Fas (Fas cell surface death receptor) - Rat Genome Database

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Gene: Fas (Fas cell surface death receptor) Rattus norvegicus
Symbol: Fas
Name: Fas cell surface death receptor
RGD ID: 619831
Description: Enables protease binding activity and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to cobalt ion; cellular response to cytokine stimulus; and nervous system development. Located in several cellular components, including apical dendrite; external side of plasma membrane; and sarcolemma. Part of CD95 death-inducing signaling complex. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; intrinsic apoptotic pathway; INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apo-1 antigen; apoptosis-mediating surface antigen FAS; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas antigen (ATP1); Fas receptor; FASLG receptor; FasR; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; Tumor necrosis factor receptor superfamily, member 6
RGD Orthologs
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81241,212,155 - 241,245,774 (+)NCBIGRCr8
mRatBN7.21231,798,963 - 231,832,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,798,960 - 231,832,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,190,049 - 240,223,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,111,767 - 247,145,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,949,944 - 239,983,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,589,785 - 252,624,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,589,785 - 252,624,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,812,248 - 259,846,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,259,443 - 238,274,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,423,465 - 238,438,767 (+)NCBI
Celera1228,912,823 - 228,946,152 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (IEP)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
alcoholic hepatitis  (IEP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
asthma  (IEP)
atherosclerosis  (IEP,ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (ISO,ISS)
Autoimmune Lymphoproliferative Syndrome, Type IA  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
brain glioma  (IDA)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP,ISO)
brain ischemia  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
Chest Trauma  (IEP)
chorioamnionitis  (ISO)
chronic conjunctivitis  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (IEP)
Chronic Uveitis  (ISO)
clonorchiasis  (IEP)
Colonic Neoplasms  (IEP)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
cryptorchidism  (IEP)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Disease Progression  (ISO)
endophthalmitis  (IEP)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (IEP)
Familial Thoracic Aortic Aneurysm 6  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (IEP)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (IEP,ISO)
hematopoietic system disease  (ISO)
hepatitis B  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
heroin dependence  (IEP)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperoxia  (IEP,ISO)
hypersplenism  (ISO)
Hypothermia  (IEP)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (IDA)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (IEP)
intrahepatic cholangiocarcinoma  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (IEP)
limited scleroderma  (ISO)
liver disease  (IEP)
Liver Injury  (ISO)
Liver Reperfusion Injury  (IEP,IMP)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Lymphomatoid Papulosis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
male infertility  (IEP)
melanoma  (ISO)
Metabolic Brain Diseases  (IEP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP)
mixed connective tissue disease  (ISO)
Moyamoya disease  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Multisystemic Smooth Muscle Dysfunction Syndrome  (ISO)
myasthenia gravis  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (IDA)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
ocular hypertension  (IEP)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Parkinson's disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (IDA)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA)
retinal detachment  (IEP,IMP)
retinoblastoma  (ISO)
rheumatoid arthritis  (ISO)
sciatic neuropathy  (IEP)
seminoma  (ISO)
Sepsis  (IEP)
Sjogren's syndrome  (ISO,ISS)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (IDA,IEP)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO,ISS)
Taste Disorders  (ISO)
Temporomandibular Joint Osteoarthritis  (IEP)
Testicular Injury  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (IDA,IEP,ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (IEP)
urinary bladder cancer  (ISO)
varicocele  (IEP)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
visual epilepsy  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropropane  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-bromohexadecanoic acid  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-nitrotoluene  (EXP)
25-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-tert-butylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
Actein  (EXP)
adefovir pivoxil  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
Aloe emodin  (ISO)
Aloperine  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpinumisoflavone  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP)
arachidonic acid  (ISO)
arecoline  (EXP)
arjunolic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
Aurothioglucose  (ISO)
benazepril  (EXP)
bentonite  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
Beta-Solamarine  (ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromochloroacetic acid  (EXP)
bucladesine  (EXP)
bufalin  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
Cacalol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carnosic acid  (ISO)
carvedilol  (ISO)
casticin  (ISO)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cetrorelix  (EXP,ISO)
CGP 52608  (ISO)
charcoal  (EXP)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
cidofovir anhydrous  (ISO)
Cinobufotalin  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofazimine  (EXP)
clofibrate  (ISO)
clorgyline  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copanlisib  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
cytarabine  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzofurans  (ISO)
dibromoacetic acid  (ISO)
dichlorine  (EXP)
dichlorvos  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroartemisinin  (EXP)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
Echimidine  (ISO)
elemental selenium  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
ferrosoferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fotemustine  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
Fulvic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gibberellin A3  (EXP)
Gingerenone A  (ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
glucose  (ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (EXP)
GSK690693  (ISO)
guggulsterone  (EXP)
GW 4064  (EXP)
Heliotrine  (EXP,ISO)
heparin  (ISO)
heroin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxyurea  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
ICI D1694  (ISO)
idelalisib  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP,ISO)
isosilybin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene D4  (ISO)
Licochalcone A  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lovastatin  (EXP,ISO)
luteolin  (EXP)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (ISO)
magnesium oxide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
masoprocol  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (EXP)
mifepristone  (ISO)
miquelianin  (EXP)
mitogen  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (ISO)
Morroniside  (ISO)
myriocin  (ISO)
Myrtucommulone A  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naproxen  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitrobenzene  (ISO)
nitroglycerin  (ISO)
Nodularin  (ISO)
notoginsenoside R1  (ISO)
Nutlin-3  (ISO)
nystatin  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
octreotide  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP,ISO)
olmesartan  (ISO)
orlistat  (ISO)
osthole  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
pemetrexed  (ISO)
Pendulone  (ISO)
Pentoxifylline  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
perifosine  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phoxim  (ISO)
picoxystrobin  (ISO)
pifithrin-?  (EXP,ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
procyanidin B3  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propofol  (ISO)
propranolol  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
reactive oxygen species  (ISO)
regorafenib  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
risperidone  (ISO)
Roridin A  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sucrose  (EXP)
Suillin  (ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrazolium violet  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiazoles  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiosalicylic acid  (EXP)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (EXP,ISO)
tolclofos-methyl  (ISO)
toluene  (EXP)
Tomentosin  (ISO)
topotecan  (ISO)
transplatin  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanillic acid  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vinorelbine  (ISO)
vismodegib  (ISO)
vorinostat  (ISO)
withaferin A  (EXP)
wortmannin  (ISO)
Y-27632  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (IBA,IEA,ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (IMP,ISO)
B cell mediated immunity  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to cobalt ion  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to estrogen stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hydrostatic pressure  (IEP)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to phenylalanine  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEP)
chordate embryonic development  (IEP)
circadian rhythm  (ISO)
dendrite regeneration  (IMP)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
Fas signaling pathway  (ISO)
gene expression  (ISO)
hepatocyte apoptotic process  (ISO)
immune response  (IEA)
inflammatory cell apoptotic process  (ISO)
liver regeneration  (IEP)
lymphocyte apoptotic process  (ISO)
maternal process involved in female pregnancy  (IEP)
motor neuron apoptotic process  (IBA,IEA,ISO)
necroptotic signaling pathway  (IBA,IEA,ISO)
negative regulation of apoptotic process  (IBA,IEA,ISO)
negative regulation of B cell activation  (ISO)
negative regulation of Schwann cell migration  (IMP)
negative regulation of Schwann cell proliferation  (IMP)
negative thymic T cell selection  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle atresia  (IEP)
ovulation cycle  (IEP)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
regulation of apoptotic process  (IMP)
regulation of B cell differentiation  (ISO)
regulation of cell population proliferation  (IMP)
regulation of hematopoietic progenitor cell differentiation  (ISO)
regulation of lipid storage  (IEP)
regulation of myeloid cell differentiation  (ISO)
regulation of stress-activated MAPK cascade  (IBA,IEA,ISO)
regulation of T cell differentiation  (ISO)
response to cycloheximide  (IEP)
response to cytokine  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to fluoride  (IEP)
response to glucocorticoid  (ISO)
response to growth factor  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (IEP)
response to ischemia  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to toxic substance  (IEP,ISO)
response to xenobiotic stimulus  (IEP)
spermatogenesis  (IEP)
spleen development  (ISO)
T cell homeostasis  (ISO)
telencephalon development  (IEP)
tumor necrosis factor-mediated signaling pathway  (IEA)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury. Ackery A, etal., J Neurotrauma. 2006 May;23(5):604-16.
