TAC1 (tachykinin precursor 1) - Rat Genome Database

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Gene: TAC1 (tachykinin precursor 1) Homo sapiens
Analyze
Symbol: TAC1
Name: tachykinin precursor 1
RGD ID: 619560
HGNC Page HGNC:11517
Description: Enables neurokinin receptor binding activity and receptor ligand activity. Involved in several processes, including defense response to symbiont; detection of temperature stimulus involved in sensory perception of pain; and positive regulation of sensory perception of pain. Located in extracellular space. Biomarker of asthma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Hs.2563; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; neuropeptide gamma; neuropeptide K; NK2; NKNA; NPK; PPT; preprotachykinin; protachykinin; protachykinin-1; substance K; substance P; TAC2; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38797,732,086 - 97,740,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl797,732,084 - 97,740,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37797,361,398 - 97,369,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36797,199,311 - 97,207,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 34797,006,025 - 97,014,433NCBI
Celera792,055,970 - 92,064,483 (+)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef791,962,648 - 91,971,157 (+)NCBIHuRef
CHM1_1797,291,306 - 97,299,818 (+)NCBICHM1_1
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetylcholine  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
alfuzosin  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (ISO)
amoxapine  (ISO)
amphetamine  (ISO)
Anetholtrithion  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apomorphine  (ISO)
aprepitant  (ISO)
arsenite(3-)  (EXP)
ATP  (ISO)
Azoxymethane  (ISO)
baclofen  (ISO)
batimastat  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Botulinum toxin type A  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbamazepine  (EXP)
carmustine  (EXP)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
corn oil  (ISO)
CP-96345(1+)  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cytarabine  (EXP)
decabromodiphenyl ether  (ISO)
desipramine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazepam  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
diprotium oxide  (ISO)
disodium cromoglycate  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (EXP)
dodecane  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
ethanol  (ISO)
Evodiamine  (ISO)
fluphenazine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gabapentin  (ISO)
genistein  (ISO)
ginsenoside Re  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
haloperidol  (ISO)
herbimycin  (ISO)
histamine  (EXP,ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
icatibant  (ISO)
iloprost  (ISO)
imipramine  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
iron dichloride  (EXP)
isoprenaline  (ISO)
kainic acid  (ISO)
Kallidin  (ISO)
lead(0)  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
maneb  (ISO)
mercury atom  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
methamphetamine  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
mianserin  (ISO)
misoprostol  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N-Vanillyloleamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (ISO)
nedocromil  (EXP)
nimesulide  (ISO)
nitroglycerin  (ISO)
nizatidine  (EXP)
nonane  (ISO)
Norbinaltorphimine  (ISO)
NS-398  (ISO)
O-methyleugenol  (EXP)
Olopatadine hydrochloride  (ISO)
omega-conotoxin GVIA  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
pemirolast  (ISO)
perfluorooctanoic acid  (EXP)
phencyclidine  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 12,13-dibutanoate  (ISO)
phosphoramidon  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
pregabalin  (ISO)
progesterone  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
quinpirole  (ISO)
ranitidine  (EXP)
reserpine  (ISO)
resiniferatoxin  (ISO)
rofecoxib  (EXP)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
scopolamine  (ISO)
serotonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
SKF 38393  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
sorbinil  (ISO)
streptozocin  (ISO)
sucrose  (ISO)
T-2 toxin  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
toluene 2,6-diisocyanate  (ISO)
triadimefon  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
Triptolide  (EXP)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP)
U-73122  (ISO)
U69593  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
water  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA)
associative learning  (ISO)
cell-cell signaling  (TAS)
cellular response to nerve growth factor stimulus  (IEA,ISO)
chemical synaptic transmission  (IEA)
detection of abiotic stimulus  (TAS)
detection of temperature stimulus involved in sensory perception of pain  (IDA)
inflammatory response  (IBA,IEA,ISO)
innate immune response  (IDA)
insemination  (TAS)
long-term memory  (ISO)
negative regulation of heart rate  (ISO)
negative regulation of systemic arterial blood pressure  (IDA)
neuropeptide signaling pathway  (IEA)
positive regulation of action potential  (ISO)
positive regulation of acute inflammatory response  (ISO)
positive regulation of corticosterone secretion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,IDA,ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of flagellated sperm motility  (IDA)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of sensory perception of pain  (IDA)
positive regulation of stress fiber assembly  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
regulation of blood pressure  (ISO)
regulation of sensory perception of pain  (IDA)
response to hormone  (ISO)
response to lipopolysaccharide  (ISO)
response to pain  (IEA,ISO)
sensory perception of pain  (IEA,ISO)
tachykinin receptor signaling pathway  (IBA,IDA,IEA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin. Caudle RM, etal., BMC Neurosci. 2007 May 10;8:30.
2. Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension. Chen MJ and Lai YL, Toxicol Appl Pharmacol. 2003 Mar 15;187(3):178-85.
3. Substance P and its receptor neurokinin 1 expression in asthmatic airways. Chu HW, etal., J Allergy Clin Immunol. 2000 Oct;106(4):713-22.
4. Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. Evangelista S, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Substance P is involved in the cutaneous blood flow increase response to sympathetic nerve stimulation in persistently inflamed rats. Koeda T, etal., J Physiol Sci. 2007 Dec;57(6):361-6. Epub 2007 Dec 4.
7. The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Lau HY and Bhatia M, J Pathol. 2006 Feb;208(3):364-71.
8. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure. Li PC, etal., Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L912-20. Epub 2008 Mar 7.
9. Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. McKay LC and Feldman JL, Am J Respir Crit Care Med. 2008 Jul 1;178(1):89-95. Epub 2008 Apr 17.
10. Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats. Nagashima A, etal., Brain Res. 1989 May 22;487(2):392-6.
11. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Piedimonte G, etal., Am J Physiol. 1999 Oct;277(4 Pt 1):L831-40.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. Sio SW, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):36-46. Epub 2009 Oct 1.
14. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Wang Y, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1517-23. Epub 2008 Mar 12.
Additional References at PubMed
PMID:1312203   PMID:1708336   PMID:2284201   PMID:3038549   PMID:3770210   PMID:7692486   PMID:7961636   PMID:8125298   PMID:8702757   PMID:8957234   PMID:9272936   PMID:9482938  
PMID:9548509   PMID:9655475   PMID:9846828   PMID:9847074   PMID:10189055   PMID:10491292   PMID:11104584   PMID:11113362   PMID:11160316   PMID:11278902   PMID:11342427   PMID:11591789  
PMID:11786503   PMID:11919172   PMID:11921119   PMID:11950831   PMID:12074933   PMID:12382579   PMID:12383866   PMID:12477932   PMID:12486316   PMID:12528114   PMID:12548712   PMID:12578734  
PMID:12603817   PMID:12609765   PMID:12686752   PMID:12690205   PMID:12705477   PMID:12716968   PMID:12752772   PMID:12854086   PMID:12871824   PMID:14532289   PMID:14564346   PMID:14589248  
PMID:14703707   PMID:14749007   PMID:15130944   PMID:15358539   PMID:15489334   PMID:15544859   PMID:15690122   PMID:15729363   PMID:15761654   PMID:15899028   PMID:16169070   PMID:16503654  
PMID:16754659   PMID:16816831   PMID:16877367   PMID:16952549   PMID:17087112   PMID:17101218   PMID:17175032   PMID:17257983   PMID:17264209   PMID:17370082   PMID:17376622   PMID:17409218  
PMID:17437961   PMID:17448763   PMID:17450584   PMID:17494790   PMID:17588657   PMID:17655760   PMID:17655832   PMID:17667845   PMID:17703412   PMID:17709376   PMID:17855557   PMID:17940602  
PMID:17949241   PMID:17975140   PMID:18061399   PMID:18179473   PMID:18197882   PMID:18211417   PMID:18289674   PMID:18316470   PMID:18363037   PMID:18507649   PMID:18577758   PMID:18599605  
PMID:18603306   PMID:18615578   PMID:18941231   PMID:18990442   PMID:19036058   PMID:19046942   PMID:19086053   PMID:19200949   PMID:19207952   PMID:19246391   PMID:19258923   PMID:19279355  
PMID:19381016   PMID:19598235   PMID:19685709   PMID:19695094   PMID:19812951   PMID:19855234   PMID:19874574   PMID:19885583   PMID:19909213   PMID:19913121   PMID:20029189   PMID:20160043  
PMID:20173430   PMID:20207019   PMID:20237496   PMID:20347265   PMID:20405330   PMID:20417061   PMID:20468064   PMID:20497485   PMID:20503287   PMID:20526012   PMID:20529207   PMID:20580442  
PMID:20628086   PMID:20692311   PMID:20861424   PMID:20940324   PMID:21076839   PMID:21091716   PMID:21107196   PMID:21160161   PMID:21167238   PMID:21368235   PMID:21375557   PMID:21550738  
PMID:21671725   PMID:21873635   PMID:21900206   PMID:21926539   PMID:22020760   PMID:22057425   PMID:22115773   PMID:22189180   PMID:22354721   PMID:22392530   PMID:22429353   PMID:22449753  
PMID:22572771   PMID:22681041   PMID:22733436   PMID:22836729   PMID:22906243   PMID:22961239   PMID:23257919   PMID:23345604   PMID:23420374   PMID:23597562   PMID:23719583   PMID:23737731  
PMID:23827863   PMID:23862763   PMID:23873242   PMID:23977290   PMID:23995243   PMID:24010162   PMID:24084156   PMID:24286592   PMID:24374326   PMID:24486589   PMID:24563019   PMID:24577568  
PMID:24603459   PMID:24660773   PMID:24844859   PMID:24908181   PMID:24969128   PMID:25135735   PMID:25690155   PMID:25750171   PMID:25783846   PMID:26038607   PMID:26349209   PMID:26852662  
PMID:27027429   PMID:27146034   PMID:27456549   PMID:27501920   PMID:27908224   PMID:28192115   PMID:28423013   PMID:28460633   PMID:28500728   PMID:28521029   PMID:28554099   PMID:28714876  
PMID:28817088   PMID:29412499   PMID:29478144   PMID:29745819   PMID:29939909   PMID:30021884   PMID:30232261   PMID:30485833   PMID:30684188   PMID:31971954   PMID:32266968   PMID:32430478  
PMID:33307260   PMID:33999474   PMID:34146741   PMID:34692834   PMID:34830018   PMID:35353932   PMID:35726575   PMID:35820276   PMID:36461799   PMID:36549466   PMID:36549578   PMID:36651605  
PMID:37132595   PMID:37408182   PMID:37852938   PMID:37931511   PMID:37944618   PMID:38376747  


Genomics

Comparative Map Data
TAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38797,732,086 - 97,740,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl797,732,084 - 97,740,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37797,361,398 - 97,369,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36797,199,311 - 97,207,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 34797,006,025 - 97,014,433NCBI
Celera792,055,970 - 92,064,483 (+)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef791,962,648 - 91,971,157 (+)NCBIHuRef
CHM1_1797,291,306 - 97,299,818 (+)NCBICHM1_1
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)NCBI
Tac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3967,555,061 - 7,562,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm39 Ensembl
GRCm3867,555,061 - 7,562,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv3767,505,071 - 7,512,973 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3667,505,071 - 7,512,973 (+)NCBIMGSCv36mm8
Celera67,693,231 - 7,701,130 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map63.31NCBI
Tac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8436,645,344 - 36,653,548 (+)NCBIGRCr8
mRatBN7.2435,679,183 - 35,687,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl435,679,704 - 35,687,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx440,638,023 - 40,645,989 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0436,564,213 - 36,572,177 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0434,981,526 - 34,989,526 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0433,638,853 - 33,646,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl433,638,709 - 33,646,819 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0433,499,891 - 33,507,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,649,666 - 32,657,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1432,768,205 - 32,776,170 (+)NCBI
Celera431,183,136 - 31,191,779 (+)NCBICelera
Cytogenetic Map4q21NCBI
Tac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543213,991,414 - 13,999,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543213,991,647 - 13,999,665 (+)NCBIChiLan1.0ChiLan1.0
TAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26115,561,721 - 115,570,273 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17163,826,347 - 163,834,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0789,675,834 - 89,684,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17103,257,450 - 103,266,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7103,257,501 - 103,266,389 (+)Ensemblpanpan1.1panPan2
TAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11422,631,106 - 22,640,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,632,642 - 22,640,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,207,754 - 22,215,926 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01422,451,048 - 22,459,223 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11422,597,269 - 22,605,445 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01422,330,414 - 22,338,555 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01422,594,017 - 22,602,196 (+)NCBIUU_Cfam_GSD_1.0
Tac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511835,921,952 - 35,930,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365852,932,727 - 2,941,384 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365852,932,783 - 2,941,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl977,197,536 - 77,206,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1977,197,403 - 77,206,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2984,764,564 - 84,773,747 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12151,339,085 - 51,347,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2151,339,095 - 51,347,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604253,024,229 - 53,032,700 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248134,542,011 - 4,550,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248134,542,226 - 4,550,378 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TAC1
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3(chr7:95127070-97873487)x1 copy number loss See cases [RCV000135435] Chr7:95127070..97873487 [GRCh38]
Chr7:94756382..97502799 [GRCh37]
Chr7:94594318..97340735 [NCBI36]
Chr7:7q21.3		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q21.3(chr7:97403740-97858352)x1 copy number loss See cases [RCV000140904] Chr7:97403740..97858352 [GRCh38]
Chr7:97033052..97487664 [GRCh37]
Chr7:96870988..97325600 [NCBI36]
Chr7:7q21.3		 uncertain significance
GRCh38/hg38 7q21.3(chr7:97698133-97744122)x3 copy number gain See cases [RCV000140731] Chr7:97698133..97744122 [GRCh38]
Chr7:97327445..97373434 [GRCh37]
Chr7:97165381..97211370 [NCBI36]
Chr7:7q21.3		 likely benign
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7q21.3(chr7:96066104-97428089)x3 copy number gain See cases [RCV000446344] Chr7:96066104..97428089 [GRCh37]
Chr7:7q21.3		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q21.3(chr7:97003103-97868063)x3 copy number gain See cases [RCV000511595] Chr7:97003103..97868063 [GRCh37]
Chr7:7q21.3		 likely benign
GRCh37/hg19 7q21.2-22.1(chr7:92445452-99686985)x1 copy number loss Split hand-foot malformation 1 [RCV000656540] Chr7:92445452..99686985 [GRCh37]
Chr7:7q21.2-22.1		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_003182.3(TAC1):c.12C>G (p.Leu4=) single nucleotide variant not provided [RCV000907018] Chr7:97732624 [GRCh38]
Chr7:97361936 [GRCh37]
Chr7:7q21.3		 benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_003182.3(TAC1):c.294T>C (p.His98=) single nucleotide variant not provided [RCV000917732] Chr7:97736303 [GRCh38]
Chr7:97365615 [GRCh37]
Chr7:7q21.3		 likely benign
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1		 pathogenic
NC_000007.13:g.(?_96318236)_(97493828_?)dup duplication not provided [RCV003123049] Chr7:96318236..97493828 [GRCh37]
Chr7:7q21.3		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
