CREBBP (CREB binding protein) - Rat Genome Database

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Gene: CREBBP (CREB binding protein) Homo sapiens
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Symbol: CREBBP
Name: CREB binding protein
RGD ID: 619552
HGNC Page HGNC:2348
Description: Enables several functions, including DNA-binding transcription factor binding activity; N-acyltransferase activity; and transcription coregulator activity. Involved in several processes, including N-terminal peptidyl-lysine acetylation; positive regulation of double-strand break repair via homologous recombination; and regulation of DNA-templated transcription. Located in chromatin and nuclear body. Is active in cytoplasm. Implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Biomarker of Huntington's disease and pre-eclampsia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CBP; CREB-binding protein; histone lysine acetyltransferase CREBBP; KAT3A; MKHK1; protein-lysine acetyltransferase CREBBP; RSTS; RSTS1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,725,054 - 3,880,713 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,725,054 - 3,880,713 (-)EnsemblGRCh38hg38GRCh38
GRCh37163,775,055 - 3,930,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,715,056 - 3,870,122 (-)NCBINCBI36Build 36hg18NCBI36
Build 34163,716,569 - 3,870,712NCBI
Celera163,981,749 - 4,136,789 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,743,994 - 3,898,607 (-)NCBIHuRef
CHM1_1163,775,055 - 3,930,225 (-)NCBICHM1_1
T2T-CHM13v2.0163,752,324 - 3,907,918 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (IAGP)
acute myeloid leukemia  (IAGP,ISS)
adenoid cystic carcinoma  (EXP,IAGP)
Agenesis of Corpus Callosum  (IAGP)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 1  (EXP)
atrial heart septal defect  (IAGP)
Au-Kline Syndrome  (IAGP)
autism spectrum disorder  (ISS)
Colorectal Neoplasms  (IAGP)
Developmental Disabilities  (IAGP)
diffuse large B-cell lymphoma  (IAGP)
epilepsy  (IAGP)
esophagus squamous cell carcinoma  (EXP)
follicular lymphoma  (EXP)
gastric adenocarcinoma  (IAGP)
genetic disease  (IAGP)
glaucoma  (IAGP)
glioblastoma  (IAGP)
head and neck squamous cell carcinoma  (IAGP)
hepatocellular carcinoma  (IAGP)
Hirschsprung Disease 1  (IAGP)
Hirschsprung's disease  (IAGP)
Huntington's disease  (IEP,ISO)
idiopathic generalized epilepsy  (IAGP)
intellectual disability  (IAGP)
Kohlschutter-Tonz syndrome  (IAGP)
lung adenocarcinoma  (EXP)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (EXP)
lung squamous cell carcinoma  (IAGP)
Marfanoid Mental Retardation Syndrome, Autosomal  (IAGP)
medulloblastoma  (IAGP)
melanoma  (IAGP)
Menke-Hennekam Syndrome  (IAGP)
Menke-Hennekam Syndrome 1  (IAGP)
multiple myeloma  (IAGP)
myelodysplastic syndrome  (ISS)
Myocardial Reperfusion Injury  (ISO)
Nervous System Malformations  (IAGP)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (IAGP)
Neurodevelopmental Disorders  (IAGP)
pre-eclampsia  (IEP)
Prostatic Neoplasms  (EXP)
Rubinstein-Taybi syndrome  (EXP,IAGP,ISO,ISS)
scoliosis  (IAGP)
Sezary's disease  (EXP)
short-rib thoracic dysplasia 9 with or without polydactyly  (IAGP)
skin melanoma  (IAGP)
squamous cell carcinoma  (EXP)
teratoma  (IAGP)
Thumb Deformity  (IAGP)
transitional cell carcinoma  (EXP,IAGP)
urinary bladder cancer  (EXP)
Uterine Cervical Neoplasms  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-tert-butylhydroquinone  (EXP)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
androst-4-ene-3,17-dione  (EXP)
aripiprazole  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
aurantio-obtusin  (EXP)
azoxystrobin  (EXP)
BAPTA  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP)
beta-lapachone  (EXP)
bezafibrate  (EXP)
bicalutamide  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
bucladesine  (EXP,ISO)
butanal  (EXP)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP)
calcitriol  (ISO)
calyculin a  (EXP)
camptothecin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (ISO)
chaetocin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
ciglitazone  (EXP)
cisplatin  (EXP)
clobetasol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
curcumin  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (EXP)
DDD  (EXP)
DDE  (EXP)
DDT  (EXP)
deoxynivalenol  (EXP)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
elemental selenium  (EXP)
enzalutamide  (EXP)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenthion  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
fulvestrant  (EXP,ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
ibrutinib  (EXP)
inulin  (ISO)
irinotecan  (EXP)
KT 5823  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
linoleic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
medroxyprogesterone acetate  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (EXP)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
niclosamide  (EXP)
nicotine  (ISO)
o-anisidine  (EXP)
okadaic acid  (EXP)
oleic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
propanal  (EXP)
propiconazole  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
temozolomide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vincristine  (EXP)
vitamin E  (EXP)
vorinostat  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to cocaine  (ISO)
canonical NF-kappaB signal transduction  (IDA)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to nutrient levels  (IDA)
cellular response to UV  (IDA)
cellular response to virus  (ISO)
chromatin remodeling  (IEA)
embryonic digit morphogenesis  (TAS)
face morphogenesis  (ISO)
germ-line stem cell population maintenance  (ISO)
homeostatic process  (NAS)
long-term memory  (ISO)
N-terminal peptidyl-lysine acetylation  (IDA)
negative regulation of interferon-beta production  (ISO)
negative regulation of transcription by RNA polymerase I  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of viral process  (ISO)
positive regulation of cell adhesion molecule production  (ISO)
positive regulation of CREB transcription factor activity  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO,ISS)
positive regulation of double-strand break repair via homologous recombination  (IDA)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of protein localization to nucleus  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP)
protein acetylation  (IDA,TAS)
protein destabilization  (IMP)
protein modification process  (ISO)
protein-containing complex assembly  (TAS)
regulation of cellular response to heat  (TAS)
regulation of DNA-templated transcription  (IEA,ISO,TAS)
regulation of smoothened signaling pathway  (TAS)
response to hypoxia  (TAS)
response to interleukin-1  (ISO)
response to ischemia  (ISO)
rhythmic process  (IEA)
signal transduction  (NAS,TAS)
stimulatory C-type lectin receptor signaling pathway  (TAS)

Cellular Component

Molecular Function