2. Samsum Ant Venom Exerts Anticancer Activity Through Immunomodulation In Vitro and In Vivo. Al-Tamimi J, etal., Cancer Biother Radiopharm. 2018 Mar;33(2):65-73. doi: 10.1089/cbr.2017.2400.
3. Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): a possible mechanism for lymphopenia. Amasaki Y, etal., Clin Exp Immunol. 1995 Feb;99(2):245-50.
4. Fas antigen (CD95) expression in peripheral blood progenitor cells from patients with leukaemia and lymphoma. Anthony RS, etal., Leuk Lymphoma. 1998 Aug;30(5-6):449-58.
5. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
6. Expression of Fas and Fas ligand in human testicular germ cell tumours. Baldini E, etal., Int J Androl. 2007 Oct 3;.
7. Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis. Balkundi DR, etal., Biol Reprod. 2003 Aug;69(2):718-24. Epub 2003 Apr 16.
8. Apoptosis of tubular epithelial cells in glycogen nephrosis during diabetes. Bamri-Ezzine S, etal., Lab Invest. 2003 Jul;83(7):1069-80.
9. CD95 (FAS/APO-1) antigen is a new prognostic marker of blast cells of acute lymphoblastic leukaemia patients. Baryshnikov AYu, etal., Adv Exp Med Biol. 1999;457:251-8.
10. Fas/Fas-ligand expressions in primary breast cancer are significant predictors of its skeletal spread. Bebenek M, etal., Anticancer Res. 2007 Jan-Feb;27(1A):215-8.
11. Increased placental apoptosis in maternal food restricted gestations: role of the Fas pathway. Belkacemi L, etal., Placenta. 2009 Sep;30(9):739-51. doi: 10.1016/j.placenta.2009.06.003. Epub 2009 Jul 18.
12. Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis. Bettinardi A, etal., Blood. 1997 Feb 1;89(3):902-9.
13. Expression of Fas-Fas ligand antigens and apoptotic marker APO2.7 by the human conjunctival epithelium. Positive correlation with class II HLA DR expression in inflammatory ocular surface disorders. Brignole F, etal., Exp Eye Res. 1998 Dec;67(6):687-97.
14. FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury. Casha S, etal., Exp Neurol. 2005 Dec;196(2):390-400. Epub 2005 Oct 3.
15. The Fas system may have a role in male reproduction. Celik-Ozenci C, etal., Fertil Steril. 2006 Apr;85 Suppl 1:1168-78.
16. Tributyltin impacts in metabolic syndrome development through disruption of angiotensin II receptor signaling pathways in white adipose tissue from adult female rats. Ceotto Freitas-Lima L, etal., Toxicol Lett. 2018 Aug 29. pii: S0378-4274(18)31826-5. doi: 10.1016/j.toxlet.2018.08.018.
17. The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins. Cheema ZF, etal., BMC Neurosci. 2004 Mar 23;5:11.
18. Fas/Apo -1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. Cheema ZF, etal., J Neurosci. 1999 Mar 1;19(5):1754-70.
19. Cross-Talk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis: a possible regulatory mechanism for ovarian follicle atresia. Chen Q, etal., Endocrinology 2005 Feb;146(2):808-15. Epub 2004 Nov 4.
20. Expression in transgenic mice of dominant interfering Fas mutations: a model for human autoimmune lymphoproliferative syndrome. Choi Y, etal., Clin Immunol. 1999 Oct;93(1):34-45.
21. Serum sFAS levels are elevated in ANCA-positive vasculitis compared with other autoimmune diseases. Christensson M, etal., J Clin Immunol. 2002 Jul;22(4):220-7.
22. Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells. Chua CC, etal., Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2606-13.
23. Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. Ciribilli Y and Borlak J, Oncotarget. 2017 Oct 23;8(60):101808-101831. doi: 10.18632/oncotarget.21981. eCollection 2017 Nov 24.
24. Significance of Fas and retinoblastoma protein expression during the progression of Barrett's metaplasia to adenocarcinoma. Coppola D, etal., Ann Surg Oncol. 1999 Apr-May;6(3):298-304.
25. Fas/Fas-Ligand pathway is impaired in patients with type 2 diabetes. Influence of hypertension and insulin resistance. Cosson E, etal., Diabetes Metab. 2005 Feb;31(1):47-54.
26. Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease. Cubero FJ, etal., Cell Death Dis. 2019 Feb 8;10(2):115. doi: 10.1038/s41419-019-1391-x.
27. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici C, etal., J Immunol. 2006 Mar 1;176(5):3173-80.
28. Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Dasari VR, etal., Neurochem Res. 2008 Jan;33(1):134-49. Epub 2007 Aug 17.
29. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. Davis AR, etal., J Neurotrauma. 2007 May;24(5):823-34.
30. Fas antigen/CD-95 upregulation and activation during castration-induced regression of the rat ventral prostate gland. de la Taille A, etal., Prostate. 1999 Jul 1;40(2):89-96.
31. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain. Dowling P, etal., J Exp Med. 1996 Oct 1;184(4):1513-8.
32. A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. Dzietko M, etal., Ann Neurol. 2008 Dec;64(6):664-73. doi: 10.1002/ana.21516.
33. Association of promoter polymorphisms of Fas -FasL genes with development of Chronic Myeloid Leukemia. Edathara PM, etal., Tumour Biol. 2015 Nov 13.
34. H(2)O(2) induces upregulation of Fas and Fas ligand expression in NGF-differentiated PC12 cells: modulation by cAMP. Facchinetti F, etal., J Neurosci Res 2002 Jul 15;69(2):178-88.
35. Fas 670 promoter polymorphism is associated to susceptibility, clinical presentation, and survival in adult T cell leukemia. Farre L, etal., J Leukoc Biol. 2008 Jan;83(1):220-2. Epub 2007 Oct 25.
36. Fas and Fas-L expression in Huntington's disease and Parkinson's disease. Ferrer I, etal., Neuropathol Appl Neurobiol. 2000 Oct;26(5):424-33.
37. apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. Feuk L, etal., Hum Genet 2000 Oct;107(4):391-6.
38. Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57Bl/6-lpr/lpr mice. Fleck M, etal., Arthritis Rheum. 1998 Dec;41(12):2175-84.
39. Tumor Fas (APO-1/CD95) up-regulation results in increased apoptosis and survival times for rats with intracranial malignant gliomas. Frankel B, etal., Neurosurgery. 2001 Jul;49(1):168-75; discussion 175-6.
40. Serum soluble Fas/APO-1 is increased in patients with primary Sjogren's syndrome. Fujihara T, etal., Clin Rheumatol. 1998;17(6):496-9.
41. Upregulation of Fas/Fas ligand in inclusion body myositis. Fyhr IM and Oldfors A, Ann Neurol. 1998 Jan;43(1):127-30.
42. Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis. Gallagher SF, etal., J Gastrointest Surg. 2005 Apr;9(4):467-74; discussion 474-5. doi: 10.1016/j.gassur.2004.12.008.
43. The protective role of hydrogen sulfide in myocardial ischemia-reperfusion-induced injury in diabetic rats. Gao Y, etal., Int J Cardiol. 2011 Oct 20;152(2):177-83. doi: 10.1016/j.ijcard.2010.07.012. Epub 2011 Feb 12.
44. Modulation of Fas receptor proteins and dynamin during opiate addiction and induction of opiate withdrawal in rat brain. Garcia-Fuster MJ, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):421-31. Epub 2003 Oct 3.
45. Blood-soluble Fas levels are increased in type 2 diabetic patients with peripheral vascular disease. Garcia-Unzueta MT, etal., Horm Metab Res. 2006 Oct;38(10):673-7.
46. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
47. Dysregulation of the Fas/FasL system in an experimental animal model of HELLP syndrome. Gibbens J, etal., Pregnancy Hypertens. 2017 Apr;8:26-30. doi: 10.1016/j.preghy.2017.02.004. Epub 2017 Feb 24.
48. Neutrophil gelatinase-associated lipocalin protects renal tubular epithelial cell in ischemic/reperfusion injury rats via apoptosis-regulating proteins. Gong L, etal., Ren Fail. 2012;34(6):777-83. doi: 10.3109/0886022X.2012.678173. Epub 2012 Apr 16.
49. miR-411 suppresses acute spinal cord injury via downregulation of Fas ligand in rats. Gong ZM, etal., Biochem Biophys Res Commun. 2018 Jun 22;501(2):501-506. doi: 10.1016/j.bbrc.2018.05.022. Epub 2018 May 16.
50. Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer. Gratas C, etal., Cancer Res. 1998 May 15;58(10):2057-62.
51. In vivo responses to vaccination with Mage-b, GM-CSF and thioglycollate in a highly metastatic mouse breast tumor model, 4T1. Gravekamp C, etal., Cancer Immunol Immunother. 2007 Dec 20;.
52. Clinical relevance of CD95 (Fas/Apo-1) on T cells of patients with B-cell chronic lymphocytic leukemia. Groneberg C, etal., Exp Hematol. 2003 Aug;31(8):682-5.
53. Fas/APO-1/CD95 system as a mediator of granulosa cell apoptosis in ovarian follicle atresia. Hakuno N, etal., Endocrinology. 1996 May;137(5):1938-48.
54. Levels of soluble Fas/APO-1 in patients with Behcet's disease. Hamzaoui K, etal., Mediators Inflamm. 1998;7(2):111-4.
55. Double role of Fas ligand in the apoptosis of intervertebral disc cells in vitro. Han D, etal., Acta Biochim Biophys Sin (Shanghai). 2009 Nov;41(11):938-47.
56. Insulitis in human type 1 diabetes. Hanafusa T and Imagawa A, Ann N Y Acad Sci. 2008 Dec;1150:297-9.
57. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. Hao Z, etal., J Exp Med. 2004 May 17;199(10):1355-65.
58. Pentoxifylline attenuates cytokine stress and Fas system in syngeneic liver proteins induced experimental autoimmune hepatitis. Hendawy N, Biomed Pharmacother. 2017 Aug;92:316-323. doi: 10.1016/j.biopha.2017.05.084. Epub 2017 May 25.
59. Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration. Hinton DR, etal., Arch Ophthalmol. 1998 Feb;116(2):203-9.
60. Fas/Fas-ligand expressions in peripheral-blood mononuclear cells of patients with myelodysplastic syndromes. Hirano T, etal., Res Commun Mol Pathol Pharmacol. 2003;113-114:315-28.
61. Granulocyte colony-stimulating factor reduces cardiomyocyte apoptosis and improves cardiac function in adriamycin-induced cardiomyopathy in rats. Hou XW, etal., Cardiovasc Drugs Ther. 2006 Apr;20(2):85-91.
62. Tumor necrosis factor alpha and interleukin 1beta up-regulate gastric mucosal Fas antigen expression in Helicobacter pylori infection. Houghton J, etal., Infect Immun. 2000 Mar;68(3):1189-95.
63. The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons. Huang X, etal., PLoS One. 2013 Aug 7;8(8):e71553. doi: 10.1371/journal.pone.0071553. Print 2013.
64. FAS and FAS-L expression by tumor cells and lymphocytes in breast carcinomas and their lymph node metastases. Ioachim HL, etal., Pathol Res Pract. 2005;200(11-12):743-51.
65. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. Itoh N, etal., J Exp Med. 1997 Aug 18;186(4):613-8.
66. The role of Fas-Fas ligand-mediated apoptosis in autoimmune lacrimal gland disease in MRL/MpJ mice. Jabs DA, etal., Invest Ophthalmol Vis Sci. 2001 Feb;42(2):399-401.
67. Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes. Jaita G, etal., Endocrinology. 2005 Nov;146(11):4737-44. Epub 2005 Aug 11.
68. Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice. Jeong JH, etal., J Control Release. 2009 Dec 14.
69. Anti-apoptosis effects of oxymatrine protect the liver from warm ischemia reperfusion injury in rats. Jiang H, etal., World J Surg. 2005 Nov;29(11):1397-401.
70. [Expression and distribution of Fas and Fas-L in the nasal polyps]. Jin H, etal., Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Mar;39(3):143-6.
71. Retinal glial cell responses and Fas/FasL activation in rats with chronic ocular hypertension. Ju KR, etal., Brain Res. 2006 Nov 29;1122(1):209-21. Epub 2006 Oct 11.
72. Involvement of mitochondrial- and Fas-mediated dual mechanism in CoCl2-induced apoptosis of rat PC12 cells. Jung JY and Kim WJ, Neurosci Lett. 2004 Nov 23;371(2-3):85-90.
73. FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer. Kang S, etal., Cancer Genet Cytogenet. 2008 Jan 1;180(1):1-5.
74. Expression of Fas and Fas ligand mRNA in rat and human preimplantation embryos. Kawamura K, etal., Mol Hum Reprod. 2001 May;7(5):431-6.
75. Fas (APO-1/CD95) mRNA is down-regulated in liver regeneration after hepatectomy in rats. Kiba T, etal., J Gastroenterol. 2000;35(1):34-8.
76. Metabolic loading of guanosine induces chondrocyte apoptosis via the Fas pathway. Kim DJ, etal., Exp Mol Med. 2006 Aug 31;38(4):401-7.
77. The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells. Kim KW, etal., Spine (Phila Pa 1976). 2007 Oct 15;32(22):2443-8.
78. Rapid induction of Fas antigen mRNA expression in vivo by cycloheximide. Kimura K and Yamamoto M, Cell Biochem Funct. 1997 Jun;15(2):81-6.
79. A variant mRNA species encoding a truncated form of Fas antigen in the rat liver. Kimura K, etal., Biochem Biophys Res Commun 1994 Jan 28;198(2):666-74.
80. Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia. Kitagawa M, etal., Leukemia. 1998 Apr;12(4):486-92.
81. Expression of functional Fas antigen on adult T-cell leukemia. Kotani T, etal., Leuk Res. 1994 Apr;18(4):305-10.
82. FAS-dependent cell death in alpha-synuclein transgenic oligodendrocyte models of multiple system atrophy. Kragh CL, etal., PLoS One. 2013;8(1):e55243. doi: 10.1371/journal.pone.0055243. Epub 2013 Jan 25.
83. Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury. Kuhla A, etal., Apoptosis. 2015 Apr;20(4):500-11. doi: 10.1007/s10495-015-1088-2.
84. Expression levels of FAS are regulated through an evolutionary conserved element in intron 2, which modulates cystic fibrosis disease severity. Kumar V, etal., Genes Immun. 2008 Dec;9(8):689-96. doi: 10.1038/gene.2008.63. Epub 2008 Aug 7.
85. Fas ligand is enriched in the caveolae membrane domains of thymic epithelial cells. Lalor D, etal., Cell Immunol 2004 Jul;230(1):10-6.
86. Evaluation of the maternal and umbilical vein serum sFas/sFasL system in pregnancies complicated by preeclampsia with intrauterine growth retardation. Laskowska M, etal., Eur J Obstet Gynecol Reprod Biol. 2006 Jun 1;126(2):155-9. Epub 2005 Sep 19.
87. The Fas system is a key regulator of germ cell apoptosis in the testis. Lee J, etal., Endocrinology. 1997 May;138(5):2081-8.
88. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Lee J, etal., Endocrinology. 1999 Feb;140(2):852-8.
89. Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD. Lee S, etal., Bone Marrow Transplant. 1997 Nov;20(10):883-8.
90. Expression of Fas and Fas-related molecules in human hepatocellular carcinoma. Lee SH, etal., Hum Pathol. 2001 Mar;32(3):250-6. doi: 10.1053/hupa.2001.22769.
91. In vivo expression of soluble Fas and FAP-1: possible mechanisms of Fas resistance in human hepatoblastomas. Lee SH, etal., J Pathol. 1999 Jun;188(2):207-12. doi: 10.1002/(SICI)1096-9896(199906)188:2<207::AID-PATH337>3.0.CO;2-8.
92. Associations between the FAS -670 A/G and -1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis. Lee YH, etal., Mol Biol Rep. 2012 Dec;39(12):10671-9. doi: 10.1007/s11033-012-1957-5. Epub 2012 Oct 5.
93. Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis. Li C, etal., Pharmacogenet Genomics. 2006 Apr;16(4):245-51.
94. Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma. Li C, etal., Pharmacogenet Genomics. 2006 Apr;16(4):253-63.
95. Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells. Li H, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G263-75. Epub 2007 Nov 8.
96. Liraglutide attenuates atherosclerosis via inhibiting ER-induced macrophage derived microvesicles production in T2DM rats. Li J, etal., Diabetol Metab Syndr. 2017 Dec 1;9:94. doi: 10.1186/s13098-017-0289-y. eCollection 2017.
97. Alleviation of ischemia-reperfusion injury in rat liver transplantation by induction of small interference RNA targeting Fas. Li X, etal., Langenbecks Arch Surg. 2007 May;392(3):345-51. Epub 2007 Jan 19.
98. Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury. Li Y, etal., Front Mol Neurosci. 2018 Jun 19;11:210. doi: 10.3389/fnmol.2018.00210. eCollection 2018.
99. The role of impaired insulin/IGF action in primary diabetic encephalopathy. Li ZG, etal., Brain Res. 2005 Mar 10;1037(1-2):12-24.
100. Prophylactic efficacy of patchoulene epoxide against ethanol-induced gastric ulcer in rats: Influence on oxidative stress, inflammation and apoptosis. Liang J, etal., Chem Biol Interact. 2018 Mar 1;283:30-37. doi: 10.1016/j.cbi.2018.01.014. Epub 2018 Jan 12.
101. Association between FAS polymorphism and prostate cancer development. Lima L, etal., Prostate Cancer Prostatic Dis. 2008;11(1):94-8. Epub 2007 Jul 31.
102. [Regulation of sishen wan on Bax/Bcl-2 mRNA, Fas/FasL in colonic tissue from rats with colitis]. Liu D, etal., Zhongguo Zhong Yao Za Zhi. 2011 Dec;36(24):3484-8.
103. FasL shedding is reduced by hypothermia in experimental stroke. Liu L, etal., J Neurochem. 2008 Jul;106(2):541-50. Epub 2008 Apr 12.
104. [The relationship between expression of fas mRNA and apoptosis after traumatic brain injury in rats and the role of GM-1 in protecting the brain] Liu QJ, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul;36(4):477-9.
105. Effects of apigenin on the expression levels of B-cell lymphoma-2, Fas and Fas ligand in renal ischemia-reperfusion injury in rats. Liu Y, etal., Exp Ther Med. 2017 Dec;14(6):5345-5354. doi: 10.3892/etm.2017.5241. Epub 2017 Oct 2.
106. Up-regulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat. Lizama C, etal., Apoptosis. 2007 Mar;12(3):499-512. Epub 2006 Dec 29.
107. The death ligand TRAIL in diabetic nephropathy. Lorz C, etal., J Am Soc Nephrol. 2008 May;19(5):904-14. Epub 2008 Feb 20.
108. NFAT-1 hyper-activation by methionine enkephalin (MENK) significantly induces cell apoptosis of rats C6 glioma in vivo and in vitro. Lu WC, etal., Int Immunopharmacol. 2018 Mar;56:1-8. doi: 10.1016/j.intimp.2018.01.005. Epub 2018 Jan 9.
109. A study of promoter and intronic markers of ApoI/Fas gene and the interaction with Fas ligand in relapsing multiple sclerosis. Lucas M, etal., Eur Neurol. 2004;52(1):12-7. Epub 2004 Jun 22.
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148. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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