Plcb3 (phospholipase C beta 3) - Rat Genome Database

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Gene: Plcb3 (phospholipase C beta 3) Rattus norvegicus
Analyze
Symbol: Plcb3
Name: phospholipase C beta 3
RGD ID: 61993
Description: Enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and post-Golgi vesicle-mediated transport. Located in cytosol and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphaq family; protein kinase C (PKC) signaling pathway; INTERACTS WITH (R)-noradrenaline; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; phosphoinositide phospholipase C-beta-3; phospholipase C, beta 3 (phosphatidylinositol-specific); phospholipase C-beta-3; PLC-beta-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Plcb3Tn(sb-T2/Bart3)2.69Mcwi
Genetic Models: F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,572,499 - 213,589,585 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1213,574,166 - 213,589,583 (-)EnsemblGRCr8
mRatBN7.21204,143,257 - 204,160,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,144,956 - 204,160,228 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1212,495,137 - 212,510,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,590,221 - 219,605,490 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,281,275 - 212,296,544 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,207,887 - 222,224,993 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,209,575 - 222,224,910 (-)Ensemblrn6Rnor6.0
Rnor_5.01229,198,739 - 229,215,831 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41209,628,425 - 209,643,694 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1201,678,898 - 201,694,162 (-)NCBICelera
RGSC_v3.11209,786,729 - 209,802,063 (-)NCBI
RH 3.4 Map11521.0RGD
Cytogenetic Map1q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
caffeine  (ISO)
calcitriol  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenamidone  (ISO)
fenthion  (ISO)
FR900359  (ISO)
hypochlorous acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
oxytocin  (ISO)
ozone  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sunitinib  (ISO)
thifluzamide  (ISO)
thiram  (ISO)
Triptolide  (EXP)
U-73122  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IDA,IEA)
membrane  (IEA)
nucleus  (IEA)
postsynaptic cytosol  (IEA,ISO)
protein-containing complex  (IEA,ISO)
sarcolemma  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport. Diaz Anel AM Biochem J. 2007 Aug 15;406(1):157-65.
2. Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme? Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29.
3. Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases. Friedrich B, etal., Brain Res. 2012 Oct 24;1481:37-48. doi: 10.1016/j.brainres.2012.08.005. Epub 2012 Aug 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. Hwang JI, etal., J Biol Chem. 2005 Apr 1;280(13):12467-73. Epub 2005 Jan 4.
6. Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3. Jhon DY, etal., J Biol Chem 1993 Mar 25;268(9):6654-61.
7. Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction. Ju H, etal., Circulation. 1998 Mar 10;97(9):892-9.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner. Kelley GG, etal., J Biol Chem. 2006 Feb 3;281(5):2639-48. Epub 2005 Nov 28.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Li Z, etal., Science 2000 Feb 11;287(5455):1046-9.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
19. Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits. Smrcka AV and Sternweis PC, J Biol Chem. 1993 May 5;268(13):9667-74.
20. Defective sarcolemmal phospholipase C signaling in diabetic cardiomyopathy. Tappia PS, etal., Mol Cell Biochem. 2004 Jun;261(1-2):193-9.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Targeted disruption of the mouse phospholipase C beta3 gene results in early embryonic lethality. Wang S, etal., FEBS Lett 1998 Dec 18;441(2):261-5.
Additional References at PubMed
PMID:9332346   PMID:12821674   PMID:17298601   PMID:18450967   PMID:18468998   PMID:19538471   PMID:25468996   PMID:30431106  


Genomics

Comparative Map Data
Plcb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,572,499 - 213,589,585 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1213,574,166 - 213,589,583 (-)EnsemblGRCr8
mRatBN7.21204,143,257 - 204,160,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,144,956 - 204,160,228 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1212,495,137 - 212,510,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,590,221 - 219,605,490 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,281,275 - 212,296,544 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,207,887 - 222,224,993 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,209,575 - 222,224,910 (-)Ensemblrn6Rnor6.0
Rnor_5.01229,198,739 - 229,215,831 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41209,628,425 - 209,643,694 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1201,678,898 - 201,694,162 (-)NCBICelera
RGSC_v3.11209,786,729 - 209,802,063 (-)NCBI
RH 3.4 Map11521.0RGD
Cytogenetic Map1q43NCBI
PLCB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,251,530 - 64,269,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,251,530 - 64,269,150 (+)Ensemblhg38GRCh38
GRCh371164,019,002 - 64,036,924 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,775,698 - 63,791,604 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341163,775,697 - 63,791,604NCBI
Celera1161,345,878 - 61,363,808 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,321,780 - 60,364,717 (+)NCBIHuRef
CHM1_11163,901,992 - 63,919,919 (+)NCBICHM1_1
T2T-CHM13v2.01164,241,551 - 64,259,480 (+)NCBIT2T-CHM13v2.0
Plcb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,931,081 - 6,951,738 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,929,693 - 6,953,838 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38196,953,708 - 6,975,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,952,325 - 6,976,470 (-)Ensemblmm10GRCm38
MGSCv37197,028,203 - 7,044,242 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36197,020,757 - 7,036,796 (-)NCBIMGSCv36mm8
Celera196,730,717 - 6,746,754 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.1NCBI
Plcb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,810,544 - 20,827,267 (-)Ensembl
ChiLan1.0NW_00495542220,810,871 - 20,827,267 (-)NCBIChiLan1.0ChiLan1.0
PLCB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,478,680 - 65,496,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,523,825 - 66,542,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,608,651 - 59,626,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,953,587 - 62,971,393 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,953,587 - 62,971,393 (+)EnsemblpanPan2panpan1.1
PLCB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,793,848 - 52,809,065 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,793,838 - 52,809,070 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1851,400,704 - 51,415,897 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01853,839,019 - 53,854,234 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,839,022 - 53,854,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,941,907 - 52,957,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,517,439 - 52,532,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,301,344 - 53,316,539 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plcb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,491,781 - 8,508,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,934,060 - 4,950,570 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,934,123 - 4,950,564 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,843,340 - 7,860,193 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.127,844,931 - 7,860,183 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,911,755 - 6,927,069 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,964,850 - 9,982,573 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,966,618 - 9,982,317 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038107,305,688 - 107,323,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,039,870 - 22,055,579 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476722,038,058 - 22,055,715 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Plcb3
85 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000028720
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
D1Wox66  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,161,679 - 204,161,853 (+)MAPPERmRatBN7.2
Rnor_6.01222,226,306 - 222,226,479NCBIRnor6.0
Rnor_5.01229,217,158 - 229,217,331UniSTSRnor5.0
RGSC_v3.41209,645,144 - 209,645,317UniSTSRGSC3.4
Celera1201,695,487 - 201,695,660UniSTS
Cytogenetic Map1q43UniSTS
RH133323  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81213,573,940 - 213,574,129 (+)Marker Load Pipeline
mRatBN7.21204,144,730 - 204,144,919 (+)MAPPERmRatBN7.2
Rnor_6.01222,209,361 - 222,209,549NCBIRnor6.0
Rnor_5.01229,200,213 - 229,200,401UniSTSRnor5.0
RGSC_v3.41209,628,200 - 209,628,388UniSTSRGSC3.4
