250758	PMID:28776200	PMID:28934222
PMID:30093406

Genomics

Comparative Map Data

Rgs14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	9,254,112 - 9,268,233 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	9,254,149 - 9,268,233 (-)	Ensembl				GRCr8
mRatBN7.2	17	9,248,982 - 9,263,104 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	9,249,019 - 9,263,104 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	9,265,278 - 9,279,405 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,795,224 - 10,809,305 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	9,261,669 - 9,275,796 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,777,925 - 9,792,007 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,777,842 - 9,792,007 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	11,887,270 - 11,901,352 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	15,293,100 - 15,307,162 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	9,327,534 - 9,341,623 (-)	NCBI		Celera
RGSC_v3.1	17	15,293,099 - 15,307,162 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

RGS14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	177,357,924 - 177,372,596 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	177,357,924 - 177,372,596 (+)	Ensembl			hg38	GRCh38
GRCh37	5	176,784,925 - 176,799,597 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	176,717,450 - 176,732,205 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	176,717,449 - 176,732,204	NCBI
Celera	5	171,701,669 - 171,716,413 (-)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	171,705,499 - 171,720,237 (+)	NCBI		HuRef
CHM1_1	5	176,217,893 - 176,232,649 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	177,901,146 - 177,915,812 (+)	NCBI		T2T-CHM13v2.0

Rgs14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	55,517,269 - 55,532,504 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	55,517,545 - 55,532,500 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	55,369,732 - 55,384,687 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	55,369,732 - 55,384,687 (+)	Ensembl			mm10	GRCm38
MGSCv37	13	55,471,093 - 55,486,048 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	54,849,935 - 54,864,851 (+)	NCBI		MGSCv36	mm8
MGSCv36	13	55,379,393 - 55,394,309 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	13	B1	NCBI
cM Map	13	29.8	NCBI

Rgs14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	29,602,820 - 29,616,210 (+)	Ensembl
ChiLan1.0	NW_004955408	29,602,654 - 29,616,793 (+)	NCBI	ChiLan1.0	ChiLan1.0

RGS14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	172,441,892 - 172,456,648 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	170,581,431 - 170,596,187 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	172,659,323 - 172,674,084 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	179,721,876 - 179,736,608 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	179,721,876 - 179,739,453 (+)	Ensembl			panPan2	panpan1.1

RGS14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	35,984,970 - 35,999,386 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	35,985,132 - 35,999,294 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	35,952,393 - 35,966,792 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	36,351,200 - 36,365,605 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	36,310,038 - 36,365,601 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	36,176,431 - 36,190,828 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	36,362,626 - 36,377,029 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	36,871,876 - 36,886,282 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rgs14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	122,617,771 - 122,633,949 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	1,643,616 - 1,658,638 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	1,650,480 - 1,658,823 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RGS14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	80,574,415 - 80,590,003 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	80,574,411 - 80,589,998 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	82,278,839 - 82,294,432 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RGS14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	79,370,320 - 79,385,355 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	79,370,087 - 79,387,192 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666075	10,559,155 - 10,573,950 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rgs14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	12,707,825 - 12,723,279 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	12,705,392 - 12,722,919 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Rgs14
101 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	171
Count of miRNA genes:	122
Interacting mature miRNAs:	145
Transcripts:	ENSRNOT00000021596
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9201365	23653323	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9201365	23653323	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	4299130	21293263	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7979968	16317111	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9201365	23653323	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2115149	21881669	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22871563	Rat

Markers in Region

RGS14_3061

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	9,249,457 - 9,250,045 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	9,778,364 - 9,778,951	NCBI	Rnor6.0
Rnor_5.0	17	11,887,709 - 11,888,296	UniSTS	Rnor5.0
RGSC_v3.4	17	15,293,539 - 15,294,126	UniSTS	RGSC3.4
Celera	17	9,327,973 - 9,328,560	UniSTS
Cytogenetic Map	17	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	159	91	90	59	92	59	6	355	192	11	135	80	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC095305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC121413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U92279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021596 ⟹ ENSRNOP00000021596

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	9,254,149 - 9,268,233 (-)	Ensembl
mRatBN7.2 Ensembl	17	9,249,019 - 9,263,104 (-)	Ensembl
Rnor_6.0 Ensembl	17	9,777,925 - 9,792,007 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090536 ⟹ ENSRNOP00000073077

