L1cam (L1 cell adhesion molecule) - Rat Genome Database

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Gene: L1cam (L1 cell adhesion molecule) Rattus norvegicus
Symbol: L1cam
Name: L1 cell adhesion molecule
RGD ID: 619777
Description: Enables PDZ domain binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to ethanol; and neuron differentiation. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse. Used to study hydrocephalus. Biomarker of anxiety disorder; depressive disorder; and hypothyroidism. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
Previously known as: Hsas; Hyd; L1; L1 cell adhesion molecule (mapped); L1cam_mapped; N-CAM L1; N-CAM-L1; NCAM-L1; NCAML1; nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1; neuron-glia cell adhesion molecule; NgCAM; NILE
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: L1cam_v1   L1cam_v2   L1camem2Jgn   L1camem1Jgn  
Genetic Models: SD-L1camem2Jgn SD-L1camem1Jgn
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X156,748,597 - 156,775,116 (-)NCBIGRCr8
mRatBN7.2X151,597,270 - 151,623,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,597,277 - 151,623,857 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,738,430 - 153,754,814 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,301,656 - 157,318,040 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,973,488 - 154,989,873 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,901,244 - 156,928,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,909,913 - 156,928,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,649,353 - 152,676,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,784,792 - 159,801,553 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,279,868 - 136,293,057 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Alzheimer's disease  (ISO)
anxiety disorder  (IEP)
aphasia  (ISO)
autistic disorder  (ISO)
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 23  (ISO)
Barth syndrome  (ISO)
bipolar disorder  (ISO)
cerebellar ataxia  (ISO)
cerebellar hypoplasia  (ISO)
cerebral creatine deficiency syndrome 1  (ISO)
Chromosome Xq28 Duplication Syndrome  (ISO)
colorectal cancer  (ISO)
Congenital Hand Deformities  (ISO)
depressive disorder  (IEP)
Developmental Disabilities  (ISO)
dyskeratosis congenita  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
favism  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
hereditary spastic paraplegia  (ISO)
Hirschsprung's disease  (ISO)
Huntington's disease  (ISO)
hydrocephalus  (ISO)
hypothyroidism  (IEP)
immunodeficiency 33  (ISO)
intellectual disability  (ISO)
lung non-small cell carcinoma  (ISO)
MASA syndrome  (ISO,ISS)
Neoplasm Metastasis  (ISO)
Neurologic Gait Disorders  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
paraplegia  (ISO)
Parkinson's disease  (ISO)
Partial Agenesis of Corpus Callosum, X-Linked  (ISO)
Peripheral Nerve Injuries  (IDA,ISO)
periventricular nodular heterotopia  (ISO)
pheochromocytoma  (ISO)
Posthemorrhagic Hydrocephalus  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Spinal Cord Compression  (ISO)
Splenomegaly  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
uterine cancer  (ISO)
X-Linked Hydrocephalus  (IMP,ISO)
X-Linked Hydrocephalus, with Congenital Idiopathic Intestinal Pseudoobstruction  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
Altertoxin II  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
Mesaconitine  (EXP)
methanol  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
nitrofen  (EXP)
Ondansetron  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
saracatinib  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
tebufenpyrad  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon development  (ISO,ISS)
axon guidance  (IEA,ISO,ISS)
axonal fasciculation  (IMP)
calcium-mediated signaling  (ISO)
cell adhesion  (IEA)
cell migration  (IEA,ISO,ISS)
cell surface receptor signaling pathway  (ISO)
cell-cell adhesion mediated by integrin  (ISO)
cell-matrix adhesion  (IEA,ISO,ISS)
cellular response to dexamethasone stimulus  (IEP)
cellular response to ethanol  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to thyroxine stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cerebellar neuron development  (IMP)
dopaminergic neuron differentiation  (IEP)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IBA,ISO)
homotypic cell-cell adhesion  (ISO)
leukocyte cell-cell adhesion  (ISO)
maintenance of synapse structure  (ISO)
modulation of chemical synaptic transmission  (EXP,IDA)
neuron differentiation  (IEP)
neuron projection development  (ISO,ISS)
positive regulation of axon extension  (IMP)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cell-substrate adhesion  (IDA)
protein localization to plasma membrane raft  (IDA)
regulation of ERK1 and ERK2 cascade  (IDA)
regulation of neuron projection development  (IMP)
regulation of protein phosphorylation  (IMP)
regulation of synapse assembly  (ISO)
response to activity  (IEP)
response to thyroid hormone  (IEP)
response to toluene  (IDA)
synapse organization  (IBA,IEA,ISO,ISS)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain. Alvarez-Dolado M, etal., Mol Cell Neurosci. 2000 Oct;16(4):499-514.
2. Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. Arlt MJ, etal., Cancer Res. 2006 Jan 15;66(2):936-43.
3. Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. Ben QW, etal., Ann Surg Oncol. 2010 Aug;17(8):2213-21. Epub 2010 Feb 17.
4. Neural cell adhesion molecule L1-transfected embryonic stem cells promote functional recovery after excitotoxic lesion of the mouse striatum. Bernreuther C, etal., J Neurosci. 2006 Nov 8;26(45):11532-9.
5. Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice. Cui YF, etal., Brain. 2010 Jan;133(Pt 1):189-204. Epub 2009 Dec 7.
6. A silent mutation, C924T (G308G), in the L1CAM gene results in X linked hydrocephalus (HSAS). Du YZ, etal., J Med Genet. 1998 Jun;35(6):456-62.
7. miR-29a modulates neuronal differentiation through targeting REST in mesenchymal stem cells. Duan P, etal., PLoS One. 2014 May 19;9(5):e97684. doi: 10.1371/journal.pone.0097684. eCollection 2014.
8. Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. Emmert AS, etal., J Neurosurg. 2019 Feb 8:1-14. doi: 10.3171/2018.10.JNS181015.
9. L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Fogel M, etal., Lancet. 2003 Sep 13;362(9387):869-75.
10. Nerve growth factor enhances expression of neuron-glia cell adhesion molecule in PC12 cells. Friedlander DR, etal., J Cell Biol. 1986 Feb;102(2):413-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Adhesion molecule L1 overexpressed under the control of the neuronal Thy-1 promoter improves myelination after peripheral nerve injury in adult mice. Guseva D, etal., Exp Neurol. 2011 Jun;229(2):339-52. Epub 2011 Mar 2.
13. Binding partners L1 cell adhesion molecule and the ezrin-radixin-moesin (ERM) proteins are involved in development and the regenerative response to injury of hippocampal and cortical neurons. Haas MA, etal., Eur J Neurosci. 2004 Sep;20(6):1436-44.
14. L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer. Hai J, etal., Clin Cancer Res. 2012 Apr 1;18(7):1914-24. doi: 10.1158/1078-0432.CCR-11-2893. Epub 2012 Feb 3.
15. Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons. Hoffman EJ, etal., Neuroscience. 2008 Dec 2;157(3):556-65. doi: 10.1016/j.neuroscience.2008.08.071. Epub 2008 Sep 25.
16. Antidepressant-like effects of 3,6'-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats. Hu Y, etal., Neurochem Int. 2010 Feb;56(3):461-5. Epub 2009 Dec 14.
17. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
18. X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Jouet M, etal., Nat Genet. 1994 Jul;7(3):402-7.
19. L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. Kaifi JT, etal., Mod Pathol. 2007 Nov;20(11):1183-90. Epub 2007 Sep 14.
20. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. Koroll M, etal., J Biol Chem 2001 Apr 6;276(14):10646-54.
21. An association study between polymorphism of L1CAM gene and schizophrenia in a Japanese sample. Kurumaji A, etal., Am J Med Genet. 2001 Jan 8;105(1):99-104.
22. Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma. Lin B, etal., PLoS One. 2010 Apr 19;5(4):e10210.
23. Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. L├╝thl A, etal., Nature. 1994 Dec 22-29;372(6508):777-9. doi: 10.1038/372777a0.
24. Exercise increases mRNA levels for adhesion molecules N-CAM and L1 correlating with BDNF response. Macias M, etal., Neuroreport. 2002 Dec 20;13(18):2527-30.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Transforming growth factor beta1 and ethanol affect transcription and translation of genes and proteins for cell adhesion molecules in B104 neuroblastoma cells. Miller MW, etal., J Neurochem. 2006 May;97(4):1182-90.
27. Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing. Miura M, etal., FEBS Lett 1991 Sep 2;289(1):91-5.
28. Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma. Molatore S, etal., Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18493-8. doi: 10.1073/pnas.1003956107. Epub 2010 Oct 11.
29. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. Montgomery AM, etal., J Cell Biol. 1996 Feb;132(3):475-85.
30. Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with post-hemorrhagic hydrocephalus of prematurity. Morales DM, etal., Mol Cell Proteomics. 2011 Dec 20.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Heterozygous L1-deficient mice express an autism-like phenotype. Sauce B, etal., Behav Brain Res. 2015 Oct 1;292:432-42. doi: 10.1016/j.bbr.2015.05.040. Epub 2015 Jun 14.
36. Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent. Schafer H, etal., Carcinogenesis. 2012 Jan;33(1):84-93. doi: 10.1093/carcin/bgr262. Epub 2011 Nov 17.
37. TGF-beta1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells. Schafer H, etal., Oncogene. 2012 Feb 20. doi: 10.1038/onc.2012.44.
38. Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth. Shimada T, etal., J Cell Biol. 2008 Jun 2;181(5):817-29. doi: 10.1083/jcb.200712138.
39. Mesostriatal dopaminergic axons transiently express high levels of NILE during development. Shults CW, etal., Exp Neurol. 1992 Jun;116(3):275-85.
40. Involvement of the nerve growth factor-inducible large external glycoprotein (NILE) in neurite fasciculation in primary cultures of rat brain. Stallcup WB and Beasley L, Proc Natl Acad Sci U S A. 1985 Feb;82(4):1276-80.
41. Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes. Strekalova H, etal., Neurobiol Aging. 2006 Jan;27(1):1-9.
42. A deletion of five nucleotides in the L1CAM gene in a Japanese family with X-linked hydrocephalus. Takechi T, etal., Hum Genet. 1996 Mar;97(3):353-6.
43. Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases. Tang N, etal., J Neurochem. 2006 Mar;96(5):1480-90.
44. Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts. Tang N, etal., J Neurochem. 2011 Nov;119(4):859-67. doi: 10.1111/j.1471-4159.2011.07467.x. Epub 2011 Oct 11.
45. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. Tapanes-Castillo A, etal., Neurogenetics. 2010 Feb;11(1):53-71. Epub 2009 Jun 30.
46. Neurotrophins 3 and 4 differentially regulate NCAM, L1 and N-cadherin expression during peripheral nerve regeneration. Thornton MR, etal., Biotechnol Appl Biochem. 2008 Feb;49(Pt 2):165-74.
47. Effect of dexamethasone on the nerve growth factor-induced increase in the NILE glycoprotein in PC12 cells. Tocco MD, etal., J Neurosci Res. 1992 Jan;31(1):28-32.
48. "Juvenile stress" alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: relevance for stress-related psychopathologies. Tsoory MM, etal., J Neurosci Res. 2010 Feb 1;88(2):369-80.
49. MASA syndrome is due to mutations in the neural cell adhesion gene L1CAM. Vits L, etal., Nat Genet. 1994 Jul;7(3):408-13.
50. State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. Wakabayashi Y, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1199-205. Epub 2008 Mar 15.
51. L1cam acts as a modifier gene for members of the endothelin signalling pathway during enteric nervous system development. Wallace AS, etal., Neurogastroenterol Motil. 2011 Nov;23(11):e510-22. doi: 10.1111/j.1365-2982.2011.01692.x. Epub 2011 Mar 14.
52. Toluene disruption of the functions of L1 cell adhesion molecule at concentrations associated with occupational exposures. White KM, etal., Pediatr Res. 2016 Jul;80(1):145-50. doi: 10.1038/pr.2016.40. Epub 2016 Mar 8.
53. Transplanted L1 expressing radial glia and astrocytes enhance recovery after spinal cord injury. Xu JC, etal., J Neurotrauma. 2011 Sep;28(9):1921-37. Epub 2011 Aug 31.
54. The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM. Yap CC, etal., J Cell Biol. 2008 Feb 25;180(4):827-42. doi: 10.1083/jcb.200707143.
Additional References at PubMed
PMID:2466966   PMID:2723751   PMID:7613634   PMID:7669058   PMID:8117278   PMID:8125140   PMID:8557754   PMID:9048906   PMID:11283023   PMID:11948808   PMID:12070130   PMID:12453492  
PMID:12514225   PMID:12533613   PMID:12900915   PMID:14608600   PMID:14705138   PMID:15803510   PMID:15880726   PMID:15905095   PMID:15911348   PMID:16022864   PMID:16537644   PMID:16554297  
PMID:17151951   PMID:17234591   PMID:18321067   PMID:18464795   PMID:18478542   PMID:18550718   PMID:18650339   PMID:19185025   PMID:19458237   PMID:19581412   PMID:20124415   PMID:20463227  
PMID:20621658   PMID:20964729   PMID:21423176   PMID:22815787   PMID:22973895   PMID:23050935   PMID:24155914   PMID:24223996   PMID:27559042   PMID:31426714   PMID:38728789  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X156,748,597 - 156,775,116 (-)NCBIGRCr8
mRatBN7.2X151,597,270 - 151,623,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,597,277 - 151,623,857 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,738,430 - 153,754,814 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,301,656 - 157,318,040 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,973,488 - 154,989,873 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,901,244 - 156,928,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,909,913 - 156,928,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,649,353 - 152,676,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,784,792 - 159,801,553 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,279,868 - 136,293,057 (+)NCBICelera
Cytogenetic MapXq37NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X153,861,514 - 153,886,173 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,861,514 - 153,886,173 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,126,969 - 153,151,627 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,780,581 - 152,794,505 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,648,233 - 152,662,158NCBI
CeleraX153,360,655 - 153,375,083 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,783,485 - 141,798,078 (-)NCBIHuRef
CHM1_1X153,001,369 - 153,026,043 (-)NCBICHM1_1
T2T-CHM13v2.0X152,135,195 - 152,159,857 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X72,897,384 - 72,924,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,897,384 - 72,939,711 (-)EnsemblGRCm39 Ensembl
GRCm38X73,853,778 - 73,880,838 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,853,778 - 73,896,105 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,099,119 - 71,126,173 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,107,755 - 70,122,524 (-)NCBIMGSCv36mm8
CeleraX65,106,167 - 65,133,066 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.43NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955580549,368 - 561,486 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580548,442 - 561,580 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2X153,902,285 - 153,927,077 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X153,905,891 - 153,930,683 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,412,303 - 143,437,090 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,298,690 - 153,324,228 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,298,690 - 153,324,228 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X121,708,695 - 121,722,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,708,894 - 121,733,365 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,037,463 - 107,051,578 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,849,997 - 124,864,112 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,850,009 - 124,874,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,619,271 - 120,633,384 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,134,526 - 123,148,641 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,895,999 - 122,910,117 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2X118,998,614 - 119,024,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809736,319 - 761,973 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809736,385 - 768,822 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 EnsemblX124,595,651 - 124,618,307 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,595,649 - 124,618,292 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,160,416 - 142,182,924 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1X128,285,128 - 128,309,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,285,130 - 128,299,570 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,154,181 - 66,179,381 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624946513,297 - 525,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946512,413 - 533,669 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in L1cam
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:110
Interacting mature miRNAs:115
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,600,403 - 151,600,681 (-)MAPPERmRatBN7.2
Rnor_6.0X156,924,648 - 156,924,925NCBIRnor6.0
Rnor_5.01152,672,716 - 152,672,993UniSTSRnor5.0
RGSC_v3.4X159,787,923 - 159,788,200UniSTSRGSC3.4
Celera1136,289,649 - 136,289,926UniSTS
Cytogenetic MapXq37UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,600,155 - 151,600,415 (-)MAPPERmRatBN7.2
Rnor_6.0X156,924,914 - 156,925,173NCBIRnor6.0
Rnor_5.01152,672,982 - 152,673,241UniSTSRnor5.0
Celera1136,289,915 - 136,290,174UniSTS
Cytogenetic MapXq37UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,598,493 - 151,599,274 (-)MAPPERmRatBN7.2
Rnor_6.0X156,926,055 - 156,926,835NCBIRnor6.0
Rnor_5.01152,674,123 - 152,674,903UniSTSRnor5.0
RGSC_v3.4X159,786,013 - 159,786,793UniSTSRGSC3.4
Celera1136,291,056 - 136,291,836UniSTS
Cytogenetic MapXq37UniSTS

Genetic Models
This gene L1cam is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 68 28 4
Low 3 43 18 2 19 2 5 5 6 7 29 11 5
Below cutoff 29 29 29 3 6 8 3


RefSeq Acc Id: ENSRNOT00000080945   ⟹   ENSRNOP00000075170
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,597,277 - 151,613,659 (-)Ensembl
Rnor_6.0 EnsemblX156,911,345 - 156,928,033 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084390   ⟹   ENSRNOP00000075314
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,597,277 - 151,610,330 (-)Ensembl
Rnor_6.0 EnsemblX156,909,913 - 156,928,057 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114250   ⟹   ENSRNOP00000093196
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,597,442 - 151,623,857 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118735   ⟹   ENSRNOP00000094708
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,597,277 - 151,623,857 (-)Ensembl
RefSeq Acc Id: NM_017345   ⟹   NP_059041
Rat AssemblyChrPosition (strand)Source
GRCr8X156,748,597 - 156,764,983 (-)NCBI
mRatBN7.2X151,597,273 - 151,613,659 (-)NCBI
Rnor_6.0X156,911,345 - 156,928,056 (+)NCBI
Rnor_5.01152,649,353 - 152,676,124 (+)NCBI
RGSC_v3.4X159,784,792 - 159,801,553 (-)RGD
Celera1136,279,868 - 136,293,057 (+)NCBI
RefSeq Acc Id: XM_017602140   ⟹   XP_017457629
Rat AssemblyChrPosition (strand)Source
GRCr8X156,748,597 - 156,775,116 (-)NCBI
mRatBN7.2X151,597,270 - 151,623,775 (-)NCBI
Rnor_6.0X156,901,244 - 156,928,056 (+)NCBI
RefSeq Acc Id: XM_017602141   ⟹   XP_017457630
Rat AssemblyChrPosition (strand)Source
GRCr8X156,748,597 - 156,775,116 (-)NCBI
mRatBN7.2X151,597,270 - 151,623,775 (-)NCBI
Rnor_6.0X156,901,244 - 156,928,064 (+)NCBI
RefSeq Acc Id: XR_010061232
Rat AssemblyChrPosition (strand)Source
GRCr8X156,749,903 - 156,775,112 (-)NCBI
RefSeq Acc Id: NP_059041   ⟸   NM_017345
- Peptide Label: precursor
- UniProtKB: Q05695 (UniProtKB/Swiss-Prot),   D3ZPC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457630   ⟸   XM_017602141
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AMQ8 (UniProtKB/TrEMBL),   A0A8I6AJJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457629   ⟸   XM_017602140
- Peptide Label: isoform X1
- UniProtKB: Q05695 (UniProtKB/Swiss-Prot),   D3ZPC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075170   ⟸   ENSRNOT00000080945
RefSeq Acc Id: ENSRNOP00000075314   ⟸   ENSRNOT00000084390
RefSeq Acc Id: ENSRNOP00000094708   ⟸   ENSRNOT00000118735
RefSeq Acc Id: ENSRNOP00000093196   ⟸   ENSRNOT00000114250
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05695-F1-model_v2 AlphaFold Q05695 1-1259 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619777 AgrOrtholog
BioCyc Gene G2FUF-658 BioCyc
Ensembl Genes ENSRNOG00000061230 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080945.2 UniProtKB/TrEMBL
  ENSRNOT00000084390.2 UniProtKB/TrEMBL
  ENSRNOT00000114250.1 UniProtKB/TrEMBL
  ENSRNOT00000118735.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurofascin/L1/NrCAM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50687 UniProtKB/Swiss-Prot
Pfam Bravo_FIGEY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen L1cam PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061230 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KA95_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-10-17 L1cam  L1 cell adhesion molecule  L1cam_mapped  L1 cell adhesion molecule (mapped)  Data merged from RGD:2986 737654 APPROVED
2005-11-18 L1cam  L1 cell adhesion molecule  NCAML1  neural cell adhesion molecule L1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-11-17 L1cam_mapped  L1 cell adhesion molecule (mapped)  L1cam  L1 cell adhesion molecule  Symbol and Name updated 1556543 APPROVED
2002-08-07 NCAML1  neural cell adhesion molecule L1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 L1cam  L1 cell adhesion molecule (Hydrocephalus, stenosis of aqueduct of Sylvius 1)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has high homology to the mouse L1 homolog 633424
gene_process may have a role in anxiety-like responses 1300205
gene_regulation mRNA expression increased by stress 1300206