ABCC2 (ATP binding cassette subfamily C member 2) - Rat Genome Database

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Gene: ABCC2 (ATP binding cassette subfamily C member 2) Homo sapiens
Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
RGD ID: 619569
Description: Enables ABC-type glutathione S-conjugate transporter activity; ABC-type xenobiotic transporter activity; and bilirubin transmembrane transporter activity. Involved in carboxylic acid transport; xenobiotic export from cell; and xenobiotic transmembrane transport. Located in apical plasma membrane and cell surface. Implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Biomarker of cholestasis and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ABC30; ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; CMOAT; cMRP; DJS; KIAA1010; MRP2; multidrug resistance-associated protein 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381099,782,640 - 99,852,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1099,782,640 - 99,852,594 (+)EnsemblGRCh38hg38GRCh38
GRCh3710101,542,397 - 101,612,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,532,493 - 101,601,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410101,532,562 - 101,601,571NCBI
Celera1095,279,806 - 95,349,643 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1095,169,835 - 95,239,503 (+)NCBIHuRef
CHM1_110101,824,911 - 101,894,368 (+)NCBICHM1_1
T2T-CHM13v2.010100,665,562 - 100,736,331 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+/-)-Aegeline  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP,ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2',3'-dideoxyadenosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',4',7-trihydroxyisoflavone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloromethylfluorescein diacetate  (EXP)
5-fluorouracil  (EXP)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-methoxypsoralen  (EXP)
6-bromoindirubin-3'-oxime  (EXP)
6-carboxyfluorescein  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
8-Epidiosbulbin E acetate  (ISO)
abietic acid  (ISO)
acadesine  (ISO)
acetamide  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-amanitin  (ISO)
aluminium hydroxide  (ISO)
amiodarone  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
angelicin  (ISO)
antimonite  (EXP)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
azathioprine  (EXP,ISO)
aztreonam  (ISO)
benzbromarone  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzoylaconine  (EXP)
benzoylhypaconine  (EXP)
benzoylmesaconine  (EXP)
benzylpenicillin  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (ISO)
biochanin A  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Boldine  (ISO)
bortezomib  (EXP)
bosentan  (EXP,ISO)
bromfenac  (EXP)
bromosulfophthalein  (EXP)
bucladesine  (EXP,ISO)
buspirone  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
butylated hydroxyanisole  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcein  (EXP)
calcein am  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (ISO)
carboplatin  (EXP)
carmustine  (EXP)
carvedilol  (ISO)
cefaloridine  (ISO)
cefalotin  (ISO)
celecoxib  (EXP)
cerivastatin  (EXP)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (EXP)
chlordecone  (EXP)
chlorogenic acid  (ISO)
chloroquine  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
chrysin  (EXP)
chrysophanol  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
clavulanic acid  (EXP)
clobazam  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clotrimazole  (EXP)
colforsin daropate hydrochloride  (EXP)
coniferyl aldehyde  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
curcumin  (EXP,ISO)
cyazofamid  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
dapsone  (ISO)
daunorubicin  (EXP)
demethoxycurcumin  (EXP)
deoxycholic acid  (EXP,ISO)
desloratadine  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethyl maleate  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
dothiepin  (EXP)
doxorubicin  (ISO)
E3040  (EXP)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
Erucin  (EXP)
estrone 3-sulfate  (EXP,ISO)
etacrynic acid  (EXP)
ethambutol  (ISO)
ethoxyquin  (ISO)
etoposide  (EXP)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (EXP,ISO)
fipronil  (ISO)
Fluo-3  (ISO)
fluoxetine  (EXP)
flutamide  (ISO)
fluvastatin  (EXP,ISO)
formononetin  (EXP,ISO)
fosinopril  (EXP,ISO)
FR900359  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
furosemide  (EXP,ISO)
fusidic acid  (ISO)
geneticin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
Ginkgolide A  (EXP)
ginkgolide B  (EXP)
ginsenoside Rb2  (ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (ISO)
glafenine  (ISO)
glucose  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP)
Goe 6976  (EXP,ISO)
gold atom  (EXP)
gold(0)  (EXP)
guggulsterone  (ISO)
GW 4064  (ISO)
hepoxilin A3  (ISO)
heptachlor  (EXP)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
Hypaconitine  (EXP,ISO)
icariside II  (EXP,ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (ISO)
KT 5720  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP,ISO)
L-methionine  (ISO)
leukotriene C4  (EXP,ISO)
levetiracetam  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (EXP,ISO)
loperamide  (ISO)
lopinavir  (EXP)
loratadine  (EXP)
lovastatin  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP)
macitentan  (EXP)
manganese(II) chloride  (ISO)
Maprotiline  (ISO)
Meclizine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (EXP)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (ISO)
metiram  (EXP)
metronidazole  (ISO)
microcystin LF  (EXP)
microcystin RR  (EXP)
microcystin-LR  (EXP,ISO)
Midecamycin  (EXP,ISO)
mifepristone  (ISO)
MK 571  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(glucosyluronic acid)bilirubin  (ISO)
monosodium L-glutamate  (ISO)
montelukast  (EXP)
Muraglitazar  (ISO)