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	9,249,430 - 9,262,647 (-)	Ensembl
Rnor_6.0 Ensembl	17	9,777,842 - 9,791,781 (-)	Ensembl

RefSeq Acc Id:

NM_053764 ⟹ NP_446216

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,254,149 - 9,268,233 (-)	NCBI
mRatBN7.2	17	9,249,019 - 9,263,104 (-)	NCBI
Rnor_6.0	17	9,777,925 - 9,792,007 (-)	NCBI
Rnor_5.0	17	11,887,270 - 11,901,352 (-)	NCBI
RGSC_v3.4	17	15,293,100 - 15,307,162 (-)	RGD
Celera	17	9,327,534 - 9,341,623 (-)	RGD

Sequence:

show sequence

GCACTTCTGTGTGCTGACACATCCTTGGAGCCTTCAGACTGAGCCAGACTCCAGGCTCCTCGCT
GGGCACAAGGAGGCTCCTGCTAGACACTTCCTGTGGCAGAGAAAAGAGGTAGTGAGCTGGTGTT
TCAGGATGTAAGGGCCCGGAGGAGCAGAGCGAGCTCTCTCCACTGCTTGCCCGCCACCCTGAGA
GTGCTGGTCGGTGTTTCCACAATCCTTGTGGTGGGTGGCCCCCCGTGGAGGGGACCTGTGAGCA
ACGGAGGCATGCCAGGGAAGCCCAAGCACTTGGGTGTCCCCAACGGGCGCATGGTCCTGGCTGT
CTCTGATGGAGAACTGACCAGCACATCAGGTTCCCAGGCCCAGGGTGAGGGCAGAGGCAGCTCC
CTCAGCATCCACAGCCTCCCCAGTGGCCCCAGCAGCCCCTTCTCCACTGATGAGCAGCCTGTGG
CCAGCTGGGCCCAGTCCTTTGAGCGGCTGCTGCAAGACCCACGGGGTCTGGCTTACTTCACTGA
GTTCCTGAAGAAGGAATTCAGCGCCGAGAATGTAACTTTCTGGCAAGCCTGCGAGCGTTTCCAA
CAGATCCCAGCCAGCGACACCAAACAGCTAGCTCAGGAGGCCCACAACATCTACCATGAGTTCC
TGTCCAGCCAGGCACTGAGCCCAGTGAACATCGACCGACAGGCCTGGCTTAGTGAGGAGGTGCT
GGCCCAGCCCAGGCCCGATATGTTCCGAGCACAGCAGCTTCAGATCTTCAATTTGATGAAGTTC
GACAGCTACGCGCGCTTCGTCAAATCCCCGCTGTACCAAGAGTGCCTGCTGGCCGAGGCCGAGG
GACGCCCCCTGCGGGAACCTGGATCCTCACACCTCGGGAGCCCGGACACTGCGAGGAAGAAGCC
AAAGCTGAAGCCTGGAAAGTCACTGCCGCTCGGTGTGGAAGAGTTGGGGCAGCTGCCGCTTGCT
GAGGGCCGCCCTCTCCGCAAGTCCTTTCGTAGAGAGATGCCGGGTGGAGCTGTGAATTCGGCCC
TGCGACGAGAGTCTCAGGGATCCCTGAATTCTTCCGCGAGTCTGGACCTGGGCTTCCTTGCCTT
TGTGAGCAGCAAATCCGAGAGCCACCGAAAGAGCCTTGGAAGTGGAGAGGGTGAGAGCGAAAGC
