Cnr2 (cannabinoid receptor 2) - Rat Genome Database

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Gene: Cnr2 (cannabinoid receptor 2) Rattus norvegicus
Analyze
Symbol: Cnr2
Name: cannabinoid receptor 2
RGD ID: 619713
Description: Enables cannabinoid receptor activity. Involved in several processes, including negative regulation of GABAergic synaptic transmission; negative regulation of mast cell activation; and negative regulation of nitric-oxide synthase activity. Located in dendrite and neuronal cell body. Is extrinsic component of cytoplasmic side of plasma membrane. Is active in postsynaptic membrane. Used to study Huntington's disease; arthritis; and sciatic neuropathy. Biomarker of pancreatitis. Orthologous to human CNR2 (cannabinoid receptor 2); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cannabinoid receptor 2 (macrophage); cannabinoid receptor 2 gene; CB-2; CB2; CB2 receptor; CB2C; CNR2C; peripheral cannabinoid receptor; rCB2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,408,968 - 153,435,092 (+)NCBIGRCr8
mRatBN7.25148,125,222 - 148,151,548 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,125,604 - 148,151,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5150,824,702 - 150,850,276 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,598,978 - 152,624,546 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,580,980 - 152,606,559 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,242,010 - 154,268,126 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,260,062 - 154,268,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,006,539 - 158,032,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,674,754 - 154,702,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15154,709,561 - 154,712,096 (+)NCBI
Celera5146,533,227 - 146,558,688 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
5-aza-2'-deoxycytidine  (ISO)
AB-Fubinaca  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
Adb-fubinaca  (ISO)
afimoxifene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
anandamide  (EXP,ISO)
arachidonic acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
Cannabichromene  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
celastrol  (ISO)
citalopram  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP,ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
dextran sulfate  (ISO)
dibenzofuran  (ISO)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP)
fipronil  (EXP)
folic acid  (ISO)
gemcitabine  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
HU-308  (EXP,ISO)
hydrogen peroxide  (ISO)
Ibudilast  (EXP)
ibuprofen  (ISO)
imipramine  (EXP)
indazoles  (ISO)
indoles  (ISO)
Interferon beta-1b  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
Methanandamide  (ISO)
methapyrilene  (ISO)
methylarsonic acid  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nabilone  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paeoniflorin  (EXP)
palmitoyl ethanolamide  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
piperidines  (ISO)
poly(I:C)  (EXP)
pyrazoles  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quetiapine fumarate  (ISO)
ricinoleic acid  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 203580  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
SR 144528  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tianeptine  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
WIN 55212-2  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and molecular characterization of the rat CB2 cannabinoid receptor. Brown SM, etal., Biochim Biophys Acta 2002 Jul 19;1576(3):255-64.
2. Ultrastructural localization of neuronal brain CB2 cannabinoid receptors. Brusco A, etal., Ann N Y Acad Sci. 2008 Oct;1139:450-7. doi: 10.1196/annals.1432.037.
3. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Brusco A, etal., Synapse. 2008 Dec;62(12):944-9.
4. Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. Carlisle SJ, etal., Int Immunopharmacol 2002 Jan;2(1):69-82.
5. Dual effect of anandamide on rat placenta nitric oxide synthesis. Cella M, etal., Placenta. 2008 Aug;29(8):699-707. Epub 2008 Jun 18.
6. Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats. Chen L, etal., J Pain. 2009 Jul;10(7):732-9. Epub 2009 May 5.
7. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Clayton N, etal., Pain 2002 Apr;96(3):253-60.
8. Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. De Filippis D, etal., Br J Pharmacol. 2008 Aug;154(8):1672-9. Epub 2008 Jun 16.
9. Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. Duncan M, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G78-G87. Epub 2008 May 15.
10. The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation. Esposito G, etal., J Biol Chem 2002 Dec 27;277(52):50348-54.
11. The endocannabinoid system is modulated in response to spinal cord injury in rats. Garcia-Ovejero D, etal., Neurobiol Dis. 2009 Jan;33(1):57-71. Epub 2008 Sep 30.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor. Griffin G, etal., J Pharmacol Exp Ther 2000 Mar;292(3):886-94.
15. Endogenous cannabinoids contribute to remote ischemic preconditioning via cannabinoid CB2 receptors in the rat heart. Hajrasouliha AR, etal., Eur J Pharmacol. 2008 Jan 28;579(1-3):246-52. Epub 2007 Oct 5.
16. Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833. Hu B, etal., Pain. 2009 Jun;143(3):206-12. Epub 2009 Apr 3.
17. Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. Kurjak M, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):623-32. Epub 2008 Oct 1.
18. Involvement of cannabinoid CB1- and CB2-receptors in the modulation of exocrine pancreatic secretion. Linari G, etal., Pharmacol Res. 2009 Mar;59(3):207-14. Epub 2008 Nov 27.
19. Cannabinoid CB(2)-selective inverse agonist protects against antigen-induced bone loss. Lunn CA, etal., Immunopharmacol Immunotoxicol. 2007;29(3-4):387-401.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Functional CB2 type cannabinoid receptors at CNS synapses. Morgan NH, etal., Neuropharmacology. 2009 Sep;57(4):356-68. Epub 2009 Jul 16.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Onaivi ES, etal., Ann N Y Acad Sci. 2008 Oct;1139:434-49.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease. Sagredo O, etal., Glia. 2009 Aug 15;57(11):1154-67.
28. Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain. Torres E, etal., J Neurochem. 2010 Jan 12.
29. Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. Zhang J, etal., Eur J Neurosci 2003 Jun;17(12):2750-4.
Additional References at PubMed
PMID:12477932   PMID:15277313   PMID:15317842   PMID:15525273   PMID:15728830   PMID:16356641   PMID:16472786   PMID:17045344   PMID:17356307   PMID:17499236   PMID:17545311   PMID:17585904  
PMID:18308297   PMID:18469844   PMID:18578993   PMID:19115376   PMID:19357281   PMID:19476641   PMID:19496827   PMID:19860893   PMID:20627823   PMID:20665820   PMID:20803619   PMID:21443454  
PMID:21486787   PMID:21595923   PMID:22198001   PMID:22331871   PMID:22366450   PMID:22490961   PMID:22532560   PMID:22683515   PMID:22791651   PMID:22795792   PMID:23081739   PMID:23152849  
PMID:23219970   PMID:23592773   PMID:23657829   PMID:23711022   PMID:23711495   PMID:23738526   PMID:24005231   PMID:24041123   PMID:24963491   PMID:25348153   PMID:25374096   PMID:25504573  
PMID:25894754   PMID:25895887   PMID:25963415   PMID:26470810   PMID:26833913   PMID:26880264   PMID:27013280   PMID:27261088   PMID:27285468   PMID:27769788   PMID:27935269   PMID:28336953  
PMID:28364261   PMID:28431968   PMID:28837063   PMID:28843453   PMID:28899427   PMID:29197803   PMID:29791076   PMID:30022523   PMID:30793435   PMID:31139184   PMID:31446615   PMID:31472278  
PMID:31625133   PMID:31697924   PMID:31894322   PMID:31981721   PMID:32375160   PMID:32715907   PMID:32824740   PMID:33809047   PMID:33907944   PMID:35650684   PMID:36210711   PMID:38780511  


Genomics

Comparative Map Data
Cnr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,408,968 - 153,435,092 (+)NCBIGRCr8
mRatBN7.25148,125,222 - 148,151,548 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,125,604 - 148,151,548 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5150,824,702 - 150,850,276 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,598,978 - 152,624,546 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,580,980 - 152,606,559 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,242,010 - 154,268,126 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,260,062 - 154,268,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,006,539 - 158,032,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,674,754 - 154,702,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15154,709,561 - 154,712,096 (+)NCBI
Celera5146,533,227 - 146,558,688 (+)NCBICelera
Cytogenetic Map5q36NCBI
CNR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,870,515 - 23,913,362 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,870,515 - 23,913,362 (-)EnsemblGRCh38hg38GRCh38
GRCh37124,197,005 - 24,239,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,073,047 - 24,112,404 (-)NCBINCBI36Build 36hg18NCBI36
Build 34123,945,765 - 23,985,123NCBI
Celera122,529,091 - 22,570,596 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef122,452,107 - 22,493,123 (-)NCBIHuRef
CHM1_1124,313,205 - 24,352,708 (-)NCBICHM1_1
T2T-CHM13v2.0123,705,612 - 23,750,778 (-)NCBIT2T-CHM13v2.0
Cnr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,622,500 - 135,647,530 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,622,705 - 135,647,518 (+)EnsemblGRCm39 Ensembl
GRCm384135,895,189 - 135,920,219 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,895,394 - 135,920,207 (+)EnsemblGRCm38mm10GRCm38
MGSCv374135,451,319 - 135,476,130 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,167,559 - 135,192,283 (+)NCBIMGSCv36mm8
Celera4134,096,250 - 134,121,016 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.01NCBI
Cnr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,763,742 - 3,795,069 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,763,742 - 3,795,069 (-)NCBIChiLan1.0ChiLan1.0
CNR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,024,666 - 203,070,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,127,725 - 202,173,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0123,066,153 - 23,108,065 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,046,009 - 24,135,236 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,050,008 - 24,051,090 (-)Ensemblpanpan1.1panPan2
CNR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,640,636 - 75,662,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,658,999 - 75,660,126 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,229,153 - 72,230,280 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,199,651 - 76,221,314 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,213,197 - 76,221,306 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,040,679 - 73,041,806 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,047,309 - 74,048,436 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,053,153 - 75,054,280 (+)NCBIUU_Cfam_GSD_1.0
Cnr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,193,178 - 43,215,797 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364749,019,067 - 9,020,110 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364749,019,044 - 9,020,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,659,169 - 81,692,550 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1681,659,162 - 81,692,550 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,363,944 - 75,366,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,777,793 - 108,815,738 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20108,813,579 - 108,814,661 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660337,526,675 - 7,569,788 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,389,444 - 8,390,538 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247648,388,375 - 8,422,961 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnr2
197 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:548
Count of miRNA genes:241
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000012342, ENSRNOT00000074998
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
D19S605  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,135,526 - 148,137,137 (+)MAPPERmRatBN7.2
Rnor_6.05154,252,110 - 154,253,720NCBIRnor6.0
Rnor_5.05158,016,579 - 158,018,189UniSTSRnor5.0
RGSC_v3.45154,685,273 - 154,686,883UniSTSRGSC3.4
Celera5146,542,955 - 146,544,565UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:495964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,149,222 - 148,149,430 (+)MAPPERmRatBN7.2
Rnor_6.05154,265,801 - 154,266,008NCBIRnor6.0
Rnor_5.05158,030,564 - 158,030,771UniSTSRnor5.0
RGSC_v3.45154,700,227 - 154,700,434UniSTSRGSC3.4
Celera5146,556,579 - 146,556,786UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010066464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF176350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF218846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF286721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF286722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ694960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ694961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN420349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX494784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012342   ⟹   ENSRNOP00000012342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,148,519 - 148,151,548 (+)Ensembl
Rnor_6.0 Ensembl5154,265,097 - 154,268,126 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074998   ⟹   ENSRNOP00000066697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,143,482 - 148,151,548 (+)Ensembl
Rnor_6.0 Ensembl5154,260,062 - 154,268,124 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114527   ⟹   ENSRNOP00000078684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,125,629 - 148,151,548 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119033   ⟹   ENSRNOP00000088855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,125,604 - 148,149,605 (+)Ensembl
RefSeq Acc Id: NM_001164142   ⟹   NP_001157614
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,427,032 - 153,435,092 (+)NCBI
mRatBN7.25148,143,482 - 148,151,548 (+)NCBI
Rnor_6.05154,260,062 - 154,268,126 (+)NCBI
Rnor_5.05158,006,539 - 158,032,977 (+)NCBI
RGSC_v3.45154,674,754 - 154,702,552 (+)RGD
Celera5146,550,845 - 146,558,688 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001164143   ⟹   NP_001157615
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,409,184 - 153,435,092 (+)NCBI
mRatBN7.25148,125,629 - 148,151,548 (+)NCBI
Rnor_6.05154,242,214 - 154,268,126 (+)NCBI
Rnor_5.05158,006,539 - 158,032,977 (+)NCBI
RGSC_v3.45154,674,754 - 154,702,552 (+)RGD
Celera5146,533,227 - 146,558,688 (+)RGD
Sequence:
RefSeq Acc Id: NM_020543   ⟹   NP_065418
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,432,063 - 153,435,092 (+)NCBI
mRatBN7.25148,148,519 - 148,151,548 (+)NCBI
