SLC22A6 (solute carrier family 22 member 6) - Rat Genome Database

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Gene: SLC22A6 (solute carrier family 22 member 6) Homo sapiens
Analyze
Symbol: SLC22A6
Name: solute carrier family 22 member 6
RGD ID: 619572
HGNC Page HGNC:10970
Description: Enables several functions, including alpha-ketoglutarate transmembrane transporter activity; prostaglandin transmembrane transporter activity; and secondary active transmembrane transporter activity. Involved in carboxylic acid transport; renal tubular secretion; and sodium-independent organic anion transport. Located in basolateral plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ55736; HOAT1; hPAHT; hROAT1; MGC45260; OAT1; organic anion transporter 1; PAH transporter; PAHT; para-aminohippurate transporter; renal organic anion transporter 1; ROAT1; solute carrier family 22 (organic anion transporter), member 6; solute carrier family 22, member 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,976,597 - 62,984,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,936,385 - 62,984,967 (-)Ensemblhg38GRCh38
GRCh371162,744,069 - 62,752,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,500,645 - 62,509,045 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341162,500,645 - 62,509,045NCBI
Celera1160,068,114 - 60,076,514 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,073,118 - 59,081,543 (-)NCBIHuRef
CHM1_11162,626,827 - 62,635,253 (-)NCBICHM1_1
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
calcinosis  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-D  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-azaorotic acid  (ISO)
5-formyltetrahydrofolic acid  (EXP,ISO)
6-carboxyfluorescein  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
9-[2-(phosphonomethoxy)ethyl]guanine  (EXP)
acetylsalicylic acid  (EXP)
adefovir  (EXP,ISO)
adipic acid  (EXP)
aflatoxin B1  (EXP)
allopurinol  (ISO)
amitriptyline  (EXP)
ammonium chloride  (ISO)
angelicin  (ISO)
aristolochic acid A  (EXP)
aristolochic acids  (EXP,ISO)
aurantio-obtusin  (EXP)
bacitracin  (ISO)
baicalein  (EXP)
bendroflumethiazide  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP)
benzylpenicillin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromosulfophthalein  (EXP)
cadmium dichloride  (EXP,ISO)
cefaclor  (EXP)
cefaloridine  (EXP,ISO)
cefdinir  (EXP)
cefoselis sulfate  (EXP)
cefotiam  (EXP)
ceftibuten  (EXP)
ceftizoxime  (EXP)
chlorpyrifos-methyl  (EXP)
chrysophanol  (EXP)
cidofovir anhydrous  (EXP)
ciguatoxin CTX1B  (ISO)
cimetidine  (EXP)
cisplatin  (EXP,ISO)
clothianidin  (EXP)
cyazofamid  (EXP)
D-gluconic acid  (EXP)
diazepam  (EXP)
diclofenac  (EXP)
diethyl hydrogen phosphate  (ISO)
diiodine  (ISO)
disodium cromoglycate  (ISO)
doxycycline  (EXP)
emodin  (EXP)
estrone 3-sulfate  (EXP)
eugenol  (ISO)
fenitrothion  (EXP)
fluorescein (lactone form)  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
furosemide  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glutaric acid  (EXP)
glutathione  (EXP)
glycidol  (ISO)
GW 4064  (ISO)
herbicide  (ISO)
hydrochlorothiazide  (ISO)
hypoxanthine  (ISO)
ibuprofen  (EXP)
icariin  (ISO)
imperatorin  (ISO)
indometacin  (EXP)
isoimperatorin  (ISO)
ketoprofen  (EXP)
linoleic acid  (EXP)
luteolin  (EXP)
malathion  (EXP)
mefenamic acid  (EXP)
Mercuric oxide  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (ISO)
mercury(0)  (EXP,ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylmercury chloride  (ISO)
mianserin  (EXP)
minocycline  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naproxen  (EXP)
Nonylphenol  (ISO)
Obtusifolin  (EXP)
ochratoxin A  (EXP,ISO)
octanoic acid  (ISO)
oroxylin A  (EXP)
oxytetracycline  (EXP)
p-aminohippuric acid  (EXP,ISO)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (ISO)
perfluoroheptanoic acid  (EXP,ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
prostaglandin E2  (ISO)
purines  (ISO)
pyrazine-2-carboxylic acid  (EXP)
quercetin  (EXP,ISO)
quercetin 3-sulfate  (EXP)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
Rhein  (EXP)
riddelliine  (ISO)
rutin  (ISO)
salicylates  (EXP)
salicylic acid  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium hydrogencarbonate  (ISO)
streptozocin  (ISO)
succinic acid  (EXP)
sulindac  (EXP)
taurocholic acid  (EXP)
tenofovir disoproxil fumarate  (EXP)
testosterone  (ISO)
tetracycline  (EXP)
thiram  (EXP)
trans-piceid  (ISO)
traumatic acid  (EXP,ISO)
triazolam  (EXP)
umbelliferone  (EXP)
valsartan  (ISO)
vancomycin  (ISO)
wedelolactone  (EXP)
wogonin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Expression cloning and characterization of a novel multispecific organic anion transporter. Sekine T, etal., J Biol Chem 1997 Jul 25;272(30):18526-9.