myricetin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nelfinavir  (EXP)
neomycin  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (EXP)
nocodazole  (EXP)
norgestimate  (EXP)
notoginsenoside R1  (EXP,ISO)
Nutlin-3  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
olmesartan  (EXP)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
organoselenium compound  (EXP)
orphenadrine  (ISO)
ortho-Aminoazotoluene  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP,ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
paroxetine  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phalloidin  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
physcion  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP,ISO)
pitavastatin(1-)  (EXP,ISO)
platinum  (EXP)
platinum(0)  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP)
propane-1,2-diol  (ISO)
protein kinase inhibitor  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
Prulifloxacin  (ISO)
psoralen  (ISO)
pyrazinecarboxamide  (ISO)
pyrrolidines  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
robinetin  (EXP)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP)
rubitecan  (EXP)
S-(2,4-dinitrophenyl)glutathione  (EXP,ISO)
S-nitrosoglutathione  (ISO)
saquinavir  (EXP)
selenium atom  (ISO)
senecionine  (EXP,ISO)
sevoflurane  (ISO)
simvastatin  (EXP,ISO)
sincalide  (EXP)
sirolimus  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium hydrogencarbonate  (ISO)
sodium selenide  (EXP)
sorafenib  (EXP)
soybean oil  (ISO)
spironolactone  (ISO)
stilbene oxide  (ISO)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulfasalazine  (ISO)
sulfinpyrazone  (EXP)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP,ISO)
tartrazine  (EXP)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tectorigenin  (ISO)
Temocaprilat  (ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
texas red  (ISO)
Theaflavin 3,3'-digallate  (EXP)
thiacloprid  (ISO)
thioacetamide  (ISO)
thiophanate-methyl  (ISO)
thyroxine  (ISO)
Thyroxine glucuronide  (ISO)
tiagabine  (ISO)
tianeptine  (ISO)
ticlopidine  (EXP,ISO)
titanium dioxide  (EXP)
tolvaptan  (EXP)
topiramate  (ISO)
topotecan  (EXP)
trans-piceid  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (EXP)
vincaleukoblastine  (EXP,ISO)
vincristine  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
Y-27632  (EXP)
Yangonin  (ISO)
yohimbine  (ISO)
zearalenone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibiotic metabolic process  (ISO)
benzylpenicillin metabolic process  (ISO)
bile acid and bile salt transport  (IMP,ISO)
bile acid signaling pathway  (ISO)
bilirubin transport  (IMP)
canalicular bile acid transport  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
detoxification of mercury ion  (ISO)
female pregnancy  (ISO)
heme catabolic process  (TAS)
intracellular chloride ion homeostasis  (ISO)
leukotriene transport  (IMP,ISO)
lipid transport  (IEA)
mercury ion transport  (ISO)
monoatomic anion transmembrane transport  (IEA)
negative regulation of gene expression  (ISS)
organic anion transport  (ISO)
prostaglandin transport  (ISO)
regulation of bile acid secretion  (ISO)
response to antineoplastic agent  (ISO)
response to arsenic-containing substance  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucagon  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
thyroid hormone transport  (ISO)
transepithelial transport  (ISS)
transmembrane transport  (IBA,IEA,TAS)
transport across blood-brain barrier  (NAS)
xenobiotic catabolic process  (ISO)
xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
xenobiotic export from cell  (IMP)
xenobiotic metabolic process  (TAS)
xenobiotic transmembrane transport  (IMP)
xenobiotic transport across blood-brain barrier  (ISS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients. Au A, etal., J Clin Pharm Ther. 2014 Dec;39(6):685-90. doi: 10.1111/jcpt.12197. Epub 2014 Jul 24.
2. Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms. Bolder U, etal., Cell Stress Chaperones. 2006 Spring;11(1):89-100.
3. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. Buchler M, etal., J Biol Chem 1996 Jun 21;271(25):15091-8.
4. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Cheng Q, etal., Mol Pharm. 2008 Jan-Feb;5(1):77-91. Epub 2008 Jan 12.
5. MRP2 haplotypes confer differential susceptibility to toxic liver injury. Choi JH, etal., Pharmacogenet Genomics. 2007 Jun;17(6):403-15. doi: 10.1097/01.fpc.0000236337.41799.b3.
6. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Crocenzi FA, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G449-59. Epub 2003 Apr 17.
7. Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. Daly AK, etal., Gastroenterology. 2007 Jan;132(1):272-81. doi: 10.1053/j.gastro.2006.11.023. Epub 2006 Nov 17.
8. Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Dietrich CG, etal., Gastroenterology. 2004 Apr;126(4):1044-53.
9. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. Geier A, etal., J Hepatol. 2005 Dec;43(6):1021-30. Epub 2005 Jul 1.
10. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
11. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
12. Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients. Han B, etal., Lung Cancer. 2011 May;72(2):238-43. doi: 10.1016/j.lungcan.2010.09.001. Epub 2010 Oct 12.
13. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Han JY, etal., Cancer. 2007 Jul 1;110(1):138-47.
14. The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
15. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. Hirouchi M, etal., Pharm Res. 2005 Apr;22(4):661-6. Epub 2005 Apr 7.
16. Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer. Hoblinger A, etal., Digestion. 2009;80(1):36-9. Epub 2009 May 19.
17. Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. Hoffmann K, etal., Epilepsy Res. 2006 Apr;69(1):1-14. Epub 2006 Feb 28.
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