Pex2 (peroxisomal biogenesis factor 2) - Rat Genome Database

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Gene: Pex2 (peroxisomal biogenesis factor 2) Rattus norvegicus
Analyze
Symbol: Pex2
Name: peroxisomal biogenesis factor 2
RGD ID: 61814
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cell population proliferation; and pexophagy. Predicted to act upstream of or within several processes, including bile acid biosynthetic process; cholesterol homeostasis; and regulation of cholesterol biosynthetic process. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PAF-1; peroxin-2; peroxisomal membrane protein 3; peroxisomal membrane protein 3 35 kDa; peroxisomal membrane protein 3, 35 kDa; peroxisome assembly factor 1; peroxisome assembly factor-1; peroxisome biogenesis factor 2; Pxmp3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8297,957,479 - 97,973,767 (+)NCBIGRCr8
mRatBN7.2296,050,380 - 96,072,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl296,045,958 - 96,073,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2102,587,325 - 102,603,512 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02100,708,411 - 100,724,598 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0295,763,317 - 95,779,508 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0298,251,756 - 98,269,185 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl298,252,925 - 98,269,184 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02117,990,545 - 118,007,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4298,361,891 - 98,378,715 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1298,306,852 - 98,323,677 (+)NCBI
Celera291,566,959 - 91,583,216 (+)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Cdc73/Paf1 complex  (IBA,IEA,ISO)
peroxisomal membrane  (IBA,IDA,IEA,ISO)
peroxisome  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A mouse model for Zellweger syndrome. Baes M, etal., Nat Genet. 1997 Sep;17(1):49-57.
2. Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder. Faust PL and Hatten ME, J Cell Biol. 1997 Dec 1;139(5):1293-305.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Transmembrane topology of the peroxin, Pex2p, an essential component for the peroxisome assembly. Harano T, etal., J Biochem (Tokyo). 1999 Jun;125(6):1168-74.
5. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Peroxisome assembly factor 1: nonsense mutation in a peroxisome-deficient Chinese hamster ovary cell mutant and deletion analysis. Tsukamoto T, etal., Mol Cell Biol 1994 Aug;14(8):5458-65.
Additional References at PubMed
PMID:1546315   PMID:1750930   PMID:9765053   PMID:10528859   PMID:12746876   PMID:12751901   PMID:14673138   PMID:15489334   PMID:18359941   PMID:18987311   PMID:19208625   PMID:19946888  
PMID:21525035   PMID:21554508   PMID:27597759  


Genomics

Comparative Map Data
Pex2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8297,957,479 - 97,973,767 (+)NCBIGRCr8
mRatBN7.2296,050,380 - 96,072,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl296,045,958 - 96,073,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2102,587,325 - 102,603,512 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02100,708,411 - 100,724,598 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0295,763,317 - 95,779,508 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0298,251,756 - 98,269,185 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl298,252,925 - 98,269,184 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02117,990,545 - 118,007,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4298,361,891 - 98,378,715 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1298,306,852 - 98,323,677 (+)NCBI
Celera291,566,959 - 91,583,216 (+)NCBICelera
Cytogenetic Map2q23NCBI
PEX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38876,980,258 - 77,001,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl876,980,258 - 77,001,044 (-)EnsemblGRCh38hg38GRCh38
GRCh37877,892,494 - 77,913,280 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36878,055,049 - 78,075,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 34878,057,712 - 78,074,994NCBI
Celera873,885,870 - 73,906,661 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef873,378,964 - 73,399,755 (-)NCBIHuRef
CHM1_1877,944,088 - 77,964,880 (-)NCBICHM1_1
T2T-CHM13v2.0877,409,691 - 77,430,483 (-)NCBIT2T-CHM13v2.0
Pex2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3935,625,248 - 5,643,655 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl35,625,248 - 5,641,299 (-)EnsemblGRCm39 Ensembl
GRCm3835,560,188 - 5,578,596 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl35,560,188 - 5,576,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv3735,560,188 - 5,576,239 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3635,543,577 - 5,559,201 (-)NCBIMGSCv36mm8
