Aldh3a2 (aldehyde dehydrogenase 3 family, member A2)

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Gene: Aldh3a2 (aldehyde dehydrogenase 3 family, member A2) Rattus norvegicus

Analyze

Symbol:

Aldh3a2

Name:

aldehyde dehydrogenase 3 family, member A2

RGD ID:

61866

Description:

Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in formaldehyde metabolic process and response to reactive oxygen species. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2); PARTICIPATES IN phytanic acid degradation pathway; Refsum disease pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alcohol dehydrogenase family 3 subfamily A2; alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase 3A2; aldehyde dehydrogenase 4; aldehyde dehydrogenase family 3 member A2; aldehyde dehydrogenase family 3, subfamily A2; Aldh4; FALDH; fatty aldehyde dehydrogenase; microsomal aldehyde dehydrogenase; msALDH

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	45,928,313 - 45,949,366 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,908,524 - 45,949,281 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	50,630,818 - 50,651,382 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	50,121,209 - 50,141,773 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	45,624,781 - 45,645,345 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	47,525,486 - 47,546,535 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	47,525,493 - 47,546,345 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	47,300,324 - 47,321,002 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	47,400,518 - 47,421,064 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	47,414,148 - 47,434,687 (-)	NCBI
Celera	10	45,182,182 - 45,202,711 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

common variable immunodeficiency 2 (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Meckel Syndrome 9 (ISO)

Potocki-Lupski syndrome (ISO)

Sjogren-Larsson syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxyethyl methacrylate (ISO)

2-methylcholine (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,3',5-triiodo-L-thyronine (EXP)

3-chloropropane-1,2-diol (EXP)

5-fluorouracil (ISO)

acetaldehyde (ISO)

acetamide (EXP)

aconitine (EXP)

acrolein (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

antimonite (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bexarotene (EXP)

bezafibrate (ISO)

bicalutamide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

captan (ISO)

carbon nanotube (ISO)

chloroform (EXP)

ciprofibrate (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crotonaldehyde (EXP)

cycloheximide (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibenzofuran (EXP)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

dicrotophos (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

erythromycin estolate (EXP)

finasteride (EXP)

folic acid (ISO)

folpet (ISO)

fumonisin B1 (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

indometacin (EXP)

inulin (ISO)

isoprenaline (ISO)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methapyrilene (EXP)

N-nitrosodiethylamine (ISO)

nefazodone (EXP)

nickel sulfate (ISO)

ochratoxin A (EXP,ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

permethrin (ISO)

phenobarbital (EXP,ISO)

PhIP (EXP)

phlorizin (ISO)

phytol (ISO)

picoxystrobin (ISO)

pirinixic acid (EXP,ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

sulindac (EXP)

sunitinib (ISO)

tamoxifen (ISO)

Tanshinone I (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (EXP)

thapsigargin (EXP)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular aldehyde metabolic process (IBA,IEA,ISO)

central nervous system development (IEA,ISO)

epidermis development (IEA,ISO)

fatty acid metabolic process (IEA)

formaldehyde metabolic process (IDA)

hexadecanal metabolic process (IEA,ISO,ISS)

peripheral nervous system development (IEA,ISO)

phytol metabolic process (IEA,ISO)

response to reactive oxygen species (IDA)

sesquiterpenoid metabolic process (ISO)

Cellular Component

cytoplasm (IBA)

endoplasmic reticulum (IDA,ISO)

endoplasmic reticulum membrane (IDA)

intracellular membrane-bounded organelle (IEA,ISO)

membrane (IEA,ISO)

peroxisome (ISO)

Molecular Function

3-chloroallyl aldehyde dehydrogenase activity (IBA,IDA)

aldehyde dehydrogenase (NAD+) activity (IBA,ISO)

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity (IEA)

long-chain-alcohol oxidase activity (IEA,ISO)

long-chain-aldehyde dehydrogenase activity (IEA,ISO,ISS)

medium-chain-aldehyde dehydrogenase activity (IEA,ISO,ISS)

