Pde3b (phosphodiesterase 3B) - Rat Genome Database

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Gene: Pde3b (phosphodiesterase 3B) Rattus norvegicus
Analyze
Symbol: Pde3b
Name: phosphodiesterase 3B
RGD ID: 61943
Description: Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and phosphoprotein binding activity. Involved in negative regulation of cAMP/PKA signal transduction and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Predicted to be part of guanyl-nucleotide exchange factor complex. Orthologous to human PDE3B (phosphodiesterase 3B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; insulin signaling pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGI PDE; CGI-PDE B; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cyclic GMP-inhibited phosphodiesterase B; phosphodiesterase 3B cGMP inhibited; phosphodiesterase 3B cGMP-inhibited; phosphodiesterase 3B, cGMP inhibited; phosphodiesterase 3B, cGMP-inhibited; RcGIPl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,041,207 - 178,204,503 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1178,041,207 - 178,204,503 (+)EnsemblGRCr8
mRatBN7.21168,606,762 - 168,770,078 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,607,022 - 168,769,334 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1176,935,830 - 177,090,997 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,121,900 - 184,277,053 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01176,834,530 - 176,989,699 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,892,841 - 184,078,071 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,892,841 - 184,078,071 (+)Ensemblrn6Rnor6.0
Rnor_5.01190,865,614 - 191,050,207 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,409,282 - 172,577,108 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1166,458,524 - 166,609,913 (+)NCBICelera
RGSC_v3.11172,545,390 - 172,713,217 (+)NCBI
Cytogenetic Map1q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
CL316243  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
isoprenaline  (EXP)
ketoconazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
raloxifene  (ISO)
roflumilast  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triazines  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. Harndahl L, etal., J Biol Chem 2002 Oct 4;277(40):37446-55.
5. Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3). He R, etal., Cell Biochem Biophys. 1998;29(1-2):89-111. doi: 10.1007/BF02737830.
6. Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: differential subcellular localization and regulated expression by cyclic AMP. Liu H and Maurice DH, Br J Pharmacol. 1998 Dec;125(7):1501-10.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cyclic nucleotide phosphodiesterase 3 expression in vivo: evidence for tissue-specific expression of phosphodiesterase 3A or 3B mRNA and activity in the aorta and adipose tissue of atherosclerosis-prone insulin-resistant rats. Nagaoka T, etal., Diabetes. 1998 Jul;47(7):1135-44.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. A newly identified 50 kDa protein, which is associated with phosphodiesterase 3B, is phosphorylated by insulin in rat adipocytes. Onuma H, etal., Biochem Biophys Res Commun. 2005 Nov 25;337(3):976-82. Epub 2005 Oct 3.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase. Taira M, etal., J Biol Chem 1993 Sep 5;268(25):18573-9.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Vascular smooth muscle cell phosphodiesterase (PDE) 3 and PDE4 activities and levels are regulated by cyclic AMP in vivo. Tilley DG and Maurice DH, Mol Pharmacol. 2002 Sep;62(3):497-506.
18. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, etal., Biochem Pharmacol. 2008 Oct 1;76(7):884-93. Epub 2008 Jul 26.
