Ido1 (indoleamine 2,3-dioxygenase 1) - Rat Genome Database

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Gene: Ido1 (indoleamine 2,3-dioxygenase 1) Rattus norvegicus
Analyze
Symbol: Ido1
Name: indoleamine 2,3-dioxygenase 1
RGD ID: 619989
Description: Enables amino acid binding activity; indoleamine 2,3-dioxygenase activity; and oxygen binding activity. Involved in tryptophan catabolic process to kynurenine. Predicted to be located in smooth muscle contractile fiber and stereocilium bundle. Predicted to be active in cytoplasm. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; sleeping sickness pathway; INTERACTS WITH ammonium chloride; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ido; IDO-1; Indo; indoleamine 2,3-dioxygenase; indoleamine 23-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,133,259 - 74,145,328 (+)NCBIGRCr8
mRatBN7.21667,430,654 - 67,442,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,430,578 - 67,442,730 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,707,823 - 72,719,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01676,112,135 - 76,124,005 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,361,330 - 71,373,199 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01672,216,326 - 72,228,098 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,216,326 - 72,228,098 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,866,330 - 71,878,339 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,866,340 - 71,878,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,866,604 - 71,878,638 (+)NCBI
Celera1665,330,156 - 65,341,814 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
aconitic acid  (ISO)
acyclovir  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
anthranilic acid  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
bazedoxifene  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fumaric acid  (ISO)
gadodiamide hydrate  (ISO)
glucose  (ISO)
glycerol 1-phosphate  (ISO)
hexachlorobenzene  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indolin-2-one  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
kynurenine  (ISO)
L-tryptophan  (ISO)
lasofoxifene  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
malathion  (ISO)
malic acid  (ISO)
medroxyprogesterone acetate  (ISO)
muramyl dipeptide  (ISO)
N-nitrosodiethylamine  (EXP)
neopterin  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitroglycerin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
phenethyl caffeate  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
succinic acid  (ISO)
sulfasalazine  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tolerogenic Plasmacytoid Dendritic Cells Control Paracoccidioides brasiliensis Infection by Inducting Regulatory T Cells in an IDO-Dependent Manner. Araújo EF, etal., PLoS Pathog. 2016 Dec 19;12(12):e1006115. doi: 10.1371/journal.ppat.1006115. eCollection 2016 Dec.
2. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Bessede A, etal., Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.
3. Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development. Cannazza G, etal., Neurochem Res. 2001 May;26(5):511-4.
4. Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Changsirivathanathamrong D, etal., Crit Care Med. 2011 Dec;39(12):2678-83. doi: 10.1097/CCM.0b013e31822827f2.
5. Tryptophan catabolism reflects disease activity in human tuberculosis. Collins JM, etal., JCI Insight. 2020 May 21;5(10). pii: 137131. doi: 10.1172/jci.insight.137131.
6. Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway. Dang Y, etal., Free Radic Biol Med. 2000 Feb 15;28(4):615-24.
7. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. De Luca A, etal., PLoS Pathog. 2013;9(7):e1003486. doi: 10.1371/journal.ppat.1003486. Epub 2013 Jul 11.
8. LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism. Fallarino F, etal., Immunobiology. 2015 Feb;220(2):315-21. doi: 10.1016/j.imbio.2014.09.017. Epub 2014 Sep 28.
9. Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection. Fox JM, etal., J Leukoc Biol. 2014 Sep;96(3):447-52. doi: 10.1189/jlb.3AB0114-046RR. Epub 2014 May 5.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery. Geisler S, etal., Int J Infect Dis. 2020 Feb;91:162-168. doi: 10.1016/j.ijid.2019.12.005. Epub 2019 Dec 9.
12. IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis. Guo G, etal., Cell Cycle. 2019 Oct;18(20):2598-2613. doi: 10.1080/15384101.2019.1652471. Epub 2019 Aug 15.
13. Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells. Hoshi M, etal., Infect Immun. 2014 Nov;82(11):4487-95. doi: 10.1128/IAI.02113-14. Epub 2014 Aug 11.
14. Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. Huang L, etal., PLoS One. 2013 Jun 13;8(6):e66546. doi: 10.1371/journal.pone.0066546. Print 2013.
15. Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice. Juda MB, etal., Epilepsia. 2019 Apr;60(4):626-635. doi: 10.1111/epi.14675. Epub 2019 Feb 15.
16. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
17. Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. Littlejohn TK, etal., J Biol Chem 2003 Aug 8;278(32):29525-31. Epub 2003 May 24.
18. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Epidermal Growth Factor Receptor-Responsive Indoleamine 2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri Infection. Mukherjee T, etal., J Infect Dis. 2019 May 5;219(11):1841-1851. doi: 10.1093/infdis/jiz009.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3. Noh KT, etal., J Biol Chem. 2017 Feb 24;292(8):3290-3298. doi: 10.1074/jbc.M116.764464. Epub 2017 Jan 11.
23. Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
24. Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. Peng K and Monack DM, Infect Immun. 2010 Jun;78(6):2723-33. doi: 10.1128/IAI.00008-10. Epub 2010 Apr 12.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis. Put K, etal., PLoS One. 2016 Feb 25;11(2):e0150075. doi: 10.1371/journal.pone.0150075. eCollection 2016.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Synergistic transcriptional activation of indoleamine dioxygenase by IFN-gamma and tumor necrosis factor-alpha. Robinson CM, etal., J Interferon Cytokine Res 2003 Aug;23(8):413-21.
31. Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients. Schulz S, etal., Clin Exp Immunol. 2015 Jun;180(3):484-98. doi: 10.1111/cei.12586.
32. Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. Staudacher A, etal., Allergy. 2015 Nov;70(11):1432-9. doi: 10.1111/all.12699. Epub 2015 Sep 2.
33. The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Too LK, etal., Behav Brain Res. 2014 Aug 15;270:179-95. doi: 10.1016/j.bbr.2014.05.018. Epub 2014 May 17.
34. Indoleamine 2,3-Dioxygenase Activity During Acute Toxoplasmosis and the Suppressed T Cell Proliferation in Mice. Ufermann CM, etal., Front Cell Infect Microbiol. 2019 Jun 5;9:184. doi: 10.3389/fcimb.2019.00184. eCollection 2019.
35. Indoleamine 2,3-Dioxygenase Activity in Chlamydia muridarum and Chlamydia pneumoniae Infected Mouse Lung Tissues. Virok DP, etal., Front Cell Infect Microbiol. 2019 Jun 12;9:192. doi: 10.3389/fcimb.2019.00192. eCollection 2019.
36. Role of indoleamine 2,3-dioxygenase in health and disease. Yeung AW, etal., Clin Sci (Lond). 2015 Oct;129(7):601-72. doi: 10.1042/CS20140392.
37. Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Zhong W, etal., Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.
38. High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response. Ziklo N, etal., BMC Infect Dis. 2019 Mar 4;19(1):218. doi: 10.1186/s12879-019-3843-4.
Additional References at PubMed
PMID:2419335   PMID:9712583   PMID:11751753   PMID:16319139   PMID:16477023   PMID:16688932   PMID:17645734   PMID:17671174   PMID:17868070   PMID:18077788   PMID:18436652   PMID:18475196  
PMID:18480171   PMID:19177450   PMID:19234212   PMID:19234218   PMID:19283707   PMID:19602041   PMID:19741271   PMID:19935463   PMID:19944758   PMID:22172881   PMID:22424783   PMID:22454246  
PMID:22751107   PMID:23607691   PMID:25310899   PMID:25498102   PMID:25829217   PMID:26506443   PMID:26636969   PMID:27366867   PMID:27870896   PMID:27994058   PMID:28118532   PMID:30736955  
PMID:36879035  


Genomics

Comparative Map Data
Ido1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81674,133,259 - 74,145,328 (+)NCBIGRCr8
mRatBN7.21667,430,654 - 67,442,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,430,578 - 67,442,730 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1672,707,823 - 72,719,592 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01676,112,135 - 76,124,005 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,361,330 - 71,373,199 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01672,216,326 - 72,228,098 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,216,326 - 72,228,098 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,866,330 - 71,878,339 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41671,866,340 - 71,878,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11671,866,604 - 71,878,638 (+)NCBI
Celera1665,330,156 - 65,341,814 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
IDO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,913,891 - 39,928,790 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,902,275 - 39,928,790 (+)EnsemblGRCh38hg38GRCh38
GRCh37839,771,410 - 39,786,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,890,485 - 39,905,107 (+)NCBINCBI36Build 36hg18NCBI36
Build 34839,890,484 - 39,905,102NCBI
Celera838,723,061 - 38,737,682 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef838,304,038 - 38,319,017 (+)NCBIHuRef
CHM1_1839,817,930 - 39,832,909 (+)NCBICHM1_1
T2T-CHM13v2.0840,190,729 - 40,205,625 (+)NCBIT2T-CHM13v2.0
Ido1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,074,148 - 25,086,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,074,152 - 25,087,025 (-)EnsemblGRCm39 Ensembl
GRCm38824,584,133 - 24,596,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,584,136 - 24,597,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37825,694,613 - 25,707,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,049,686 - 26,062,554 (-)NCBIMGSCv36mm8
Celera826,068,313 - 26,081,132 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map812.76NCBI
Ido1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555362,943,611 - 2,955,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555362,944,770 - 2,955,829 (-)NCBIChiLan1.0ChiLan1.0
IDO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2758,370,241 - 58,385,003 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1834,087,337 - 34,102,106 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0839,108,310 - 39,123,611 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1836,606,721 - 36,632,371 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl836,617,312 - 36,632,352 (+)Ensemblpanpan1.1panPan2
IDO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11625,391,759 - 25,407,161 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1625,391,754 - 25,407,048 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1625,901,596 - 25,916,857 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01627,218,925 - 27,234,204 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1627,218,820 - 27,234,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11625,516,922 - 25,532,182 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01626,072,694 - 26,087,946 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,131,508 - 26,146,796 (-)NCBIUU_Cfam_GSD_1.0
Ido1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494348,593,856 - 48,608,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936843657,979 - 672,700 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936843658,058 - 672,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,245,196 - 9,260,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,245,283 - 9,260,140 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21710,913,978 - 10,928,837 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1837,930,910 - 37,950,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl837,930,562 - 37,946,505 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660523,981,103 - 3,996,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ido1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247803,685,069 - 3,697,474 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247803,684,941 - 3,697,506 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ido1
237 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000051363
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 12 12 15 19 19 1 45 35 7 1 31 19

Sequence


Ensembl Acc Id: ENSRNOT00000051363   ⟹   ENSRNOP00000050320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,430,578 - 67,442,730 (+)Ensembl
Rnor_6.0 Ensembl1672,216,326 - 72,228,098 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117293   ⟹   ENSRNOP00000078965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1667,430,578 - 67,442,730 (+)Ensembl
RefSeq Acc Id: NM_023973   ⟹   NP_076463
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81674,133,259 - 74,145,328 (+)NCBI
mRatBN7.21667,430,654 - 67,442,726 (+)NCBI
Rnor_6.01672,216,326 - 72,228,098 (+)NCBI
Rnor_5.01671,866,330 - 71,878,339 (+)NCBI
RGSC_v3.41671,866,340 - 71,878,373 (+)RGD
Celera1665,330,156 - 65,341,814 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_076463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG30573 (Get FASTA)   NCBI Sequence Viewer  
  EDM09039 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050320.3
  ENSRNOP00000078965.1
GenBank Protein Q9ERD9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_076463   ⟸   NM_023973
- Sequence:
Ensembl Acc Id: ENSRNOP00000050320   ⟸   ENSRNOT00000051363
Ensembl Acc Id: ENSRNOP00000078965   ⟸   ENSRNOT00000117293

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERD9-F1-model_v2 AlphaFold Q9ERD9 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619989 AgrOrtholog
BioCyc Gene G2FUF-10943 BioCyc
BioCyc Pathway PWY-5651 [L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde] BioCyc
BioCyc Pathway Image PWY-5651 BioCyc
Ensembl Genes ENSRNOG00000031189 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051363.3 UniProtKB/TrEMBL
  ENSRNOT00000117293.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Indolamine_dOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp/Indoleamine_2_3_dOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:66029 UniProtKB/Swiss-Prot
NCBI Gene 66029 ENTREZGENE
PANTHER INDOLEAMINE 2,3-DIOXYGENASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ido1 PhenoGen
PROSITE IDO_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IDO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031189 RatGTEx
Superfamily-SCOP SSF140959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZM07_RAT UniProtKB/TrEMBL
  F1LMC9_RAT UniProtKB/TrEMBL
  I23O1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-04 Ido1  indoleamine 2,3-dioxygenase 1  Indo  indoleamine-pyrrole 2,3 dioxygenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Indo  indoleamine-pyrrole 2,3 dioxygenase    indoleamine 2,3-dioxygenase  Name updated 1299863 APPROVED
2004-09-10 Indo  indoleamine 2,3-dioxygenase  Ido    Symbol and Name updated 1299863 APPROVED
2002-08-07 Ido  indoleamine 2,3-dioxygenase      Symbol and Name status set to provisional 70820 PROVISIONAL