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

arginine and proline metabolic pathway (IEA)

ascorbate and aldarate metabolic pathway (IEA)

beta-alanine metabolic pathway (IEA)

fatty acid metabolic pathway (IEA)

gluconeogenesis pathway (IEA)

glycerolipid metabolic pathway (IEA)

glycolysis pathway (IEA)

glycolysis/gluconeogenesis pathway (IEA)

histidine metabolic pathway (IEA)

lysine degradation pathway (IEA)

pentose and glucuronate interconversion pathway (IEA)

phytanic acid degradation pathway (ISO)

propanoate metabolic pathway (IEA)

pyruvate metabolic pathway (IEA)

Refsum disease pathway (ISO)

tryptophan metabolic pathway (IEA)

valine, leucine and isoleucine degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.	Demozay D, etal., J Biol Chem 2004 Feb 20;279(8):6261-70. Epub 2003 Nov 24.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Immunocytochemical and biochemical demonstration of formaldhyde dehydrogenase (class III alcohol dehydrogenase) in the nucleus.	Iborra FJ, etal., J Histochem Cytochem 1992 Dec;40(12):1865-78.
5.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
6.	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase.	Miyauchi K, etal., J Biol Chem 1991 Oct 15;266(29):19536-42.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:8528251	PMID:9133646	PMID:12865426	PMID:15110319	PMID:17510064	PMID:18035827	PMID:18614015	PMID:23376485	PMID:25047030	PMID:25286108

Genomics

Comparative Map Data

Aldh3a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	45,928,313 - 45,949,366 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,908,524 - 45,949,281 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	50,630,818 - 50,651,382 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	50,121,209 - 50,141,773 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	45,624,781 - 45,645,345 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	47,525,486 - 47,546,535 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	47,525,493 - 47,546,345 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	47,300,324 - 47,321,002 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	47,400,518 - 47,421,064 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	47,414,148 - 47,434,687 (-)	NCBI
Celera	10	45,182,182 - 45,202,711 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

ALDH3A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	19,648,136 - 19,677,596 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	19,648,136 - 19,685,760 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	19,551,449 - 19,580,909 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	19,492,656 - 19,521,500 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	19,492,682 - 19,521,495	NCBI
Celera	17	16,965,422 - 16,994,253 (+)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	18,931,182 - 18,960,005 (+)	NCBI		HuRef
CHM1_1	17	19,560,917 - 19,589,757 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	19,596,758 - 19,626,215 (+)	NCBI		T2T-CHM13v2.0

Aldh3a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	61,114,240 - 61,158,267 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	61,114,243 - 61,158,290 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	61,223,417 - 61,267,528 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	61,223,417 - 61,267,464 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	61,058,257 - 61,080,629 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	61,060,950 - 61,083,322 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	61,674,448 - 61,696,820 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B2	NCBI
cM Map	11	37.96	NCBI

Aldh3a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	140,760 - 162,742 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	141,592 - 162,376 (-)	NCBI	ChiLan1.0	ChiLan1.0

ALDH3A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	59,452,286 - 59,494,725 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	31,455,386 - 31,482,985 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	36,599,830 - 36,628,102 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	36,599,835 - 36,628,102 (-)	Ensembl	panpan1.1		panPan2

ALDH3A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	40,515,768 - 40,641,377 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	40,515,030 - 40,641,463 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	40,657,648 - 40,782,777 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	40,676,970 - 40,739,907 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	40,593,134 - 40,717,947 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	40,538,776 - 40,664,129 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	40,731,446 - 40,856,529 (-)	NCBI		UU_Cfam_GSD_1.0

Aldh3a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	60,436,975 - 60,460,173 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936881	127,023 - 150,292 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936881	127,090 - 150,269 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDH3A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	59,936,848 - 59,954,358 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	59,936,838 - 59,953,677 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	62,591,931 - 62,608,903 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDH3A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	18,213,284 - 18,241,261 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	18,213,487 - 18,239,271 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	2,605,746 - 2,633,744 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldh3a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	5,912,273 - 5,938,007 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624849	5,911,711 - 5,941,706 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aldh3a2
77 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	636
Count of miRNA genes:	289
Interacting mature miRNAs:	361
Transcripts:	ENSRNOT00000066109
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	42876766	79813922	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat

Markers in Region

D10Rat63

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	45,939,295 - 45,939,457 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	47,536,469 - 47,536,628	NCBI	Rnor6.0
Rnor_5.0	10	47,311,307 - 47,311,466	UniSTS	Rnor5.0
RGSC_v3.4	10	47,411,494 - 47,411,653	UniSTS	RGSC3.4
RGSC_v3.4	10	47,411,493 - 47,411,653	RGD	RGSC3.4
RGSC_v3.1	10	47,425,117 - 47,425,276	RGD
Celera	10	45,193,158 - 45,193,300	UniSTS
RH 3.4 Map	10	530.49	UniSTS
RH 3.4 Map	10	530.49	RGD
RH 2.0 Map	10	508.5	RGD
SHRSP x BN Map	10	41.9499	RGD
FHH x ACI Map	10	39.32	RGD
Cytogenetic Map	10	q22	UniSTS

D10Got73

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	45,939,198 - 45,939,456 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	47,536,372 - 47,536,627	NCBI	Rnor6.0
Rnor_5.0	10	47,311,210 - 47,311,465	UniSTS	Rnor5.0
RGSC_v3.4	10	47,411,396 - 47,411,652	RGD	RGSC3.4
RGSC_v3.4	10	47,411,397 - 47,411,652	UniSTS	RGSC3.4
RGSC_v3.1	10	47,425,019 - 47,425,275	RGD
Celera	10	45,193,061 - 45,193,299	UniSTS
RH 2.0 Map	10	526.9	RGD
Cytogenetic Map	10	q22	UniSTS

RH129148

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	45,928,401 - 45,928,616 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	47,525,575 - 47,525,789	NCBI	Rnor6.0
Rnor_5.0	10	47,300,413 - 47,300,627	UniSTS	Rnor5.0
RGSC_v3.4	10	47,400,600 - 47,400,814	UniSTS	RGSC3.4
Celera	10	45,182,264 - 45,182,478	UniSTS
RH 3.4 Map	10	530.08	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH140634

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	45,945,941 - 45,946,763 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	47,543,111 - 47,543,932	NCBI	Rnor6.0
Rnor_5.0	10	47,317,951 - 47,318,772	UniSTS	Rnor5.0
RGSC_v3.4	10	47,418,138 - 47,418,959	UniSTS	RGSC3.4
Celera	10	45,199,785 - 45,200,606	UniSTS
RH 3.4 Map	10	528.67	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH140757

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	45,948,794 - 45,949,001 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	47,545,964 - 47,546,170	NCBI	Rnor6.0
Rnor_5.0	10	47,320,804 - 47,321,010	UniSTS	Rnor5.0
RGSC_v3.4	10	47,420,991 - 47,421,197	UniSTS	RGSC3.4
Celera	10	45,202,638 - 45,202,844	UniSTS
RH 3.4 Map	10	529.89	UniSTS
Cytogenetic Map	10	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	1	1	74	35	41	11	1
Low							7	10					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB727458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV109765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DW311997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV780143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M73714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000066109 ⟹ ENSRNOP00000061762

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	45,928,320 - 45,949,281 (-)	Ensembl
Rnor_6.0 Ensembl	10	47,525,493 - 47,546,037 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000077461 ⟹ ENSRNOP00000070512

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	45,931,900 - 45,948,892 (-)	Ensembl
Rnor_6.0 Ensembl	10	47,526,531 - 47,546,345 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094032 ⟹ ENSRNOP00000091575

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	45,931,738 - 45,948,892 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102182 ⟹ ENSRNOP00000090663

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	45,908,524 - 45,948,892 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103164 ⟹ ENSRNOP00000091330

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	45,928,306 - 45,949,281 (-)	Ensembl

RefSeq Acc Id:

NM_031731 ⟹ NP_113919

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	45,928,320 - 45,948,868 (-)	NCBI
Rnor_6.0	10	47,525,493 - 47,546,037 (-)	NCBI
Rnor_5.0	10	47,300,324 - 47,321,002 (-)	NCBI
RGSC_v3.4	10	47,400,518 - 47,421,064 (-)	RGD
Celera	10	45,182,182 - 45,202,711 (-)	RGD

