Acox1 (acyl-CoA oxidase 1) - Rat Genome Database

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Gene: Acox1 (acyl-CoA oxidase 1) Rattus norvegicus
Analyze
Symbol: Acox1
Name: acyl-CoA oxidase 1
RGD ID: 619757
Description: Enables anion binding activity; palmitoyl-CoA oxidase activity; and protein homodimerization activity. Involved in fatty acid beta-oxidation using acyl-CoA oxidase. Located in peroxisome. Biomarker of obesity and steatotic liver disease. Human ortholog(s) of this gene implicated in Mitchell syndrome and peroxisomal acyl-CoA oxidase deficiency. Orthologous to human ACOX1 (acyl-CoA oxidase 1); PARTICIPATES IN alpha-linolenic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH (R)-lipoic acid; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACO; aCoA; acyl-coA oxidase; acyl-CoA oxidase 1, palmitoyl; acyl-Coenzyme A oxidase 1; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; LOC100910385; palmitoyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 1; peroxisomal acyl-coenzyme A oxidase 1-like; peroxisomal fatty acyl-CoA oxidase; RATACOA1; straight-chain acyl-CoA oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,905,083 - 101,930,136 (-)NCBIGRCr8
mRatBN7.210101,406,197 - 101,431,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,406,197 - 101,431,232 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,470,116 - 106,493,643 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,933,212 - 105,956,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,328,652 - 101,352,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,724,534 - 104,748,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,722,958 - 104,748,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,537,761 - 103,561,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,281,977 - 106,319,382 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,294,947 - 106,310,607 (-)NCBI
Celera1099,981,033 - 100,004,515 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
acetamide  (EXP)
Actein  (EXP)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alloxan  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anandamide  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chloroethene  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (EXP)
ciprofibrate  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
clozapine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicamba  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dioscin  (EXP,ISO)
dipentyl phthalate  (EXP)
dipropyl phthalate  (EXP)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
finasteride  (EXP)
fludioxonil  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fomesafen  (ISO)
FR900359  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
furan  (EXP)
Ganoderic acid A  (ISO)
Gastrodin  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
inulin  (ISO)
isosilybin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
linalool  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
meldonium  (ISO)
Mesaconitine  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (EXP,ISO)
Muraglitazar  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nafenopin  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nodularin  (EXP)
nordihydroguaiaretic acid  (EXP)
obeticholic acid  (ISO)
olanzapine  (EXP)
olaparib  (ISO)
oleic acid  (ISO)
oxybenzone  (EXP)
Oxyfluorfen  (ISO)
palmitoyl-CoA  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP,ISO)
perfluorodecanoic acid  (EXP)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin B1  (ISO)
procymidone  (ISO)
propamocarb  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
pterostilbene  (EXP)
puerarin  (ISO)
pyrroloquinoline quinone  (EXP)
quizalofop-ethyl  (EXP)
raffinose  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
scopoletin  (EXP)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
sucrose  (ISO)
sulfasalazine  (ISO)
taurine  (EXP)
tebuconazole  (ISO)
tectoridin  (ISO)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP,ISO)
testosterone  (ISO)
testosterone cypionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(picolinato)chromium  (EXP)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
peroxisomal matrix  (TAS)
peroxisomal membrane  (IEA,ISO)
peroxisome  (IBA,IDA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase. Kawaguchi A, etal., J Biochem. 1980 Nov;88(5):1481-6. doi: 10.1093/oxfordjournals.jbchem.a133118.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase. Miyazawa S, etal., J Biol Chem 1987 Jun 15;262(17):8131-7.
6. Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase. Nakajima Y, etal., J Biochem. 2002 Mar;131(3):365-74.
7. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase. Van Veldhoven PP, etal., J Biol Chem. 1992 Oct 5;267(28):20065-74.
14. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:3036801   PMID:7876265   PMID:8117268   PMID:8798738   PMID:8943006   PMID:11156684   PMID:12477932   PMID:12915479   PMID:14651853   PMID:15489334   PMID:16236453   PMID:17458872  
PMID:17603022   PMID:17881773   PMID:18281296   PMID:18421861   PMID:18536048   PMID:19946888   PMID:20178365   PMID:20195242   PMID:23209302   PMID:26092479   PMID:27923787   PMID:28077576  


Genomics

Comparative Map Data
Acox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,905,083 - 101,930,136 (-)NCBIGRCr8
mRatBN7.210101,406,197 - 101,431,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,406,197 - 101,431,232 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,470,116 - 106,493,643 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,933,212 - 105,956,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,328,652 - 101,352,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,724,534 - 104,748,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,722,958 - 104,748,050 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,537,761 - 103,561,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,281,977 - 106,319,382 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,294,947 - 106,310,607 (-)NCBI
Celera1099,981,033 - 100,004,515 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
ACOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,941,507 - 75,979,166 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,941,507 - 75,979,177 (-)EnsemblGRCh38hg38GRCh38
GRCh371773,937,588 - 73,975,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,449,183 - 71,487,039 (-)NCBINCBI36Build 36hg18NCBI36
Build 341771,453,259 - 71,487,020NCBI
Celera1770,527,638 - 70,565,551 (-)NCBICelera
Cytogenetic Map17q25.1ENTREZGENE
HuRef1769,363,233 - 69,401,119 (-)NCBIHuRef
CHM1_11774,002,525 - 74,040,340 (-)NCBICHM1_1
T2T-CHM13v2.01776,834,659 - 76,872,295 (-)NCBIT2T-CHM13v2.0
Acox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,062,714 - 116,089,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,062,714 - 116,089,871 (-)EnsemblGRCm39 Ensembl
GRCm3811116,171,883 - 116,199,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,171,888 - 116,199,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,033,202 - 116,060,359 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,987,978 - 116,015,135 (-)NCBIMGSCv36mm8
Celera11127,936,007 - 127,963,704 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.96NCBI
Acox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555066,286,648 - 6,312,716 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555066,286,824 - 6,309,764 (+)NCBIChiLan1.0ChiLan1.0
ACOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,985,727 - 92,022,709 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,810,438 - 96,847,726 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,890,817 - 69,928,342 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,441,856 - 75,479,568 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,445,923 - 75,479,571 (-)Ensemblpanpan1.1panPan2
ACOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,658,692 - 4,682,667 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,658,090 - 4,679,096 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,338,792 - 5,363,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,328,698 - 5,353,076 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,328,746 - 5,392,641 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,368,568 - 5,392,890 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,478,345 - 5,502,565 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,538,510 - 5,562,844 (+)NCBIUU_Cfam_GSD_1.0
Acox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,272,135 - 5,296,650 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,112,565 - 1,140,228 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,115,607 - 1,140,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,439,361 - 5,479,546 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,450,913 - 5,479,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,472,406 - 5,484,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,706,009 - 45,745,564 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,706,360 - 45,740,247 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,459,017 - 16,498,942 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,846,729 - 5,867,427 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,844,824 - 5,867,439 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acox1
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:698
Count of miRNA genes:249
Interacting mature miRNAs:297
Transcripts:ENSRNOT00000042372, ENSRNOT00000046754
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
RH128790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,406,255 - 101,406,439 (+)MAPPERmRatBN7.2
Rnor_6.010104,723,058 - 104,723,241NCBIRnor6.0
Rnor_5.010103,562,380 - 103,562,563UniSTSRnor5.0
RGSC_v3.410106,280,501 - 106,280,684UniSTSRGSC3.4
Celera1099,979,557 - 99,979,740UniSTS
Cytogenetic Map10q32.3UniSTS
PMC199556P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,412,196 - 101,412,286 (+)MAPPERmRatBN7.2
Rnor_6.010104,728,999 - 104,729,088NCBIRnor6.0
Rnor_5.010103,556,533 - 103,556,622UniSTSRnor5.0
RGSC_v3.410106,286,442 - 106,286,531UniSTSRGSC3.4
Celera1099,985,472 - 99,985,561UniSTS
Cytogenetic Map10q32.3UniSTS
PMC21059P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,406,415 - 101,407,050 (+)MAPPERmRatBN7.2
Rnor_6.010104,723,218 - 104,723,852NCBIRnor6.0
Rnor_5.010103,561,769 - 103,562,403UniSTSRnor5.0
RGSC_v3.410106,280,661 - 106,281,295UniSTSRGSC3.4
Celera1099,979,717 - 99,980,351UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000042372   ⟹   ENSRNOP00000051538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,197 - 101,431,223 (-)Ensembl
Rnor_6.0 Ensembl10104,724,534 - 104,748,003 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000046754   ⟹   ENSRNOP00000042132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,198 - 101,431,227 (-)Ensembl
Rnor_6.0 Ensembl10104,722,958 - 104,748,050 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103476   ⟹   ENSRNOP00000083504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,198 - 101,418,993 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108949   ⟹   ENSRNOP00000087983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,406,197 - 101,431,232 (-)Ensembl
RefSeq Acc Id: NM_001414015   ⟹   NP_001400944
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,905,083 - 101,930,136 (-)NCBI
mRatBN7.210101,406,197 - 101,431,252 (-)NCBI
RefSeq Acc Id: NM_017340   ⟹   NP_059036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,905,083 - 101,930,136 (-)NCBI
mRatBN7.210101,406,197 - 101,431,252 (-)NCBI
Rnor_6.010104,724,534 - 104,748,003 (-)NCBI
Rnor_5.010103,537,761 - 103,561,087 (+)NCBI
RGSC_v3.410106,281,977 - 106,319,382 (-)RGD
Celera1099,981,033 - 100,004,515 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269680   ⟹   XP_063125750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,905,083 - 101,929,676 (-)NCBI
RefSeq Acc Id: NP_059036   ⟸   NM_017340
- Peptide Label: isoform 2
- UniProtKB: P11354 (UniProtKB/Swiss-Prot),   P07872 (UniProtKB/Swiss-Prot),   A6HKU7 (UniProtKB/TrEMBL),   F1LQC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051538   ⟸   ENSRNOT00000042372
RefSeq Acc Id: ENSRNOP00000042132   ⟸   ENSRNOT00000046754
RefSeq Acc Id: ENSRNOP00000083504   ⟸   ENSRNOT00000103476
RefSeq Acc Id: ENSRNOP00000087983   ⟸   ENSRNOT00000108949
RefSeq Acc Id: NP_001400944   ⟸   NM_001414015
- Peptide Label: isoform 1
- UniProtKB: F1LQC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125750   ⟸   XM_063269680
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A041 (UniProtKB/TrEMBL),   A0A8I6A8D0 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07872-F1-model_v2 AlphaFold P07872 1-661 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697908
Promoter ID:EPDNEW_R8432
Type:initiation region
Name:Acox1_1
Description:acyl-CoA oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010104,748,013 - 104,748,073EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619757 AgrOrtholog
BioCyc Gene G2FUF-22621 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000008755 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032083 UniProtKB/Swiss-Prot
  ENSRNOG00060026651 UniProtKB/Swiss-Prot
  ENSRNOG00065019270 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042372 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000042372.7 UniProtKB/Swiss-Prot
  ENSRNOT00000046754 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000046754.6 UniProtKB/Swiss-Prot
  ENSRNOT00000103476.1 UniProtKB/TrEMBL
  ENSRNOT00000108949.1 UniProtKB/TrEMBL
  ENSRNOT00055055490 UniProtKB/Swiss-Prot
  ENSRNOT00060046319 UniProtKB/Swiss-Prot
  ENSRNOT00065032439 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109722 IMAGE-MGC_LOAD
InterPro ACO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50681 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93508 IMAGE-MGC_LOAD
NCBI Gene 50681 ENTREZGENE
PANTHER PEROXISOMAL ACYL-COENZYME A OXIDASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ACOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acox1 PhenoGen
PIRSF Acyl-CoA_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008755 RatGTEx
  ENSRNOG00055032083 RatGTEx
  ENSRNOG00060026651 RatGTEx
  ENSRNOG00065019270 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A041 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8D0 ENTREZGENE, UniProtKB/TrEMBL
  A6HKU5_RAT UniProtKB/TrEMBL
  A6HKU6_RAT UniProtKB/TrEMBL
  A6HKU7 ENTREZGENE, UniProtKB/TrEMBL
  A6HKU8_RAT UniProtKB/TrEMBL
  ACOX1_RAT UniProtKB/Swiss-Prot
  F1LQC1 ENTREZGENE, UniProtKB/TrEMBL
  F1M609_RAT UniProtKB/TrEMBL
  P07872 ENTREZGENE
  P11354 ENTREZGENE
UniProt Secondary P11354 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Acox1  acyl-CoA oxidase 1  LOC100910385  peroxisomal acyl-coenzyme A oxidase 1-like  Data merged from RGD:6498976 737654 PROVISIONAL
2016-06-08 Acox1  acyl-CoA oxidase 1  Acox1  acyl-CoA oxidase 1, palmitoyl  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910385  peroxisomal acyl-coenzyme A oxidase 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-07-28 Acox1  acyl-CoA oxidase 1, palmitoyl  Acox1  acyl-Coenzyme A oxidase 1, palmitoyl  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Acox1  acyl-Coenzyme A oxidase 1, palmitoyl  RATACOA1  acyl-coA oxidase  Symbol and Name updated 1299863 APPROVED
2002-08-07 RATACOA1  acyl-coA oxidase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 661 amino acids  
gene_protein enzyme contains three polypeptide components of which two are derived from post-translational proteolytic cleavage of the full length transcript