Kcnab2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2) - Rat Genome Database

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Gene: Kcnab2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2) Rattus norvegicus
Analyze
Symbol: Kcnab2
Name: potassium voltage-gated channel subfamily A regulatory beta subunit 2
RGD ID: 61828
Description: Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and microtubule. Part of potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2); INTERACTS WITH 1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: K(+) channel subunit beta-2; kv-beta-2; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium channel, voltage-gated shaker-related subfamily A regulatory beta subunit 2; potassium voltage gated channel, shaker related subfamily, beta member 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; voltage-gated potassium channel subunit beta-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85168,182,228 - 168,270,760 (-)NCBIGRCr8
mRatBN7.25162,899,511 - 162,988,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,901,896 - 162,988,243 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,605,037 - 165,691,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,426,639 - 167,512,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,388,842 - 167,474,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,570,327 - 169,658,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,572,517 - 169,658,875 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05173,123,990 - 173,212,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,624,099 - 169,710,725 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,634,286 - 169,720,913 (-)NCBI
Celera5161,132,556 - 161,217,754 (-)NCBICelera
RH 3.4 Map51140.7RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
carmustine  (ISO)
choline  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
etoposide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
permethrin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4. Accili EA, etal., J Physiol. 1998 Oct 15;512 ( Pt 2):325-36.
2. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci C, etal., J Biol Chem 2003 Feb 21;278(8):6128-35.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Gong J, etal., Science. 1999 Sep 3;285(5433):1565-9.
6. Voltage-dependent K+ channel beta subunits in muscle: differential regulation during postnatal development and myogenesis. Grande M, etal., J Cell Physiol. 2003 May;195(2):187-93.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. Ovsepian SV, etal., J Physiol. 2013 Apr 1;591(Pt 7):1771-91. doi: 10.1113/jphysiol.2012.249706. Epub 2013 Jan 14.
11. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Poliak S, etal., Neuron. 1999 Dec;24(4):1037-47.
12. The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD. Proepper C, etal., Neuroscience. 2014 Mar 7;261:133-43. doi: 10.1016/j.neuroscience.2013.10.045. Epub 2013 Nov 6.
13. Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Rettig J, etal., Nature 1994 May 26;369(6478):289-94.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Voltage-gated K+ channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain. Rhodes KJ, etal., J Neurosci. 1996 Aug 15;16(16):4846-60.
18. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Tipparaju SM, etal., Biochemistry. 2008 Aug 26;47(34):8840-54. doi: 10.1021/bi800301b. Epub 2008 Aug 2.
21. Cdk-mediated phosphorylation of the Kvbeta2 auxiliary subunit regulates Kv1 channel axonal targeting. Vacher H, etal., J Cell Biol. 2011 Mar 7;192(5):813-24. doi: 10.1083/jcb.201007113. Epub 2011 Feb 28.
Additional References at PubMed
PMID:7649300   PMID:8608002   PMID:10884227   PMID:11086297   PMID:11825900   PMID:12963709   PMID:14569011   PMID:15062979   PMID:16002581   PMID:16079148   PMID:16569641   PMID:21296056  
PMID:22871113   PMID:24029230   PMID:25066316  


Genomics

Comparative Map Data
Kcnab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85168,182,228 - 168,270,760 (-)NCBIGRCr8
mRatBN7.25162,899,511 - 162,988,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,901,896 - 162,988,243 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,605,037 - 165,691,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,426,639 - 167,512,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,388,842 - 167,474,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,570,327 - 169,658,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,572,517 - 169,658,875 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05173,123,990 - 173,212,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,624,099 - 169,710,725 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,634,286 - 169,720,913 (-)NCBI
Celera5161,132,556 - 161,217,754 (-)NCBICelera
RH 3.4 Map51140.7RGD
Cytogenetic Map5q36NCBI
KCNAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815,992,676 - 6,101,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl15,990,927 - 6,101,193 (+)EnsemblGRCh38hg38GRCh38
GRCh3716,052,736 - 6,161,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,008,967 - 6,083,110 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416,020,645 - 6,094,789NCBI
Celera15,201,212 - 5,275,339 (+)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,201,765 - 5,310,071 (+)NCBIHuRef
CHM1_116,041,041 - 6,149,632 (+)NCBICHM1_1
T2T-CHM13v2.015,518,502 - 5,626,866 (+)NCBIT2T-CHM13v2.0
Kcnab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,475,201 - 152,561,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,475,199 - 152,562,367 (-)EnsemblGRCm39 Ensembl
GRCm384152,390,744 - 152,477,549 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,390,742 - 152,477,910 (-)EnsemblGRCm38mm10GRCm38
MGSCv374151,764,853 - 151,851,588 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364151,234,544 - 151,321,279 (-)NCBIMGSCv36mm8
Celera4154,677,910 - 154,763,618 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.08NCBI
Kcnab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,369,288 - 6,442,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,371,212 - 6,442,888 (-)NCBIChiLan1.0ChiLan1.0
KCNAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21222,123,611 - 222,235,524 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,764,655 - 220,877,249 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v014,755,412 - 4,866,424 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,012,647 - 6,120,438 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,013,072 - 6,120,438 (+)Ensemblpanpan1.1panPan2
KCNAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1559,936,432 - 60,021,945 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl559,936,528 - 60,021,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha559,947,614 - 60,032,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,152,884 - 60,238,334 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,152,939 - 60,237,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,152,983 - 60,238,041 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,019,378 - 60,104,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,420,808 - 60,506,161 (+)NCBIUU_Cfam_GSD_1.0
Kcnab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,463,300 - 30,502,711 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936623940,678 - 985,388 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936623972,288 - 987,949 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl666,928,381 - 67,016,845 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1666,928,374 - 67,016,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2661,880,875 - 61,923,103 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,636,352 - 125,743,821 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,638,962 - 125,708,768 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,784,200 - 29,893,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248185,253,773 - 5,327,000 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248185,251,304 - 5,326,796 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnab2
471 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:77
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000015840
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat

Markers in Region
RH94672  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,987,799 - 162,987,983 (+)MAPPERmRatBN7.2
Rnor_6.05169,658,618 - 169,658,801NCBIRnor6.0
Rnor_5.05173,212,381 - 173,212,564UniSTSRnor5.0
RGSC_v3.45169,710,468 - 169,710,651UniSTSRGSC3.4
Celera5161,217,497 - 161,217,680UniSTS
RH 3.4 Map51140.7UniSTS
Cytogenetic Map5q36UniSTS
BE103035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,982,322 - 162,982,473 (+)MAPPERmRatBN7.2
Rnor_6.05169,653,141 - 169,653,291NCBIRnor6.0
Rnor_5.05173,206,904 - 173,207,054UniSTSRnor5.0
RGSC_v3.45169,704,991 - 169,705,141UniSTSRGSC3.4
Celera5161,212,020 - 161,212,170UniSTS
RH 3.4 Map51142.4UniSTS
Cytogenetic Map5q36UniSTS
RH138171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,901,917 - 162,902,611 (+)MAPPERmRatBN7.2
Rnor_6.05169,572,734 - 169,573,427NCBIRnor6.0
Rnor_5.05173,126,397 - 173,127,090UniSTSRnor5.0
RGSC_v3.45169,624,121 - 169,624,814UniSTSRGSC3.4
Celera5161,132,578 - 161,133,271UniSTS
RH 3.4 Map51139.9UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X76724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015840   ⟹   ENSRNOP00000015840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,901,896 - 162,988,057 (-)Ensembl
Rnor_6.0 Ensembl5169,572,712 - 169,658,875 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087043   ⟹   ENSRNOP00000073699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,901,896 - 162,937,047 (-)Ensembl
Rnor_6.0 Ensembl5169,572,517 - 169,630,340 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101700   ⟹   ENSRNOP00000085478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,901,896 - 162,988,243 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111948   ⟹   ENSRNOP00000082892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,902,068 - 162,959,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113173   ⟹   ENSRNOP00000081886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,901,896 - 162,988,243 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119416   ⟹   ENSRNOP00000096391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,901,896 - 162,928,901 (-)Ensembl
RefSeq Acc Id: NM_017304   ⟹   NP_059000
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,184,613 - 168,270,760 (-)NCBI
mRatBN7.25162,901,896 - 162,988,057 (-)NCBI
Rnor_6.05169,572,712 - 169,658,875 (-)NCBI
Rnor_5.05173,123,990 - 173,212,638 (-)NCBI
RGSC_v3.45169,624,099 - 169,710,725 (-)RGD
Celera5161,132,556 - 161,217,754 (-)RGD
Sequence:
RefSeq Acc Id: XM_017593214   ⟹   XP_017448703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,270,469 (-)NCBI
mRatBN7.25162,899,511 - 162,987,771 (-)NCBI
Rnor_6.05169,570,327 - 169,658,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593215   ⟹   XP_017448704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,242,246 (-)NCBI
mRatBN7.25162,899,511 - 162,959,531 (-)NCBI
Rnor_6.05169,570,327 - 169,630,324 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109386   ⟹   XP_038965314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,270,466 (-)NCBI
mRatBN7.25162,899,511 - 162,987,758 (-)NCBI
RefSeq Acc Id: XM_063287267   ⟹   XP_063143337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,242,246 (-)NCBI
RefSeq Acc Id: XM_063287268   ⟹   XP_063143338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,242,246 (-)NCBI
RefSeq Acc Id: XM_063287269   ⟹   XP_063143339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,242,246 (-)NCBI
RefSeq Acc Id: XM_063287270   ⟹   XP_063143340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,242,246 (-)NCBI
RefSeq Acc Id: XM_063287271   ⟹   XP_063143341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,182,228 - 168,213,319 (-)NCBI
RefSeq Acc Id: NP_059000   ⟸   NM_017304
- UniProtKB: P62483 (UniProtKB/Swiss-Prot),   A6IUI6 (UniProtKB/TrEMBL),   A0A8I5ZVX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448703   ⟸   XM_017593214
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448704   ⟸   XM_017593215
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q7L3 (UniProtKB/TrEMBL),   A0A8I5ZVX6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073699   ⟸   ENSRNOT00000087043
Ensembl Acc Id: ENSRNOP00000015840   ⟸   ENSRNOT00000015840
RefSeq Acc Id: XP_038965314   ⟸   XM_039109386
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZVX6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082892   ⟸   ENSRNOT00000111948
Ensembl Acc Id: ENSRNOP00000096391   ⟸   ENSRNOT00000119416
Ensembl Acc Id: ENSRNOP00000081886   ⟸   ENSRNOT00000113173
Ensembl Acc Id: ENSRNOP00000085478   ⟸   ENSRNOT00000101700
RefSeq Acc Id: XP_063143340   ⟸   XM_063287270
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063143338   ⟸   XM_063287268
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063143339   ⟸   XM_063287269
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063143337   ⟸   XM_063287267
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143341   ⟸   XM_063287271
- Peptide Label: isoform X7
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62483-F1-model_v2 AlphaFold P62483 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694315
Promoter ID:EPDNEW_R4830
Type:multiple initiation site
Name:Kcnab2_1
Description:potassium voltage-gated channel subfamily A regulatory beta subunit2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,630,341 - 169,630,401EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61828 AgrOrtholog
BioCyc Gene G2FUF-39004 BioCyc
Ensembl Genes ENSRNOG00000011550 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015840.4 UniProtKB/TrEMBL
  ENSRNOT00000087043.2 UniProtKB/TrEMBL
  ENSRNOT00000101700.1 UniProtKB/TrEMBL
  ENSRNOT00000111948.1 UniProtKB/TrEMBL
  ENSRNOT00000113173.1 UniProtKB/TrEMBL
  ENSRNOT00000119416.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro K_chnl_volt-dep_bsu_KCNAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNAB-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNAB1 UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNAB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29738 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29738 ENTREZGENE
PANTHER PTHR43150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnab2 PhenoGen
PRINTS KCNAB1CHANEL UniProtKB/TrEMBL
  KCNAB2CHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNABCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011550 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC236448
UniProt A0A0G2K670_RAT UniProtKB/TrEMBL
  A0A8I5ZVX6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYT6_RAT UniProtKB/TrEMBL
  A0A8I6APC7_RAT UniProtKB/TrEMBL
  A0A8I6GCY0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q7L3 ENTREZGENE, UniProtKB/TrEMBL
  A6IUI6 ENTREZGENE, UniProtKB/TrEMBL
  KCAB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P97381 UniProtKB/Swiss-Prot
  Q60942 UniProtKB/Swiss-Prot
  Q64284 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnab2  potassium voltage-gated channel subfamily A regulatory beta subunit 2  Kcnab2  potassium channel, voltage gated subfamily A regulatory beta subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-02 Kcnab2  potassium channel, voltage gated subfamily A regulatory beta subunit 2  Kcnab2  potassium channel, voltage-gated shaker-related subfamily A regulatory beta subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-27 Kcnab2  potassium channel, voltage-gated shaker-related subfamily A regulatory beta subunit 2  Kcnab2  potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnab2  potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2  Kcnab2  potassium voltage-gated channel, shaker-related subfamily, beta member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnab2  potassium voltage-gated channel, shaker-related subfamily, beta member 2    potassium voltage gated channel, shaker related subfamily, beta member 2  Name updated 1299863 APPROVED
2002-06-10 Kcnab2  potassium voltage gated channel, shaker related subfamily, beta member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the nervous system 61642