Sequence:

show sequence

GGCGGATGGAAGCCAGCTGTCCCGAGAAGCAGTGAACTGTGGCGTCATCCCGAGCAGTGCCTTA
CCGGTATTGTGCTGCTTCACCTGCCTCGCTCGGCGTTCTCCTCAGGCCCCGCCATGGAGCGACA
GGTCCAACGACTTCGCCAGACGTTCCGGTCCGGCCGATCGCGGCCGCTGCGTTTCCGACTGCAG
CAGCTCGAGGCCCTCCGGAGGATGGTGCAAGAGCGAGAGAAGGACATCTTGGCAGCCATCGCAG
CAGACCTGAGCAAAAGTGAACTCAATGCATACAGTCATGAAGTCATTACCATCCTTGGGGAGAT
TGACTTCATGCTGGGGAATCTTCCTGAATTGGCCTCTGCTCGGCCAGCGAAGAAGAACCTGCTT
ACCATGATGGACGAGGCCTATGTTCAGCCAGAGCCTCTGGGAGTCGTGCTGATTATTGGAGCTT
GGAACTATCCTTTTGTTCTGACCCTGCAGCCACTGGTGGGAGCCATTGCTGCAGGAAATGCTGC
CATTGTTAAGCCCTCGGAACTCAGTGAAAACACGGCTAAGATCTTGGCTGAACTCCTCCCTCAG
TATTTAGACCAGGACCTGTACATGATTGTTAATGGCGGCGTTGAAGAAACCACAGAGCTTCTGA
GGCAGCGGTTTGATCACATTCTCTACACAGGAAACACCGCAGTTGGAAAAATTGTCATGGAGGC
TGCTGCCAAGCACCTGACCCCTGTGACCCTGGAGCTCGGGGGCAAAAGCCCATGCTACATTGAC
AGAGACTGTGACCTGGACGTTGCTTGCAGACGGATAACCTGGGGAAAGTACATGAATTGTGGTC
AGACCTGTATTGCTCCTGACTATATCCTGTGTGAAGCCTCCCTCCAGGATCAAATCGTACAGAA
GATTAAGGATACGGTGAAGGACTTTTATGGGGAAAATGTAAAAGCTTCTCCTGATTATGAAAGG
ATCATCAACCTTCGTCACTTTAAGAGGATAAAAAGTTTGCTTGAAGGACAGAAAATAGCTTTTG
GTGGGGAGACTGATGAAGCTACACGCTACATAGCCCCAACCATACTCACTGATGTTGACCCTAA
CTCCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTCCCAATAGTGTCTGTGAAAAATGTG
GAGGAAGCCATAAATTTCATAAATGATCGCGAAAAGCCCCTGGCACTCTACATATTTTCTCACA
ACAATAAGCTCATCAAACGGGTGATTGATGAGACATCCAGTGGTGGAGTCACAGGCAATGATGT
CATCATGCACTTCACTGTTAATTCTTTGCCCTTTGGAGGTGTGGGTGCCAGTGGAATGGGGGCT
TATCATGGCAAATACAGTTTCGATACCTTTTCTCATCAGCGCCCCTGCTTGTTAAAAGGGTTAA
AGGGAGAGAGTGTTAACAAACTCAGGTACCCTCCCAACAGCGAGTCCAAGGTCAGCTGGTCGAA