Celera35,637,555 - 5,653,606 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map31.96NCBI
Pex2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554443,811,973 - 3,830,666 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554443,811,972 - 3,830,666 (+)NCBIChiLan1.0ChiLan1.0
PEX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2792,717,778 - 92,735,460 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1868,345,570 - 68,363,805 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0873,508,349 - 73,526,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1875,145,061 - 75,163,338 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl875,146,255 - 75,147,172 (-)Ensemblpanpan1.1panPan2
PEX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12924,943,563 - 24,960,834 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2925,206,108 - 25,223,363 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02925,055,730 - 25,073,096 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2925,055,743 - 25,073,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12925,130,967 - 25,148,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02925,148,141 - 25,165,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02925,500,349 - 25,517,613 (-)NCBIUU_Cfam_GSD_1.0
Pex2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530354,180,390 - 54,197,777 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367021,573,650 - 1,591,004 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367021,573,616 - 1,626,323 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl459,252,337 - 59,270,116 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1459,252,330 - 59,270,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2464,716,680 - 64,745,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PEX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1872,513,975 - 72,532,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl872,514,307 - 72,517,003 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603968,748,476 - 68,767,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pex2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474414,240,570 - 14,245,183 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474414,227,430 - 14,245,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pex2
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:120
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000011579
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
BE111495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,049,755 - 96,049,915 (+)MAPPERmRatBN7.2
Rnor_6.0298,252,415 - 98,252,574NCBIRnor6.0
Rnor_5.02117,990,974 - 117,991,133UniSTSRnor5.0
RGSC_v3.4298,361,381 - 98,361,540UniSTSRGSC3.4
Celera291,566,449 - 91,566,608UniSTS
RH 3.4 Map2679.6UniSTS
Cytogenetic Map2q24UniSTS
AI043801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,065,305 - 96,065,397 (+)MAPPERmRatBN7.2
Rnor_6.0298,267,968 - 98,268,059NCBIRnor6.0
Rnor_5.02118,006,527 - 118,006,618UniSTSRnor5.0
RGSC_v3.4298,377,499 - 98,377,590UniSTSRGSC3.4
Celera291,582,000 - 91,582,091UniSTS
RH 3.4 Map2730.8UniSTS
Cytogenetic Map2q24UniSTS
AI233233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,066,119 - 96,066,333 (+)MAPPERmRatBN7.2
Rnor_6.0298,268,782 - 98,268,995NCBIRnor6.0
Rnor_5.02118,007,341 - 118,007,554UniSTSRnor5.0
RGSC_v3.4298,378,313 - 98,378,526UniSTSRGSC3.4
Celera291,582,814 - 91,583,027UniSTS
RH 3.4 Map2622.4UniSTS
Cytogenetic Map2q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 35 11 8
Low 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001388504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001388505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001388506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC063169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D30616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D30617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM078955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM104606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000011579   ⟹   ENSRNOP00000011579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl296,050,187 - 96,066,523 (+)Ensembl
Rnor_6.0 Ensembl298,252,925 - 98,269,184 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095560   ⟹   ENSRNOP00000076831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl296,045,958 - 96,073,404 (+)Ensembl
RefSeq Acc Id: NM_001388504   ⟹   NP_001375433
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8297,957,630 - 97,973,767 (+)NCBI
mRatBN7.2296,050,386 - 96,066,523 (+)NCBI
RefSeq Acc Id: NM_001388505   ⟹   NP_001375434
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8297,957,630 - 97,973,767 (+)NCBI
mRatBN7.2296,050,386 - 96,066,523 (+)NCBI
RefSeq Acc Id: NM_001388506   ⟹   NP_001375435
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8297,957,630 - 97,973,767 (+)NCBI