CGGCCCGGGAAGTACTGCTGCGTGTATCTACCTGATGGCACGGCCTCCTTGGCCCTGGCTCGAC
CTGGCCTCACCATCCGTGACATGCTGGCAGGCATCTGTGAGAAGAGAGGCCTCTCTCTACCTGA
CATTAAGGTCTACCTGGTGGGCAAAGAACAGAAGGCCCTGGTCCTGGATCAGGACTGCACCGTG
CTGGCAGACCAGGAAGTGCGACTGGAAAACAGGATCACCTTCCAGCTGGAGTTGGTCGGCCTGG
AGCGTGTGGTACGGATCTCTGCTAAGCCCACCAAGCGTCTGCAGGAGGCGCTGCAGCCTATCTT
GGCCAAGCACGGCCTGAGCCTGGATCAGGTGGTCCTACACAGGCCAGGAGAGAAGCAGCTAGTG
GATTTGGAGAATCTAGTGAGCTCAGTGGCTTCACAGACACTGGTTTTGGACACTCTTCCAGATG
CAAAGACAAGGGAAGCCAGCAGCATACCTCCCTGCCGCAGCCAGGGATGCCTCCCTAGAACCCA
GACCAAGGACAGTCACCTTCCTCCACTGTCCTCCAGTTTGTCGGTAGAAGATGCCAGTGGTTCT
ACTGGGAAACGACAGACCTGCGACATTGAAGGCCTAGTGGAGCTGCTGAATCGTGTGCAGAGCA
GCGGGGCCCATGACCAGAGGGGACTTCTTCGCAAAGAGGACCTGGTCCTTCCAGAATTTCTGCA
GCTTCCTTCCCAAAGACCAGGTTCTCAGGAGGCTCCACCATAGACTGAATCAACTATTCAGCCC
AGGGAGGGCCCTTCAGACTCCACCATCCACTCGGTCCTCTGACACCTGTGTAACAATCCAGGCT
GTCTGCATGGTGCCTGGGCAAACCAAGCATGCCACGGGTCTGTGCTGCATGCCCTGTCTGTACC
AGGAGTGTCTTTGGTCCCTTTCTGCTGTGGGCAGGCCCACAGAAAGGGCCAGGAAGGGGTGGCT
ACTTGTTCTCTCATAGGTTTACCTACCAATTCCTCACAGTAGGCCATCAAGGGGAGGTGGGCCT
TGTCCCTTGGCATAAGCATACTGAACATGAAGAGGTGACTTTGGCAGTGTCAGCCTCCTTGACT
TGTTCTAGGCTTTAGCAGGGGGCAGGAAGGAGGGGCTGGCCCCTCCTTAAAGAGTTGGTGTAAG
AAAGACCTGGGTGTACTACTGGGCAACCCCTCCCTCCATCCACAGATTTTGCTGTACATATGGA
TTTTATGGTTGGCTTGGGGCAGCTGGGTTTGTCCTGGATGTATGATACTGTTATAATAATAATT
ATTATTATTCAGCCACGAGGTGTCTTTTTTTTGTCTTTTTTTTTCGGAGCTGGGAACCGAACCC
AGGGCCTTGCGCTTGTTAGGCAAGCGCTCTACCACTGAGCTAAATCCCCAACCCCATGAGGTGT
CTTTCTTGTATGCCACTCTGCCCTGTGTAGTCTCACTACCCCACTGCCTCTGTGCCAGGCCAGG
AAGTTTTGGGGAACCTTAGTGTATACCTCCTCACTTCTTGTTTTCAGAATCTCTCTCCCCAAGG
CATAGGATATAGAAGGCAGGGGGGGGGGAGCAGAATGGAGAGGGAGAGAGCGCCACCCCCCACC
CCCTACTGTTCTTGGCCATCACCCAGCTGCTCCACAATGTCCATGGGAGATGAATGTATCCTTT
TTGTTTCTGTTCTGTTTCTGTTGGTGATACAATGTATC

