Txnrd2 (thioredoxin reductase 2) - Rat Genome Database

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Gene: Txnrd2 (thioredoxin reductase 2) Rattus norvegicus
Analyze
Symbol: Txnrd2
Name: thioredoxin reductase 2
RGD ID: 61960
Description: Enables protein homodimerization activity and thioredoxin-disulfide reductase (NADPH) activity. Involved in response to hyperoxia; response to selenium ion; and response to xenobiotic stimulus. Located in several cellular components, including dendrite; mitochondrion; and neuronal cell body. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human TXNRD2 (thioredoxin reductase 2); PARTICIPATES IN pyrimidine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC93435; thioredoxin reductase 2, mitochondrial; thioredoxin reductase TR3; Tr3; Trxr2; Trxrd2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,024,321 - 96,072,475 (-)NCBIGRCr8
mRatBN7.21182,519,996 - 82,568,156 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,519,999 - 82,568,156 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,248,515 - 91,296,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,909,738 - 83,957,780 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,963,250 - 83,011,292 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,667,994 - 86,716,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,667,997 - 86,716,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,762,304 - 89,809,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,513,361 - 84,561,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,553,962 - 84,602,292 (-)NCBI
Celera1181,297,140 - 81,345,203 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(E)-cinnamyl alcohol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
abexinostat  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
auranofin  (EXP,ISO)
Aurothioglucose  (ISO)
avobenzone  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium sulfide  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
deguelin  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dithionitrobenzoic acid  (ISO)
elemental selenium  (EXP,ISO)
eugenol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
folpet  (ISO)
furan  (EXP)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
juglone  (ISO)
L-ascorbic acid  (EXP)
lipoamide  (ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
mechlorethamine  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metam  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel sulfate  (ISO)
obeticholic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
potassium tellurite  (ISO)
propiconazole  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sodium aurothiomalate  (EXP)
sodium dichromate  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thallium  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (IBA)
cytosol  (IBA,IEA,ISO)
dendrite  (IDA)
mitochondrion  (IBA,IDA,IEA,ISO)
neuronal cell body  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. Jeong W, etal., J Biol Chem. 2004 Jan 30;279(5):3142-50. Epub 2003 Nov 7.
4. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver. Lee SR, etal., J Biol Chem 1999 Feb 19;274(8):4722-34.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Hyperbaric oxygen preconditioning ameliorates anxiety-like behavior and cognitive impairments via upregulation of thioredoxin reductases in stressed rats. Peng Y, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1018-25. Epub 2010 May 19.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Selenium deficiency as a model of experimental pre-eclampsia in rats. Vanderlelie J, etal., Reproduction. 2004 Nov;128(5):635-41.
15. Effects of dietary selenium on post-ischemic expression of antioxidant mRNA. Venardos K, etal., Mol Cell Biochem. 2005 Feb;270(1-2):131-8.
16. [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. Zhao XQ, etal., Sheng Li Xue Bao. 2010 Jun 25;62(3):261-8.
17. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Zhu XL, etal., Neurosci Lett. 2009 Jan 2;449(1):24-7. Epub 2008 Sep 6.
Additional References at PubMed
PMID:10215850   PMID:10721726   PMID:11060283   PMID:12477932   PMID:15485910   PMID:15489334   PMID:16774913   PMID:17291446   PMID:17707404   PMID:18775783   PMID:20126492   PMID:23226354  
PMID:23613536   PMID:24601690   PMID:25055978   PMID:26674287   PMID:38513765  