GRCh37/hg19 7q21.2-22.1(chr7:92721627-98311537)x1 copy number loss not provided [RCV002474498] Chr7:92721627..98311537 [GRCh37]
Chr7:7q21.2-22.1		 pathogenic
NM_003182.3(TAC1):c.193T>C (p.Phe65Leu) single nucleotide variant not specified [RCV004072713] Chr7:97733792 [GRCh38]
Chr7:97363104 [GRCh37]
Chr7:7q21.3		 uncertain significance
NM_003182.3(TAC1):c.366G>A (p.Met122Ile) single nucleotide variant not specified [RCV004114700] Chr7:97739896 [GRCh38]
Chr7:97369208 [GRCh37]
Chr7:7q21.3		 uncertain significance
NM_003182.3(TAC1):c.322G>A (p.Gly108Ser) single nucleotide variant not specified [RCV004466134] Chr7:97736331 [GRCh38]
Chr7:97365643 [GRCh37]
Chr7:7q21.3		 uncertain significance
NC_000007.13:g.(?_94024344)_(100860555_?)del deletion not provided [RCV004578536] Chr7:94024344..100860555 [GRCh37]
Chr7:7q21.3-22.1		 pathogenic
GRCh37/hg19 7q11.23-21.3(chr7:74666254-97791584)x1 copy number loss not provided [RCV004819352] Chr7:74666254..97791584 [GRCh37]
Chr7:7q11.23-21.3		 pathogenic
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR206hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI17855557
MIR206hsa-miR-206Tarbaseexternal_infoReporter GenePOSITIVE
MIR206hsa-miR-206Mirecordsexternal_infoNANA17855557
MIR320Ahsa-miR-320aMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI17855557
MIR302Ahsa-miR-302a-3pMirtarbaseexternal_infoReporter assayNon-Functional MTI17855557
MIR302Ahsa-miR-302a-3pTarbaseexternal_infoReporter GeneNEGATIVE
MIR130Ahsa-miR-130a-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI17855557

Predicted Target Of
Summary Value
Count of predictions:1104
Count of miRNA genes:482
Interacting mature miRNAs:527
Transcripts:ENST00000319273, ENST00000346867, ENST00000350485, ENST00000491437, ENST00000495916
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597180459GWAS1276533_Hprotachykinin-1 measurement QTL GWAS1276533 (human)4e-59protachykinin-1 measurement79773702097737021Human

Markers in Region
WI-19154  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37797,369,336 - 97,369,593UniSTSGRCh37
Build 36797,207,272 - 97,207,529RGDNCBI36
Celera792,064,035 - 92,064,292RGD
Cytogenetic Map7q21-q22UniSTS
HuRef791,970,709 - 91,970,966UniSTS
CRA_TCAGchr7v2796,691,824 - 96,692,081UniSTS
GeneMap99-GB4 RH Map7506.18UniSTS
Whitehead-RH Map7469.4UniSTS
D1S3260  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37797,369,257 - 97,369,562UniSTSGRCh37
Build 36797,207,193 - 97,207,498RGDNCBI36
Celera792,063,956 - 92,064,261RGD
Cytogenetic Map7q21-q22UniSTS
HuRef791,970,630 - 91,970,935UniSTS
CRA_TCAGchr7v2796,691,745 - 96,692,050UniSTS
TNG Radiation Hybrid Map754406.0UniSTS
Stanford-G3 RH Map74569.0UniSTS
GeneMap99-G3 RH Map74569.0UniSTS
TAC2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37797,361,920 - 97,362,045UniSTSGRCh37
Build 36797,199,856 - 97,199,981RGDNCBI36
Celera792,056,619 - 92,056,744RGD
Cytogenetic Map7q21-q22UniSTS
HuRef791,963,297 - 91,963,422UniSTS
CRA_TCAGchr7v2796,684,408 - 96,684,533UniSTS
STS-U37529  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37797,369,490 - 97,369,668UniSTSGRCh37
Build 36797,207,426 - 97,207,604RGDNCBI36
Celera792,064,189 - 92,064,367RGD
Cytogenetic Map7q21-q22UniSTS
HuRef791,970,863 - 91,971,041UniSTS
CRA_TCAGchr7v2796,691,978 - 96,692,156UniSTS
GeneMap99-GB4 RH Map7511.59UniSTS
NCBI RH Map71054.1UniSTS
TAC1_3236  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37797,369,210 - 97,369,862UniSTSGRCh37
Build 36797,207,146 - 97,207,798RGDNCBI36
Celera792,063,909 - 92,064,561RGD
HuRef791,970,583 - 91,971,235UniSTS
CRA_TCAGchr7v2796,691,698 - 96,692,350UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1151 2287 2612 2046 4811 1414 1738 358 911 199 2158 5437 5159 17 3645 702 1524 1278 164 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF050655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF050656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF050657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF050658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN992454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000319273   ⟹   ENSP00000321106
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl797,732,086 - 97,740,472 (+)Ensembl
Ensembl Acc Id: ENST00000346867   ⟹   ENSP00000289574
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl797,732,084 - 97,740,465 (+)Ensembl
Ensembl Acc Id: ENST00000350485   ⟹   ENSP00000289576
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl797,732,084 - 97,740,438 (+)Ensembl
Ensembl Acc Id: ENST00000491437
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl797,733,954 - 97,740,063 (+)Ensembl
Ensembl Acc Id: ENST00000495916
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl797,732,161 - 97,733,090 (+)Ensembl
RefSeq Acc Id: NM_003182   ⟹   NP_003173
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38797,732,086 - 97,740,472 (+)NCBI
GRCh37797,361,271 - 97,369,784 (+)ENTREZGENE
Build 36797,199,311 - 97,207,720 (+)NCBI Archive
HuRef791,962,648 - 91,971,157 (+)ENTREZGENE
CHM1_1797,291,306 - 97,299,818 (+)NCBI
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBI
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013996   ⟹   NP_054702
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38797,732,086 - 97,740,472 (+)NCBI
GRCh37797,361,271 - 97,369,784 (+)ENTREZGENE
Build 36797,199,311 - 97,207,720 (+)NCBI Archive
HuRef791,962,648 - 91,971,157 (+)ENTREZGENE
CHM1_1797,291,306 - 97,299,818 (+)NCBI
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBI
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013997   ⟹   NP_054703
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38797,732,086 - 97,740,472 (+)NCBI
GRCh37797,361,271 - 97,369,784 (+)ENTREZGENE
Build 36797,199,311 - 97,207,720 (+)NCBI Archive
HuRef791,962,648 - 91,971,157 (+)ENTREZGENE
CHM1_1797,291,306 - 97,299,818 (+)NCBI
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBI
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013998   ⟹   NP_054704
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38797,732,086 - 97,740,472 (+)NCBI
GRCh37797,361,271 - 97,369,784 (+)ENTREZGENE
Build 36797,199,311 - 97,207,720 (+)NCBI Archive
HuRef791,962,648 - 91,971,157 (+)ENTREZGENE
CHM1_1797,291,306 - 97,299,818 (+)NCBI
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBI
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_003173 (Get FASTA)   NCBI Sequence Viewer  
  NP_054702 (Get FASTA)   NCBI Sequence Viewer  
  NP_054703 (Get FASTA)   NCBI Sequence Viewer  
  NP_054704 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA60159 (Get FASTA)   NCBI Sequence Viewer  
  AAA60160 (Get FASTA)   NCBI Sequence Viewer  
  AAA79195 (Get FASTA)   NCBI Sequence Viewer  
  AAC15701 (Get FASTA)   NCBI Sequence Viewer  
  AAC15702 (Get FASTA)   NCBI Sequence Viewer  
  AAC15703 (Get FASTA)   NCBI Sequence Viewer  
  AAC15704 (Get FASTA)   NCBI Sequence Viewer  
  AAH18047 (Get FASTA)   NCBI Sequence Viewer  
  AAQ96888 (Get FASTA)   NCBI Sequence Viewer  
  AAQ96889 (Get FASTA)   NCBI Sequence Viewer  
  AAQ96890 (Get FASTA)   NCBI Sequence Viewer  
  AAQ96891 (Get FASTA)   NCBI Sequence Viewer  
  BAD96677 (Get FASTA)   NCBI Sequence Viewer  
  CAA38351 (Get FASTA)   NCBI Sequence Viewer  
  CAG28529 (Get FASTA)   NCBI Sequence Viewer  
  CAG46531 (Get FASTA)   NCBI Sequence Viewer  
  EAL24116 (Get FASTA)   NCBI Sequence Viewer  
  EAL24117 (Get FASTA)   NCBI Sequence Viewer  
  EAL24118 (Get FASTA)   NCBI Sequence Viewer  
  EAL24119 (Get FASTA)   NCBI Sequence Viewer  
  EAW76734 (Get FASTA)   NCBI Sequence Viewer  
  EAW76735 (Get FASTA)   NCBI Sequence Viewer  