ATTCTTCCTGCTGAAACAGTTCAACAAAGGAAGGCTGCAGCTGCTGCTTCTCGTGTGCTTGGTT
GCGGTTGCAGCTGTGATCGTCAAGGATCAGCTGTGATGACTTCCTTGTAGCCTCTACTGAAGTA
CCCCTCGGCCAAATGGTTAACACACCAATGCTTTTAAAATTGTACCCAAACCAGGAAATGAAAT
TCACAGGTGAACTGCAGTCAAACCTAAGTTGTTGCCACAAACCACTGATGAAACTCAGTGCTTC
AGCCAAATCCCAGCATTTGTCAGCCGTGCAGGTGCTGAGAGGGTGGAGACTGGGAGGGGCGACA
CCTAGTCCATGGCAGCGGGATGTCAGGGAGACTCGACAACTGCTCCCGCAGCTCTTTGCTCCAG
GACATAGCTCTGCCCACCCGGTGTCAACACCCTCCAGGCTTTCCAGCTGTCCTCTGATTGCTGA
GGTTCCTGTTAGGGACCGAGGTACTAAACCTGGGCGGGTGGATTTGTCGGCCTCATCCATTGTG
GCTCGAGACCGGCCTTCGGGAGTCGGCTCTCAGTCTAAACATCCTTTCTCATTCATAGTGTGTC
ACCCGAAGATGCTTGTTTGTGACATTGTGACAGTCTGTCATGACTGTCCCGGTGCCTTTGTGAT
GACTTAAACTACACTGAGGAGCTTGCCAACTTGTGAATGCCCTTCAGAGGGTCTGGCAGTCACA
GCTGTTCCAGAGCCCGAGGGCAGAAGATTCCGGAGCCCGGGAGTTTGAGGCCAACCTAGGCAAC
ATAATGGGACCCTCTCATTATTATTCCTCCATAACAATCCCCTCGAGACCCTCGATTTGAATGT
TATATAGGTCTTCAGGATAAATCTGCTTATTTTCACAGCACAACACAAAAAAAATTTACTTTTG
AAATCTTAGAGAGATTCCTACAGATCTTAGCATGGAGCTGTTCCTGTAGTGAAAGGGGGGTTAT
TAGACATGAGGCTTCAGAACTCATGGGGCAGGGTTGTTGGAGACTACCGTGAGCTGAGGGGGCA
CACTGAAGCGATGGGATGGCCAGAAGCGCACCTGAGCAAGCGGGGCAGCATTCTCTGTCAGACC
CTAACATGGCTACACAGGGATGTGGCAGAGAGATCTGTGTGGCCCTGCTGCCAGGGCCTGGTTA
GGCCTGAAGCTCCAAGCTGCAGAGGTCTCATTGCCTTCCCAGGATCCAAATTAAGACTGCCCAC
TCAATGAGAATGTCACTTGCGTATGTACAACCATGTTTGCTGAGTAACCTGTTCCACCGTTGAG
GCTGTCTGAAGTGTATTGTATGAGGTATCAAGAACGAGTCATTGGCCCATTTGGCAAATAGTTG
CTTATGTAGCAATTGTCATGGACTAATCATAAAATATTTTGCACAAAATTTCAATGTTGAACTT
GCACTCACTGTTGTTAAATTATAAATCACAGCTTCTAGTTAGGCCAAAATATTTACATACTCTA
CTAATCTTCAAAATAAATGTATCCCATACCTTA

