Grn (granulin precursor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Grn (granulin precursor) Rattus norvegicus
Analyze
Symbol: Grn
Name: granulin precursor
RGD ID: 61983
Description: Predicted to enable protein-folding chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Is active in glutamatergic synapse. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acrogranin; epithelin; granulin; granulins; PEPI; PGRN; proepithelin; progranulin; prostate cancer cell-derived growth factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,887,834 - 87,893,938 (+)NCBIGRCr8
mRatBN7.21087,387,672 - 87,393,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,387,638 - 87,393,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,424,835 - 92,430,942 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,890,037 - 91,896,139 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,283,370 - 87,289,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Celera1086,096,583 - 86,102,687 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) adipate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butyric acid  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
felbamate  (EXP)
fenamidone  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (EXP)
hypochlorous acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
LY294002  (EXP)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
nitroglycerin  (EXP)
Osajin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
Pomiferin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation involved in immune response  (ISO,ISS)
blastocyst hatching  (ISO)
chondrocyte proliferation  (IMP)
embryo implantation  (ISO)
epithelial cell proliferation  (ISO)
locomotory exploration behavior  (ISO)
lysosomal lumen acidification  (ISO,ISS)
lysosomal protein catabolic process  (ISO)
lysosomal transport  (ISO,ISS)
lysosome organization  (ISO,ISS)
maintenance of synapse structure  (ISO)
male mating behavior  (IMP)
microglial cell activation involved in immune response  (ISO,ISS)
negative regulation of hydrolase activity  (ISO)
negative regulation of inflammatory response  (ISO,ISS)
negative regulation of innate immune response  (ISO,ISS)
negative regulation of microglial cell activation  (ISO,ISS)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of neutrophil activation  (ISO,ISS)
negative regulation of respiratory burst involved in inflammatory response  (ISO,ISS)
neural precursor cell proliferation  (IMP)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of aspartic-type peptidase activity  (ISO,ISS)
positive regulation of axon regeneration  (ISO,ISS)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of defense response to bacterium  (ISO,ISS)
positive regulation of dendritic spine development  (IMP)
positive regulation of endothelial cell migration  (ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of inflammatory response to wounding  (ISO,ISS)
positive regulation of lysosome organization  (ISO,ISS)
positive regulation of neuron apoptotic process  (ISO,ISS)
positive regulation of neuron projection development  (IMP)
positive regulation of protein folding  (ISO,ISS)
positive regulation of trophectodermal cell proliferation  (ISO)
protein stabilization  (ISO,ISS)
regulation of inflammatory response  (IBA)
regulation of lysosome organization  (ISO)
response to estradiol  (IDA)
retina development in camera-type eye  (ISO)
signal transduction  (IEA)
synaptic vesicle endocytosis  (IMP)
trophectodermal cell proliferation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Low plasma progranulin levels in children with autism. Al-Ayadhi LY and Mostafa GA, J Neuroinflammation. 2011 Sep 5;8:111.
2. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Baker M, etal., Nature. 2006 Aug 24;442(7105):916-9. Epub 2006 Jul 16.
3. The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor. Bhandari V, etal., Endocrinology 1993 Dec;133(6):2682-9.
4. Progranulin mutations in Dutch familial frontotemporal lobar degeneration. Bronner IF, etal., Eur J Hum Genet. 2007 Mar;15(3):369-74. Epub 2007 Jan 17.
5. Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. Brouwers N, etal., Neurology. 2008 Aug 26;71(9):656-64. Epub 2008 Jun 18.
6. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Chen-Plotkin AS, etal., Acta Neuropathol. 2010 Jan;119(1):111-22. Epub 2009 Aug 2.
7. Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family. Chiang HH, etal., Alzheimers Dement. 2008 Nov;4(6):414-20.
8. Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus. Chiba S, etal., J Reprod Dev. 2007 Apr;53(2):297-307. Epub 2006 Dec 20.
9. Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Cruchaga C, etal., Arch Neurol. 2011 May;68(5):581-6. Epub 2011 Jan 10.
10. Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly. Dickson DW, etal., Neurodegener Dis. 2010;7(1-3):170-4. Epub 2010 Mar 3.
11. The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. Egashira Y, etal., J Neuroinflammation. 2013 Aug 23;10:105. doi: 10.1186/1742-2094-10-105.
12. Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males. Fenoglio C, etal., Genes Immun. 2010 Sep;11(6):497-503. Epub 2010 May 13.
13. Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. Finch N, etal., Brain. 2009 Mar;132(Pt 3):583-91. doi: 10.1093/brain/awn352. Epub 2009 Jan 21.
14. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Galimberti D, etal., Neurol Sci. 2013 Jun;34(6):899-903. doi: 10.1007/s10072-012-1151-5. Epub 2012 Jul 14.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Core features of frontotemporal dementia recapitulated in progranulin knockout mice. Ghoshal N, etal., Neurobiol Dis. 2011 Sep 10.
17. GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease. Jasinska-Myga B, etal., Eur J Neurol. 2009 Aug;16(8):909-11. doi: 10.1111/j.1468-1331.2009.02621.x. Epub 2009 Mar 31.
18. Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin. Kelley BJ, etal., Arch Neurol. 2010 Feb;67(2):171-7.
19. Further evidence for plasma progranulin as a biomarker in bipolar disorder. Kittel-Schneider S, etal., J Affect Disord. 2014 Mar;157:87-91. doi: 10.1016/j.jad.2014.01.006. Epub 2014 Jan 25.
20. Progranulin expression in advanced human atherosclerotic plaque. Kojima Y, etal., Atherosclerosis. 2009 Sep;206(1):102-8. Epub 2009 Feb 23.
21. Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings. Lopez de Munain A, etal., Biol Psychiatry. 2008 May 15;63(10):946-52. Epub 2007 Oct 22.
22. Reduced serum progranulin level might be associated with Parkinson's disease risk. Mateo I, etal., Eur J Neurol. 2013 Dec;20(12):1571-3. doi: 10.1111/ene.12090. Epub 2013 Feb 9.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Mukherjee O, etal., Ann Neurol. 2006 Sep;60(3):314-22.
25. Progranulin expression is upregulated after spinal contusion in mice. Naphade SB, etal., Acta Neuropathol. 2010 Jan;119(1):123-33. Epub 2009 Nov 28.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. Pereson S, etal., J Pathol. 2009 Oct;219(2):173-81.
29. Activity-dependent secretion of progranulin from synapses. Petoukhov E, etal., J Cell Sci. 2013 Dec 1;126(Pt 23):5412-21. doi: 10.1242/jcs.132076. Epub 2013 Sep 17.
30. Microglial upregulation of progranulin as a marker of motor neuron degeneration. Philips T, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1191-200.
31. Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations. Pickering-Brown SM, etal., Brain. 2008 Mar;131(Pt 3):721-31. doi: 10.1093/brain/awm331. Epub 2008 Jan 11.
32. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. Plowman GD, etal., J Biol Chem 1992 Jun 25;267(18):13073-8.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation. Skoglund L, etal., Neurogenetics. 2009 Feb;10(1):27-34. Epub 2008 Oct 15.
38. Progranulin genetic variability contributes to amyotrophic lateral sclerosis. Sleegers K, etal., Neurology. 2008 Jul 22;71(4):253-9. Epub 2008 Jan 9.
39. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
40. Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats. Suzuki M, etal., Physiol Behav. 2000 Mar;68(5):707-13.
41. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Tang W, etal., Science. 2011 Apr 22;332(6028):478-84. Epub 2011 Mar 10.
42. Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses. Tapia L, etal., J Neurosci. 2011 Aug 3;31(31):11126-32.
43. Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis. Vercellino M, etal., Mult Scler. 2011 Oct;17(10):1194-201. Epub 2011 May 25.
44. An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. Viswanathan J, etal., Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):747-50. doi: 10.1002/ajmg.b.30889.
45. Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation. Xu K, etal., J Biol Chem. 2007 Apr 13;282(15):11347-55. Epub 2007 Feb 15.
46. Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. Zhu S, etal., Brain Res. 2013 Sep 12;1530:54-65. doi: 10.1016/j.brainres.2013.07.023. Epub 2013 Jul 22.
Additional References at PubMed
PMID:2236009   PMID:2268320   PMID:11068878   PMID:12524533   PMID:12526812   PMID:14651853   PMID:15901638   PMID:16493179   PMID:18378771   PMID:20026663   PMID:20479936   PMID:21092856  
PMID:22206666   PMID:22658674   PMID:23041626   PMID:23376485   PMID:23533145   PMID:24006456   PMID:24625528   PMID:26370502   PMID:27571908   PMID:27789271   PMID:28073925   PMID:28453791  
PMID:28541286   PMID:28609022   PMID:28743268   PMID:29992506   PMID:31640144   PMID:39218796  


Genomics

Comparative Map Data
Grn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,887,834 - 87,893,938 (+)NCBIGRCr8
mRatBN7.21087,387,672 - 87,393,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,387,638 - 87,393,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,424,835 - 92,430,942 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,890,037 - 91,896,139 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,283,370 - 87,289,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Celera1086,096,583 - 86,102,687 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
GRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,345,302 - 44,353,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,345,246 - 44,353,106 (+)EnsemblGRCh38hg38GRCh38
GRCh371742,422,670 - 42,430,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,778,017 - 39,785,996 (+)NCBINCBI36Build 36hg18NCBI36
Build 341739,778,016 - 39,785,996NCBI
Celera1739,132,112 - 39,140,095 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,186,768 - 38,194,753 (+)NCBIHuRef
CHM1_11742,658,166 - 42,666,146 (+)NCBICHM1_1
T2T-CHM13v2.01745,199,297 - 45,207,105 (+)NCBIT2T-CHM13v2.0
Grn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,321,333 - 102,327,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,321,141 - 102,327,874 (+)EnsemblGRCm39 Ensembl
GRCm3811102,430,507 - 102,436,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,430,315 - 102,437,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,291,636 - 102,298,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,246,597 - 102,252,895 (+)NCBIMGSCv36mm8
Celera11114,140,482 - 114,146,970 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
Grn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,368,428 - 17,372,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,368,600 - 17,371,981 (+)NCBIChiLan1.0ChiLan1.0
GRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,557,091 - 20,565,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,521,447 - 22,529,431 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,046,329 - 13,054,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,211,784 - 13,219,793 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,211,784 - 13,219,609 (-)Ensemblpanpan1.1panPan2
GRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,077,430 - 19,085,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,077,427 - 19,082,268 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,467,174 - 18,474,620 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,771,801 - 19,779,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,771,806 - 19,779,115 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,625,608 - 18,633,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,808,582 - 18,816,025 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,952,849 - 18,960,290 (-)NCBIUU_Cfam_GSD_1.0
Grn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,390,156 - 18,401,106 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541793,523 - 800,217 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541793,548 - 800,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,893,770 - 18,900,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,893,772 - 18,900,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,212,414 - 19,216,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,037,344 - 62,045,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,036,412 - 62,045,614 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,804,031 - 32,812,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795704,252 - 707,165 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795704,066 - 708,721 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grn
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:145
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000028557, ENSRNOT00000040472
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Wox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,632 - 87,393,760 (+)MAPPERmRatBN7.2
Rnor_6.01090,383,063 - 90,383,190NCBIRnor6.0
Rnor_5.01090,171,594 - 90,171,721UniSTSRnor5.0
RGSC_v3.41091,542,095 - 91,542,222UniSTSRGSC3.4
Celera1086,102,543 - 86,102,670UniSTS
Cytogenetic Map10q32.1UniSTS
D10Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,676 - 87,393,763 (+)MAPPERmRatBN7.2
Rnor_6.01090,383,107 - 90,383,193NCBIRnor6.0
Rnor_5.01090,171,638 - 90,171,724UniSTSRnor5.0
RGSC_v3.41091,542,139 - 91,542,225UniSTSRGSC3.4
Celera1086,102,587 - 86,102,673UniSTS
Cytogenetic Map10q32.1UniSTS
RH128403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,473 - 87,393,670 (+)MAPPERmRatBN7.2
Rnor_6.01090,382,904 - 90,383,100NCBIRnor6.0
Rnor_5.01090,171,435 - 90,171,631UniSTSRnor5.0
RGSC_v3.41091,541,936 - 91,542,132UniSTSRGSC3.4
Celera1086,102,384 - 86,102,580UniSTS
Cytogenetic Map10q32.1UniSTS
D16195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,393,599 - 87,393,772 (+)MAPPERmRatBN7.2
Rnor_6.01090,383,030 - 90,383,202NCBIRnor6.0
Rnor_5.01090,171,561 - 90,171,733UniSTSRnor5.0
RGSC_v3.41091,542,062 - 91,542,234UniSTSRGSC3.4
Celera1086,102,510 - 86,102,682UniSTS
Cytogenetic Map10q32.1UniSTS
RH138782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,389,133 - 87,389,267 (+)MAPPERmRatBN7.2
Rnor_6.01090,378,564 - 90,378,697NCBIRnor6.0
Rnor_5.01090,167,095 - 90,167,228UniSTSRnor5.0
RGSC_v3.41091,537,596 - 91,537,729UniSTSRGSC3.4
Celera1086,098,044 - 86,098,177UniSTS
RH 3.4 Map10879.99UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028557   ⟹   ENSRNOP00000028557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,387,638 - 87,393,767 (+)Ensembl
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000040472   ⟹   ENSRNOP00000043881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,387,672 - 87,393,775 (+)Ensembl
Rnor_6.0 Ensembl1090,377,103 - 90,383,205 (+)Ensembl
RefSeq Acc Id: NM_001145842   ⟹   NP_001139314
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,887,834 - 87,893,938 (+)NCBI
mRatBN7.21087,387,672 - 87,393,777 (+)NCBI
Rnor_6.01090,377,103 - 90,383,207 (+)NCBI
Rnor_5.01090,165,634 - 90,171,738 (+)NCBI
RGSC_v3.41091,536,135 - 91,542,239 (+)RGD
Celera1086,096,583 - 86,102,687 (+)RGD
Sequence:
RefSeq Acc Id: NM_017113   ⟹   NP_058809
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,887,834 - 87,893,938 (+)NCBI
mRatBN7.21087,387,672 - 87,393,777 (+)NCBI
Rnor_6.01090,377,103 - 90,383,207 (+)NCBI
Rnor_5.01090,165,634 - 90,171,738 (+)NCBI
RGSC_v3.41091,536,135 - 91,542,239 (+)RGD
Celera1086,096,583 - 86,102,687 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767981   ⟹   XP_008766203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,887,854 - 87,893,938 (+)NCBI
mRatBN7.21087,387,752 - 87,393,762 (+)NCBI
Rnor_6.01090,377,173 - 90,383,103 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058809   ⟸   NM_017113
- Peptide Label: isoform a precursor
- UniProtKB: G3V8V1 (UniProtKB/TrEMBL),   A6HJK0 (UniProtKB/TrEMBL),   A6HJK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139314   ⟸   NM_001145842
- Peptide Label: isoform b precursor
- UniProtKB: F1LMP7 (UniProtKB/TrEMBL),   Q6IN42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766203   ⟸   XM_008767981
- Peptide Label: isoform X1
- UniProtKB: P23785 (UniProtKB/Swiss-Prot),   A6HJK4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028557   ⟸   ENSRNOT00000028557
Ensembl Acc Id: ENSRNOP00000043881   ⟸   ENSRNOT00000040472
Protein Domains
GRANULINS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23785-F1-model_v2 AlphaFold P23785 1-588 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697788
Promoter ID:EPDNEW_R8312
Type:initiation region
Name:Grn_1
Description:granulin precursor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,377,118 - 90,377,178EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61983 AgrOrtholog
BioCyc Gene G2FUF-23107 BioCyc
Ensembl Genes ENSRNOG00000021031 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028557 ENTREZGENE
  ENSRNOT00000040472 ENTREZGENE
  ENSRNOT00000124158 ENTREZGENE
Gene3D-CATH 2.10.25.160 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098196 IMAGE-MGC_LOAD
InterPro Granulin UniProtKB/Swiss-Prot
  Granulin_fam UniProtKB/Swiss-Prot
  Granulin_sf UniProtKB/Swiss-Prot
KEGG Report rno:29143 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91745 IMAGE-MGC_LOAD
NCBI Gene 29143 ENTREZGENE
PANTHER PROGRANULIN UniProtKB/Swiss-Prot
  PTHR12274 UniProtKB/Swiss-Prot
Pfam Granulin UniProtKB/Swiss-Prot
PhenoGen Grn PhenoGen
PROSITE GRANULINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021031 RatGTEx
SMART GRAN UniProtKB/Swiss-Prot
Superfamily-SCOP Granulin repeat UniProtKB/Swiss-Prot
UniProt A6HJK0 ENTREZGENE, UniProtKB/TrEMBL
  A6HJK1 ENTREZGENE, UniProtKB/TrEMBL
  A6HJK2_RAT UniProtKB/TrEMBL
  A6HJK3_RAT UniProtKB/TrEMBL
  A6HJK4 ENTREZGENE, UniProtKB/TrEMBL
  A6HJK5_RAT UniProtKB/TrEMBL
  A6HJK6_RAT UniProtKB/TrEMBL
  A6HJK7_RAT UniProtKB/TrEMBL
  A6HJK8_RAT UniProtKB/TrEMBL
  A6HJK9_RAT UniProtKB/TrEMBL
  F1LMP7 ENTREZGENE, UniProtKB/TrEMBL
  G3V8V1 ENTREZGENE, UniProtKB/TrEMBL
  GRN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IN42 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-20 Grn  granulin precursor  Grn  granulin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grn  granulin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein epithelin precursor is processed to epithelin 1 and epithelin 2 proteins 61623