  EAW76736 (Get FASTA)   NCBI Sequence Viewer  
  EAW76737 (Get FASTA)   NCBI Sequence Viewer  
  EAW76738 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000289574
  ENSP00000289574.4
  ENSP00000289576
  ENSP00000289576.4
  ENSP00000321106
  ENSP00000321106.5
GenBank Protein P20366 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_003173   ⟸   NM_003182
- Peptide Label: isoform beta precursor
- UniProtKB: Q549V2 (UniProtKB/Swiss-Prot),   Q549V1 (UniProtKB/Swiss-Prot),   Q549V0 (UniProtKB/Swiss-Prot),   Q53GH4 (UniProtKB/Swiss-Prot),   Q00072 (UniProtKB/Swiss-Prot),   O60601 (UniProtKB/Swiss-Prot),   O60600 (UniProtKB/Swiss-Prot),   Q6FHM1 (UniProtKB/Swiss-Prot),   P20366 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_054702   ⟸   NM_013996
- Peptide Label: isoform alpha precursor
- UniProtKB: P20366 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_054703   ⟸   NM_013997
- Peptide Label: isoform gamma precursor
- UniProtKB: P20366 (UniProtKB/Swiss-Prot),   Q9Y494 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_054704   ⟸   NM_013998
- Peptide Label: isoform delta precursor
- UniProtKB: P20366 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000289574   ⟸   ENST00000346867
Ensembl Acc Id: ENSP00000289576   ⟸   ENST00000350485
Ensembl Acc Id: ENSP00000321106   ⟸   ENST00000319273
Protein Domains
Tachykinin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20366-F1-model_v2 AlphaFold P20366 1-129 view protein structure

Promoters
RGD ID:7211147
Promoter ID:EPDNEW_H11320
Type:initiation region
Name:TAC1_2
Description:tachykinin precursor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11321  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38797,731,908 - 97,731,968EPDNEW
RGD ID:7211149
Promoter ID:EPDNEW_H11321
Type:initiation region
Name:TAC1_1
Description:tachykinin precursor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11320  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38797,732,086 - 97,732,146EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11517 AgrOrtholog
COSMIC TAC1 COSMIC
Ensembl Genes ENSG00000006128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000319273 ENTREZGENE
  ENST00000319273.10 UniProtKB/Swiss-Prot
  ENST00000346867 ENTREZGENE
  ENST00000346867.4 UniProtKB/Swiss-Prot
  ENST00000350485 ENTREZGENE
  ENST00000350485.8 UniProtKB/Swiss-Prot
GTEx ENSG00000006128 GTEx
HGNC ID HGNC:11517 ENTREZGENE
Human Proteome Map TAC1 Human Proteome Map
InterPro Tachy_Neuro_lke_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tachykinin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tachykinin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6863 UniProtKB/Swiss-Prot
NCBI Gene 6863 ENTREZGENE
OMIM 162320 OMIM
PANTHER PROTACHYKININ-1 UniProtKB/Swiss-Prot
  TACHYKININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TACHYKININ PRECURSOR 1 UniProtKB/TrEMBL
Pfam Tachykinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36297 PharmGKB
PRINTS PROTACHYKNIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TACHYKININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O60600 ENTREZGENE
  O60601 ENTREZGENE
  P20366 ENTREZGENE
  Q00072 ENTREZGENE
  Q53GH4 ENTREZGENE
  Q549V0 ENTREZGENE
  Q549V1 ENTREZGENE
  Q549V2 ENTREZGENE
  Q6FHM1 ENTREZGENE
  Q9Y494 ENTREZGENE, UniProtKB/TrEMBL
  TKN1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary O60600 UniProtKB/Swiss-Prot
  O60601 UniProtKB/Swiss-Prot
  Q00072 UniProtKB/Swiss-Prot
  Q53GH4 UniProtKB/Swiss-Prot
  Q549V0 UniProtKB/Swiss-Prot
  Q549V1 UniProtKB/Swiss-Prot
  Q549V2 UniProtKB/Swiss-Prot
  Q6FHM1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 TAC1  tachykinin precursor 1  TAC1  tachykinin, precursor 1  Symbol and/or name change 5135510 APPROVED