Tuba1a (tubulin, alpha 1A) - Rat Genome Database

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Gene: Tuba1a (tubulin, alpha 1A) Rattus norvegicus
Analyze
Symbol: Tuba1a
Name: tubulin, alpha 1A
RGD ID: 619717
Description: Enables protein domain specific binding activity. Predicted to be involved in several processes, including learning or memory; microtubule cytoskeleton organization; and nervous system development. Located in membrane raft and myelin sheath. Human ortholog(s) of this gene implicated in lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to human TUBA1A (tubulin alpha 1a); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-tubulin; alpha-tubulin 1; Tuba1; tubulin alpha-1 chain; tubulin alpha-1A chain; tubulin, alpha 1
RGD Orthologs
Human
Mouse
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Tuba1a-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,992,151 - 131,996,850 (-)NCBIGRCr8
mRatBN7.27130,113,214 - 130,116,880 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,081,032 - 130,196,186 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,917,920 - 131,921,586 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,143,494 - 134,147,160 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,055,997 - 134,059,663 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,637,287 - 140,640,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,637,287 - 140,640,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,143,854 - 115,147,520 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,729,405 - 137,733,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,805,841 - 137,809,508 (-)NCBI
Celera7126,598,383 - 126,602,049 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-lariciresinol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
9-cis-retinoic acid  (EXP)
abiraterone  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boron nitride  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
geldanamycin  (ISO)
glucose  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
minocycline  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel dichloride  (ISO)
nintedanib  (ISO)
nocodazole  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol red  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
procymidone  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
withaferin A  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Refinement of cortical dysgeneses spectrum associated with TUBA1A mutations. Bahi-Buisson N, etal., J Med Genet. 2008 Oct;45(10):647-53. doi: 10.1136/jmg.2008.058073. Epub 2008 Aug 26.
2. The local electrostatic environment determines cysteine reactivity of tubulin. Britto PJ, etal., J Biol Chem 2002 Aug 9;277(32):29018-27.
3. Behavioral and neuromorphological characterization of a novel Tuba1 mutant mouse. Furuse T, etal., Behav Brain Res. 2012 Feb 1;227(1):167-74. doi: 10.1016/j.bbr.2011.11.002. Epub 2011 Nov 11.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding. Hussain NK, etal., J Biol Chem 2003 Aug 1;278(31):28823-30. Epub 2003 May 15.
6. Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. Ivings L, etal., Biochem J 2002 May 1;363(Pt 3):599-608.
7. A revised nomenclature for the human and rodent alpha-tubulin gene family. Khodiyar VK, etal., Genomics. 2007 May 31;.
8. MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Lanciotti A, etal., Neurobiol Dis. 2010 Mar;37(3):581-95. Epub 2009 Nov 26.
9. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Refining the phenotype of alpha-1a Tubulin (TUBA1A) mutation in patients with classical lissencephaly. Morris-Rosendahl DJ, etal., Clin Genet. 2008 Nov;74(5):425-33. doi: 10.1111/j.1399-0004.2008.01093.x.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). Poirier K, etal., Hum Mutat. 2007 Nov;28(11):1055-64.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain. Sun Y, etal., J Proteomics. 2011 Apr 1;74(4):547-57. doi: 10.1016/j.jprot.2011.01.009. Epub 2011 Jan 22.
21. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
22. The cryptophycin-tubulin ring structure indicates two points of curvature in the tubulin dimer. Watts NR, etal., Biochemistry 2002 Oct 22;41(42):12662-9.
23. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
Additional References at PubMed
PMID:3753592   PMID:6269058   PMID:6927856   PMID:7328649   PMID:7908909   PMID:8631991   PMID:11145988   PMID:11953448   PMID:11958514   PMID:12134159   PMID:12236585   PMID:14760703  
PMID:15121898   PMID:15143158   PMID:15489334   PMID:15713690   PMID:15865439   PMID:16418269   PMID:16446153   PMID:16854843   PMID:17118269   PMID:17634366   PMID:17686994   PMID:18195004  
PMID:18506390   PMID:19056867   PMID:19103752   PMID:19199708   PMID:19292454   PMID:19377471   PMID:19666135   PMID:19961433   PMID:20131911   PMID:21357695   PMID:21400108   PMID:21525035  
PMID:21630459   PMID:22022409   PMID:22082260   PMID:22120110   PMID:22871113   PMID:22972992   PMID:23106098   PMID:23358242   PMID:24561039   PMID:26296893   PMID:26306046   PMID:26316108  
PMID:26658218   PMID:26975406   PMID:27314403   PMID:29476059   PMID:29568061   PMID:30274285   PMID:30582931   PMID:31904090   PMID:35486479  


Genomics

Comparative Map Data
Tuba1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,992,151 - 131,996,850 (-)NCBIGRCr8
mRatBN7.27130,113,214 - 130,116,880 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,081,032 - 130,196,186 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,917,920 - 131,921,586 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,143,494 - 134,147,160 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,055,997 - 134,059,663 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,637,287 - 140,640,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,637,287 - 140,640,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,143,854 - 115,147,520 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,729,405 - 137,733,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,805,841 - 137,809,508 (-)NCBI
Celera7126,598,383 - 126,602,049 (-)NCBICelera
Cytogenetic Map7q36NCBI
TUBA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,184,795 - 49,189,080 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,184,686 - 49,189,324 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,578,578 - 49,582,863 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,864,849 - 47,869,128 (-)NCBINCBI36Build 36hg18NCBI36
Celera1248,371,440 - 48,375,724 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,609,646 - 46,614,178 (-)NCBIHuRef
CHM1_11249,544,342 - 49,548,875 (-)NCBICHM1_1
T2T-CHM13v2.01249,146,977 - 49,151,264 (-)NCBIT2T-CHM13v2.0
Tuba1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,847,728 - 98,851,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,847,718 - 98,851,584 (-)EnsemblGRCm39 Ensembl
GRCm381598,949,847 - 98,953,501 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,949,837 - 98,953,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,780,278 - 98,783,932 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,777,881 - 98,781,535 (-)NCBIMGSCv36mm8
Celera15101,099,071 - 101,102,725 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1555.29NCBI
LOC610636
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,811,491 - 25,818,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,637,391 - 26,644,728 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,826,736 - 25,834,074 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13725,731,112 - 25,738,448 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,667,143 - 25,673,793 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,687,138 - 25,694,480 (+)NCBIUU_Cfam_GSD_1.0
LOC101972766
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,200,736 - 66,205,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,958,985 - 6,964,299 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,959,656 - 6,964,299 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,185,532 - 15,190,428 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,186,059 - 15,190,211 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,592,446 - 15,596,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103238261
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,419,046 - 45,423,574 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,418,748 - 45,423,685 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,712,750 - 200,717,153 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101715424
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248163,001,252 - 3,006,166 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tuba1a
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:132
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000006322, ENSRNOT00000042123
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D5Arb10  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.17137,893,337 - 137,893,591RGD