Additional References at PubMed
PMID:9762842   PMID:9887087   PMID:9950961   PMID:10049739   PMID:10462545   PMID:10964714   PMID:11855680   PMID:11907186   PMID:12429554   PMID:12472777   PMID:12477932   PMID:12874449  
PMID:14644751   PMID:14675047   PMID:14702039   PMID:14749323   PMID:14984259   PMID:15037815   PMID:15039295   PMID:15145940   PMID:15200431   PMID:15284288   PMID:15864112   PMID:15914676  
PMID:16024787   PMID:16046403   PMID:16164645   PMID:16189514   PMID:16344560   PMID:16648942   PMID:16920720   PMID:17038320   PMID:17344191   PMID:17353191   PMID:17502342   PMID:17585018  
PMID:18365245   PMID:18818201   PMID:19034961   PMID:19056867   PMID:19060904   PMID:19082692   PMID:19088254   PMID:19308960   PMID:19343046   PMID:19400747   PMID:19403644   PMID:19854166  
PMID:19892921   PMID:21164499   PMID:21832049   PMID:21865262   PMID:21873635   PMID:21945944   PMID:22108572   PMID:22169006   PMID:23255614   PMID:23376485   PMID:23630107   PMID:23640180  
PMID:23832370   PMID:24185403   PMID:24530383   PMID:25234312   PMID:25354943   PMID:26377792   PMID:26823285   PMID:27053689   PMID:27226107   PMID:28371506   PMID:28472795   PMID:28514442  
PMID:28534121   PMID:28572241   PMID:29273507   PMID:29285751   PMID:29422382   PMID:29795395   PMID:30653465   PMID:31691080   PMID:31724834   PMID:32100958   PMID:32818533   PMID:33961781  
PMID:35307651   PMID:35406626   PMID:36316339   PMID:36692015   PMID:40355756  


Genomics

Comparative Map Data
SLC22A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,976,597 - 62,984,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,936,385 - 62,984,967 (-)Ensemblhg38GRCh38
GRCh371162,744,069 - 62,752,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,500,645 - 62,509,045 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341162,500,645 - 62,509,045NCBI
Celera1160,068,114 - 60,076,514 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,073,118 - 59,081,543 (-)NCBIHuRef
CHM1_11162,626,827 - 62,635,253 (-)NCBICHM1_1
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBIT2T-CHM13v2.0
Slc22a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39198,595,360 - 8,605,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl198,595,403 - 8,605,663 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38198,617,996 - 8,628,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl198,618,039 - 8,628,299 (+)Ensemblmm10GRCm38
MGSCv37198,692,486 - 8,702,789 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36198,685,086 - 8,693,568 (+)NCBIMGSCv36mm8
Celera198,376,155 - 8,386,458 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.44NCBI
Slc22a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,951,493 - 214,960,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1214,951,867 - 214,960,311 (+)EnsemblGRCr8
mRatBN7.21205,522,579 - 205,531,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1213,928,527 - 213,936,740 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,966,506 - 220,974,728 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01213,659,221 - 213,667,443 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,824,809 - 224,833,284 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)Ensemblrn6Rnor6.0
Rnor_5.01231,761,600 - 231,772,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41211,294,178 - 211,302,398 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1203,036,078 - 203,044,298 (+)NCBICelera
RGSC_v3.11211,452,399 - 211,460,822 (+)NCBI
Cytogenetic Map1q43NCBI
Slc22a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599301,981 - 311,447 (+)Ensembl
ChiLan1.0NW_004955599302,026 - 307,503 (+)NCBIChiLan1.0ChiLan1.0
SLC22A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2964,198,167 - 64,206,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11165,243,334 - 65,251,869 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,328,476 - 58,336,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,680,016 - 61,688,223 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,680,016 - 61,688,223 (-)EnsemblpanPan2panpan1.1
