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Gene: Pten (phosphatase and tensin homolog) Rattus norvegicus
Symbol: Pten
Name: phosphatase and tensin homolog
RGD ID: 61995
Description: Exhibits several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; dephosphorylation; and generation of neurons. Localizes to several cellular components, including dendritic spine; mitochondrion; and postsynaptic membrane. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including fatty liver disease; fetal alcohol spectrum disorder; glucose metabolism disease (multiple); renal cell carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); macrocephaly-autism syndrome; and nervous system cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog); PARTICIPATES IN altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; endometrial cancer pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
Also known as: Mmac; MMAC1; mutated in multiple advanced cancers 1; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; TEP1
Homo sapiens (human) : PTEN (phosphatase and tensin homolog)  HGNC  Alliance
Mus musculus (house mouse) : Pten (phosphatase and tensin homolog)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pten (phosphatase and tensin homolog)
Pan paniscus (bonobo/pygmy chimpanzee) : PTEN (phosphatase and tensin homolog)
Canis lupus familiaris (dog) : PTEN (phosphatase and tensin homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pten (phosphatase and tensin homolog)
Sus scrofa (pig) : PTEN (phosphatase and tensin homolog)
Chlorocebus sabaeus (African green monkey) : PTEN (phosphatase and tensin homolog)
Heterocephalus glaber (naked mole-rat) : Pten (phosphatase and tensin homolog)
more info ...
Allele / Splice: Ptenem1Sage  
Genetic Models: SD-Ptenem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01251,421,814 - 251,487,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,421,596 - 251,487,832 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01258,651,829 - 258,717,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,771,027 - 236,837,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,935,049 - 237,001,284 (+)NCBI
Celera1227,746,622 - 227,812,108 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations