Adcy2 (adenylate cyclase 2) - Rat Genome Database

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Gene: Adcy2 (adenylate cyclase 2) Rattus norvegicus
Analyze
Symbol: Adcy2
Name: adenylate cyclase 2
RGD ID: 619965
Description: Exhibits several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Localizes to integral component of plasma membrane; membrane raft; and protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; endothelin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AC2; adenylate cyclase 2 (brain); adenylate cyclase type 2; adenylate cyclase type II; adenylyl cyclase 2; ATP pyrophosphate-lyase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2134,375,639 - 34,822,237 (+)NCBI
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0137,043,071 - 37,698,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0139,075,253 - 39,080,014 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0138,434,800 - 39,001,909 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4174,543,466 - 5,040,433 (+)NCBIRGSC3.4rn4RGSC3.4
Celera132,960,049 - 33,391,637 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
asthma  (ISO)
bipolar disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Baragli A, etal., Cell Signal. 2008 Mar;20(3):480-92. doi: 10.1016/j.cellsig.2007.10.033. Epub 2007 Nov 22.
2. Chen J, etal., Science. 1995 May 26;268(5214):1166-9.
3. Feinstein PG, etal., Proc Natl Acad Sci U S A 1991 Nov 15;88(22):10173-7.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Halls ML and Cooper DM, EMBO J. 2010 Aug 18;29(16):2772-87. doi: 10.1038/emboj.2010.168. Epub 2010 Jul 27.
7. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
8. KEGG
9. MGD data from the GO Consortium
10. NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
12. Piggott LA, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40. Epub 2008 Sep 4.
13. Pipeline to import KEGG annotations from KEGG into RGD
14. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Pipeline to import SMPDB annotations from SMPDB into RGD
16. RGD automated data pipeline
17. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. RGD automated import pipeline for gene-chemical interactions
19. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
20. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
21. Tesmer JJ, etal., Science. 1999 Jul 30;285(5428):756-60.
22. Wang HY and Burns LH, J Neurobiol. 2006 Oct;66(12):1302-10.
Additional References at PubMed
PMID:9069282   PMID:9417641   PMID:9870949   PMID:11549699   PMID:19008230   PMID:22871113   PMID:22906005  


Genomics

Comparative Map Data
Adcy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2134,375,639 - 34,822,237 (+)NCBI
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0137,043,071 - 37,698,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0139,075,253 - 39,080,014 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0138,434,800 - 39,001,909 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4174,543,466 - 5,040,433 (+)NCBIRGSC3.4rn4RGSC3.4
Celera132,960,049 - 33,391,637 (+)NCBICelera
Cytogenetic Map1p11NCBI
ADCY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl57,396,138 - 7,830,081 (+)EnsemblGRCh38hg38GRCh38
GRCh3857,396,138 - 7,830,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3757,396,251 - 7,830,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3657,449,343 - 7,883,194 (+)NCBINCBI36hg18NCBI36
Build 3457,449,344 - 7,883,194NCBI
Celera57,439,102 - 7,871,262 (+)NCBI
Cytogenetic Map5p15.31NCBI
HuRef57,378,757 - 7,709,814 (+)NCBIHuRef
HuRef57,725,521 - 7,811,956 (+)NCBIHuRef
CHM1_157,396,258 - 7,830,278 (+)NCBICHM1_1
Adcy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391368,768,162 - 69,147,719 (-)NCBIGRCm39mm39
GRCm39 Ensembl1368,768,162 - 69,147,660 (-)Ensembl
GRCm381368,620,043 - 68,999,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1368,620,043 - 68,999,541 (-)EnsemblGRCm38mm10GRCm38
MGSCv371368,758,920 - 69,138,419 (-)NCBIGRCm37mm9NCBIm37
MGSCv361369,087,431 - 69,466,658 (-)NCBImm8
Celera1370,976,336 - 71,362,097 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Adcy2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555045,004,903 - 5,376,328 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,990,634 - 5,376,990 (+)NCBIChiLan1.0ChiLan1.0
ADCY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.157,540,762 - 7,975,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl57,540,790 - 7,975,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v057,718,581 - 8,154,006 (+)NCBIMhudiblu_PPA_v0panPan3
ADCY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1346,139,931 - 6,527,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3410,648,056 - 11,035,866 (-)NCBI
ROS_Cfam_1.0346,045,474 - 6,434,089 (-)NCBI
UMICH_Zoey_3.1346,095,233 - 6,483,250 (-)NCBI
UNSW_CanFamBas_1.0346,075,965 - 6,464,063 (-)NCBI
UU_Cfam_GSD_1.0346,288,901 - 6,677,489 (-)NCBI
Adcy2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213239,063,958 - 239,560,683 (-)NCBI
SpeTri2.0NW_00493664347,830 - 338,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1674,305,745 - 74,524,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11674,305,729 - 74,729,999 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21680,359,861 - 80,498,999 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,989,077 - 7,415,282 (+)NCBI
ChlSab1.1 Ensembl46,989,169 - 7,414,617 (+)Ensembl
Vero_WHO_p1.0NW_02366606421,200,037 - 21,628,571 (-)NCBI
Adcy2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247515,004,186 - 5,409,891 (+)NCBI

Position Markers
RH132673  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,821,898 - 34,822,099 (+)MAPPER
Rnor_6.0137,698,053 - 37,698,253NCBIRnor6.0
Rnor_5.0139,079,677 - 39,079,877UniSTSRnor5.0
RGSC_v3.4175,040,096 - 5,040,296UniSTSRGSC3.4
Celera133,391,300 - 33,391,500UniSTS
Cytogenetic Map17p14UniSTS
RH129915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,815 - 34,723,021 (+)MAPPER
mRatBN7.21529,079,099 - 29,079,905 (+)MAPPER
Rnor_6.01534,266,157 - 34,266,962NCBIRnor6.0
Rnor_6.0137,559,558 - 37,559,763NCBIRnor6.0
Rnor_5.01538,156,352 - 38,157,157UniSTSRnor5.0
Rnor_5.0138,939,804 - 38,940,009UniSTSRnor5.0
RGSC_v3.41533,722,975 - 33,723,780UniSTSRGSC3.4
RGSC_v3.4174,920,805 - 4,921,010UniSTSRGSC3.4
Celera1528,655,020 - 28,655,825UniSTS
Celera133,295,388 - 33,295,593UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
RH71322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,825 - 34,722,996 (+)MAPPER
mRatBN7.21338,190,170 - 38,190,341 (+)MAPPER
Rnor_6.01343,080,194 - 43,080,364NCBIRnor6.0
Rnor_6.0137,559,568 - 37,559,738NCBIRnor6.0
Rnor_5.01348,181,613 - 48,181,783UniSTSRnor5.0
Rnor_5.0138,939,814 - 38,939,984UniSTSRnor5.0
RGSC_v3.41339,308,325 - 39,308,495UniSTSRGSC3.4
RGSC_v3.4174,920,815 - 4,920,985UniSTSRGSC3.4
Celera1338,513,040 - 38,513,210UniSTS
Celera133,295,398 - 33,295,568UniSTS
Cytogenetic Map13q11UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
MARC_4677-4678:996679594:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,722,607 - 34,722,680 (+)MAPPER
mRatBN7.21529,080,316 - 29,081,409 (+)MAPPER
Rnor_6.01534,267,374 - 34,268,466NCBIRnor6.0
Rnor_6.0137,559,350 - 37,559,422NCBIRnor6.0
Rnor_5.01538,157,569 - 38,158,661UniSTSRnor5.0
Rnor_5.0138,939,596 - 38,939,668UniSTSRnor5.0
RGSC_v3.41533,724,192 - 33,725,284UniSTSRGSC3.4
RGSC_v3.4174,920,597 - 4,920,669UniSTSRGSC3.4
Celera1528,656,237 - 28,657,329UniSTS
Celera133,295,180 - 33,295,252UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map15p13UniSTS
D5S1607E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2134,693,066 - 34,694,119 (+)MAPPER
Rnor_6.0137,516,712 - 37,517,764NCBIRnor6.0
Rnor_5.0138,896,677 - 38,897,729UniSTSRnor5.0
RGSC_v3.4174,888,656 - 4,889,708UniSTSRGSC3.4
Celera133,265,638 - 33,266,690UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1164407321Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)125439343579402Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)125439343579402Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)125439343579402Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1186804543724576Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1457869349578693Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11131448975844121Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11249343957493439Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11362925158629251Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11614314349547474Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11614314349547474Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12034156058000154Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12107930566079305Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12130082249454378Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12181262344409802Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12340642849547474Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12340642849547474Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12340642868406428Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)12429779978748000Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13148945479689689Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13444911279449112Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13444911279449112Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13585416780854167Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13585416780854167Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13585416780854167Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13603316579689689Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13603316579689689Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:246
Interacting mature miRNAs:313
Transcripts:ENSRNOT00000047627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 11 58 18 19 11 8
Low 3 43 43 27 19 27 16 17 18
Below cutoff 13 13 13 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047627   ⟹   ENSRNOP00000038994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)Ensembl
RefSeq Acc Id: NM_031007   ⟹   NP_112269
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2134,375,887 - 34,822,236 (+)NCBI
Rnor_6.0137,043,071 - 37,698,390 (+)NCBI
Rnor_5.0138,434,800 - 39,001,909 (+)NCBI
Rnor_5.0139,075,253 - 39,080,014 (+)NCBI
RGSC_v3.4174,543,466 - 5,040,433 (+)RGD
Celera132,960,049 - 33,391,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092032   ⟹   XP_038947960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2134,375,641 - 34,822,237 (+)NCBI
RefSeq Acc Id: XM_039092037   ⟹   XP_038947965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2134,375,642 - 34,822,237 (+)NCBI
RefSeq Acc Id: XM_039092038   ⟹   XP_038947966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2134,375,640 - 34,783,103 (+)NCBI
RefSeq Acc Id: XM_039092044   ⟹   XP_038947972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2134,375,639 - 34,762,623 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_112269   ⟸   NM_031007
- Sequence:
RefSeq Acc Id: ENSRNOP00000038994   ⟸   ENSRNOT00000047627
RefSeq Acc Id: XP_038947972   ⟸   XM_039092044
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947966   ⟸   XM_039092038
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947960   ⟸   XM_039092032
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038947965   ⟸   XM_039092037
- Peptide Label: isoform X2
Protein Domains
Guanylate cyclase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619965 AgrOrtholog
Ensembl Genes ENSRNOG00000032150 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000038994 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047627 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot
  Adcy UniProtKB/Swiss-Prot
  Adcy_conserved_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81636 UniProtKB/Swiss-Prot
NCBI Gene 81636 ENTREZGENE
Pfam AC_N UniProtKB/Swiss-Prot
  DUF1053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy2 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADCY2_RAT UniProtKB/Swiss-Prot
  F1LV12_RAT UniProtKB/TrEMBL
  P26769 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Adcy2  adenylate cyclase 2  Adcy2  adenylate cyclase 2 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcy2  adenylate cyclase 2 (brain)  Adcy2  adenylate cyclase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Adcy2  adenylate cyclase 2    adenylyl cyclase 2  Name updated 1299863 APPROVED
2002-08-07 Adcy2  adenylyl cyclase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the membrane 724707
gene_regulation activity is insensitive to Ca2+/calmodulin 724792