SLC22A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,736,669 - 53,745,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,736,959 - 53,744,396 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1852,342,543 - 52,350,303 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01854,782,055 - 54,789,820 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,782,215 - 54,790,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,884,029 - 53,891,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,458,362 - 53,466,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,245,739 - 54,253,490 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc22a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,235,014 - 10,242,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581349,057 - 356,059 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936581348,719 - 356,246 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,802,349 - 8,817,337 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.128,809,547 - 8,817,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,152,459 - 8,160,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,918,081 - 10,926,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,918,770 - 10,925,983 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038108,270,857 - 108,278,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,363,431 - 1,368,534 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249261,363,322 - 1,368,768 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc22a6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v129,305,144 - 9,313,284 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in SLC22A6
59 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q12.3(chr11:62433886-63096003)x3 copy number gain See cases [RCV000053620] Chr11:62433886..63096003 [GRCh38]
Chr11:62201358..62863475 [GRCh37]
Chr11:61957934..62620051 [NCBI36]
Chr11:11q12.3		 pathogenic
NM_004790.4(SLC22A6):c.794C>T (p.Ser265Phe) single nucleotide variant Malignant melanoma [RCV000069573] Chr11:62981845 [GRCh38]
Chr11:62749317 [GRCh37]
Chr11:62505893 [NCBI36]
Chr11:11q12.3		 not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11q12.3-13.1(chr11:62893226-64335043)x1 copy number loss See cases [RCV000140879] Chr11:62893226..64335043 [GRCh38]
Chr11:62660698..64102515 [GRCh37]
Chr11:62417274..63859091 [NCBI36]
Chr11:11q12.3-13.1		 likely pathogenic
GRCh37/hg19 11q12.3(chr11:61840997-62987330)x1 copy number loss See cases [RCV000448355] Chr11:61840997..62987330 [GRCh37]
Chr11:11q12.3		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_153276.3(SLC22A6):c.620T>A (p.Met207Lys) single nucleotide variant not specified [RCV004311267] Chr11:62983545 [GRCh38]
Chr11:62751017 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_153276.3(SLC22A6):c.1470C>T (p.Tyr490=) single nucleotide variant not provided [RCV000965839] Chr11:62977279 [GRCh38]
Chr11:62744751 [GRCh37]
Chr11:11q12.3		 benign
GRCh37/hg19 11q12.3(chr11:62314663-62788240)x3 copy number gain not provided [RCV000849841] Chr11:62314663..62788240 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11q12.3(chr11:62487052-62788240)x3 copy number gain not provided [RCV000846292] Chr11:62487052..62788240 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1428C>A (p.Ser476Arg) single nucleotide variant not specified [RCV004305171] Chr11:62977321 [GRCh38]
Chr11:62744793 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1454T>C (p.Met485Thr) single nucleotide variant not specified [RCV004326641] Chr11:62977295 [GRCh38]
Chr11:62744767 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11q12.3(chr11:62714816-63383226)x3 copy number gain not provided [RCV001260131] Chr11:62714816..63383226 [GRCh37]
Chr11:11q12.3		 uncertain significance
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
GRCh37/hg19 11q12.3(chr11:62670903-62820292) copy number loss not specified [RCV002052929] Chr11:62670903..62820292 [GRCh37]
Chr11:11q12.3		 uncertain significance
NC_000011.9:g.(?_58916346)_(64972349_?)dup duplication Leukocyte adhesion deficiency 3 [RCV003113394]|not provided [RCV003113393] Chr11:58916346..64972349 [GRCh37]
Chr11:11q12.1-13.1		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_153276.3(SLC22A6):c.44G>A (p.Arg15His) single nucleotide variant not specified [RCV004329826] Chr11:62984647 [GRCh38]
Chr11:62752119 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1360C>T (p.Arg454Trp) single nucleotide variant not specified [RCV004100851] Chr11:62979489 [GRCh38]
Chr11:62746961 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1147C>T (p.Leu383Phe) single nucleotide variant not specified [RCV004127724] Chr11:62979839 [GRCh38]