Rnor_6.05154,265,097 - 154,268,126 (+)NCBI
Rnor_5.05158,006,539 - 158,032,977 (+)NCBI
RGSC_v3.45154,674,754 - 154,702,552 (+)RGD
Celera5146,555,875 - 146,558,688 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110690   ⟹   XP_038966618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,426,532 - 153,435,092 (+)NCBI
mRatBN7.25148,142,951 - 148,151,053 (+)NCBI
RefSeq Acc Id: XM_063288329   ⟹   XP_063144399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,408,968 - 153,435,092 (+)NCBI
RefSeq Acc Id: XM_063288330   ⟹   XP_063144400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,408,968 - 153,435,092 (+)NCBI
RefSeq Acc Id: XR_010066464
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,426,537 - 153,435,092 (+)NCBI
RefSeq Acc Id: NP_065418   ⟸   NM_020543
- Peptide Label: isoform 2
- UniProtKB: A6IT74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157615   ⟸   NM_001164143
- Peptide Label: isoform 1
- UniProtKB: Q9EP74 (UniProtKB/Swiss-Prot),   Q9QZN9 (UniProtKB/Swiss-Prot),   C6G964 (UniProtKB/TrEMBL),   C6G965 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157614   ⟸   NM_001164142
- Peptide Label: isoform 1
- UniProtKB: Q9EP74 (UniProtKB/Swiss-Prot),   Q9QZN9 (UniProtKB/Swiss-Prot),   C6G964 (UniProtKB/TrEMBL),   C6G965 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012342   ⟸   ENSRNOT00000012342
Ensembl Acc Id: ENSRNOP00000066697   ⟸   ENSRNOT00000074998
RefSeq Acc Id: XP_038966618   ⟸   XM_039110690
- Peptide Label: isoform X2
- UniProtKB: A6IT74 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088855   ⟸   ENSRNOT00000119033
Ensembl Acc Id: ENSRNOP00000078684   ⟸   ENSRNOT00000114527
RefSeq Acc Id: XP_063144400   ⟸   XM_063288330
- Peptide Label: isoform X1
- UniProtKB: Q9QZN9 (UniProtKB/Swiss-Prot),   Q9EP74 (UniProtKB/Swiss-Prot),   C6G964 (UniProtKB/TrEMBL),   C6G965 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144399   ⟸   XM_063288329
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZN9-F1-model_v2 AlphaFold Q9QZN9 1-360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694160
Promoter ID:EPDNEW_R4684
Type:single initiation site
Name:Cnr2_1
Description:cannabinoid receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05154,260,074 - 154,260,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619713 AgrOrtholog
BioCyc Gene G2FUF-39525 BioCyc
Ensembl Genes ENSRNOG00000009260 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012342.5 UniProtKB/Swiss-Prot
  ENSRNOT00000074998.3 UniProtKB/Swiss-Prot
  ENSRNOT00000114527.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119033.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Canbinoid_rcpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cnbnoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 57302 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22750:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CNR2 RGD
PhenoGen Cnr2 PhenoGen
PRINTS CANABINOID2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CANNABINOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009260 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IT74 ENTREZGENE, UniProtKB/TrEMBL
  C6G964 ENTREZGENE, UniProtKB/TrEMBL
  C6G965 ENTREZGENE, UniProtKB/TrEMBL
  CNR2_RAT UniProtKB/Swiss-Prot
  Q9EP74 ENTREZGENE
  Q9QZN9 ENTREZGENE
UniProt Secondary Q9EP74 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Cnr2  cannabinoid receptor 2  Cnr2  cannabinoid receptor 2 (macrophage)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-24 Cnr2  cannabinoid receptor 2 (macrophage)  Cnr2  cannabinoid receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-01 Cnr2  cannabinoid receptor 2  Cnr2  cannabinoid receptor 2 (macrophage)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cnr2  cannabinoid receptor 2 (macrophage)    cannabinoid receptor 2 gene  Name updated 1299863 APPROVED
2002-08-07 Cnr2  cannabinoid receptor 2 gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in activated peritoneal macrophages and microglia in brain cortex 632457
gene_homology has high homology to mouse and human homologs except for divergence in the carboxy terminal region, which is involved in regulation of receptor desensitization 632455
gene_homology aa sequence shares 93% identity with mouse Cnr2 and 81% with human CNR2 632458
gene_physical_interaction binds to adenylate cyclase 632458
gene_process may modulate nitrous oxide (NO) levels in CNS neurons 632454
gene_process may be involved with nociceptive pain and/or inflammatory hypersensitivity 632456
gene_process may be involved with nociceptive pain and/or inflammatory hypersensitivity 1299243
gene_process activates mitogen-activated protein (MAP) kinase 632455
gene_protein predicted protein contains 410 aa residues 632455
gene_regulation expression levels are modulated by cellular activation state 632457
gene_transcript contains 3 exons interrupted by 2 introns 632455