Enables several functions, including epidermal growth factor receptor binding activity; insulin receptor substrate binding activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; cellular response to ionizing radiation; and signal transduction in response to DNA damage. Predicted to act upstream of or within several processes, including embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA, [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein
[Cannabidiol co-treated with moringin] results in increased expression of GRB2 mRNA, [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of GRB2 mRNA
Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]]
[Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of GRB2 mRNA, [Oxygen co-treated with Ozone] results in decreased expression of GRB2 mRNA
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA, [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein
[Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of GRB2 mRNA, [Oxygen co-treated with Ozone] results in decreased expression of GRB2 mRNA
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA, [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein
[sodium arsenite results in increased phosphorylation of SHC1 protein] promotes the reaction [SHC1 protein modified form binds to GRB2 protein], sodium arsenite promotes the reaction [SHC1 protein modified form binds to GRB2 protein]
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.
Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel.
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.
Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes.
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.
Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoforms.
