Prkce (protein kinase C, epsilon) - Rat Genome Database

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Gene: Prkce (protein kinase C, epsilon) Rattus norvegicus
Symbol: Prkce
Name: protein kinase C, epsilon
RGD ID: 61925
Description: Enables several functions, including SH3 domain binding activity; diacylglycerol-dependent serine/threonine kinase activity; and protein serine/threonine kinase binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of mitochondrial calcium ion concentration; and negative regulation of mitochondrial membrane potential. Located in Golgi membrane and T-tubule. Is active in glutamatergic synapse; neuromuscular junction; and presynaptic cytosol. Used to study hypertension. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCE (protein kinase C epsilon); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (R)-adrenaline; (S)-nicotine; 1,1-dichloroethene.
Type: protein-coding
Previously known as: nPKC-epsilon; Pkce; protein kinase C epsilon type
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8613,718,050 - 14,204,931 (-)NCBIGRCr8
mRatBN7.267,965,048 - 8,451,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,965,048 - 8,451,719 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx68,241,962 - 8,728,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,551,358 - 9,037,685 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.068,078,663 - 8,564,995 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.069,483,400 - 9,973,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.069,404,548 - 9,883,579 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.469,631,234 - 10,097,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.169,631,241 - 10,097,311 (+)NCBI
Celera67,696,161 - 8,179,574 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (EXP)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arjunolic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chelerythrine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
daidzein  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dobutamine  (ISO)
dofetilide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Droloxifene  (ISO)
ethanol  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP,ISO)
gingerol  (ISO)
haloperidol  (EXP)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
Licochalcone A  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lysophosphatidylcholine  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylene blue  (ISO)
methylparaben  (ISO)
morin  (ISO)
myxothiazol  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
PD123319  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin E2  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
Ro 31-8220  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium cyanide  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin D  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
cell-substrate adhesion  (IEA,ISO)
cellular response to ethanol  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (IMP)
cellular response to prostaglandin E stimulus  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
insulin secretion  (IEA,ISO)
intracellular signal transduction  (IBA,IDA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO,ISS)
locomotory exploration behavior  (IEA,ISO)
macrophage activation involved in immune response  (IEA,ISO)
MAPK cascade  (IEA,ISO)
mucus secretion  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of mitochondrial calcium ion concentration  (IMP)
negative regulation of mitochondrial membrane potential  (IMP)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of release of sequestered calcium ion into cytosol  (IMP)
positive regulation of actin filament polymerization  (IEA,ISO,ISS)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell-substrate adhesion  (IEA,ISO)
positive regulation of cellular glucuronidation  (IEA,ISO)
positive regulation of cytokinesis  (IEA,ISO,ISS)
positive regulation of epithelial cell migration  (IEA,ISO,ISS)
positive regulation of fibroblast migration  (IEA,ISO,ISS)
positive regulation of insulin secretion  (IEA,ISO)
positive regulation of lipid catabolic process  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mucus secretion  (IEA,ISO)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO)
positive regulation of wound healing  (IEA,ISO,ISS)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA)
regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO)
regulation of lipid metabolic process  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
response to morphine  (IEA,ISO)
synaptic transmission, GABAergic  (IEA,ISO)
TRAM-dependent toll-like receptor 4 signaling pathway  (IEA,ISO,ISS)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
2. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
3. The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon. Csukai M, etal., J Biol Chem 1997 Nov 14;272(46):29200-6.
4. Post-conditioning protects cardiomyocytes from apoptosis via PKC(epsilon)-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. Dong S, etal., Mol Cell Biochem. 2010 Aug;341(1-2):195-206. doi: 10.1007/s11010-010-0450-5. Epub 2010 Apr 11.
5. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Fenton RA, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H718-25. Epub 2009 Jun 12.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. CASK associates with glutamate receptor interacting protein and signaling molecules. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
9. MicroRNA-143 promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase Cepsilon. Hong H, etal., Basic Res Cardiol. 2017 Sep 8;112(6):60. doi: 10.1007/s00395-017-0649-7.
10. Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family. Housey GM, etal., Proc Natl Acad Sci U S A 1987 Feb;84(4):1065-9.
11. PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists. Iwata M, etal., Biochem Biophys Res Commun. 2005 Feb 25;327(4):1105-13. doi: 10.1016/j.bbrc.2004.12.128.
12. The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling. Jacob AI, etal., J Mol Endocrinol. 2010 Mar;44(3):155-69. Epub 2009 Dec 1.
13. Protein kinase C isozymes in hypertension and hypertrophy: insight from SHHF rat hearts. Johnsen DD, etal., Mol Cell Biochem. 2005 Feb;270(1-2):63-9.
14. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. Kuroda S, etal., J Cell Biol 1999 Feb 8;144(3):403-11.
15. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. Mohammadi K, etal., J Biol Chem 2001 Nov 9;276(45):42050-6.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
20. The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction. Obis T, etal., Mol Brain. 2015 Dec 1;8(1):80. doi: 10.1186/s13041-015-0171-5.
21. The structure, expression, and properties of additional members of the protein kinase C family. Ono Y, etal., J Biol Chem 1988 May 15;263(14):6927-32.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Cellular and intracellular localization of epsilon-subspecies of protein kinase C in the rat brain; presynaptic localization of the epsilon-subspecies. Saito N, etal., Brain Res. 1993 Apr 2;607(1-2):241-8.
28. Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes. Seed Ahmed M, etal., PLoS One. 2015 Sep 23;10(9):e0135781. doi: 10.1371/journal.pone.0135781. eCollection 2015.
29. Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins. Tokunaga C, etal., Biochem Biophys Res Commun 1998 Mar 17;244(2):353-9.
30. Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells. Williams HC, etal., Circ Res. 2012 Jun 22;111(1):56-65. doi: 10.1161/CIRCRESAHA.111.255745. Epub 2012 May 22.
31. Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm. Young E, etal., Hippocampus 2002;12(4):457-64.
Additional References at PubMed
PMID:3691811   PMID:8940095   PMID:9447980   PMID:10407019   PMID:10431815   PMID:10879655   PMID:11118818   PMID:11696589   PMID:11738801   PMID:11746497   PMID:11884367   PMID:11934807  
PMID:11940581   PMID:11950946   PMID:12064598   PMID:12496267   PMID:12551921   PMID:12566450   PMID:12590138   PMID:12606313   PMID:12626328   PMID:12665507   PMID:12665800   PMID:12694383  
PMID:12763745   PMID:12829427   PMID:12837755   PMID:12943654   PMID:12967635   PMID:14529276   PMID:14534528   PMID:14561782   PMID:14578604   PMID:14613966   PMID:14679204   PMID:14963000  
PMID:15039458   PMID:15096499   PMID:15181371   PMID:15339253   PMID:15499382   PMID:15532718   PMID:15596539   PMID:15632189   PMID:15695813   PMID:15764590   PMID:15769752   PMID:15805233  
PMID:15838306   PMID:15886222   PMID:15905535   PMID:15949469   PMID:16084468   PMID:16270034   PMID:16336199   PMID:16564619   PMID:16574982   PMID:16648180   PMID:16720572   PMID:16757566  
PMID:16793902   PMID:16836642   PMID:16870611   PMID:16899053   PMID:16960097   PMID:17035302   PMID:17038313   PMID:17091491   PMID:17202284   PMID:17300177   PMID:17307294   PMID:17350763  
PMID:17513490   PMID:17553064   PMID:17569658   PMID:17577736   PMID:17603037   PMID:17611075   PMID:17660387   PMID:17673178   PMID:17675573   PMID:17728104   PMID:17728398   PMID:17762167  
PMID:17875639   PMID:17908177   PMID:17951366   PMID:17964599   PMID:17989210   PMID:18070622   PMID:18182053   PMID:18184652   PMID:18323529   PMID:18342576   PMID:18380541   PMID:18388183  
PMID:18390563   PMID:18408135   PMID:18417696   PMID:18480594   PMID:18486624   PMID:18496674   PMID:18534741   PMID:18556656   PMID:18586884   PMID:18604201   PMID:18668351   PMID:18789391  
PMID:18804478   PMID:18957990   PMID:18973552   PMID:19057126   PMID:19098115   PMID:19101610   PMID:19160413   PMID:19166962   PMID:19249914   PMID:19286950   PMID:19324912   PMID:19339511  
PMID:19373133   PMID:19401415   PMID:19429666   PMID:19432558   PMID:19470841   PMID:19563686   PMID:19593582   PMID:19685039   PMID:19842549   PMID:19879903   PMID:19929130   PMID:20052676  
PMID:20177957   PMID:20307649   PMID:20538683   PMID:20558438   PMID:20585956   PMID:20665664   PMID:20837910   PMID:20951185   PMID:21075822   PMID:21118579   PMID:21162303   PMID:21183751  
PMID:21236337   PMID:21625957   PMID:21855786   PMID:21880866   PMID:21899994   PMID:22139554   PMID:22233927   PMID:22259083   PMID:22323716   PMID:22426212   PMID:22427674   PMID:22453000  
PMID:22550975   PMID:22699119   PMID:22761303   PMID:22936275   PMID:23427086   PMID:23479225   PMID:23564461   PMID:23636617   PMID:23846691   PMID:23911427   PMID:24011917   PMID:24058702  
