CFTR (CF transmembrane conductance regulator) - Rat Genome Database

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Gene: CFTR (CF transmembrane conductance regulator) Homo sapiens
Symbol: CFTR
Name: CF transmembrane conductance regulator
RGD ID: 619566
HGNC Page HGNC:1884
Description: Enables several functions, including ATP hydrolysis activity; PDZ domain binding activity; and Sec61 translocon complex binding activity. Involved in several processes, including bicarbonate transport; cellular response to forskolin; and positive regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum membrane; and endosome. Part of protein-containing complex. Implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Biomarker of Alzheimer's disease; cholelithiasis; cystic fibrosis; prostatic hypertrophy; and salpingitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ABC35; ABCC7; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; CF; CFTR/MRP; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulating; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator, atp-binding cassette (sub-family c, member 7); dJ760C5.1; MRP7; TNR-CFTR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CFTRP1   CFTRP2   CFTRP3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387117,480,025 - 117,668,665 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7117,287,120 - 117,715,971 (+)EnsemblGRCh38hg38GRCh38
GRCh377117,120,079 - 117,308,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367116,907,253 - 117,095,955 (+)NCBINCBI36Build 36hg18NCBI36
Build 347116,713,967 - 116,902,666NCBI
Celera7111,928,196 - 112,116,895 (+)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7111,485,640 - 111,674,189 (+)NCBIHuRef
CHM1_17117,053,369 - 117,242,163 (+)NCBICHM1_1
T2T-CHM13v2.07118,795,361 - 118,984,026 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27116,515,451 - 116,704,154 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)