Pde3b (phosphodiesterase 3B) - Rat Genome Database

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Gene: Pde3b (phosphodiesterase 3B) Rattus norvegicus
Analyze
Symbol: Pde3b
Name: phosphodiesterase 3B
RGD ID: 61943
Description: Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and phosphoprotein binding activity. Involved in negative regulation of cAMP/PKA signal transduction and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Predicted to be part of guanyl-nucleotide exchange factor complex. Orthologous to human PDE3B (phosphodiesterase 3B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; insulin signaling pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGI PDE; CGI-PDE B; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cyclic GMP-inhibited phosphodiesterase B; phosphodiesterase 3B cGMP inhibited; phosphodiesterase 3B cGMP-inhibited; phosphodiesterase 3B, cGMP inhibited ; phosphodiesterase 3B, cGMP-inhibited; RcGIPl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,041,207 - 178,204,503 (+)NCBIGRCr8
mRatBN7.21168,606,762 - 168,770,078 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,607,022 - 168,769,334 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,935,830 - 177,090,997 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,121,900 - 184,277,053 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01176,834,530 - 176,989,699 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,892,841 - 184,078,071 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,892,841 - 184,078,071 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,865,614 - 191,050,207 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,409,282 - 172,577,108 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,545,390 - 172,713,217 (+)NCBI
Celera1166,458,524 - 166,609,913 (+)NCBICelera
Cytogenetic Map1q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
ketoconazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
raloxifene  (ISO)
roflumilast  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triazines  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. Harndahl L, etal., J Biol Chem 2002 Oct 4;277(40):37446-55.
5. Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3). He R, etal., Cell Biochem Biophys. 1998;29(1-2):89-111. doi: 10.1007/BF02737830.
6. Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: differential subcellular localization and regulated expression by cyclic AMP. Liu H and Maurice DH, Br J Pharmacol. 1998 Dec;125(7):1501-10.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phosphodiesterase 3A or 3B mRNA and activity in the aorta and adipose tissue of atherosclerosis-prone insulin-resistant rats. Nagaoka T, etal., Diabetes. 1998 Jul;47(7):1135-44.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. A newly identified 50 kDa protein, which is associated with phosphodiesterase 3B, is phosphorylated by insulin in rat adipocytes. Onuma H, etal., Biochem Biophys Res Commun. 2005 Nov 25;337(3):976-82. Epub 2005 Oct 3.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase. Taira M, etal., J Biol Chem 1993 Sep 5;268(25):18573-9.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo. Tilley DG and Maurice DH, Mol Pharmacol. 2002 Sep;62(3):497-506.
18. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, etal., Biochem Pharmacol. 2008 Oct 1;76(7):884-93. Epub 2008 Jul 26.
Additional References at PubMed
PMID:8562305   PMID:9102399   PMID:10454575   PMID:10952971   PMID:11641262   PMID:14736883   PMID:15961276   PMID:16503395   PMID:17286556   PMID:17884339   PMID:18586889   PMID:19486524  
PMID:19946888   PMID:20471454   PMID:21152070   PMID:21393242   PMID:21435395   PMID:22967108   PMID:22990990   PMID:35030973  