Additional References at PubMed
PMID:8562305   PMID:9102399   PMID:10454575   PMID:10952971   PMID:11641262   PMID:14736883   PMID:15961276   PMID:16503395   PMID:17286556   PMID:17884339   PMID:18586889   PMID:19486524  
PMID:19946888   PMID:20471454   PMID:21152070   PMID:21393242   PMID:21435395   PMID:22967108   PMID:22990990   PMID:35030973  


Genomics

Comparative Map Data
Pde3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,041,207 - 178,204,503 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1178,041,207 - 178,204,503 (+)EnsemblGRCr8
mRatBN7.21168,606,762 - 168,770,078 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,607,022 - 168,769,334 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1176,935,830 - 177,090,997 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,121,900 - 184,277,053 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01176,834,530 - 176,989,699 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,892,841 - 184,078,071 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,892,841 - 184,078,071 (+)Ensemblrn6Rnor6.0
Rnor_5.01190,865,614 - 191,050,207 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,409,282 - 172,577,108 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1166,458,524 - 166,609,913 (+)NCBICelera
RGSC_v3.11172,545,390 - 172,713,217 (+)NCBI
Cytogenetic Map1q34NCBI
PDE3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,643,804 - 14,899,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,643,663 - 14,874,614 (+)Ensemblhg38GRCh38
GRCh371114,665,350 - 14,920,867 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,621,907 - 14,848,926 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341114,621,906 - 14,848,926NCBI
Celera1114,790,352 - 15,020,727 (+)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,328,113 - 14,576,051 (+)NCBIHuRef
CHM1_11114,664,181 - 14,892,596 (+)NCBICHM1_1
T2T-CHM13v2.01114,739,099 - 14,995,688 (+)NCBIT2T-CHM13v2.0
Pde3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397114,014,388 - 114,137,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7114,014,516 - 114,138,486 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387114,415,222 - 114,537,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7114,415,281 - 114,539,251 (+)Ensemblmm10GRCm38
MGSCv377121,558,768 - 121,681,451 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367114,206,462 - 114,327,893 (+)NCBIMGSCv36mm8
Celera7114,368,837 - 114,491,103 (+)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.46NCBI
Pde3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541429,783,963 - 29,909,685 (+)Ensembl
ChiLan1.0NW_00495541429,783,999 - 29,911,329 (+)NCBIChiLan1.0ChiLan1.0
PDE3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,024,754 - 17,239,818 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,985,620 - 17,200,694 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,746,301 - 14,961,316 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,437,060 - 14,653,070 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,437,060 - 14,648,616 (+)EnsemblpanPan2panpan1.1
PDE3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12137,364,940 - 37,532,152 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2137,364,623 - 37,530,597 (+)NCBIcanFam3CanFam3.1
Dog10K_Boxer_Tasha2136,866,331 - 37,033,861 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02138,252,613 - 38,465,284 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.02138,403,153 - 38,625,755 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2138,252,494 - 38,464,418 (+)EnsemblROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl2138,578,056 - 38,627,025 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12137,502,202 - 37,670,266 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02137,681,141 - 37,858,115 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02137,969,597 - 38,137,719 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pde3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494747,887,624 - 48,054,011 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365283,923,379 - 4,087,188 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365283,922,436 - 4,087,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl244,412,833 - 44,726,216 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1244,416,934 - 44,614,075 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2247,572,598 - 47,653,532 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1150,050,168 - 50,254,797 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl150,047,477 - 50,254,807 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038147,554,281 - 147,796,470 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,492,897 - 6,635,823 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247666,492,803 - 6,636,059 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pde3b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1287,016,316 - 87,135,460 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pde3b