Chr11:62747311 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.569C>T (p.Ala190Val) single nucleotide variant not specified [RCV004121315] Chr11:62983596 [GRCh38]
Chr11:62751068 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.700C>G (p.Gln234Glu) single nucleotide variant not specified [RCV004100242] Chr11:62981939 [GRCh38]
Chr11:62749411 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.929G>A (p.Arg310Gln) single nucleotide variant not specified [RCV004090720] Chr11:62981093 [GRCh38]
Chr11:62748565 [GRCh37]
Chr11:11q12.3		 likely benign
NM_153276.3(SLC22A6):c.449T>C (p.Met150Thr) single nucleotide variant not specified [RCV004172720] Chr11:62983968 [GRCh38]
Chr11:62751440 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.319G>A (p.Asp107Asn) single nucleotide variant not specified [RCV004091665] Chr11:62984372 [GRCh38]
Chr11:62751844 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.893G>A (p.Arg298Gln) single nucleotide variant not specified [RCV004231776] Chr11:62981288 [GRCh38]
Chr11:62748760 [GRCh37]
Chr11:11q12.3		 likely benign
NM_153276.3(SLC22A6):c.164C>T (p.Ala55Val) single nucleotide variant not specified [RCV004127358] Chr11:62984527 [GRCh38]
Chr11:62751999 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1438G>A (p.Glu480Lys) single nucleotide variant not specified [RCV004078620] Chr11:62977311 [GRCh38]
Chr11:62744783 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.185G>C (p.Gly62Ala) single nucleotide variant not specified [RCV004263685] Chr11:62984506 [GRCh38]
Chr11:62751978 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.858G>T (p.Arg286Ser) single nucleotide variant not specified [RCV004270003] Chr11:62981323 [GRCh38]
Chr11:62748795 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.664G>A (p.Val222Met) single nucleotide variant not specified [RCV004275292] Chr11:62981975 [GRCh38]
Chr11:62749447 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.785T>C (p.Phe262Ser) single nucleotide variant not specified [RCV004346991] Chr11:62981854 [GRCh38]
Chr11:62749326 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1099A>C (p.Ile367Leu) single nucleotide variant not specified [RCV004346124] Chr11:62979887 [GRCh38]
Chr11:62747359 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1431G>A (p.Met477Ile) single nucleotide variant not specified [RCV004354581] Chr11:62977318 [GRCh38]
Chr11:62744790 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3 copy number gain not specified [RCV003986944] Chr11:56895955..69295402 [GRCh37]
Chr11:11q12.1-13.3		 likely pathogenic
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
NM_153276.3(SLC22A6):c.1392G>T (p.Met464Ile) single nucleotide variant not specified [RCV004451337] Chr11:62977357 [GRCh38]
Chr11:62744829 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.640A>T (p.Met214Leu) single nucleotide variant not specified [RCV004451341] Chr11:62981999 [GRCh38]
Chr11:62749471 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1456C>A (p.Pro486Thr) single nucleotide variant not specified [RCV004451339] Chr11:62977293 [GRCh38]
Chr11:62744765 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.239G>A (p.Arg80His) single nucleotide variant not specified [RCV004451340] Chr11:62984452 [GRCh38]
Chr11:62751924 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.254A>C (p.Gln85Pro) single nucleotide variant not specified [RCV004672255] Chr11:62984437 [GRCh38]
Chr11:62751909 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1247C>A (p.Pro416His) single nucleotide variant not specified [RCV004672256] Chr11:62979739 [GRCh38]
Chr11:62747211 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.485G>A (p.Arg162Gln) single nucleotide variant not specified [RCV004672257] Chr11:62983680 [GRCh38]
Chr11:62751152 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.375C>A (p.Asp125Glu) single nucleotide variant not specified [RCV004672258] Chr11:62984042 [GRCh38]
Chr11:62751514 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.665T>G (p.Val222Gly) single nucleotide variant not specified [RCV004672259] Chr11:62981974 [GRCh38]
Chr11:62749446 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1552G>A (p.Asp518Asn) single nucleotide variant not specified [RCV004672260] Chr11:62977197 [GRCh38]