hide sequence

RefSeq Acc Id:

XM_006246529 ⟹ XP_006246591

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	45,928,313 - 45,949,366 (-)	NCBI
Rnor_6.0	10	47,525,486 - 47,546,535 (-)	NCBI
Rnor_5.0	10	47,300,324 - 47,321,002 (-)	NCBI

Sequence:

show sequence

ACCGCCATTGCTGAGCAGCCCCAGATGGGGCTAATTAGTCTAGAGAGGAGATTTGGAGAACCTC
GGAAGATACGCATTAAAGAGGATTAAAAATCGGTGTGGGATATGACAATGCTTGTGTGTGTACA
ATGGATCCACCTTCTTCGTGCGCGTCATCCAGCCCACCCCAGTCACAGCCAGCGACTTTGCCTC
TGAATCTGAGGCGCCCTAGGCGAAGGGAGGTTGCTTCCGGCCTGGTGAGCACCTCGGGGCCTCA
GTTCCTCTTCCTAGAGGACGCTGGGCTCTTTTCTGAAGCCAGAACAATTCTTCCGCGTCTTTGC
GTGCCAAAAACTGCACCTACACACCCCCGCCCCGGAGCAGCAATCGGAAGGCTCGGTTAGTGGT
ATGGGGGCGTGGCCTCGTGGTCTTGTGCAGCGGCCCAGCCAATGGGTACGCACTTTGTCGTTAG
CGGCGGAGCGCTGGGGTTTGGTCCACACAAGGGTTTGGTCTGGGCCAGTAGGCGGATGGAAGCC
AGCTGTCCCGAGAAGCAGTGAACTGTGGCGTCATCCCGAGCAGTGCCTTACCGGTATTGTGCTG
CTTCACCTGCCTCGCTCGGCGTTCTCCTCAGGCCCCGCCATGGAGCGACAGGTCCAACGACTTC
GCCAGACGTTCCGGTCCGGCCGATCGCGGCCGCTGCGTTTCCGACTGCAGCAGCTCGAGGCCCT
CCGGAGGATGGTGCAAGAGCGAGAGAAGGACATCTTGGCAGCCATCGCAGCAGACCTGAGCAAA
AGTGAACTCAATGCATACAGTCATGAAGTCATTACCATCCTTGGGGAGATTGACTTCATGCTGG
GGAATCTTCCTGAATTGGCCTCTGCTCGGCCAGCGAAGAAGAACCTGCTTACCATGATGGACGA
GGCCTATGTTCAGCCAGAGCCTCTGGGAGTCGTGCTGATTATTGGAGCTTGGAACTATCCTTTT
GTTCTGACCCTGCAGCCACTGGTGGGAGCCATTGCTGCAGGAAATGCTGCCATTGTTAAGCCCT
CGGAACTCAGTGAAAACACGGCTAAGATCTTGGCTGAACTCCTCCCTCAGTATTTAGACCAGGA
CCTGTACATGATTGTTAATGGCGGCGTTGAAGAAACCACAGAGCTTCTGAGGCAGCGGTTTGAT
CACATTCTCTACACAGGAAACACCGCAGTTGGAAAAATTGTCATGGAGGCTGCTGCCAAGCACC
TGACCCCTGTGACCCTGGAGCTCGGGGGCAAAAGCCCATGCTACATTGACAGAGACTGTGACCT
GGACGTTGCTTGCAGACGGATAACCTGGGGAAAGTACATGAATTGTGGTCAGACCTGTATTGCT
CCTGACTATATCCTGTGTGAAGCCTCCCTCCAGGATCAAATCGTACAGAAGATTAAGGATACGG
TGAAGGACTTTTATGGGGAAAATGTAAAAGCTTCTCCTGATTATGAAAGGATCATCAACCTTCG
TCACTTTAAGAGGATAAAAAGTTTGCTTGAAGGACAGAAAATAGCTTTTGGTGGGGAGACTGAT
GAAGCTACACGCTACATAGCCCCAACCATACTCACTGATGTTGACCCTAACTCCAAGGTGATGC
AAGAAGAAATTTTTGGACCAATTCTCCCAATAGTGTCTGTGAAAAATGTGGAGGAAGCCATAAA
TTTCATAAATGATCGCGAAAAGCCCCTGGCACTCTACATATTTTCTCACAACAATAAGCTCATC
AAACGGGTGATTGATGAGACATCCAGTGGTGGAGTCACAGGCAATGATGTCATCATGCACTTCA
CTGTTAATTCTTTGCCCTTTGGAGGTGTGGGTGCCAGTGGAATGGGGGCTTATCATGGCAAATA
