Gabra6 (gamma-aminobutyric acid type A receptor subunit alpha6) - Rat Genome Database

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Gene: Gabra6 (gamma-aminobutyric acid type A receptor subunit alpha6) Rattus norvegicus
Analyze
Symbol: Gabra6
Name: gamma-aminobutyric acid type A receptor subunit alpha6
RGD ID: 61861
Description: Enables diazepam binding activity; heterocyclic compound binding activity; and inhibitory extracellular ligand-gated monoatomic ion channel activity. Contributes to GABA-A receptor activity; GABA-gated chloride ion channel activity; and benzodiazepine receptor activity. Involved in GABAergic synaptic transmission and response to ethanol. Located in dendrite; neuronal cell body membrane; and synaptic membrane. Part of receptor complex. Is active in several cellular components, including cerebellar Golgi cell to granule cell synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic specialization membrane. Used to study obesity. Orthologous to human GABRA6 (gamma-aminobutyric acid type A receptor subunit alpha6); INTERACTS WITH (S)-nicotine; ammonium chloride; Ampullosporin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABA(A) receptor subunit alpha-6; GABA-A receptor alpha-6 subunit; GABAAR subunit alpha-6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid (GABA-A) receptor subunit alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6; gamma-aminobutyric acid type A receptor alpha 6 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   ANT  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81027,311,965 - 27,327,337 (-)NCBIGRCr8
mRatBN7.21026,810,411 - 26,825,768 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,810,423 - 26,825,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1031,546,343 - 31,560,549 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01031,034,879 - 31,049,081 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,521,557 - 26,535,757 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,847,447 - 27,862,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,847,439 - 27,862,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01027,691,630 - 27,706,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41027,474,071 - 27,489,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11027,475,119 - 27,490,123 (-)NCBI
Celera1026,323,497 - 26,337,672 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit. Carr LG, etal., Alcohol. 2003 Aug-Oct;31(1-2):93-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GABAA receptors: structure, function, pharmacology, and related disorders. Ghit A, etal., J Genet Eng Biotechnol. 2021 Aug 21;19(1):123. doi: 10.1186/s43141-021-00224-0.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. Hadley SH and Amin J, J Physiol. 2007 Jun 15;581(Pt 3):1001-18. Epub 2007 Mar 29.
6. Cerebellar GABAA receptor selective for a behavioural alcohol antagonist. Luddens H, etal., Nature 1990 Aug 16;346(6285):648-51.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. Nusser Z, etal., J Neurosci. 1996 Jan;16(1):103-14.
10. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Nusser Z, etal., J Neurosci. 1998 Mar 1;18(5):1693-703.
11. Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat. Poltl A, etal., J Neurochem. 2003 Dec;87(6):1444-55.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion. Rosmond R, etal., Int J Obes Relat Metab Disord. 2002 Jul;26(7):938-41.
16. Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene. Santhakumar V, etal., J Neurosci. 2006 Mar 22;26(12):3357-64.
17. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
18. Presynaptic GABAA receptors facilitate GABAergic transmission to dopaminergic neurons in the ventral tegmental area of young rats. Xiao C, etal., J Physiol. 2007 May 1;580(Pt.3):731-43. Epub 2007 Feb 15.
Additional References at PubMed
PMID:1312131   PMID:1312132   PMID:1346133   PMID:1379501   PMID:1665550   PMID:1966765   PMID:15579538   PMID:15950783   PMID:18056985   PMID:22521829   PMID:23602886   PMID:25128322  
PMID:26134650   PMID:27388150   PMID:34332026  


