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Gene: Polr2m (RNA polymerase II subunit M) Rattus norvegicus

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Symbol:

Polr2m

Name:

RNA polymerase II subunit M

RGD ID:

619847

Description:

Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in maintenance of ER location. Predicted to be located in neuronal cell body and nuclear envelope. Predicted to be part of RNA polymerase II, core complex and transcription preinitiation complex. Predicted to be active in I band. Orthologous to human POLR2M (RNA polymerase II subunit M); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; Glurr; glutamate receptor, ionotropic; glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A; glutamate receptor-like protein 1A; Grinl1a; polymerase (RNA) II (DNA directed) polypeptide M; polymerase (RNA) II subunit M

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	81,012,770 - 81,020,201 (-)	NCBI		GRCr8
mRatBN7.2	8	72,131,992 - 72,139,423 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	72,131,530 - 72,243,036 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	77,667,823 - 77,675,017 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	75,940,776 - 75,947,970 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	73,777,837 - 73,785,031 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	77,985,190 - 77,992,621 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	77,985,190 - 78,096,390 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	75,083,485 - 75,089,089 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	75,947,162 - 75,954,593 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	75,966,215 - 75,973,647 (-)	NCBI
Celera	8	69,596,104 - 69,603,298 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

ammonium chloride (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cisplatin (EXP)

clothianidin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

disulfiram (ISO)

diuron (EXP)

doxorubicin (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

ethanol (EXP,ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

isotretinoin (ISO)

leflunomide (EXP)

methotrexate (ISO)

nitrates (ISO)

okadaic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

progesterone (EXP)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

maintenance of ER location (IBA,ISO)

transcription elongation by RNA polymerase II (IEA)

Cellular Component

DNA-directed RNA polymerase complex (IEA)

I band (IBA)

neuronal cell body (ISO)

nuclear envelope (ISO)

nucleus (IEA)

RNA polymerase II, core complex (IBA,ISO)

transcription preinitiation complex (ISO,ISS)

Molecular Function

protein binding (ISO)

RNA polymerase II complex binding (ISO)

transcription elongation factor activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Information Derived from GenBank Report	RGD, Sept. 2003
6.	Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1by in situ hybridization.	Roginski RS, etal., Cytogenet Cell Genet 2001;93(1-2):143-4.
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14602821	PMID:15233991	PMID:22231121

Genomics

Comparative Map Data

Polr2m
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	81,012,770 - 81,020,201 (-)	NCBI		GRCr8
mRatBN7.2	8	72,131,992 - 72,139,423 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	72,131,530 - 72,243,036 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	77,667,823 - 77,675,017 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	75,940,776 - 75,947,970 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	73,777,837 - 73,785,031 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	77,985,190 - 77,992,621 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	77,985,190 - 78,096,390 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	75,083,485 - 75,089,089 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	75,947,162 - 75,954,593 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	75,966,215 - 75,973,647 (-)	NCBI
Celera	8	69,596,104 - 69,603,298 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

POLR2M
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	57,706,714 - 57,717,557 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	57,706,695 - 57,782,762 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	57,998,912 - 58,009,755 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	55,786,193 - 55,797,045 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	55,786,206 - 55,797,044	NCBI
Celera	15	34,888,598 - 34,899,440 (+)	NCBI		Celera
Cytogenetic Map	15	q21.3	NCBI
HuRef	15	34,821,915 - 34,832,716 (+)	NCBI		HuRef
CHM1_1	15	58,116,357 - 58,127,725 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	55,509,157 - 55,519,990 (+)	NCBI		T2T-CHM13v2.0

Polr2m
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	71,385,719 - 71,393,265 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	71,385,719 - 71,393,217 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	71,478,437 - 71,485,983 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	71,478,437 - 71,485,935 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	71,326,244 - 71,333,790 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	71,277,004 - 71,284,476 (-)	NCBI		MGSCv36	mm8
Celera	9	68,665,682 - 68,673,226 (-)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	39.85	NCBI

Polr2m
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	16,635,458 - 16,641,974 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	16,633,975 - 16,642,085 (-)	NCBI	ChiLan1.0	ChiLan1.0

POLR2M
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	46,968,850 - 46,979,760 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	51,151,599 - 51,162,463 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	36,674,521 - 36,685,343 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	54,986,213 - 54,997,202 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	54,873,644 - 54,997,202 (+)	Ensembl	panpan1.1		panPan2

POLR2M
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	22,865,988 - 22,875,988 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	22,838,128 - 22,848,524 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	23,025,104 - 23,035,502 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	30	22,957,173 - 22,967,531 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	23,042,445 - 23,052,849 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	23,183,821 - 23,194,221 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101961977
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	111,162,138 - 111,163,310 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936949	198,444 - 199,829 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLR2M
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	114,256,460 - 114,266,875 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	114,256,457 - 114,266,862 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	126,383,491 - 126,393,872 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLR2M
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	25,792,584 - 25,802,580 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	25,791,219 - 25,802,383 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	115,511,258 - 115,521,899 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Polr2m
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624781	14,055,412 - 14,065,167 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Polr2m
20 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	97
Count of miRNA genes:	88
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000071264
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30856404	75856404	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	31737729	76737729	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	35582032	80582032	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	50095249	82460899	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	28242912	73242912	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	30848154	82460899	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	40713066	82925667	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	41866876	75097878	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	35551938	80551938	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	54237644	85365202	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	50095249	82460899	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	54237644	85365202	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	30848154	82460899	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	54259986	100382532	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	30848154	82460899	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	50095249	82460899	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	54043744	98968765	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	49805831	94805831	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	30848154	82460899	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	54237644	99103503	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
6	6	31	34	30	18	6	18	6	58	24	19	10	19	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_183402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC132740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF326772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY724533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077999 ⟹ ENSRNOP00000075263

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	72,155,822 - 72,243,036 (-)	Ensembl
Rnor_6.0 Ensembl	8	78,009,015 - 78,096,390 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085843 ⟹ ENSRNOP00000072186

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	72,131,530 - 72,139,498 (-)	Ensembl
Rnor_6.0 Ensembl	8	77,985,190 - 77,992,621 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086185 ⟹ ENSRNOP00000068576

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	72,132,896 - 72,243,035 (-)	Ensembl
Rnor_6.0 Ensembl	8	77,986,094 - 78,096,302 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094960 ⟹ ENSRNOP00000096561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	72,155,822 - 72,243,036 (-)	Ensembl

RefSeq Acc Id:

NM_183402 ⟹ NP_899652

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	81,012,770 - 81,020,201 (-)	NCBI
mRatBN7.2	8	72,131,992 - 72,139,423 (-)	NCBI
Rnor_6.0	8	77,985,190 - 77,992,621 (-)	NCBI
Rnor_5.0	8	75,083,485 - 75,089,089 (+)	NCBI
RGSC_v3.4	8	75,947,162 - 75,954,593 (-)	RGD
Celera	8	69,596,104 - 69,603,298 (+)	RGD

Sequence:

show sequence

GGGAACCCTGCCCGCCGCACCAGCCGCAGCCCGTGCGCAATGTGCTCGCTGCCCCGCGGCTTCG
AGCCCCCAGCTCCCGAGGACTTGGGGCGGCAGAGTTCGGCGGAGCTGCGGGAGAGGTTGAGGCG
CCAGGAGAGACTTTTGCGCAACGAAAAATTCATTTGCAAATTGCCCGACAAAGGTAAAAAGATC
TCAGACACCATTGCCAAACTGAAAGCTGCCATTTCAGAACGTGAAGAGGTCAGAGGGAGAACTG
AACTATTTCATCCTGTTAGTGTAGACTGTAAGCTAAGGCATAAAGCAACCACAAGAGTTGATAC
CGACATAGACAAGGCCCAGAATTCTGACCTGATGCTTGATACTTCATCATTAGTTCCTGAATGT
TCCTCAGTAGACATTGAATCATCTAAAACAACCTCAGAAACACAGGGACCTACACATCTCACTC
ACAAAGGCAATGAAGAGACTTTGGCGACTGGCTGCACAGTGAATACCTGCCCGTCTGCCCGCAT
CACAACCCAGGATCCCTCATCTGAAGTTAATGAACATCTCCCCCAGCATTCAAGTCAAGTGGAA
GAGATTTCCAGCAGCGTCGACAGTCTGTTTATCACTAAATTGCAAAAGATCACAATTGCAGACC
AGACTGAACCCTCAGAAGAAAACACCAGCACTGAGAACTTTCCAGGACTGCAGAGTGAGACTCC
TAAGAAGCCTCATTACATGAAAGTGCTAGAAATGCGAGCTAAAAACCCAGTGCCCCCTCCTCAT
AAGTTTAAGACCAATGTGTTACCCACACAACAGAGTGACTCATCAAGTCATTGTCACAAGGGTC
AGTCTCCTGCTTCCTCAGAAGAGCATCGACGCAGGGCTAGGCAGCATCTTGATGATGTTACAGC
AGCACGCCTTCTTCCGCTCCACCACCTGCCTGCACAGCTGCTCTCCATAGAAGAGTCGCTGGCT
CTGCAGAAAGAGCAGAAGCAGAATTATGAGGAGATGCAGGCGAAGCTCGCAGCACAGAAACTAG
CCGAGAGACTGAATATTAAAATGCAGAGCTTCAATCCAGAAGGGGAGTCTTCAGGGAGATACCG
AGAAGTGAGGGATGAAGATGATGCCCAGTCCTCGGACGAATGCTGAAGATGAGCGCTGGGAGAT
CCCGGGAGTTGACTGTTGAGCTTACATTGTCTCATTGAACTTCCTAACAAGTATCAAGACAGTG
TCAGACCTTGTTGAGGGACAGCAGTTTTTTAAGTTATACAAAGGTAGCTACAAATATGAACCCA
GTTTGTCTTTCAGAAGATGATCTTCACATGCTTGAACAGTTTAATATTTGAACATTGTGTTTGG
CCGTGTTGTGTTACAGTTTTGCAGTATATTGTGCATTGGTCTGATATTTTAGTGTGAGTAGAGC
ACACGTTTTCTTTAAGATATCTGCTTTTTCCTTCTTCGTATTCTTATCAGATAGCATTGCTTAC
ACCCCTTCTGGTGAAATACTTTGTTATCCCAGGCACCTAAAGTGAATTAGGAAGGCCTGGTCCC
CTCACTCGAGAAATGAGGGGAGCAGTCTAAAGAATGGTACGCATGCTTGCATGGACACGTTCCT
GAGACGCTGGATGTGAAATGCCGCACACGACACTCAGAAACCACAACCAGTGTGTCTGCTGCTC
TGTCCTCTCTTGGGGCGACTGCTGTCTTCCTGTGATGAGGTTAAGGAGCCCTTGGAAGAAGTGC
TGGGTGGGGAGGGTCTTCTGAGCCGGTGTGGGGAGCTGCTCCTGGCTGCCCTAGGCTGAACTCA
TTGCCATCTTGGATGATAGGTCCCTGTACAGGACACTCGTGCTTGGTAAGGAAACCGGTGTTTT
TCTAAGAGTTACAGTTGAATTATCAGTATATTGCTTTTTTCCTTGTTAAACCCACAGAGATGTT
TATAGGCGCAGAAATTCCCCTCATGTCATGTATGTACACATTTGTGTTGTTTAAAATGATTATA
TGATCGTTTTCAGCAACAGATAACAATGTTATCAAAAAAGCCTTTGTCTATTATGTGGAACTTG
TAAAGGAGAAATAAAATACCAATCAGAGCAACTCCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_899652	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79379	(Get FASTA)	NCBI Sequence Viewer
	AAK92283	(Get FASTA)	NCBI Sequence Viewer
	EDL84162	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072186
	ENSRNOP00000072186.1
GenBank Protein	Q91XQ4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_899652 ⟸ NM_183402

- UniProtKB:

Q91XQ4 (UniProtKB/Swiss-Prot), A6KER1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MCSLPRGFEPPAPEDLGRQSSAELRERLRRQERLLRNEKFICKLPDKGKKISDTIAKLKAAISE
REEVRGRTELFHPVSVDCKLRHKATTRVDTDIDKAQNSDLMLDTSSLVPECSSVDIESSKTTSE
TQGPTHLTHKGNEETLATGCTVNTCPSARITTQDPSSEVNEHLPQHSSQVEEISSSVDSLFITK
LQKITIADQTEPSEENTSTENFPGLQSETPKKPHYMKVLEMRAKNPVPPPHKFKTNVLPTQQSD
SSSHCHKGQSPASSEEHRRRARQHLDDVTAARLLPLHHLPAQLLSIEESLALQKEQKQNYEEMQ
AKLAAQKLAERLNIKMQSFNPEGESSGRYREVRDEDDAQSSDEC

hide sequence

Ensembl Acc Id:

ENSRNOP00000075263 ⟸ ENSRNOT00000077999

Ensembl Acc Id:

ENSRNOP00000072186 ⟸ ENSRNOT00000085843

Ensembl Acc Id:

ENSRNOP00000068576 ⟸ ENSRNOT00000086185

Ensembl Acc Id:

ENSRNOP00000096561 ⟸ ENSRNOT00000094960

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q91XQ4-F1-model_v2	AlphaFold	Q91XQ4	1-364	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619847	AgrOrtholog
BioCyc Gene	G2FUF-29901	BioCyc
Ensembl Genes	ENSRNOG00000057676	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000085843	ENTREZGENE
	ENSRNOT00000085843.2	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7110855	IMAGE-MGC_LOAD
InterPro	GRINL1	UniProtKB/Swiss-Prot
	Tuftelin_GRINL1A/MYZAP/CCD68	UniProtKB/Swiss-Prot
KEGG Report	rno:192147	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94885	IMAGE-MGC_LOAD
NCBI Gene	192147	ENTREZGENE
PANTHER	DNA-DIRECTED RNA POLYMERASE II SUBUNIT GRINL1A	UniProtKB/Swiss-Prot
	GDOWN1	UniProtKB/Swiss-Prot
Pfam	GCOM2	UniProtKB/Swiss-Prot
PhenoGen	Polr2m	PhenoGen
PRINTS	POLR2GRINL1	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000057676	RatGTEx
UniProt	A6KER1	ENTREZGENE, UniProtKB/TrEMBL
	GRL1A_RAT	UniProtKB/Swiss-Prot
	H8Y6S5_RAT	UniProtKB/TrEMBL
	Q91XQ4	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-21	Polr2m	RNA polymerase II subunit M	Polr2m	polymerase (RNA) II subunit M	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-08	Polr2m	polymerase (RNA) II subunit M	Polr2m	polymerase (RNA) II (DNA directed) polypeptide M	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-12-06	Polr2m	polymerase (RNA) II (DNA directed) polypeptide M	Grinl1a	glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Grinl1a	glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A		glutamate receptor, ionotropic	Name updated	1299863	APPROVED
2002-08-07	Grinl1a	glutamate receptor, ionotropic			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar