Nup62 (nucleoporin 62) - Rat Genome Database

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Gene: Nup62 (nucleoporin 62) Rattus norvegicus
Analyze
Symbol: Nup62
Name: nucleoporin 62
RGD ID: 619938
Description: Enables kinesin binding activity. A structural constituent of nuclear pore. Involved in protein import into nucleus; regulation of protein import into nucleus; and spermatogenesis. Located in annulate lamellae and nuclear membrane. Part of nuclear pore. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to human NUP62 (nucleoporin 62); PARTICIPATES IN mRNA nuclear export pathway; RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 62 kDa nucleoporin; Np62; nuclear pore glycoprotein 62; nuclear pore glycoprotein p62; nucleoporin Nup62
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,435,532 - 104,451,392 (+)NCBIGRCr8
mRatBN7.2195,298,995 - 95,314,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,295,526 - 95,315,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,684,924 - 100,700,286 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,157,589 - 109,172,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,447,996 - 102,463,359 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,811,140 - 100,827,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,811,755 - 100,827,111 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,876,161 - 101,891,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,288,019 - 95,303,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,378,221 - 95,382,015 (+)NCBI
Celera189,561,555 - 89,576,634 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (ISO)
auramine O  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
gentamycin  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
leflunomide  (ISO)
leptomycin B  (EXP)
lycopene  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
Nutlin-3  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
trichostatin A  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. Ben-Efraim I and Gerace L, J Cell Biol. 2001 Jan 22;152(2):411-7.
2. Sequential recruitment of NPC proteins to the nuclear periphery at the end of mitosis. Bodoor K, etal., J Cell Sci. 1999 Jul;112 ( Pt 13):2253-64.
3. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A and Palancade B, Genes (Basel). 2014 Sep 2;5(3):767-91. doi: 10.3390/genes5030767.
4. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p. Clarkson WD, etal., J Mol Biol. 1996 Nov 8;263(4):517-24.
5. The gene encoding rat nuclear pore glycoprotein p62 is intronless. D'Onofrio M, etal., J Biol Chem 1991 Jun 25;266(18):11980-5.
6. Partial cDNA sequence encoding a nuclear pore protein modified by O-linked N-acetylglucosamine. D'Onofrio M, etal., Proc Natl Acad Sci U S A 1988 Dec;85(24):9595-9.
7. A biochemical and immunological comparison of nuclear and cytoplasmic pore complexes. Ewald A, etal., J Cell Sci. 1996 Jul;109 ( Pt 7):1813-24.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex. Guan T, etal., Mol Biol Cell. 1995 Nov;6(11):1591-603.
10. Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. Hu T, etal., J Cell Biol 1996 Aug;134(3):589-601.
11. Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study. Miyachi K, etal., J Autoimmun. 2003 May;20(3):247-54.
12. The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. Monshausen M, etal., Neuromolecular Med. 2004;6(2-3):127-44.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Puls A, etal., Proc Natl Acad Sci U S A 1997 Jun 10;94(12):6191-6.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Molecular architecture of the transport channel of the nuclear pore complex. Solmaz SR, etal., Cell. 2011 Oct 28;147(3):590-602. doi: 10.1016/j.cell.2011.09.034.
21. The stoichiometry of the nucleoporin 62 subcomplex of the nuclear pore in solution. Ulrich A, etal., Mol Biol Cell. 2014 May;25(9):1484-92. doi: 10.1091/mbc.E13-12-0745. Epub 2014 Feb 26.
22. The molecular motor KIFC1 associates with a complex containing nucleoporin NUP62 that is regulated during development and by the small GTPase RAN. Yang WX, etal., Biol Reprod. 2006 Apr;74(4):684-90. Epub 2005 Dec 21.
Additional References at PubMed
PMID:1915414   PMID:1915419   PMID:2190987   PMID:7849178   PMID:8650207   PMID:8702753   PMID:9348540   PMID:10356400   PMID:10373430   PMID:10799545   PMID:11013214   PMID:11031258  
PMID:11244088   PMID:11489947   PMID:11755531   PMID:12477932   PMID:15572682   PMID:15625236   PMID:17098863   PMID:17882263   PMID:18809582   PMID:19166812   PMID:19581287   PMID:22683860  
PMID:23777819   PMID:24107630   PMID:25349423   PMID:26025361   PMID:28406021   PMID:29057768   PMID:37802024  


Genomics

Comparative Map Data
Nup62
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,435,532 - 104,451,392 (+)NCBIGRCr8
mRatBN7.2195,298,995 - 95,314,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,295,526 - 95,315,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,684,924 - 100,700,286 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,157,589 - 109,172,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,447,996 - 102,463,359 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,811,140 - 100,827,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,811,755 - 100,827,111 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,876,161 - 101,891,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,288,019 - 95,303,545 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,378,221 - 95,382,015 (+)NCBI
Celera189,561,555 - 89,576,634 (+)NCBICelera
Cytogenetic Map1q22NCBI
NUP62
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,906,825 - 49,929,504 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,906,825 - 49,929,764 (-)EnsemblGRCh38hg38GRCh38
GRCh371950,410,082 - 50,432,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,101,894 - 55,124,598 (-)NCBINCBI36Build 36hg18NCBI36
Build 341955,101,893 - 55,124,598NCBI
Celera1947,279,595 - 47,302,503 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,786,417 - 46,809,243 (-)NCBIHuRef
CHM1_11950,411,926 - 50,434,816 (-)NCBICHM1_1
T2T-CHM13v2.01952,906,960 - 52,929,639 (-)NCBIT2T-CHM13v2.0
Nup62
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,465,512 - 44,481,260 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,465,512 - 44,480,236 (+)EnsemblGRCm39 Ensembl
GRCm38744,816,088 - 44,831,836 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,816,088 - 44,830,812 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,071,790 - 52,086,177 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,684,462 - 44,698,849 (+)NCBIMGSCv36mm8
Celera740,266,716 - 40,281,098 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.93NCBI
Nup62
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,030,894 - 1,032,462 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,012,919 - 1,033,465 (+)NCBIChiLan1.0ChiLan1.0
NUP62
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,022,278 - 56,044,867 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,943,134 - 57,965,715 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,919,731 - 46,942,318 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,835,593 - 55,858,165 (-)NCBIpanpan1.1PanPan1.1panPan2
NUP62
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,636,282 - 106,661,250 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,219,723 - 106,244,693 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,157,688 - 107,182,656 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,157,675 - 107,182,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,829,847 - 106,854,818 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,472,003 - 106,496,982 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,312,293 - 107,337,261 (+)NCBIUU_Cfam_GSD_1.0
Nup62
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,072,538 - 22,095,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,690,567 - 3,713,719 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,690,728 - 3,713,819 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUP62
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,921,627 - 54,923,227 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,921,627 - 54,945,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,696,590 - 50,727,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUP62
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,063,483 - 43,086,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,064,875 - 43,066,440 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,038,779 - 23,061,398 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nup62
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,404,245 - 4,428,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,404,367 - 4,428,231 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nup62
130 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:192
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000074847
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH133349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,314,575 - 95,314,767 (+)MAPPERmRatBN7.2
Rnor_6.01100,826,793 - 100,826,984NCBIRnor6.0
Rnor_5.01101,891,463 - 101,891,654UniSTSRnor5.0
RGSC_v3.4195,303,221 - 95,303,412UniSTSRGSC3.4
Celera189,576,310 - 89,576,501UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000074847   ⟹   ENSRNOP00000067556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,302,226 - 95,315,174 (+)Ensembl
Rnor_6.0 Ensembl1100,811,755 - 100,827,111 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117253   ⟹   ENSRNOP00000081212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,295,526 - 95,315,174 (+)Ensembl
RefSeq Acc Id: NM_023098   ⟹   NP_075586
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,436,028 - 104,451,390 (+)NCBI
mRatBN7.2195,299,536 - 95,314,900 (+)NCBI
Rnor_6.01100,811,755 - 100,827,117 (+)NCBI
Rnor_5.01101,876,161 - 101,891,789 (+)NCBI
RGSC_v3.4195,288,019 - 95,303,545 (+)RGD
Celera189,561,555 - 89,576,634 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229150   ⟹   XP_006229212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,435,532 - 104,451,392 (+)NCBI
mRatBN7.2195,298,995 - 95,314,902 (+)NCBI
Rnor_6.01100,811,140 - 100,827,119 (+)NCBI
Rnor_5.01101,876,161 - 101,891,789 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229151   ⟹   XP_006229213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,437,749 - 104,451,392 (+)NCBI
mRatBN7.2195,301,710 - 95,314,902 (+)NCBI
Rnor_6.01100,813,942 - 100,827,119 (+)NCBI
Rnor_5.01101,876,161 - 101,891,789 (+)NCBI
Sequence:
RefSeq Acc Id: NP_075586   ⟸   NM_023098
- UniProtKB: A2VCW0 (UniProtKB/Swiss-Prot),   P17955 (UniProtKB/Swiss-Prot),   A6JAS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229212   ⟸   XM_006229150
- Peptide Label: isoform X1
- UniProtKB: A2VCW0 (UniProtKB/Swiss-Prot),   P17955 (UniProtKB/Swiss-Prot),   A6JAS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229213   ⟸   XM_006229151
- Peptide Label: isoform X1
- UniProtKB: A2VCW0 (UniProtKB/Swiss-Prot),   P17955 (UniProtKB/Swiss-Prot),   A6JAS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067556   ⟸   ENSRNOT00000074847
Ensembl Acc Id: ENSRNOP00000081212   ⟸   ENSRNOT00000117253
Protein Domains
Nucleoporin NSP1-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17955-F1-model_v2 AlphaFold P17955 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690008
Promoter ID:EPDNEW_R532
Type:multiple initiation site
Name:Nup62_1
Description:nucleoporin 62
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,811,726 - 100,811,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619938 AgrOrtholog
BioCyc Gene G2FUF-59751 BioCyc
Ensembl Genes ENSRNOG00000048733 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074847.3 UniProtKB/Swiss-Prot
  ENSRNOT00000117253 ENTREZGENE
  ENSRNOT00000117253.1 UniProtKB/Swiss-Prot
  ENSRNOT00000123208 ENTREZGENE
  ENSRNOT00000155881 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8363131 IMAGE-MGC_LOAD
InterPro NSP1/NUP62 UniProtKB/Swiss-Prot
  Nucleoporin_NSP1_C UniProtKB/Swiss-Prot
KEGG Report rno:65274 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156514 IMAGE-MGC_LOAD
NCBI Gene 65274 ENTREZGENE
PANTHER NUCLEAR PORE GLYCOPROTEIN P62 UniProtKB/Swiss-Prot
  PTHR12084 UniProtKB/Swiss-Prot
Pfam Nsp1_C UniProtKB/Swiss-Prot
PhenoGen Nup62 PhenoGen
RatGTEx ENSRNOG00000048733 RatGTEx
UniProt A2VCW0 ENTREZGENE
  A6JAS7 ENTREZGENE, UniProtKB/TrEMBL
  NUP62_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2VCW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Nup62  nucleoporin 62    nuclear pore glycoprotein 62  Name updated 1299863 APPROVED
2002-08-07 Nup62  nuclear pore glycoprotein 62      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 525 amino acid residues 728932