Celera1201,678,673 - 201,678,861UniSTS
RH 3.4 Map11520.9UniSTS
Cytogenetic Map1q43UniSTS
RH142215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,161,822 - 204,162,012 (+)MAPPERmRatBN7.2
Rnor_6.01222,226,449 - 222,226,638NCBIRnor6.0
Rnor_5.01229,217,301 - 229,217,490UniSTSRnor5.0
RGSC_v3.41209,645,287 - 209,645,476UniSTSRGSC3.4
Celera1201,695,630 - 201,695,819UniSTS
RH 3.4 Map11521.0UniSTS
Cytogenetic Map1q43UniSTS


Genetic Models
This gene Plcb3 is modified in the following models/strains:
F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028720   ⟹   ENSRNOP00000028720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1213,574,166 - 213,589,583 (-)Ensembl
mRatBN7.2 Ensembl1204,144,956 - 204,160,228 (-)Ensembl
Rnor_6.0 Ensembl1222,209,575 - 222,224,910 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098773   ⟹   ENSRNOP00000078628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1213,574,166 - 213,589,423 (-)Ensembl
mRatBN7.2 Ensembl1204,144,956 - 204,160,216 (-)Ensembl
RefSeq Acc Id: NM_033350   ⟹   NP_203501
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,574,166 - 213,589,435 (-)NCBI
mRatBN7.21204,144,956 - 204,160,228 (-)NCBI
Rnor_6.01222,209,586 - 222,224,855 (-)NCBI
Rnor_5.01229,198,739 - 229,215,831 (-)NCBI
RGSC_v3.41209,628,425 - 209,643,694 (-)RGD
Celera1201,678,898 - 201,694,162 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230711   ⟹   XP_006230773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,572,499 - 213,589,583 (-)NCBI
mRatBN7.21204,143,257 - 204,160,383 (-)NCBI
Rnor_6.01222,207,887 - 222,224,993 (-)NCBI
Rnor_5.01229,198,739 - 229,215,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106564   ⟹   XP_038962492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,579,302 - 213,589,585 (-)NCBI
mRatBN7.21204,150,095 - 204,160,384 (-)NCBI
RefSeq Acc Id: NP_203501   ⟸   NM_033350
- UniProtKB: Q9QW29 (UniProtKB/Swiss-Prot),   Q99JE6 (UniProtKB/Swiss-Prot),   Q62887 (UniProtKB/Swiss-Prot),   Q45QJ4 (UniProtKB/TrEMBL),   F7FBZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230773   ⟸   XM_006230711
- Peptide Label: isoform X1
- UniProtKB: Q9QW29 (UniProtKB/Swiss-Prot),   Q99JE6 (UniProtKB/Swiss-Prot),   Q62887 (UniProtKB/Swiss-Prot),   Q45QJ4 (UniProtKB/TrEMBL),   F7FBZ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028720   ⟸   ENSRNOT00000028720
RefSeq Acc Id: XP_038962492   ⟸   XM_039106564
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000078628   ⟸   ENSRNOT00000098773
Protein Domains
C2   PI-PLC X-box   PI-PLC Y-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99JE6-F1-model_v2 AlphaFold Q99JE6 1-1234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690710
Promoter ID:EPDNEW_R1234
Type:initiation region
Name:Plcb3_1
Description:phospholipase C beta 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,224,973 - 222,225,033EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61993 AgrOrtholog
BioCyc Gene G2FUF-56576 BioCyc
BioCyc Pathway PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis] BioCyc
  PWY-6367 [D-myo-inositol-5-phosphate metabolism] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6351 BioCyc
  PWY-6367 BioCyc
  PWY-8052 BioCyc
Ensembl Genes ENSRNOG00000021150 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028720 ENTREZGENE
Gene3D-CATH 1.20.1230.10 UniProtKB/Swiss-Prot
  2.30.29.240 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.20.20.190 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
InterPro C2_Ca-dep UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  EF-hand-like_dom UniProtKB/Swiss-Prot
  Phospholipase_C_Pinositol-sp_C UniProtKB/Swiss-Prot
  Phospholipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot
  PLC-beta UniProtKB/Swiss-Prot
  PLC-beta_C UniProtKB/Swiss-Prot
  PLC-beta_C_sf UniProtKB/Swiss-Prot
  PLC-beta_PH UniProtKB/Swiss-Prot
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  PLCB1-4-like_EFh UniProtKB/Swiss-Prot
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot
NCBI Gene 29322 ENTREZGENE
PANTHER 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 UniProtKB/Swiss-Prot
  PTHR10336 UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
  PH_14 UniProtKB/Swiss-Prot
  PI-PLC-X UniProtKB/Swiss-Prot
  PI-PLC-Y UniProtKB/Swiss-Prot
  PLC-beta_C UniProtKB/Swiss-Prot
  PLCB1-4-like_EFh UniProtKB/Swiss-Prot
PhenoGen Plcb3 PhenoGen
PIRSF PLC-beta UniProtKB/Swiss-Prot
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot
PROSITE PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021150 RatGTEx
SMART PLCXc UniProtKB/Swiss-Prot
  PLCYc UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP C-terminal domain of PLC-beta UniProtKB/Swiss-Prot
  PH domain-like UniProtKB/Swiss-Prot
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
TIGR TC207503
UniProt A0A8I5ZLC4_RAT UniProtKB/TrEMBL
  F7FBZ0 ENTREZGENE, UniProtKB/TrEMBL
  PLCB3_RAT UniProtKB/Swiss-Prot
  Q45QJ4 ENTREZGENE, UniProtKB/TrEMBL
  Q62887 ENTREZGENE
  Q99JE6 ENTREZGENE
  Q9QW29 ENTREZGENE
UniProt Secondary Q62887 UniProtKB/Swiss-Prot
  Q9QW29 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Plcb3  phospholipase C, beta 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference