Pgap2 (post-GPI attachment to proteins 2) - Rat Genome Database

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Gene: Pgap2 (post-GPI attachment to proteins 2) Rattus norvegicus
Analyze
Symbol: Pgap2
Name: post-GPI attachment to proteins 2
RGD ID: 619744
Description: Involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 3. Orthologous to human PGAP2 (post-GPI attachment to proteins 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FGF receptor activating protein 1; FGF receptor-activating protein 1; Frag1; post-GPI attachment to proteins factor 2; post-GPI-attachment to proteins 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,003,593 - 166,030,088 (+)NCBIGRCr8
mRatBN7.21156,591,540 - 156,618,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,591,615 - 156,618,114 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,569,507 - 164,595,987 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,749,597 - 171,776,077 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,627,308 - 164,653,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,309,021 - 167,335,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,309,051 - 167,334,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,497,639 - 173,524,158 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,696,924 - 159,722,582 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,775,943 - 159,801,578 (+)NCBI
Celera1154,659,584 - 154,686,086 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement. Lorenzi MV, etal., Proc Natl Acad Sci U S A 1996 Aug 20;93(17):8956-61.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Tashima Y, etal., Mol Biol Cell. 2006 Mar;17(3):1410-20. Epub 2006 Jan 11.
Additional References at PubMed
PMID:15983387   PMID:29374258  


Genomics

Comparative Map Data
Pgap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,003,593 - 166,030,088 (+)NCBIGRCr8
mRatBN7.21156,591,540 - 156,618,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,591,615 - 156,618,114 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,569,507 - 164,595,987 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,749,597 - 171,776,077 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,627,308 - 164,653,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,309,021 - 167,335,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,309,051 - 167,334,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,497,639 - 173,524,158 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,696,924 - 159,722,582 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,775,943 - 159,801,578 (+)NCBI
Celera1154,659,584 - 154,686,086 (+)NCBICelera
Cytogenetic Map1q32NCBI
PGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38113,797,724 - 3,826,371 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl113,797,724 - 3,826,371 (+)EnsemblGRCh38hg38GRCh38
GRCh37113,818,954 - 3,847,601 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,786,360 - 3,804,160 (+)NCBINCBI36Build 36hg18NCBI36
Build 34113,786,359 - 3,804,159NCBI
Celera113,824,025 - 3,852,735 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,552,785 - 3,581,313 (+)NCBIHuRef
CHM1_1113,818,460 - 3,847,070 (+)NCBICHM1_1
T2T-CHM13v2.0113,863,061 - 3,891,698 (+)NCBIT2T-CHM13v2.0
Pgap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,859,153 - 101,887,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,859,415 - 101,887,774 (+)EnsemblGRCm39 Ensembl
GRCm387102,209,933 - 102,238,564 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,210,208 - 102,238,567 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,371,588 - 109,386,277 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367102,096,895 - 102,111,584 (+)NCBIMGSCv36mm8
Celera7102,591,347 - 102,606,023 (+)NCBICelera
Cytogenetic Map7E2NCBI
Pgap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,607,180 - 19,630,010 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,607,180 - 19,630,010 (+)NCBIChiLan1.0ChiLan1.0
PGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v296,063,183 - 6,091,188 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1115,302,901 - 5,330,832 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0113,669,523 - 3,697,565 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1113,782,786 - 3,810,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl113,782,786 - 3,810,678 (+)Ensemblpanpan1.1panPan2
PGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,348,328 - 26,371,266 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,348,378 - 26,370,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,119,337 - 26,142,258 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,558,856 - 26,581,839 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,567,269 - 26,629,704 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,350,292 - 26,373,168 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,566,043 - 26,588,931 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,468,306 - 26,491,221 (+)NCBIUU_Cfam_GSD_1.0
Pgap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,488,803 - 59,512,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,088,230 - 1,104,275 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,088,345 - 1,112,108 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,291,930 - 6,319,409 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,294,471 - 6,319,317 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,068,337 - 7,080,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PGAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,896,694 - 62,924,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604362,977,102 - 63,005,496 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248175,245,713 - 5,269,056 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248175,245,707 - 5,269,056 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pgap2
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:53
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000027628, ENSRNOT00000055235
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
RH133937  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,617,048 - 156,617,258 (+)MAPPERmRatBN7.2
Rnor_6.01167,334,483 - 167,334,692NCBIRnor6.0
Rnor_5.01173,523,091 - 173,523,300UniSTSRnor5.0
RGSC_v3.41159,722,352 - 159,722,561UniSTSRGSC3.4
Celera1154,685,019 - 154,685,228UniSTS
RH 3.4 Map11281.6UniSTS
Cytogenetic Map1q32UniSTS
RH140327  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,606,769 - 156,606,986 (+)MAPPERmRatBN7.2
Rnor_6.01167,324,204 - 167,324,420NCBIRnor6.0
Rnor_5.01173,512,812 - 173,513,028UniSTSRnor5.0
RGSC_v3.41159,712,073 - 159,712,289UniSTSRGSC3.4
Celera1154,674,740 - 154,674,956UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 17 11 7 11 40 22 40 11
Low 43 40 30 12 30 8 11 34 13 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB236144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000055235   ⟹   ENSRNOP00000052110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,611,288 - 156,618,114 (+)Ensembl
Rnor_6.0 Ensembl1167,309,051 - 167,334,689 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1167,321,098 - 167,324,230 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1167,309,263 - 167,321,078 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076894   ⟹   ENSRNOP00000068251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,591,615 - 156,618,113 (+)Ensembl
Rnor_6.0 Ensembl1167,309,055 - 167,334,741 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076923   ⟹   ENSRNOP00000068366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1167,320,797 - 167,324,573 (+)Ensembl
RefSeq Acc Id: NM_053895   ⟹   NP_446347
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,593 - 166,030,088 (+)NCBI
mRatBN7.21156,591,619 - 156,618,116 (+)NCBI
Rnor_6.01167,309,055 - 167,335,550 (+)NCBI
Rnor_5.01173,497,639 - 173,524,158 (+)NCBI
RGSC_v3.41159,696,924 - 159,722,582 (+)RGD
Celera1154,659,584 - 154,686,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229825   ⟹   XP_006229887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,015,154 - 166,028,726 (+)NCBI
mRatBN7.21156,591,540 - 156,618,116 (+)NCBI
Rnor_6.01167,309,021 - 167,335,550 (+)NCBI
Rnor_5.01173,497,639 - 173,524,158 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229834   ⟹   XP_006229896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,015,154 - 166,028,726 (+)NCBI
mRatBN7.21156,591,540 - 156,618,116 (+)NCBI
Rnor_6.01167,309,035 - 167,335,550 (+)NCBI
Rnor_5.01173,497,639 - 173,524,158 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229835   ⟹   XP_006229897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,018,413 - 166,028,726 (+)NCBI
mRatBN7.21156,608,966 - 156,618,116 (+)NCBI
Rnor_6.01167,326,460 - 167,335,550 (+)NCBI
Rnor_5.01173,497,639 - 173,524,158 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229837   ⟹   XP_006229899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,700 - 166,030,088 (+)NCBI
mRatBN7.21156,591,540 - 156,618,116 (+)NCBI
Rnor_6.01167,309,043 - 167,335,550 (+)NCBI
Rnor_5.01173,497,639 - 173,524,158 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588671   ⟹   XP_017444160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,028,895 (+)NCBI
mRatBN7.21156,591,540 - 156,618,116 (+)NCBI
Rnor_6.01167,309,021 - 167,335,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111279   ⟹   XP_038967207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,678 - 166,028,726 (+)NCBI
mRatBN7.21156,591,540 - 156,618,116 (+)NCBI
RefSeq Acc Id: XM_039111474   ⟹   XP_038967402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,018,269 - 166,028,726 (+)NCBI
mRatBN7.21156,606,297 - 156,618,116 (+)NCBI
RefSeq Acc Id: XM_063265073   ⟹   XP_063121143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,028,726 (+)NCBI
RefSeq Acc Id: XM_063265142   ⟹   XP_063121212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,028,726 (+)NCBI
RefSeq Acc Id: XM_063265171   ⟹   XP_063121241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,015,294 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265198   ⟹   XP_063121268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,015,294 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265230   ⟹   XP_063121300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,018,413 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265255   ⟹   XP_063121325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,028,726 (+)NCBI
RefSeq Acc Id: XM_063265289   ⟹   XP_063121359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,028,619 (+)NCBI
RefSeq Acc Id: XM_063265336   ⟹   XP_063121406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,028,726 (+)NCBI
RefSeq Acc Id: XM_063265385   ⟹   XP_063121455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,678 - 166,028,726 (+)NCBI
RefSeq Acc Id: XM_063265457   ⟹   XP_063121527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,028,726 (+)NCBI
RefSeq Acc Id: XM_063265556   ⟹   XP_063121626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,018,413 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265587   ⟹   XP_063121657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,003,687 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265623   ⟹   XP_063121693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,018,413 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265669   ⟹   XP_063121739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,022,192 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265703   ⟹   XP_063121773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,023,462 - 166,030,088 (+)NCBI