Genomics

Comparative Map Data
Pde3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,041,207 - 178,204,503 (+)NCBIGRCr8
mRatBN7.21168,606,762 - 168,770,078 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,607,022 - 168,769,334 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,935,830 - 177,090,997 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,121,900 - 184,277,053 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01176,834,530 - 176,989,699 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,892,841 - 184,078,071 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,892,841 - 184,078,071 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,865,614 - 191,050,207 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,409,282 - 172,577,108 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,545,390 - 172,713,217 (+)NCBI
Celera1166,458,524 - 166,609,913 (+)NCBICelera
Cytogenetic Map1q34NCBI
PDE3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,643,804 - 14,899,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,643,804 - 14,872,044 (+)EnsemblGRCh38hg38GRCh38
GRCh371114,665,350 - 14,920,867 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,621,907 - 14,848,926 (+)NCBINCBI36Build 36hg18NCBI36
Build 341114,621,906 - 14,848,926NCBI
Celera1114,790,352 - 15,020,727 (+)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,328,113 - 14,576,051 (+)NCBIHuRef
CHM1_11114,664,181 - 14,892,596 (+)NCBICHM1_1
T2T-CHM13v2.01114,739,099 - 14,995,688 (+)NCBIT2T-CHM13v2.0
Pde3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397114,014,388 - 114,137,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7114,014,516 - 114,138,486 (+)EnsemblGRCm39 Ensembl
GRCm387114,415,222 - 114,537,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7114,415,281 - 114,539,251 (+)EnsemblGRCm38mm10GRCm38
MGSCv377121,558,768 - 121,681,451 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367114,206,462 - 114,327,893 (+)NCBIMGSCv36mm8
Celera7114,368,837 - 114,491,103 (+)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.46NCBI
Pde3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541429,783,963 - 29,909,685 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541429,783,999 - 29,911,329 (+)NCBIChiLan1.0ChiLan1.0
PDE3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,024,754 - 17,239,818 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,985,620 - 17,200,694 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,746,301 - 14,961,316 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,437,060 - 14,653,070 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,437,060 - 14,648,616 (+)Ensemblpanpan1.1panPan2
PDE3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12137,364,940 - 37,532,152 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2137,364,623 - 37,530,597 (+)NCBICanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2136,866,331 - 37,033,861 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02138,252,613 - 38,465,284 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.02138,403,153 - 38,625,755 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12137,502,202 - 37,670,266 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02137,681,141 - 37,858,115 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02137,969,597 - 38,137,719 (+)NCBIUU_Cfam_GSD_1.0
Pde3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494747,887,624 - 48,054,011 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365283,923,379 - 4,087,188 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365283,922,436 - 4,087,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl244,412,833 - 44,726,216 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1244,416,934 - 44,614,075 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2247,572,598 - 47,653,532 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1150,050,168 - 50,254,797 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl150,047,477 - 50,254,807 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038147,554,281 - 147,796,470 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,492,897 - 6,635,823 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247666,492,803 - 6,636,059 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde3b
909 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:116
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000015498
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Wox60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,768,601 - 168,768,808 (+)MAPPERmRatBN7.2
Rnor_6.01184,077,339 - 184,077,545NCBIRnor6.0
Rnor_5.01191,049,475 - 191,049,681UniSTSRnor5.0
RGSC_v3.41172,576,376 - 172,576,582UniSTSRGSC3.4
Celera1166,609,181 - 166,609,387UniSTS
Cytogenetic Map1q34UniSTS
RH134896  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01190,944,921 - 190,945,109NCBIRnor5.0
Rnor_5.01288,697,558 - 288,697,750NCBIRnor5.0
RGSC_v3.41266,745,833 - 266,746,024UniSTSRGSC3.4
RGSC_v3.41172,469,199 - 172,469,386UniSTSRGSC3.4
Celera1254,981,639 - 254,981,830UniSTS
Celera1166,512,573 - 166,512,760UniSTS
Cytogenetic Map1q34UniSTS
AI235078  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,625,480 - 168,625,659 (+)MAPPERmRatBN7.2
Rnor_6.01183,911,827 - 183,912,005NCBIRnor6.0
Rnor_5.01190,884,600 - 190,884,778UniSTSRnor5.0
RGSC_v3.41172,428,322 - 172,428,500UniSTSRGSC3.4
Celera1166,476,944 - 166,477,122UniSTS
RH 3.4 Map11318.0UniSTS
Cytogenetic Map1q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015498   ⟹   ENSRNOP00000015498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,607,022 - 168,769,334 (+)Ensembl
Rnor_6.0 Ensembl1183,892,841 - 184,078,071 (+)Ensembl
RefSeq Acc Id: NM_017229   ⟹   NP_058925
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,207 - 178,204,503 (+)NCBI
mRatBN7.21168,606,787 - 168,770,078 (+)NCBI
Rnor_6.01183,892,841 - 184,078,071 (+)NCBI
Rnor_5.01190,865,614 - 191,050,207 (+)NCBI
RGSC_v3.41172,409,282 - 172,577,108 (+)RGD
Celera1166,458,524 - 166,609,913 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109453   ⟹   XP_038965381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,247 - 178,183,589 (+)NCBI
mRatBN7.21168,606,764 - 168,750,081 (+)NCBI
RefSeq Acc Id: XM_039109458   ⟹   XP_038965386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,160,257 - 178,204,499 (+)NCBI
mRatBN7.21168,725,748 - 168,770,078 (+)NCBI
RefSeq Acc Id: XM_039109460   ⟹   XP_038965388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,246 - 178,174,992 (+)NCBI
mRatBN7.21168,606,762 - 168,740,661 (+)NCBI
RefSeq Acc Id: XM_039109463   ⟹   XP_038965391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,247 - 178,174,611 (+)NCBI
mRatBN7.21168,606,764 - 168,740,820 (+)NCBI
RefSeq Acc Id: NP_058925   ⟸   NM_017229
- UniProtKB: Q63085 (UniProtKB/Swiss-Prot),   F1LQ35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015498   ⟸   ENSRNOT00000015498
RefSeq Acc Id: XP_038965388   ⟸   XM_039109460
- Peptide Label: isoform X3
- UniProtKB: A6I8A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965381   ⟸   XM_039109453
- Peptide Label: isoform X1
- UniProtKB: A6I8A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965391   ⟸   XM_039109463
- Peptide Label: isoform X4
- UniProtKB: A6I8A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965386   ⟸   XM_039109458
- Peptide Label: isoform X2
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63085-F1-model_v2 AlphaFold Q63085 1-1108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61943 AgrOrtholog
BioCyc Gene G2FUF-57737 BioCyc
Ensembl Genes ENSRNOG00000011417 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015498.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29516 UniProtKB/Swiss-Prot
NCBI Gene 29516 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pde3b PhenoGen
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011417 RatGTEx
SMART HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233114
UniProt A6I8A6_RAT UniProtKB/TrEMBL
  A6I8A7 ENTREZGENE, UniProtKB/TrEMBL
  A6I8A8 ENTREZGENE, UniProtKB/TrEMBL
  F1LQ35 ENTREZGENE, UniProtKB/TrEMBL
  PDE3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pde3b  phosphodiesterase 3B  Pde3b  phosphodiesterase 3B, cGMP-inhibited  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pde3b  phosphodiesterase 3B, cGMP-inhibited  Pde3b  phosphodiesterase 3B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pde3b  phosphodiesterase 3B      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in cells important for energy metabolism, including white and brown adipocytes and hepatocytes 729537