928 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:116
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000015498
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat

Markers in Region
D1Wox60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,768,601 - 168,768,808 (+)MAPPERmRatBN7.2
Rnor_6.01184,077,339 - 184,077,545NCBIRnor6.0
Rnor_5.01191,049,475 - 191,049,681UniSTSRnor5.0
RGSC_v3.41172,576,376 - 172,576,582UniSTSRGSC3.4
Celera1166,609,181 - 166,609,387UniSTS
Cytogenetic Map1q34UniSTS
RH134896  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01190,944,921 - 190,945,109NCBIRnor5.0
Rnor_5.01288,697,558 - 288,697,750NCBIRnor5.0
RGSC_v3.41266,745,833 - 266,746,024UniSTSRGSC3.4
RGSC_v3.41172,469,199 - 172,469,386UniSTSRGSC3.4
Celera1254,981,639 - 254,981,830UniSTS
Celera1166,512,573 - 166,512,760UniSTS
Cytogenetic Map1q34UniSTS
AI235078  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,625,480 - 168,625,659 (+)MAPPERmRatBN7.2
Rnor_6.01183,911,827 - 183,912,005NCBIRnor6.0
Rnor_5.01190,884,600 - 190,884,778UniSTSRnor5.0
RGSC_v3.41172,428,322 - 172,428,500UniSTSRGSC3.4
Celera1166,476,944 - 166,477,122UniSTS
RH 3.4 Map11318.0UniSTS
Cytogenetic Map1q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015498   ⟹   ENSRNOP00000015498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,041,306 - 178,204,503 (+)Ensembl
mRatBN7.2 Ensembl1168,607,022 - 168,769,334 (+)Ensembl
Rnor_6.0 Ensembl1183,892,841 - 184,078,071 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142640   ⟹   ENSRNOP00000104536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,041,207 - 178,204,503 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157387   ⟹   ENSRNOP00000101474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,041,207 - 178,204,503 (+)Ensembl
RefSeq Acc Id: NM_017229   ⟹   NP_058925
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,207 - 178,204,503 (+)NCBI
mRatBN7.21168,606,787 - 168,770,078 (+)NCBI
Rnor_6.01183,892,841 - 184,078,071 (+)NCBI
Rnor_5.01190,865,614 - 191,050,207 (+)NCBI
RGSC_v3.41172,409,282 - 172,577,108 (+)RGD
Celera1166,458,524 - 166,609,913 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109453   ⟹   XP_038965381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,247 - 178,183,589 (+)NCBI
mRatBN7.21168,606,764 - 168,750,081 (+)NCBI
RefSeq Acc Id: XM_039109458   ⟹   XP_038965386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,160,257 - 178,204,499 (+)NCBI
mRatBN7.21168,725,748 - 168,770,078 (+)NCBI
RefSeq Acc Id: XM_039109460   ⟹   XP_038965388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,246 - 178,174,992 (+)NCBI
mRatBN7.21168,606,762 - 168,740,661 (+)NCBI
RefSeq Acc Id: XM_039109463   ⟹   XP_038965391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,041,247 - 178,174,611 (+)NCBI
mRatBN7.21168,606,764 - 168,740,820 (+)NCBI
RefSeq Acc Id: NP_058925   ⟸   NM_017229
- UniProtKB: Q63085 (UniProtKB/Swiss-Prot),   F1LQ35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015498   ⟸   ENSRNOT00000015498
RefSeq Acc Id: XP_038965388   ⟸   XM_039109460
- Peptide Label: isoform X3
- UniProtKB: A6I8A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965381   ⟸   XM_039109453
- Peptide Label: isoform X1
- UniProtKB: A6I8A7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965391   ⟸   XM_039109463
- Peptide Label: isoform X4
- UniProtKB: A6I8A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965386   ⟸   XM_039109458
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000104536   ⟸   ENSRNOT00000142640
Ensembl Acc Id: ENSRNOP00000101474   ⟸   ENSRNOT00000157387
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63085-F1-model_v2 AlphaFold Q63085 1-1108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61943 AgrOrtholog
BioCyc Gene G2FUF-57737 BioCyc
Ensembl Genes ENSRNOG00000011417 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000157387 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
KEGG Report rno:29516 UniProtKB/Swiss-Prot
NCBI Gene 29516 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot
Pfam PDEase_I UniProtKB/Swiss-Prot
PhenoGen Pde3b PhenoGen
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011417 RatGTEx
SMART HDc UniProtKB/Swiss-Prot
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot
TIGR TC233114
UniProt A0ABK0LDR6_RAT UniProtKB/TrEMBL
  A0ABK0LG49_RAT UniProtKB/TrEMBL
  A6I8A6_RAT UniProtKB/TrEMBL
  A6I8A7 ENTREZGENE, UniProtKB/TrEMBL
  A6I8A8 ENTREZGENE, UniProtKB/TrEMBL
  F1LQ35 ENTREZGENE, UniProtKB/TrEMBL
  PDE3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pde3b  phosphodiesterase 3B  Pde3b  phosphodiesterase 3B, cGMP-inhibited  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pde3b  phosphodiesterase 3B, cGMP-inhibited  Pde3b  phosphodiesterase 3B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pde3b  phosphodiesterase 3B      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in cells important for energy metabolism, including white and brown adipocytes and hepatocytes 729537