CAGTTTCGATACCTTTTCTCATCAGCGCCCCTGCTTGTTAAAAGGGTTAAAGGGAGAGAGTGTT
AACAAACTCAGGTACCCTCCCAACAGCGAGTCCAAGGTCAGCTGGTCGAAATTCTTCCTGCTGA
AACAGTTCAACAAAGGAAGGCTGCAGCTGCTGCTTCTCGTGTGCTTGGTTGCGGTTGCAGCTGT
GATCGTCAAGAAATACCAAGCTCTGTGGAGGGGAAAAGCCCTGTTGGCTTCTCTGATAGTTCAG
AGACTGCGCTGGTCCAGTAAGCACTGATGGTCAGGCCTCAGCTGTCCTTTGAGAGTGAGGATCA
GCTGTGATGACTTCCTTGTAGCCTCTACTGAAGTACCCCTCGGCCAAATGGTTAACACACCAAT
GCTTTTAAAATTGTACCCAAACCAGGAAATGAAATTCACAGGTGAACTGCAGTCAAACCTAAGT
TGTTGCCACAAACCACTGATGAAACTCAGTGCTTCAGCCAAATCCCAGCATTTGTCAGCCGTGC
AGGTGCTGAGAGGGTGGAGACTGGGAGGGGCGACACCTAGTCCATGGCAGCGGGATGTCAGGGA
GACTCGACAACTGCTCCCGCAGCTCTTTGCTCCAGGACATAGCTCTGCCCACCCGGTGTCAACA
CCCTCCAGGCTTTCCAGCTGTCCTCTGATTGCTGAGGTTCCTGTTAGGGACCGAGGTACTAAAC
CTGGGCGGGTGGATTTGTCGGCCTCATCCATTGTGGCTCGAGACCGGCCTTCGGGAGTCGGCTC
TCAGTCTAAACATCCTTTCTCATTCATAGTGTGTCACCCGAAGATGCTTGTTTGTGACATTGTG
ACAGTCTGTCATGACTGTCCCGGTGCCTTTGTGATGACTTAAACTACACTGAGGAGCTTGCCAA
CTTGTGAATGCCCTTCAGAGGGTCTGGCAGTCACAGCTGTTCCAGAGCCCGAGGGCAGAAGATT
CCGGAGCCCGGGAGTTTGAGGCCAACCTAGGCAACATAATGGGACCCTCTCATTATTATTCCTC
CATAACAATCCCCTCGAGACCCTCGATTTGAATGTTATATAGGTCTTCAGGATAAATCTGCTTA
TTTTCACAGCACAACACAAAAAAAATTTACTTTTGAAATCTTAGAGAGATTCCTACAGATCTTA
GCATGGAGCTGTTCCTGTAGTGAAAGGGGGGTTATTAGACATGAGGCTTCAGAACTCATGGGGC
AGGGTTGTTGGAGACTACCGTGAGCTGAGGGGGCACACTGAAGCGATGGGATGGCCAGAAGCGC
ACCTGAGCAAGCGGGGCAGCATTCTCTGTCAGACCCTAACATGGCTACACAGGGATGTGGCAGA
GAGATCTGTGTGGCCCTGCTGCCAGGGCCTGGTTAGGCCTGAAGCTCCAAGCTGCAGAGGTCTC
ATTGCCTTCCCAGGATCCAAATTAAGACTGCCCACTCAATGAGAATGTCACTTGCGTATGTACA
ACCATGTTTGCTGAGTAACCTGTTCCACCGTTGAGGCTGTCTGAAGTGTATTGTATGAGGTATC
AAGAACGAGTCATTGGCCCATTTGGCAAATAGTTGCTTATGTAGCAATTGTCATGGACTAATCA
TAAAATATTTTGCACAAAATTTCAATGTTGAACTTGCACTCACTGTTGTTAAATTATAAATCAC
AGCTTCTAGTTAGGCCAAAATATTTACATACTCTACTAATCTTCAAAATAAATGTATCCCATAC
CTTATTGTGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113919	(Get FASTA)	NCBI Sequence Viewer
	XP_006246591	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41555	(Get FASTA)	NCBI Sequence Viewer
	EDM04679	(Get FASTA)	NCBI Sequence Viewer
	P30839	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113919 ⟸ NM_031731