Cytogenetic Map7q36UniSTS
PMC154451P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q36UniSTS
RH78682  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04209,800,159 - 209,800,341UniSTSRnor5.0
Rnor_5.02218,687,079 - 218,687,261UniSTSRnor5.0
Cytogenetic Map7q36UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000083156   ⟹   ENSRNOP00000075232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7140,637,287 - 140,640,953 (-)Ensembl
RefSeq Acc Id: NM_022298   ⟹   NP_071634
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,992,153 - 131,995,819 (-)NCBI
mRatBN7.27130,113,214 - 130,116,880 (-)NCBI
Rnor_6.07140,637,287 - 140,640,953 (-)NCBI
Rnor_5.0X115,143,854 - 115,147,520 (-)NCBI
RGSC_v3.47137,729,405 - 137,733,071 (-)RGD
Celera7126,598,383 - 126,602,049 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264205   ⟹   XP_063120275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,992,151 - 131,996,583 (-)NCBI
RefSeq Acc Id: XM_063264206   ⟹   XP_063120276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,992,151 - 131,996,585 (-)NCBI
RefSeq Acc Id: XM_063264207   ⟹   XP_063120277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,992,151 - 131,996,850 (-)NCBI
RefSeq Acc Id: NP_071634   ⟸   NM_022298
- UniProtKB: Q6P6G6 (UniProtKB/Swiss-Prot),   P68370 (UniProtKB/Swiss-Prot),   A6KCD0 (UniProtKB/TrEMBL),   A0A8I6ALV8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075232   ⟸   ENSRNOT00000083156
RefSeq Acc Id: XP_063120277   ⟸   XM_063264207
- Peptide Label: isoform X1
- UniProtKB: Q6P6G6 (UniProtKB/Swiss-Prot),   P68370 (UniProtKB/Swiss-Prot),   A6KCD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120276   ⟸   XM_063264206
- Peptide Label: isoform X1
- UniProtKB: Q6P6G6 (UniProtKB/Swiss-Prot),   P68370 (UniProtKB/Swiss-Prot),   A6KCD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120275   ⟸   XM_063264205
- Peptide Label: isoform X1
- UniProtKB: Q6P6G6 (UniProtKB/Swiss-Prot),   P68370 (UniProtKB/Swiss-Prot),   A6KCD0 (UniProtKB/TrEMBL)
Protein Domains
Tubulin/FtsZ 2-layer sandwich   Tubulin/FtsZ GTPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68370-F1-model_v2 AlphaFold P68370 1-451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695636
Promoter ID:EPDNEW_R6161
Type:single initiation site
Name:Tuba1a_1
Description:tubulin, alpha 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07140,640,985 - 140,641,045EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619717 AgrOrtholog
BioCyc Gene G2FUF-32102 BioCyc
Ensembl Genes ENSRNOG00000053468 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000060728 Ensembl
  ENSRNOG00055030562 UniProtKB/Swiss-Prot
  ENSRNOG00060010152 UniProtKB/Swiss-Prot
  ENSRNOG00065024582 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081355.2 UniProtKB/TrEMBL
  ENSRNOT00000083156.2 UniProtKB/TrEMBL
  ENSRNOT00000107560.1 UniProtKB/TrEMBL
  ENSRNOT00000110990.1 UniProtKB/TrEMBL
  ENSRNOT00055053021 UniProtKB/Swiss-Prot
  ENSRNOT00060017139 UniProtKB/Swiss-Prot
  ENSRNOT00065042175 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1330.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922126 IMAGE-MGC_LOAD
  IMAGE:7115494 IMAGE-MGC_LOAD
InterPro Alpha_tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tub_FtsZ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin/FtsZ-like_C UniProtKB/TrEMBL
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64158 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72947 IMAGE-MGC_LOAD
  MGC:93446 IMAGE-MGC_LOAD
NCBI Gene 64158 ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN ALPHA-1A CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN ALPHA-1B CHAIN UniProtKB/TrEMBL
Pfam Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tuba1a PhenoGen
PRINTS ALPHATUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053468 RatGTEx
  ENSRNOG00000060728 RatGTEx
  ENSRNOG00055030562 RatGTEx
  ENSRNOG00060010152 RatGTEx
  ENSRNOG00065024582 RatGTEx
SMART Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ALV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B5M1_RAT UniProtKB/TrEMBL
  A0A8L2R402_RAT UniProtKB/TrEMBL
  A0A8L2RAD9_RAT UniProtKB/TrEMBL
  A6KCD0 ENTREZGENE, UniProtKB/TrEMBL
  P68370 ENTREZGENE
  Q6P6G6 ENTREZGENE
  TBA1A_RAT UniProtKB/Swiss-Prot
UniProt Secondary P02551 UniProtKB/Swiss-Prot
  P05210 UniProtKB/Swiss-Prot
  P05212 UniProtKB/Swiss-Prot
  Q6P6G6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-05-17 Tuba1a  tubulin, alpha 1A      Symbol and Name updated 1624988 APPROVED
2004-09-10 Tuba1  tubulin, alpha 1    alpha-tubulin  Name updated 1299863 APPROVED
2002-08-07 Tuba1  alpha-tubulin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds epsin N-terminal homology (ENTH)1 domain proteins epsins 1 and 2 737666