RefSeq Acc Id: XM_063265742   ⟹   XP_063121812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,023,462 - 166,030,088 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446347 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229887 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229896 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229897 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229899 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967402 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121143 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121212 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121241 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121268 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121300 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121325 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121359 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121406 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121455 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121527 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121626 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121657 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121693 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121739 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121773 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121812 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB07050 (Get FASTA)   NCBI Sequence Viewer  
  BAE80228 (Get FASTA)   NCBI Sequence Viewer  
  EDM18197 (Get FASTA)   NCBI Sequence Viewer  
  EDM18198 (Get FASTA)   NCBI Sequence Viewer  
  EDM18199 (Get FASTA)   NCBI Sequence Viewer  
  EDM18200 (Get FASTA)   NCBI Sequence Viewer  
  EDM18201 (Get FASTA)   NCBI Sequence Viewer  
  EDM18202 (Get FASTA)   NCBI Sequence Viewer  
  EDM18203 (Get FASTA)   NCBI Sequence Viewer  
  EDM18204 (Get FASTA)   NCBI Sequence Viewer  
  EDM18205 (Get FASTA)   NCBI Sequence Viewer  
  EDM18206 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052110.5
  ENSRNOP00000068251
  ENSRNOP00000068251.2
GenBank Protein Q2ABP3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446347   ⟸   NM_053895
- UniProtKB: A6I724 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229887   ⟸   XM_006229825
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006229896   ⟸   XM_006229834
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QZ37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229899   ⟸   XM_006229837
- Peptide Label: isoform X11
- UniProtKB: P70561 (UniProtKB/Swiss-Prot),   Q2ABP3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229897   ⟸   XM_006229835
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017444160   ⟸   XM_017588671
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000052110   ⟸   ENSRNOT00000055235
RefSeq Acc Id: ENSRNOP00000068251   ⟸   ENSRNOT00000076894
RefSeq Acc Id: ENSRNOP00000068366   ⟸   ENSRNOT00000076923
RefSeq Acc Id: XP_038967207   ⟸   XM_039111279
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967402   ⟸   XM_039111474
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063121455   ⟸   XM_063265385
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QZ37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121657   ⟸   XM_063265587
- Peptide Label: isoform X13
- UniProtKB: A6I724 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121143   ⟸   XM_063265073
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121325   ⟸   XM_063265255
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063121212   ⟸   XM_063265142
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121527   ⟸   XM_063265457
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063121406   ⟸   XM_063265336
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QZ37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121359   ⟸   XM_063265289
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063121241   ⟸   XM_063265171
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063121268   ⟸   XM_063265198
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063121300   ⟸   XM_063265230
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063121626   ⟸   XM_063265556
- Peptide Label: isoform X12
- UniProtKB: D4ACY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121693   ⟸   XM_063265623
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063121739   ⟸   XM_063265669
- Peptide Label: isoform X12
- UniProtKB: D4ACY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121773   ⟸   XM_063265703
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063121812   ⟸   XM_063265742
- Peptide Label: isoform X16
- UniProtKB: A6I731 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2ABP3-F1-model_v2 AlphaFold Q2ABP3 1-254 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690268
Promoter ID:EPDNEW_R791
Type:multiple initiation site
Name:Pgap2_2
Description:post-GPI attachment to proteins 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R792  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01167,309,197 - 167,309,257EPDNEW
RGD ID:13690269
Promoter ID:EPDNEW_R792
Type:initiation region
Name:Pgap2_1
Description:post-GPI attachment to proteins 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R791  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01167,320,772 - 167,320,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619744 AgrOrtholog
BioCyc Gene G2FUF-58252 BioCyc
Ensembl Genes ENSRNOG00000020371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055235.6 UniProtKB/TrEMBL
  ENSRNOT00000076894.2 UniProtKB/TrEMBL
InterPro Frag1/DRAM/Sfk1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116675 UniProtKB/TrEMBL
NCBI Gene 116675 ENTREZGENE
PANTHER POST-GPI ATTACHMENT TO PROTEINS FACTOR 2 UniProtKB/Swiss-Prot
  POST-GPI ATTACHMENT TO PROTEINS FACTOR 2 UniProtKB/TrEMBL
  POST-GPI ATTACHMENT TO PROTEINS FACTOR 2 UniProtKB/TrEMBL
  PTHR12892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Frag1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pgap2 PhenoGen
RatGTEx ENSRNOG00000020371 RatGTEx
UniProt A0A8L2QZ37 ENTREZGENE, UniProtKB/TrEMBL
  A6I724 ENTREZGENE, UniProtKB/TrEMBL
  A6I731 ENTREZGENE, UniProtKB/TrEMBL
  D4ACY7 ENTREZGENE, UniProtKB/TrEMBL
  P70561 ENTREZGENE
  PGAP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70561 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-10-22 Pgap2  post-GPI attachment to proteins 2  Frag1  FGF receptor activating protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Frag1  FGF receptor activating protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Frag1  FGF receptor activating protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process activates the C-terminus alteration by chromosomal fusion 632660