- UniProtKB:

P30839 (UniProtKB/Swiss-Prot), G3V9W6 (UniProtKB/TrEMBL), A6HF75 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERQVQRLRQTFRSGRSRPLRFRLQQLEALRRMVQEREKDILAAIAADLSKSELNAYSHEVITI
LGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPFVLTLQPLVGAIAA
GNAAIVKPSELSENTAKILAELLPQYLDQDLYMIVNGGVEETTELLRQRFDHILYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRITWGKYMNCGQTCIAPDYILCEASLQDQ
IVQKIKDTVKDFYGENVKASPDYERIINLRHFKRIKSLLEGQKIAFGGETDEATRYIAPTILTD
VDPNSKVMQEEIFGPILPIVSVKNVEEAINFINDREKPLALYIFSHNNKLIKRVIDETSSGGVT
GNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPCLLKGLKGESVNKLRYPPNSESKV
SWSKFFLLKQFNKGRLQLLLLVCLVAVAAVIVKDQL

hide sequence

RefSeq Acc Id:	XP_006246591 ⟸ XM_006246529
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JY43 (UniProtKB/TrEMBL), A0A8I6AF13 (UniProtKB/TrEMBL), G3V9W6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGAWPRGLVQRPSQWVRTLSLAAERWGLVHTRVWSGPVGGWKPAVPRSSELWRHPEQCLTGIVL LHLPRSAFSSGPAMERQVQRLRQTFRSGRSRPLRFRLQQLEALRRMVQEREKDILAAIAADLSK SELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPF VLTLQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLYMIVNGGVEETTELLRQRFD HILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRITWGKYMNCGQTCIA PDYILCEASLQDQIVQKIKDTVKDFYGENVKASPDYERIINLRHFKRIKSLLEGQKIAFGGETD EATRYIAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVEEAINFINDREKPLALYIFSHNNKLI KRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPCLLKGLKGESV NKLRYPPNSESKVSWSKFFLLKQFNKGRLQLLLLVCLVAVAAVIVKKYQALWRGKALLASLIVQ RLRWSSKH hide sequence

RefSeq Acc Id:

ENSRNOP00000070512 ⟸ ENSRNOT00000077461

RefSeq Acc Id:

ENSRNOP00000061762 ⟸ ENSRNOT00000066109

RefSeq Acc Id:

ENSRNOP00000091575 ⟸ ENSRNOT00000094032

RefSeq Acc Id:

ENSRNOP00000091330 ⟸ ENSRNOT00000103164

RefSeq Acc Id:

ENSRNOP00000090663 ⟸ ENSRNOT00000102182

Protein Domains

Aldehyde dehydrogenase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P30839-F1-model_v2	AlphaFold	P30839	1-484	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61866	AgrOrtholog
BioCyc Gene	G2FUF-24818	BioCyc
Ensembl Genes	ENSRNOG00000002342	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000061762	ENTREZGENE
	ENSRNOP00000061762.2	UniProtKB/TrEMBL
	ENSRNOP00000070512.2	UniProtKB/TrEMBL
	ENSRNOP00000090663.1	UniProtKB/TrEMBL
	ENSRNOP00000091330	ENTREZGENE
	ENSRNOP00000091330.1	UniProtKB/TrEMBL
	ENSRNOP00000091575.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066109	ENTREZGENE
	ENSRNOT00000066109.4	UniProtKB/TrEMBL
	ENSRNOT00000077461.2	UniProtKB/TrEMBL
	ENSRNOT00000094032.1	UniProtKB/TrEMBL
	ENSRNOT00000102182.1	UniProtKB/TrEMBL
	ENSRNOT00000103164	ENTREZGENE
	ENSRNOT00000103164.1	UniProtKB/TrEMBL
InterPro	Ald_DH/histidinol_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_CS_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_CS_GLU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_DH_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde_DH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde_DH_NAD(P)	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65183	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	65183	ENTREZGENE
PANTHER	ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER A2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR43570	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aldedh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aldh3a2	PhenoGen
PIRSF	ALDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ALDEHYDE_DEHYDR_CYS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDEHYDE_DEHYDR_GLU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53720	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC230052
UniProt	A0A0G2JY43	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AE89_RAT	UniProtKB/TrEMBL
	A0A8I6AF13	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GJ33_RAT	UniProtKB/TrEMBL
	A6HF75	ENTREZGENE, UniProtKB/TrEMBL
	AL3A2_RAT	UniProtKB/Swiss-Prot
	G3V9W6	ENTREZGENE, UniProtKB/TrEMBL
	P30839	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-26	Aldh3a2	aldehyde dehydrogenase 3 family, member A2	Aldh3a2	aldehyde dehydrogenase family 3, subfamily A2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2001-05-08	Aldh3a2	Alcohol dehydrogenase family 3, subfamily A2			Name withdrawn, does not match Human nomenclature	62408	WITHDRAWN
2001-05-08	Aldh3a2	Aldehyde dehydrogenase family 3, subfamily A2			Name changed to reflect Human nomenclature	62408	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the endoplasmic reticulum membrane	61536

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)