Chr11:62744669 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.206G>A (p.Arg69Gln) single nucleotide variant not specified [RCV004676592] Chr11:62984485 [GRCh38]
Chr11:62751957 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1183C>T (p.Arg395Trp) single nucleotide variant not specified [RCV004676593] Chr11:62979803 [GRCh38]
Chr11:62747275 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1495G>T (p.Ala499Ser) single nucleotide variant not specified [RCV004859708] Chr11:62977254 [GRCh38]
Chr11:62744726 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.251C>T (p.Pro84Leu) single nucleotide variant not specified [RCV004859712] Chr11:62984440 [GRCh38]
Chr11:62751912 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.958G>A (p.Gly320Ser) single nucleotide variant not specified [RCV004859717] Chr11:62981064 [GRCh38]
Chr11:62748536 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.719T>G (p.Val240Gly) single nucleotide variant not specified [RCV004859718] Chr11:62981920 [GRCh38]
Chr11:62749392 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.4G>T (p.Ala2Ser) single nucleotide variant not specified [RCV004859702] Chr11:62984687 [GRCh38]
Chr11:62752159 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.892C>T (p.Arg298Trp) single nucleotide variant not specified [RCV004859705] Chr11:62981289 [GRCh38]
Chr11:62748761 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1628C>T (p.Ser543Leu) single nucleotide variant not specified [RCV004859709] Chr11:62976819 [GRCh38]
Chr11:62744291 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.802T>C (p.Phe268Leu) single nucleotide variant not specified [RCV004859706] Chr11:62981379 [GRCh38]
Chr11:62748851 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1488C>T (p.Ala496=) single nucleotide variant not specified [RCV004859707] Chr11:62977261 [GRCh38]
Chr11:62744733 [GRCh37]
Chr11:11q12.3		 likely benign
NM_153276.3(SLC22A6):c.1130T>C (p.Val377Ala) single nucleotide variant not specified [RCV004859710] Chr11:62979856 [GRCh38]
Chr11:62747328 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.584C>T (p.Ser195Leu) single nucleotide variant not specified [RCV004859711] Chr11:62983581 [GRCh38]
Chr11:62751053 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1082A>C (p.Gln361Pro) single nucleotide variant not specified [RCV004859713] Chr11:62979904 [GRCh38]
Chr11:62747376 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1408A>G (p.Ile470Val) single nucleotide variant not specified [RCV004859714] Chr11:62977341 [GRCh38]
Chr11:62744813 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1315A>T (p.Asn439Tyr) single nucleotide variant not specified [RCV004859716] Chr11:62979534 [GRCh38]
Chr11:62747006 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1009C>T (p.His337Tyr) single nucleotide variant not specified [RCV004859703] Chr11:62981013 [GRCh38]
Chr11:62748485 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.725A>T (p.Tyr242Phe) single nucleotide variant not specified [RCV004859719] Chr11:62981914 [GRCh38]
Chr11:62749386 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.727G>T (p.Ala243Ser) single nucleotide variant not specified [RCV005268512] Chr11:62981912 [GRCh38]
Chr11:62749384 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.878G>A (p.Arg293Gln) single nucleotide variant not specified [RCV005282034] Chr11:62981303 [GRCh38]
Chr11:62748775 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1069G>C (p.Val357Leu) single nucleotide variant not specified [RCV005282038] Chr11:62979917 [GRCh38]
Chr11:62747389 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1354A>G (p.Met452Val) single nucleotide variant not specified [RCV005282039] Chr11:62979495 [GRCh38]
Chr11:62746967 [GRCh37]
Chr11:11q12.3		 likely benign
NM_153276.3(SLC22A6):c.1016T>G (p.Phe339Cys) single nucleotide variant not specified [RCV005282040] Chr11:62981006 [GRCh38]
Chr11:62748478 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1411G>A (p.Val471Met) single nucleotide variant not specified [RCV005282033] Chr11:62977338 [GRCh38]
Chr11:62744810 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1493G>C (p.Ser498Thr) single nucleotide variant not specified [RCV005282035] Chr11:62977256 [GRCh38]
Chr11:62744728 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_153276.3(SLC22A6):c.1184G>C (p.Arg395Pro) single nucleotide variant not specified [RCV005282037] Chr11:62979802 [GRCh38]