PMID:24298017   PMID:24667915   PMID:24742623   PMID:24770357   PMID:24827390   PMID:24828410   PMID:24998921   PMID:25450614   PMID:25470454   PMID:25761522   PMID:25857252   PMID:26199377  
PMID:26313243   PMID:26429793   PMID:26844384   PMID:27035121   PMID:27330081   PMID:27385722   PMID:27655723   PMID:27919679   PMID:27925653   PMID:28585865   PMID:29195789   PMID:29266405  
PMID:29470978   PMID:30053369   PMID:30352252   PMID:30392913   PMID:30607888   PMID:31473978   PMID:32906765   PMID:33368632   PMID:34147527  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8613,718,050 - 14,204,931 (-)NCBIGRCr8
mRatBN7.267,965,048 - 8,451,966 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,965,048 - 8,451,719 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx68,241,962 - 8,728,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,551,358 - 9,037,685 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.068,078,663 - 8,564,995 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.069,483,400 - 9,973,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.069,404,548 - 9,883,579 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.469,631,234 - 10,097,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.169,631,241 - 10,097,311 (+)NCBI
Celera67,696,161 - 8,179,574 (-)NCBICelera
Cytogenetic Map6q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38245,651,279 - 46,187,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl245,651,345 - 46,187,990 (+)EnsemblGRCh38hg38GRCh38
GRCh37245,878,814 - 46,415,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36245,732,547 - 46,268,633 (+)NCBINCBI36Build 36hg18NCBI36
Build 34245,790,693 - 46,326,779NCBI
Celera245,717,245 - 46,253,470 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef245,617,217 - 46,153,158 (+)NCBIHuRef
CHM1_1245,810,047 - 46,345,904 (+)NCBICHM1_1
T2T-CHM13v2.0245,656,327 - 46,193,193 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391786,472,631 - 86,965,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1786,475,213 - 86,965,347 (+)EnsemblGRCm39 Ensembl
GRCm381786,167,785 - 86,657,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,167,785 - 86,657,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv371786,567,125 - 87,057,259 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361786,076,916 - 86,563,024 (+)NCBIMGSCv36mm8
Celera1790,540,474 - 91,038,578 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.74NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495544112,642,697 - 13,139,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544112,642,703 - 13,142,396 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21280,214,185 - 80,750,763 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A80,218,154 - 80,754,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A45,757,629 - 46,294,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A46,688,109 - 47,223,421 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A46,688,436 - 47,220,313 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11047,976,929 - 48,464,614 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1047,976,768 - 48,535,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1047,832,146 - 48,319,423 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01048,849,986 - 49,335,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1048,849,926 - 49,335,759 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11048,557,609 - 49,044,861 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01048,849,404 - 49,334,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,029,809 - 49,517,384 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629234,589,765 - 35,066,607 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365086,017,551 - 6,494,427 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365086,018,374 - 6,495,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl394,349,889 - 94,866,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1394,351,277 - 94,864,549 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,427,723 - 100,762,372 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11461,022,903 - 61,570,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1461,026,017 - 61,242,343 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604550,297,930 - 50,835,743 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473827,118,145 - 27,627,606 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473827,118,764 - 27,630,733 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Prkce
2420 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:52
Interacting mature miRNAs:57
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.268,275,655 - 8,275,790 (-)MAPPERmRatBN7.2
Rnor_6.069,659,961 - 9,660,095NCBIRnor6.0
Rnor_5.069,577,576 - 9,577,710UniSTSRnor5.0
RGSC_v3.469,807,867 - 9,808,002RGDRGSC3.4
RGSC_v3.469,807,868 - 9,808,002UniSTSRGSC3.4
RGSC_v3.169,807,867 - 9,808,002RGD
Celera68,004,968 - 8,005,102UniSTS
SHRSP x BN Map61.1099RGD
SHRSP x BN Map61.1099UniSTS
Cytogenetic Map6q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.268,232,099 - 8,232,286 (-)MAPPERmRatBN7.2
Rnor_6.069,704,663 - 9,704,849NCBIRnor6.0
Rnor_5.069,619,780 - 9,619,966UniSTSRnor5.0
Celera67,961,503 - 7,961,689UniSTS
Cytogenetic Map6q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,964,891 - 7,965,091 (-)MAPPERmRatBN7.2
Rnor_6.069,973,353 - 9,973,552NCBIRnor6.0
Rnor_5.069,883,536 - 9,883,735UniSTSRnor5.0
RGSC_v3.4610,097,268 - 10,097,467UniSTSRGSC3.4
Celera67,696,005 - 7,696,204UniSTS
Cytogenetic Map6q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.268,181,763 - 8,181,960 (-)MAPPERmRatBN7.2
Rnor_6.069,754,982 - 9,755,178NCBIRnor6.0
Rnor_5.069,669,040 - 9,669,236UniSTSRnor5.0
RGSC_v3.469,878,012 - 9,878,208UniSTSRGSC3.4
Celera67,911,138 - 7,911,334UniSTS
Cytogenetic Map6q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,972,792 - 7,974,085 (-)MAPPERmRatBN7.2
Rnor_6.069,964,359 - 9,965,651NCBIRnor6.0
Rnor_5.069,874,542 - 9,875,834UniSTSRnor5.0
RGSC_v3.4610,088,274 - 10,089,566UniSTSRGSC3.4
Cytogenetic Map6q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 34 3 2 11 2 64 19 27 11
Low 2 9 54 39 8 39 8 11 10 16 14 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000020959   ⟹   ENSRNOP00000020959
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl67,965,048 - 8,451,319 (-)Ensembl
Rnor_6.0 Ensembl69,790,422 - 9,973,396 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089272   ⟹   ENSRNOP00000070421
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl68,441,785 - 8,451,719 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097902   ⟹   ENSRNOP00000083427
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl67,965,048 - 8,451,319 (-)Ensembl
RefSeq Acc Id: NM_017171   ⟹   NP_058867
Rat AssemblyChrPosition (strand)Source
GRCr8613,718,050 - 14,204,288 (-)NCBI
mRatBN7.267,965,048 - 8,451,327 (-)NCBI
Rnor_6.069,483,400 - 9,973,396 (+)NCBI
Rnor_5.069,404,548 - 9,883,579 (+)NCBI
RGSC_v3.469,631,234 - 10,097,311 (+)RGD
Celera67,696,161 - 8,179,574 (-)RGD
RefSeq Acc Id: XM_039111827   ⟹   XP_038967755
Rat AssemblyChrPosition (strand)Source
GRCr8613,718,360 - 14,204,931 (-)NCBI
mRatBN7.267,965,352 - 8,451,966 (-)NCBI
RefSeq Acc Id: NP_058867   ⟸   NM_017171
- UniProtKB: P09216 (UniProtKB/Swiss-Prot),   F1LMV8 (UniProtKB/TrEMBL),   Q6DUV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020959   ⟸   ENSRNOT00000020959
RefSeq Acc Id: XP_038967755   ⟸   XM_039111827
- Peptide Label: isoform X1
- UniProtKB: P09216 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000083427   ⟸   ENSRNOT00000097902
RefSeq Acc Id: ENSRNOP00000070421   ⟸   ENSRNOT00000089272
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09216-F1-model_v2 AlphaFold P09216 1-737 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61925 AgrOrtholog
BIND 133998
BioCyc Gene G2FUF-38703 BioCyc
Ensembl Genes ENSRNOG00000015603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020959 ENTREZGENE
  ENSRNOT00000020959.8 UniProtKB/TrEMBL
  ENSRNOT00000089272.2 UniProtKB/TrEMBL
  ENSRNOT00000097902.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  nPKC_epsilon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKC_epsilon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkce PhenoGen
PIRSF PKC_delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kin_C_epsilon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015603 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary F1LMV8 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prkce  protein kinase C, epsilon      Name updated 70584 APPROVED
2001-12-12 Prkce  protein kinase C, epsilon      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED
2001-12-10 Prkce  protein kinase C, epsilon      --select from list or type below-- 69665 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 628493