Genomics

Comparative Map Data
Txnrd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,024,321 - 96,072,475 (-)NCBIGRCr8
mRatBN7.21182,519,996 - 82,568,156 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,519,999 - 82,568,156 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,248,515 - 91,296,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,909,738 - 83,957,780 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,963,250 - 83,011,292 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,667,994 - 86,716,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,667,997 - 86,716,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,762,304 - 89,809,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,513,361 - 84,561,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,553,962 - 84,602,292 (-)NCBI
Celera1181,297,140 - 81,345,203 (-)NCBICelera
Cytogenetic Map11q23NCBI
TXNRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,875,522 - 19,941,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,875,517 - 19,941,820 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,863,045 - 19,929,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,243,040 - 18,309,359 (-)NCBINCBI36Build 36hg18NCBI36
Celera223,715,110 - 3,780,635 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,482,976 - 3,549,921 (-)NCBIHuRef
CHM1_12219,862,754 - 19,929,123 (-)NCBICHM1_1
T2T-CHM13v2.02220,252,392 - 20,319,509 (-)NCBIT2T-CHM13v2.0
Txnrd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,245,167 - 18,297,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,245,134 - 18,297,823 (+)EnsemblGRCm39 Ensembl
GRCm381618,426,417 - 18,479,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,426,384 - 18,479,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,426,510 - 18,479,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,339,980 - 18,392,633 (+)NCBIMGSCv36mm8
Celera1619,000,768 - 19,053,648 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.41NCBI
Txnrd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,150,060 - 18,205,775 (+)NCBIChiLan1.0ChiLan1.0
TXNRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,502,482 - 29,570,007 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,050,064 - 32,117,323 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,636,703 - 2,704,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12218,310,134 - 18,375,681 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,311,714 - 18,375,497 (-)Ensemblpanpan1.1panPan2
TXNRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,381,823 - 29,430,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,381,975 - 29,430,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,338,309 - 29,387,889 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,783,348 - 30,833,188 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,783,323 - 30,833,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,831,592 - 28,881,196 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,456,722 - 28,506,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,542,394 - 29,592,091 (+)NCBIUU_Cfam_GSD_1.0
Txnrd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,906,728 - 138,964,122 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,791,418 - 3,847,626 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,789,940 - 3,847,286 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,356,831 - 51,383,262 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,355,731 - 51,385,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,992,386 - 55,021,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXNRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,803,178 - 5,868,224 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,813,099 - 5,866,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,062,817 - 1,128,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnrd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747514,158 - 569,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747485,012 - 569,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Txnrd2
381 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:128
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000002593
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118256654583440803Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
D11Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,553 - 82,566,702 (+)MAPPERmRatBN7.2
Rnor_6.01186,714,483 - 86,714,631NCBIRnor6.0
Rnor_5.01189,808,355 - 89,808,503UniSTSRnor5.0
RGSC_v3.41184,560,092 - 84,560,241RGDRGSC3.4
RGSC_v3.41184,560,093 - 84,560,241UniSTSRGSC3.4
RGSC_v3.11184,600,689 - 84,600,838RGD
Celera1181,343,623 - 81,343,771UniSTS
SHRSP x BN Map1138.1899UniSTS
SHRSP x BN Map1138.1899RGD
FHH x ACI Map1157.2499RGD
Cytogenetic Map11q23UniSTS
D11Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,545 - 82,566,718 (+)MAPPERmRatBN7.2
Rnor_6.01186,714,475 - 86,714,647NCBIRnor6.0
Rnor_5.01189,808,347 - 89,808,519UniSTSRnor5.0
RGSC_v3.41184,560,085 - 84,560,257UniSTSRGSC3.4
Celera1181,343,615 - 81,343,787UniSTS
Cytogenetic Map11q23UniSTS
RH128918  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,520,015 - 82,520,197 (+)MAPPERmRatBN7.2
Rnor_6.01186,668,014 - 86,668,195NCBIRnor6.0
Rnor_5.01189,762,324 - 89,762,505UniSTSRnor5.0
RGSC_v3.41184,513,381 - 84,513,562UniSTSRGSC3.4
Celera1181,297,160 - 81,297,341UniSTS
RH 3.4 Map11700.2UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002593   ⟹   ENSRNOP00000002593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,519,999 - 82,568,156 (-)Ensembl
Rnor_6.0 Ensembl1186,667,997 - 86,716,063 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081972   ⟹   ENSRNOP00000073776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1186,669,069 - 86,716,254 (-)Ensembl
RefSeq Acc Id: NM_022584   ⟹   NP_072106
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,024,321 - 96,072,475 (-)NCBI
mRatBN7.21182,519,996 - 82,568,156 (-)NCBI
Rnor_6.01186,667,994 - 86,716,063 (-)NCBI
Rnor_5.01189,762,304 - 89,809,935 (-)NCBI
RGSC_v3.41184,513,361 - 84,561,673 (-)RGD
Celera1181,297,140 - 81,345,203 (-)RGD
Sequence:
RefSeq Acc Id: NP_072106   ⟸   NM_022584
- Peptide Label: precursor
- UniProtKB: Q9Z0J5 (UniProtKB/Swiss-Prot),   A6JSG3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002593   ⟸   ENSRNOT00000002593
Ensembl Acc Id: ENSRNOP00000073776   ⟸   ENSRNOT00000081972
Protein Domains
FAD/NAD(P)-binding   Pyridine nucleotide-disulphide oxidoreductase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698303
Promoter ID:EPDNEW_R8828
Type:multiple initiation site
Name:Txnrd2_1
Description:thioredoxin reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,716,079 - 86,716,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61960 AgrOrtholog
BioCyc Gene G2FUF-20661 BioCyc
BioCyc Pathway THIOREDOX-PWY [thioredoxin pathway] BioCyc
BioCyc Pathway Image THIOREDOX-PWY BioCyc
Ensembl Genes ENSRNOG00000001890 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003511 UniProtKB/Swiss-Prot
  ENSRNOG00060012649 UniProtKB/Swiss-Prot
  ENSRNOG00065008228 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002593 UniProtKB/TrEMBL
  ENSRNOT00000002593.8 UniProtKB/Swiss-Prot
  ENSRNOT00055005458 UniProtKB/Swiss-Prot
  ENSRNOT00060021499 UniProtKB/Swiss-Prot
  ENSRNOT00065013043 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.390.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191992 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GSHR/TRXR-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nuc-diS_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_FAD/NAD UniProtKB/Swiss-Prot
  Pyr_OxRdtase_I_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin/glutathione_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50551 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93435 IMAGE-MGC_LOAD
NCBI Gene 50551 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN REDUCTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Txnrd2 PhenoGen
PIRSF Mercury_reductase_MerA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FADPNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PYRIDINE_REDOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001890 RatGTEx
  ENSRNOG00055003511 RatGTEx
  ENSRNOG00060012649 RatGTEx
  ENSRNOG00065008228 RatGTEx
Superfamily-SCOP FAD/NAD-linked_reductase_dimer UniProtKB/Swiss-Prot
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55424 UniProtKB/TrEMBL
TIGR TC219719
UniProt A6JSG3 ENTREZGENE, UniProtKB/TrEMBL
  A6JSG4_RAT UniProtKB/TrEMBL
  F1M6X5_RAT UniProtKB/TrEMBL
  Q9Z0J5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Txnrd2  thioredoxin reductase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization specifically expressed in mitochondria 61776
gene_expression enriched in liver, kidney, adrenal gland, and heart 61776
gene_protein 526 amino acids; dimeric enzyme containing selenocysteine (Secys) as the COOH-terminal penultimate residue 61776