Chr11:62747274 [GRCh37]
Chr11:11q12.3		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1802
Count of miRNA genes:667
Interacting mature miRNAs:777
Transcripts:ENST00000360421, ENST00000377871, ENST00000421062, ENST00000458333, ENST00000537349, ENST00000540654
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357380BW64_HBody weight QTL 64 (human)2.2Body weightpercent fat after exercise training116097893786978937Human
628894191GWAS2802420_Hinsomnia QTL GWAS2802420 (human)5e-09sleep behavior trait (VT:0001501)116298220862982209Human
597264974GWAS1361048_Hinsomnia QTL GWAS1361048 (human)5e-09insomnia116298220862982209Human
407317103GWAS966079_Hinsomnia QTL GWAS966079 (human)5e-09insomnia116298220862982209Human

Markers in Region
RH78059  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371162,744,176 - 62,744,352UniSTSGRCh37
Build 361162,500,752 - 62,500,928RGDNCBI36
Celera1160,068,221 - 60,068,397RGD
Cytogenetic Map11q12.3UniSTS
HuRef1159,073,225 - 59,073,401UniSTS
GeneMap99-GB4 RH Map11230.54UniSTS
NCBI RH Map11563.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
509 945 1433 878 3743 716 796 165 496 101 983 2680 2335 3 3398 489 912 586 66 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB009697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB009698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF057039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF104038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF124373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI017670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ251529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA628191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA629600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB320467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU567146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000360421   ⟹   ENSP00000353597
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1162,976,597 - 62,984,967 (-)Ensembl
Ensembl Acc Id: ENST00000377871   ⟹   ENSP00000367102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1162,976,602 - 62,984,957 (-)Ensembl
Ensembl Acc Id: ENST00000421062   ⟹   ENSP00000404441
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1162,976,794 - 62,984,690 (-)Ensembl
Ensembl Acc Id: ENST00000458333   ⟹   ENSP00000396401
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1162,976,794 - 62,984,690 (-)Ensembl
Ensembl Acc Id: ENST00000537349
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1162,979,868 - 62,983,892 (-)Ensembl
Ensembl Acc Id: ENST00000540654   ⟹   ENSP00000445946
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1162,936,385 - 62,984,824 (-)Ensembl
Ensembl Acc Id: ENST00000856538   ⟹   ENSP00000526597
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1162,976,598 - 62,984,967 (-)Ensembl
RefSeq Acc Id: NM_004790   ⟹   NP_004781
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153276   ⟹   NP_695008
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153277   ⟹   NP_695009
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153278   ⟹   NP_695010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018562   ⟹   XP_016874051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054370531   ⟹   XP_054226506
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBI
Protein Sequences
Protein RefSeqs NP_004781 (Get FASTA)   NCBI Sequence Viewer  
  NP_695008 (Get FASTA)   NCBI Sequence Viewer  
  NP_695009 (Get FASTA)   NCBI Sequence Viewer  
  NP_695010 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874051 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226506 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC70004 (Get FASTA)   NCBI Sequence Viewer  
  AAD10052 (Get FASTA)   NCBI Sequence Viewer  
  AAD19356 (Get FASTA)   NCBI Sequence Viewer  
  AAD55356 (Get FASTA)   NCBI Sequence Viewer  
  AAH33682 (Get FASTA)   NCBI Sequence Viewer  
  ACB21049 (Get FASTA)   NCBI Sequence Viewer  
  BAA75072 (Get FASTA)   NCBI Sequence Viewer  
  BAA75073 (Get FASTA)   NCBI Sequence Viewer  
  BAG51569 (Get FASTA)   NCBI Sequence Viewer  
  BAG52435 (Get FASTA)   NCBI Sequence Viewer  
  BAG60612 (Get FASTA)   NCBI Sequence Viewer  
  CAB77184 (Get FASTA)   NCBI Sequence Viewer  
  CAB94830 (Get FASTA)   NCBI Sequence Viewer  
  CAB97249 (Get FASTA)   NCBI Sequence Viewer  
  EAW74129 (Get FASTA)   NCBI Sequence Viewer  
  EAW74130 (Get FASTA)   NCBI Sequence Viewer  
  EAW74131 (Get FASTA)   NCBI Sequence Viewer  
  EAW74132 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000353597
  ENSP00000353597.4
  ENSP00000367102
  ENSP00000367102.3
  ENSP00000396401
  ENSP00000396401.2
  ENSP00000404441
  ENSP00000404441.2
  ENSP00000526597
GenBank Protein Q4U2R8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_695009   ⟸   NM_153277
- Peptide Label: isoform c
- UniProtKB: B3KRM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_695010   ⟸   NM_153278
- Peptide Label: isoform d
- UniProtKB: B3KRM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_695008   ⟸   NM_153276
- Peptide Label: isoform b
- UniProtKB: B3KRM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_004781   ⟸   NM_004790
- Peptide Label: isoform a
- UniProtKB: Q9UBG6 (UniProtKB/Swiss-Prot),   Q9NQC2 (UniProtKB/Swiss-Prot),   Q9NQA6 (UniProtKB/Swiss-Prot),   Q8N192 (UniProtKB/Swiss-Prot),   Q7LDA0 (UniProtKB/Swiss-Prot),   O95742 (UniProtKB/Swiss-Prot),   O95187 (UniProtKB/Swiss-Prot),   B2D0R6 (UniProtKB/Swiss-Prot),   A8MY93 (UniProtKB/Swiss-Prot),   Q9UEQ8 (UniProtKB/Swiss-Prot),   Q4U2R8 (UniProtKB/Swiss-Prot),   B3KRM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016874051   ⟸   XM_017018562
- Peptide Label: isoform X1
- UniProtKB: B3KRM3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000353597   ⟸   ENST00000360421
Ensembl Acc Id: ENSP00000367102   ⟸   ENST00000377871
Ensembl Acc Id: ENSP00000396401   ⟸   ENST00000458333
Ensembl Acc Id: ENSP00000404441   ⟸   ENST00000421062
Ensembl Acc Id: ENSP00000445946   ⟸   ENST00000540654
RefSeq Acc Id: XP_054226506   ⟸   XM_054370531
- Peptide Label: isoform X1
- UniProtKB: B3KRM3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000526597   ⟸   ENST00000856538
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4U2R8-F1-model_v2 AlphaFold Q4U2R8 1-563 view protein structure

Promoters
RGD ID:7220749
Promoter ID:EPDNEW_H16120
Type:initiation region
Name:SLC22A6_1
Description:solute carrier family 22 member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16121  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,984,789 - 62,984,849EPDNEW
RGD ID:7220753
Promoter ID:EPDNEW_H16121
Type:multiple initiation site
Name:SLC22A6_2
Description:solute carrier family 22 member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16120  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,984,967 - 62,985,027EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10970 AgrOrtholog
COSMIC SLC22A6 COSMIC
Ensembl Genes ENSG00000197901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000360421 ENTREZGENE
  ENST00000360421.9 UniProtKB/Swiss-Prot
  ENST00000377871 ENTREZGENE
  ENST00000377871.7 UniProtKB/Swiss-Prot
  ENST00000421062 ENTREZGENE
  ENST00000421062.2 UniProtKB/Swiss-Prot
  ENST00000458333 ENTREZGENE
  ENST00000458333.6 UniProtKB/Swiss-Prot
  ENST00000856538 ENTREZGENE
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
GTEx ENSG00000197901 GTEx
HGNC ID HGNC:10970 ENTREZGENE
Human Proteome Map SLC22A6 Human Proteome Map
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
KEGG Report hsa:9356 UniProtKB/Swiss-Prot
NCBI Gene 9356 ENTREZGENE
OMIM 607582 OMIM
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PharmGKB PA388 PharmGKB, RGD
PROSITE MFS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A8MY93 ENTREZGENE
  B2D0R6 ENTREZGENE
  B3KRM3 ENTREZGENE, UniProtKB/TrEMBL
  F5H0T7_HUMAN UniProtKB/TrEMBL
  O95187 ENTREZGENE
  O95742 ENTREZGENE
  Q4U2R8 ENTREZGENE
  Q7LDA0 ENTREZGENE
  Q8N192 ENTREZGENE
  Q9NQA6 ENTREZGENE
  Q9NQC2 ENTREZGENE
  Q9UBG6 ENTREZGENE
  Q9UEQ8 ENTREZGENE
  S22A6_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8MY93 UniProtKB/Swiss-Prot
  B2D0R6 UniProtKB/Swiss-Prot
  O95187 UniProtKB/Swiss-Prot
  O95742 UniProtKB/Swiss-Prot
  Q7LDA0 UniProtKB/Swiss-Prot
  Q8N192 UniProtKB/Swiss-Prot
  Q9NQA6 UniProtKB/Swiss-Prot
  Q9NQC2 UniProtKB/Swiss-Prot
  Q9UBG6 UniProtKB/Swiss-Prot
  Q9UEQ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-23 SLC22A6  solute carrier family 22 member 6  SLC22A6  solute carrier family 22 (organic anion transporter), member 6  Symbol and/or name change 5135510 APPROVED