mRatBN7.2296,050,386 - 96,066,523 (+)NCBI
RefSeq Acc Id: NM_017234   ⟹   NP_058930
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8297,957,630 - 97,973,767 (+)NCBI
mRatBN7.2296,050,386 - 96,066,523 (+)NCBI
Rnor_6.0298,252,925 - 98,269,184 (+)NCBI
Rnor_5.02117,990,545 - 118,007,746 (+)NCBI
RGSC_v3.4298,361,891 - 98,378,715 (+)RGD
Celera291,566,959 - 91,583,216 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232159   ⟹   XP_006232221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8297,957,479 - 97,973,767 (+)NCBI
mRatBN7.2296,050,380 - 96,072,928 (+)NCBI
Rnor_6.0298,253,101 - 98,269,185 (+)NCBI
Rnor_5.02117,990,545 - 118,007,746 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760865   ⟹   XP_008759087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8297,958,071 - 97,973,767 (+)NCBI
mRatBN7.2296,050,827 - 96,072,928 (+)NCBI
Rnor_6.0298,253,474 - 98,269,185 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281639   ⟹   XP_063137709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8297,970,399 - 97,973,767 (+)NCBI
RefSeq Acc Id: NP_058930   ⟸   NM_017234
- Peptide Label: isoform 1
- UniProtKB: P24392 (UniProtKB/Swiss-Prot),   Q63733 (UniProtKB/Swiss-Prot),   A6IH90 (UniProtKB/TrEMBL),   A0A8L2Q557 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232221   ⟸   XM_006232159
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q557 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759087   ⟸   XM_008760865
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q557 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011579   ⟸   ENSRNOT00000011579
RefSeq Acc Id: NP_001375434   ⟸   NM_001388505
- Peptide Label: isoform 1
- UniProtKB: P24392 (UniProtKB/Swiss-Prot),   Q63733 (UniProtKB/Swiss-Prot),   A6IH90 (UniProtKB/TrEMBL),   A0A8L2Q557 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001375435   ⟸   NM_001388506
- Peptide Label: isoform 2
- UniProtKB: A0A8L2Q557 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001375433   ⟸   NM_001388504
- Peptide Label: isoform 1
- UniProtKB: P24392 (UniProtKB/Swiss-Prot),   Q63733 (UniProtKB/Swiss-Prot),   A6IH90 (UniProtKB/TrEMBL),   A0A8L2Q557 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000076831   ⟸   ENSRNOT00000095560
RefSeq Acc Id: XP_063137709   ⟸   XM_063281639
- Peptide Label: isoform X2
- UniProtKB: Q63733 (UniProtKB/Swiss-Prot),   P24392 (UniProtKB/Swiss-Prot),   A0A8L2Q557 (UniProtKB/TrEMBL),   A6IH90 (UniProtKB/TrEMBL)
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24392-F1-model_v2 AlphaFold P24392 1-305 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691247
Promoter ID:EPDNEW_R1771
Type:initiation region
Name:Pex2_1
Description:peroxisomal biogenesis factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0298,253,056 - 98,253,116EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61814 AgrOrtholog
BioCyc Gene G2FUF-53669 BioCyc
Ensembl Genes ENSRNOG00000008748 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011579.3 UniProtKB/TrEMBL
  ENSRNOT00000095560.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetratricopeptide repeat domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6886755 IMAGE-MGC_LOAD
InterPro PEX2/10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEX5/PEX5L UniProtKB/TrEMBL
  Pex_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING-HC_PEX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29534 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72871 IMAGE-MGC_LOAD
NCBI Gene 29534 ENTREZGENE
PANTHER PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5 UniProtKB/TrEMBL
  PEROXISOME BIOGENESIS FACTOR 2 UniProtKB/Swiss-Prot
  PEROXISOME BIOGENESIS FACTOR 2 UniProtKB/Swiss-Prot
  PEROXISOME BIOGENESIS FACTOR 2 UniProtKB/TrEMBL
  PEROXISOME BIOGENESIS FACTOR 2 UniProtKB/TrEMBL
  PEX5-RELATED PROTEIN UniProtKB/TrEMBL
Pfam Pex2_Pex12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pex2 PhenoGen
PROSITE ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008748 RatGTEx
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like UniProtKB/TrEMBL
TIGR TC206361
UniProt A0A8L2Q557 ENTREZGENE, UniProtKB/TrEMBL
  A6IH90 ENTREZGENE, UniProtKB/TrEMBL
  A6IHR8_RAT UniProtKB/TrEMBL
  P24392 ENTREZGENE, UniProtKB/Swiss-Prot
  Q63733 ENTREZGENE
UniProt Secondary Q63733 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-01-26 Pex2  peroxisomal biogenesis factor 2  Pxmp3  peroxisomal membrane protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pxmp3  peroxisomal membrane protein 3  Pex2  peroxisome biogenesis factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Pex2  peroxisome biogenesis factor 2  Pxmp3  peroxisomal membrane protein 3  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Pxmp3  peroxisomal membrane protein 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference