Spon1 (spondin 1) - Rat Genome Database

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Gene: Spon1 (spondin 1) Rattus norvegicus
Analyze
Symbol: Spon1
Name: spondin 1
RGD ID: 619918
Description: Predicted to enable LBD domain binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human SPON1 (spondin 1); INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: f-spondin; MGC124557; spondin 1, (f-spondin) extracellular matrix protein; spondin 1, extracellular matrix protein; spondin-1; Sponf
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR.WKY-(D1Got158-D1Got161)/Njs   SHR.WKY-(D1Rat420-D1Got161)/Njs  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81177,363,526 - 177,662,689 (+)NCBIGRCr8
mRatBN7.21167,929,049 - 168,228,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,928,972 - 168,228,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,262,539 - 176,557,274 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,448,709 - 183,743,347 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01176,140,201 - 176,457,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,568,777 - 178,935,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,636,544 - 178,935,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,603,907 - 185,902,809 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,700,495 - 172,020,808 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11171,822,347 - 172,156,904 (+)NCBI
Celera1165,787,488 - 166,081,019 (+)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cytarabine  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichlorine  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
para-Nitrosodiphenylamine  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentane-2,3-dione  (EXP)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. Feinstein Y, etal., Development 1999 Aug;126(16):3637-48.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension. Klar A, etal., Cell 1992 Apr 3;69(1):95-110.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14983046   PMID:16227578   PMID:17332427   PMID:20551380  


Genomics

Comparative Map Data
Spon1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81177,363,526 - 177,662,689 (+)NCBIGRCr8
mRatBN7.21167,929,049 - 168,228,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,928,972 - 168,228,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,262,539 - 176,557,274 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,448,709 - 183,743,347 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01176,140,201 - 176,457,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,568,777 - 178,935,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,636,544 - 178,935,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,603,907 - 185,902,809 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,700,495 - 172,020,808 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11171,822,347 - 172,156,904 (+)NCBI
Celera1165,787,488 - 166,081,019 (+)NCBICelera
Cytogenetic Map1q33NCBI
SPON1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,962,723 - 14,268,133 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1113,962,723 - 14,268,133 (+)EnsemblGRCh38hg38GRCh38
GRCh371113,984,270 - 14,289,679 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,940,490 - 14,246,232 (+)NCBINCBI36Build 36hg18NCBI36
Build 341113,940,813 - 14,245,926NCBI
Celera1114,109,479 - 14,415,061 (+)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1113,663,545 - 13,968,610 (+)NCBIHuRef
CHM1_11113,982,658 - 14,288,349 (+)NCBICHM1_1
T2T-CHM13v2.01114,055,316 - 14,360,665 (+)NCBIT2T-CHM13v2.0
Spon1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397113,365,235 - 113,642,610 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7113,365,235 - 113,642,605 (+)EnsemblGRCm39 Ensembl
GRCm387113,765,998 - 114,043,375 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7113,765,998 - 114,043,370 (+)EnsemblGRCm38mm10GRCm38
MGSCv377120,909,512 - 121,186,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367113,557,321 - 113,832,556 (+)NCBIMGSCv36mm8
Celera7113,730,493 - 114,006,042 (+)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.25NCBI
Spon1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541429,179,928 - 29,475,547 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541429,180,246 - 29,475,547 (+)NCBIChiLan1.0ChiLan1.0
SPON1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2916,341,477 - 16,646,637 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,303,819 - 16,608,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,063,166 - 14,368,180 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,776,668 - 14,060,161 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1113,776,671 - 14,057,741 (+)Ensemblpanpan1.1panPan2
SPON1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12136,778,435 - 37,030,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2136,778,458 - 37,028,636 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2136,282,149 - 36,533,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02137,668,471 - 37,919,641 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2137,668,441 - 37,919,636 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12136,920,031 - 37,170,925 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02137,104,890 - 37,356,135 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02137,385,337 - 37,636,773 (+)NCBIUU_Cfam_GSD_1.0
Spon1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494748,402,233 - 48,667,809 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365284,436,688 - 4,702,431 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365284,436,217 - 4,701,835 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPON1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl244,967,986 - 45,299,677 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1244,967,982 - 45,299,677 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2248,089,227 - 48,219,499 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPON1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1150,616,983 - 50,907,120 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl150,616,007 - 50,906,622 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038148,167,732 - 148,470,955 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spon1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247665,890,255 - 6,172,174 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247665,890,266 - 6,173,154 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spon1
1856 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:382
Count of miRNA genes:216
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000042088
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Rat279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,936,424 - 167,936,647 (+)MAPPERmRatBN7.2
Rnor_6.01178,643,992 - 178,644,214NCBIRnor6.0
Rnor_5.01185,611,278 - 185,611,500UniSTSRnor5.0
RGSC_v3.41171,709,211 - 171,709,434RGDRGSC3.4
RGSC_v3.41171,709,212 - 171,709,434UniSTSRGSC3.4
RGSC_v3.11171,831,046 - 171,831,425RGD
Celera1165,794,912 - 165,795,134UniSTS
RH 2.0 Map1859.3RGD
SHRSP x BN Map185.72RGD
Cytogenetic Map1q34UniSTS
D1Rat431  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,009,655 - 168,009,850 (+)MAPPERmRatBN7.2
Rnor_6.01178,716,496 - 178,716,690NCBIRnor6.0
Rnor_5.01185,683,782 - 185,683,976UniSTSRnor5.0
RGSC_v3.41171,802,418 - 171,802,613RGDRGSC3.4
RGSC_v3.41171,802,419 - 171,802,613UniSTSRGSC3.4
RGSC_v3.11171,923,999 - 171,924,194RGD
Celera1165,868,347 - 165,868,541UniSTS
SHRSP x BN Map183.5599RGD
SHRSP x BN Map183.5599UniSTS
Cytogenetic Map1q34UniSTS
RH137699  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,149,138 - 168,149,289 (+)MAPPERmRatBN7.2
Rnor_6.01178,855,970 - 178,856,120NCBIRnor6.0
Rnor_5.01185,823,443 - 185,823,593UniSTSRnor5.0
RGSC_v3.41171,941,897 - 171,942,047UniSTSRGSC3.4
Celera1166,007,885 - 166,008,035UniSTS
RH 3.4 Map11317.1UniSTS
Cytogenetic Map1q34UniSTS


Related Rat Strains
The following Strains have been annotated to Spon1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 1 1 66 31 27 11
Low 3 21 40 25 18 25 8 11 8 4 14 8
Below cutoff 16 16 16

Sequence


RefSeq Acc Id: ENSRNOT00000087612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1178,636,693 - 178,807,906 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092099   ⟹   ENSRNOP00000074092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,928,972 - 168,228,226 (+)Ensembl
Rnor_6.0 Ensembl1178,636,544 - 178,935,051 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101199   ⟹   ENSRNOP00000080429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,928,972 - 168,228,226 (+)Ensembl
RefSeq Acc Id: NM_172067   ⟹   NP_742064
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81177,363,526 - 177,662,689 (+)NCBI
mRatBN7.21167,929,049 - 168,228,239 (+)NCBI
Rnor_6.01178,636,621 - 178,935,061 (+)NCBI
Rnor_5.01185,603,907 - 185,902,809 (+)NCBI
RGSC_v3.41171,700,495 - 172,020,808 (+)RGD
Celera1165,787,488 - 166,081,019 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_742064 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41174 (Get FASTA)   NCBI Sequence Viewer  
  AAI07656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074092
  ENSRNOP00000074092.1
  ENSRNOP00000080429.1
GenBank Protein P35446 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_742064   ⟸   NM_172067
- Peptide Label: precursor
- UniProtKB: P35446 (UniProtKB/Swiss-Prot),   F1LND6 (UniProtKB/TrEMBL),   A0A0G2K775 (UniProtKB/TrEMBL),   Q3B7D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074092   ⟸   ENSRNOT00000092099
RefSeq Acc Id: ENSRNOP00000080429   ⟸   ENSRNOT00000101199
Protein Domains
Reelin   Spondin   TSP type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35446-F1-model_v2 AlphaFold P35446 1-807 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690337
Promoter ID:EPDNEW_R851
Type:initiation region
Name:Spon1_1
Description:spondin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01178,636,683 - 178,636,743EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619918 AgrOrtholog
BioCyc Gene G2FUF-57746 BioCyc
Ensembl Genes ENSRNOG00000058003 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000092099 ENTREZGENE
  ENSRNOT00000092099.2 UniProtKB/TrEMBL
  ENSRNOT00000101199.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.2130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.4060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7935103 IMAGE-MGC_LOAD
InterPro Reeler_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reeler_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spondin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spondin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_spondin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124557 IMAGE-MGC_LOAD
NCBI Gene 64456 ENTREZGENE
PANTHER SPONDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPONDIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Reeler UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spond_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_spondin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spon1 PhenoGen
PROSITE REELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPONDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058003 RatGTEx
SMART TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K775 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G6L0_RAT UniProtKB/TrEMBL
  F1LND6 ENTREZGENE
  P35446 ENTREZGENE
  Q3B7D6 ENTREZGENE, UniProtKB/TrEMBL
  SPON1_RAT UniProtKB/Swiss-Prot
UniProt Secondary F1LND6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Spon1  spondin 1  Spon1  spondin 1, extracellular matrix protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Spon1  spondin 1, extracellular matrix protein  Spon1  spondin 1, (f-spondin) extracellular matrix protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Spon1  spondin 1, (f-spondin) extracellular matrix protein  Spon1  spondin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Spon1  spondin 1  Sponf  f-spondin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Sponf  f-spondin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression displays high level of expression in cells of the neuronal floor plate 634111