Genomics

Comparative Map Data
Gabra6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81027,311,965 - 27,327,337 (-)NCBIGRCr8
mRatBN7.21026,810,411 - 26,825,768 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,810,423 - 26,825,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1031,546,343 - 31,560,549 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01031,034,879 - 31,049,081 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,521,557 - 26,535,757 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,847,447 - 27,862,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,847,439 - 27,862,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01027,691,630 - 27,706,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41027,474,071 - 27,489,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11027,475,119 - 27,490,123 (-)NCBI
Celera1026,323,497 - 26,337,672 (-)NCBICelera
Cytogenetic Map10q21NCBI
GABRA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385161,685,721 - 161,702,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5161,547,063 - 161,702,593 (+)EnsemblGRCh38hg38GRCh38
GRCh375161,112,727 - 161,129,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365161,045,236 - 161,062,176 (+)NCBINCBI36Build 36hg18NCBI36
Build 345161,045,547 - 161,061,697NCBI
Celera5157,144,516 - 157,161,456 (+)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5156,205,057 - 156,221,975 (+)NCBIHuRef
CHM1_15160,545,077 - 160,562,018 (+)NCBICHM1_1
T2T-CHM13v2.05162,214,591 - 162,231,464 (+)NCBIT2T-CHM13v2.0
Gabra6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391142,197,264 - 42,211,977 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1142,197,264 - 42,211,899 (-)EnsemblGRCm39 Ensembl
GRCm381142,306,437 - 42,321,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1142,306,437 - 42,321,072 (-)EnsemblGRCm38mm10GRCm38
MGSCv371142,119,939 - 42,134,553 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361142,149,861 - 42,164,431 (-)NCBIMGSCv36mm8
Celera1146,139,046 - 46,153,582 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.03NCBI
Gabra6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540815,464,368 - 15,480,330 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540815,464,426 - 15,479,653 (+)NCBIChiLan1.0ChiLan1.0
GABRA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24156,868,647 - 156,885,816 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15155,008,214 - 155,025,362 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05157,072,915 - 157,089,994 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15163,767,304 - 163,784,334 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5163,767,304 - 163,784,331 (+)Ensemblpanpan1.1panPan2
GABRA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1449,208,691 - 49,225,754 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl449,208,605 - 49,226,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha449,099,501 - 49,116,828 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0449,639,863 - 49,657,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl449,640,367 - 49,657,815 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1449,446,978 - 49,464,698 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0449,579,983 - 49,597,659 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0450,103,326 - 50,121,062 (-)NCBIUU_Cfam_GSD_1.0
Gabra6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213103,533,076 - 103,548,851 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365151,980,824 - 1,998,053 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365151,982,415 - 1,997,740 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1661,855,468 - 61,872,279 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11661,855,698 - 61,872,503 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21667,083,554 - 67,100,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12364,020,770 - 64,038,419 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2364,021,842 - 64,039,563 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603413,515,669 - 13,532,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabra6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473327,910,641 - 27,926,376 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473327,910,692 - 27,926,104 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabra6
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:74
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000004877
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH138854  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,812,955 - 26,813,074 (+)MAPPERmRatBN7.2
Rnor_6.01027,849,992 - 27,850,110NCBIRnor6.0
Rnor_5.01027,694,175 - 27,694,293UniSTSRnor5.0
RGSC_v3.41027,475,805 - 27,475,923UniSTSRGSC3.4
Celera1026,325,231 - 26,325,349UniSTS
RH 3.4 Map10279.9UniSTS
Cytogenetic Map10q21UniSTS
X51986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,810,832 - 26,810,942 (+)MAPPERmRatBN7.2
Rnor_6.01027,847,869 - 27,847,978NCBIRnor6.0
Rnor_5.01027,692,052 - 27,692,161UniSTSRnor5.0
RGSC_v3.41027,473,682 - 27,473,791UniSTSRGSC3.4
Celera1026,323,108 - 26,323,217UniSTS
Cytogenetic Map10q21UniSTS


Related Rat Strains
The following Strains have been annotated to Gabra6
ANT    


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 6 56 16 17 7 9 7 35 20 51 1 21 10

Sequence


Ensembl Acc Id: ENSRNOT00000004877   ⟹   ENSRNOP00000004877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1026,810,423 - 26,825,769 (-)Ensembl
Rnor_6.0 Ensembl1027,847,439 - 27,862,868 (-)Ensembl
RefSeq Acc Id: NM_021841   ⟹   NP_068613
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81027,311,965 - 27,327,234 (-)NCBI
mRatBN7.21026,810,411 - 26,825,680 (-)NCBI
Rnor_6.01027,848,258 - 27,862,506 (-)NCBI
Rnor_5.01027,691,630 - 27,706,971 (-)NCBI
RGSC_v3.41027,474,071 - 27,489,074 (-)RGD
Celera1026,323,497 - 26,337,672 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246128   ⟹   XP_006246190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81027,311,965 - 27,327,337 (-)NCBI
mRatBN7.21026,810,411 - 26,825,768 (-)NCBI
Rnor_6.01027,847,447 - 27,862,896 (-)NCBI
Rnor_5.01027,691,630 - 27,706,971 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_068613 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246190 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC42034 (Get FASTA)   NCBI Sequence Viewer  
  CAA39273 (Get FASTA)   NCBI Sequence Viewer  
  EDM04122 (Get FASTA)   NCBI Sequence Viewer  
  EDM04123 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004877.2
GenBank Protein P30191 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068613   ⟸   NM_021841
- Peptide Label: precursor
- UniProtKB: P30191 (UniProtKB/Swiss-Prot),   G3V6G3 (UniProtKB/TrEMBL),   A6HDL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246190   ⟸   XM_006246128
- Peptide Label: isoform X1
- UniProtKB: P30191 (UniProtKB/Swiss-Prot),   A6HDL7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004877   ⟸   ENSRNOT00000004877
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30191-F1-model_v2 AlphaFold P30191 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697110
Promoter ID:EPDNEW_R7635
Type:single initiation site
Name:Gabra6_1
Description:gamma-aminobutyric acid type A receptor alpha 6 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01027,862,789 - 27,862,849EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61861 AgrOrtholog
BioCyc Gene G2FUF-25471 BioCyc
Ensembl Genes ENSRNOG00000003569 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004877.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAAa_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAa6_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gabra-1-6_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29708 UniProtKB/Swiss-Prot
NCBI Gene 29708 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabra6 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARALPHA6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003569 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HDL7 ENTREZGENE, UniProtKB/TrEMBL
  A6HDL8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6G3 ENTREZGENE, UniProtKB/TrEMBL
  GBRA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabra6  gamma-aminobutyric acid type A receptor subunit alpha6  Gabra6  gamma-aminobutyric acid type A receptor alpha 6 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra6  gamma-aminobutyric acid type A receptor alpha 6 subunit  Gabra6  gamma-aminobutyric acid (GABA) A receptor, alpha 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabra6  gamma-aminobutyric acid (GABA) A receptor, alpha 6  Gabra6  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabra6  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6    gamma-aminobutyric acid A receptor, alpha 6  Name updated 1299863 APPROVED
2002-06-10 Gabra6  gamma-aminobutyric acid A receptor, alpha 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression differentially expressed in the central nervous system 61594