hide sequence

RefSeq Acc Id:

XM_039095287 ⟹ XP_038951215

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,254,112 - 9,267,955 (-)	NCBI
mRatBN7.2	17	9,248,982 - 9,262,826 (-)	NCBI

RefSeq Acc Id:

XM_063276019 ⟹ XP_063132089

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,254,112 - 9,267,958 (-)	NCBI

RefSeq Acc Id:

XM_063276020 ⟹ XP_063132090

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,254,112 - 9,267,955 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446216	(Get FASTA)	NCBI Sequence Viewer
	XP_038951215	(Get FASTA)	NCBI Sequence Viewer
	XP_063132089	(Get FASTA)	NCBI Sequence Viewer
	XP_063132090	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53175	(Get FASTA)	NCBI Sequence Viewer
	AAH91132	(Get FASTA)	NCBI Sequence Viewer
	EDL93993	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021596
	ENSRNOP00000021596.1
GenBank Protein	O08773	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446216 ⟸ NM_053764

- UniProtKB:

O08773 (UniProtKB/Swiss-Prot), A6KAT5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGKPKHLGVPNGRMVLAVSDGELTSTSGSQAQGEGRGSSLSIHSLPSGPSSPFSTDEQPVASW
AQSFERLLQDPRGLAYFTEFLKKEFSAENVTFWQACERFQQIPASDTKQLAQEAHNIYHEFLSS
QALSPVNIDRQAWLSEEVLAQPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQECLLAEAEGRP
LREPGSSHLGSPDTARKKPKLKPGKSLPLGVEELGQLPLAEGRPLRKSFRREMPGGAVNSALRR
ESQGSLNSSASLDLGFLAFVSSKSESHRKSLGSGEGESESRPGKYCCVYLPDGTASLALARPGL
TIRDMLAGICEKRGLSLPDIKVYLVGKEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERV
VRISAKPTKRLQEALQPILAKHGLSLDQVVLHRPGEKQLVDLENLVSSVASQTLVLDTLPDAKT
REASSIPPCRSQGCLPRTQTKDSHLPPLSSSLSVEDASGSTGKRQTCDIEGLVELLNRVQSSGA
HDQRGLLRKEDLVLPEFLQLPSQRPGSQEAPP

hide sequence

Ensembl Acc Id:

ENSRNOP00000021596 ⟸ ENSRNOT00000021596

Ensembl Acc Id:

ENSRNOP00000073077 ⟸ ENSRNOT00000090536

RefSeq Acc Id:	XP_038951215 ⟸ XM_039095287
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063132089 ⟸ XM_063276019
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063132090 ⟸ XM_063276020
- Peptide Label:	isoform X2

Protein Domains

GoLoco RBD RGS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08773-F1-model_v2	AlphaFold	O08773	1-544	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620003	AgrOrtholog
BioCyc Gene	G2FUF-10199	BioCyc
Ensembl Genes	ENSRNOG00000015616	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021596	ENTREZGENE
	ENSRNOT00000021596.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.167.10	UniProtKB/Swiss-Prot
	1.10.196.10	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7376916	IMAGE-MGC_LOAD
InterPro	GoLoco_motif	UniProtKB/Swiss-Prot
	RBD1_RGS14	UniProtKB/Swiss-Prot
	RBD2_RGS14	UniProtKB/Swiss-Prot
	RBD_dom	UniProtKB/Swiss-Prot
	RGS	UniProtKB/Swiss-Prot
	RGS10/12/14-like	UniProtKB/Swiss-Prot
	RGS14_RGS	UniProtKB/Swiss-Prot
	RGS_sf	UniProtKB/Swiss-Prot
	RGS_subdom1/3	UniProtKB/Swiss-Prot
	RGS_subdomain_2	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
KEGG Report	rno:114705	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108631	IMAGE-MGC_LOAD
NCBI Gene	114705	ENTREZGENE
PANTHER	PTHR45945:SF2	UniProtKB/Swiss-Prot
	REGULATOR OF G-PROTEIN SIGNALING LOCO	UniProtKB/Swiss-Prot
Pfam	GoLoco	UniProtKB/Swiss-Prot
	RBD	UniProtKB/Swiss-Prot
	RGS	UniProtKB/Swiss-Prot
PhenoGen	Rgs14	PhenoGen
PRINTS	RGSPROTEIN	UniProtKB/Swiss-Prot
PROSITE	GOLOCO	UniProtKB/Swiss-Prot
	RBD	UniProtKB/Swiss-Prot
	RGS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000015616	RatGTEx
SMART	GoLoco	UniProtKB/Swiss-Prot
	RBD	UniProtKB/Swiss-Prot
	RGS	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48097	UniProtKB/Swiss-Prot
	SSF54236	UniProtKB/Swiss-Prot
UniProt	A0A8L2R6V5_RAT	UniProtKB/TrEMBL
	A6KAT5	ENTREZGENE, UniProtKB/TrEMBL
	O08773	ENTREZGENE
	Q5BKB9_RAT	UniProtKB/TrEMBL
	RGS14_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Rgs14	regulator of G-protein signaling 14			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Rgs14				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar