Ctsk (cathepsin K) - Rat Genome Database

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Gene: Ctsk (cathepsin K) Rattus norvegicus
Analyze
Symbol: Ctsk
Name: cathepsin K
RGD ID: 61810
Description: Predicted to enable several functions, including collagen binding activity; cysteine-type endopeptidase activity; and fibronectin binding activity. Involved in several processes, including bone resorption; cellular response to transforming growth factor beta stimulus; and cellular response to zinc ion starvation. Located in extracellular space. Biomarker of intracranial aneurysm and otitis media. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K); PARTICIPATES IN rheumatoid arthritis pathway; Toll-like receptor signaling pathway; INTERACTS WITH (S)-amphetamine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp364  
Candidate Gene For: Bp364
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,747,548 - 185,758,512 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2185,747,165 - 185,765,582 (+)EnsemblGRCr8
mRatBN7.22183,058,586 - 183,069,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2190,723,332 - 190,734,303 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,518,632 - 188,529,601 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,355,824 - 183,366,795 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,655,469 - 196,666,447 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)Ensemblrn6Rnor6.0
Rnor_5.02216,154,168 - 216,164,779 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42190,394,854 - 190,405,668 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2175,591,773 - 175,602,552 (+)NCBICelera
RGSC_v3.12190,357,607 - 190,368,421 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
(S)-amphetamine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anagliptin  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brusatol  (EXP)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
cisapride  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
cyanamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dimethyl fumarate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
guanethidine  (EXP)
haloperidol  (EXP)
Harpagoside  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
Liensinine  (ISO)
lipopolysaccharide  (ISO)
mangiferin  (ISO)
mercaptopurine  (EXP)
methylglyoxal  (EXP,ISO)
methylseleninic acid  (ISO)
Mitoquinone  (ISO)
Morroniside  (ISO)
morusin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
naringin  (ISO)
neohesperidin  (ISO)
niclosamide  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylarsine oxide  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
protosappanin A  (ISO)
puerarin  (EXP)
purine-6-thiol  (EXP)
quartz  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rubiadin  (EXP)
S-nitrosoglutathione  (ISO)
Salidroside  (ISO)
SB 203580  (ISO)
sclareol  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
xanthohumol  (ISO)
zinc atom  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and localization of cathepsin k in adult rat sertoli cells. Anway MD, etal., Biol Reprod 2004 Mar;70(3):562-9. Epub 2003 Oct 29.
2. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
3. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
7. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
8. Polarization and secretion of cathepsin K precede tartrate-resistant acid phosphatase secretion to the ruffled border area during the activation of matrix-resorbing clasts. Hollberg K, etal., J Bone Miner Metab. 2005;23(6):441-9.
9. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
10. Gene expression relevant to osteoclastogenesis in the synovium and bone marrow of mature rats with collagen-induced arthritis. Kishimoto Y, etal., Rheumatology (Oxford). 2004 Dec;43(12):1496-503. Epub 2004 Sep 7.
11. Patterns and localization of gene expression during intramembranous bone regeneration in the rat femoral marrow ablation model. Kuroda S, etal., Calcif Tissue Int. 2005 Oct;77(4):212-25. Epub 2005 Sep 28.
12. Osteopetrosis and osteoporosis: two sides of the same coin. Lazner F, etal., Hum Mol Genet 1999;8(10):1839-46.
13. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
14. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, etal., PLoS One. 2012;7(10):e47930. doi: 10.1371/journal.pone.0047930. Epub 2012 Oct 24.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Intracellular machinery for matrix degradation in bone-resorbing osteoclasts. Vaaraniemi J, etal., J Bone Miner Res 2004 Sep;19(9):1432-40. Epub 2004 Jun 14.
26. Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones. Xia L, etal., Biol Chem. 1999 Jun;380(6):679-87.
Additional References at PubMed
PMID:11082042   PMID:12782676   PMID:15489334   PMID:17181996   PMID:17916452   PMID:18664521   PMID:18974601   PMID:19834056   PMID:22365146   PMID:22952693   PMID:24912190   PMID:25558848  
PMID:29207029   PMID:29514215  


Genomics

Comparative Map Data
Ctsk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,747,548 - 185,758,512 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2185,747,165 - 185,765,582 (+)EnsemblGRCr8
mRatBN7.22183,058,586 - 183,069,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2190,723,332 - 190,734,303 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,518,632 - 188,529,601 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,355,824 - 183,366,795 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,655,469 - 196,666,447 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)Ensemblrn6Rnor6.0
Rnor_5.02216,154,168 - 216,164,779 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42190,394,854 - 190,405,668 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2175,591,773 - 175,602,552 (+)NCBICelera
RGSC_v3.12190,357,607 - 190,368,421 (+)NCBI
Cytogenetic Map2q34NCBI
CTSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,796,208 - 150,808,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,794,880 - 150,809,577 (-)Ensemblhg38GRCh38
GRCh371150,768,684 - 150,780,736 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,035,311 - 149,047,436 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341147,581,759 - 147,593,885NCBI
Celera1123,884,715 - 123,896,850 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,146,309 - 122,158,545 (-)NCBIHuRef
CHM1_11152,164,010 - 152,176,259 (-)NCBICHM1_1
T2T-CHM13v2.01149,919,861 - 149,931,947 (-)NCBIT2T-CHM13v2.0
Ctsk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,406,521 - 95,416,698 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,406,567 - 95,416,673 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38395,499,210 - 95,509,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,499,256 - 95,509,362 (+)Ensemblmm10GRCm38
MGSCv37395,303,208 - 95,313,284 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36395,584,690 - 95,594,766 (+)NCBIMGSCv36mm8
Celera396,930,391 - 96,940,481 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Ctsk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588148,748 - 158,093 (-)Ensembl
ChiLan1.0NW_004955588149,036 - 158,093 (-)NCBIChiLan1.0ChiLan1.0
CTSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,022,154 - 99,036,182 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,777,588 - 98,789,833 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,146,555 - 126,158,662 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,795,966 - 129,808,316 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,795,966 - 129,808,316 (-)EnsemblpanPan2panpan1.1
CTSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,928,725 - 59,938,293 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,929,287 - 59,938,507 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1759,375,185 - 59,382,593 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01760,945,042 - 60,954,711 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,945,043 - 61,028,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,774,900 - 59,782,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,859,083 - 59,866,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,587,454 - 60,594,862 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ctsk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,992,384 - 22,005,049 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,022,762 - 1,034,984 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,022,762 - 1,038,020 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,391,428 - 98,404,961 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1498,389,459 - 98,404,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,639,430 - 107,653,109 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,471,719 - 12,484,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,015,835 - 19,025,588 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477219,013,189 - 19,026,756 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ctsk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1361,759,854 - 61,769,187 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ctsk
60 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:53
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000028730
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH130167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21120,495,578 - 20,495,786 (+)MAPPERmRatBN7.2
mRatBN7.22183,061,435 - 183,061,643 (+)MAPPERmRatBN7.2
Rnor_6.01120,612,679 - 20,612,886NCBIRnor6.0
Rnor_6.02196,658,319 - 196,658,526NCBIRnor6.0
Rnor_5.01124,260,859 - 24,261,066UniSTSRnor5.0
Rnor_5.02216,157,018 - 216,157,225UniSTSRnor5.0
Cytogenetic Map11q11UniSTS
Cytogenetic Map2q34UniSTS
RH135289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,058,968 - 183,059,184 (+)MAPPERmRatBN7.2
Rnor_6.02196,655,852 - 196,656,067NCBIRnor6.0
Rnor_5.02216,154,551 - 216,154,766UniSTSRnor5.0
RGSC_v3.42190,395,237 - 190,395,452UniSTSRGSC3.4
Celera2175,592,156 - 175,592,371UniSTS
RH 3.4 Map21213.9UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:496617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,063,027 - 183,063,128 (+)MAPPERmRatBN7.2
Rnor_6.02196,659,911 - 196,660,011NCBIRnor6.0
Rnor_5.02216,158,610 - 216,158,710UniSTSRnor5.0
RGSC_v3.42190,399,296 - 190,399,396UniSTSRGSC3.4
Celera2175,596,215 - 175,596,315UniSTS
Cytogenetic Map2q34UniSTS
Ctsk  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,063,145 - 183,063,210 (+)MAPPERmRatBN7.2
Rnor_6.02196,660,029 - 196,660,093NCBIRnor6.0
Rnor_5.02216,158,728 - 216,158,792UniSTSRnor5.0
RGSC_v3.42190,399,414 - 190,399,478UniSTSRGSC3.4
Celera2175,596,333 - 175,596,397UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 91 59 6 355 191 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028730   ⟹   ENSRNOP00000028730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2185,747,165 - 185,765,188 (+)Ensembl
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)Ensembl
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149407   ⟹   ENSRNOP00000099313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2185,747,165 - 185,759,242 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157112   ⟹   ENSRNOP00000111490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2185,747,165 - 185,765,582 (+)Ensembl
RefSeq Acc Id: NM_031560   ⟹   NP_113748
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,747,548 - 185,758,512 (+)NCBI
mRatBN7.22183,058,586 - 183,069,551 (+)NCBI
Rnor_6.02196,655,469 - 196,666,447 (+)NCBI
Rnor_5.02216,154,168 - 216,164,779 (+)NCBI
RGSC_v3.42190,394,854 - 190,405,668 (+)RGD
Celera2175,591,773 - 175,602,552 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113748 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB65743 (Get FASTA)   NCBI Sequence Viewer  
  AAH78793 (Get FASTA)   NCBI Sequence Viewer  
  EDL85704 (Get FASTA)   NCBI Sequence Viewer  
  EDL85705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028730.3
  ENSRNOP00000111490
GenBank Protein O35186 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113748   ⟸   NM_031560
- Peptide Label: precursor
- UniProtKB: O35186 (UniProtKB/Swiss-Prot),   A6K2Z6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028730   ⟸   ENSRNOT00000028730
Ensembl Acc Id: ENSRNOP00000111490   ⟸   ENSRNOT00000157112
Ensembl Acc Id: ENSRNOP00000099313   ⟸   ENSRNOT00000149407
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35186-F1-model_v2 AlphaFold O35186 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691549
Promoter ID:EPDNEW_R2074
Type:initiation region
Name:Ctsk_1
Description:cathepsin K
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02196,655,485 - 196,655,545EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61810 AgrOrtholog
BioCyc Gene G2FUF-52092 BioCyc
Ensembl Genes ENSRNOG00000021155 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028730.7 UniProtKB/Swiss-Prot
  ENSRNOT00000157112 ENTREZGENE
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134253 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_asp_AS UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot
  Prot_inhib_I29 UniProtKB/Swiss-Prot
KEGG Report rno:29175 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93359 IMAGE-MGC_LOAD
NCBI Gene 29175 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot
  Peptidase_C1 UniProtKB/Swiss-Prot
PhenoGen Ctsk PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021155 RatGTEx
SMART Inhibitor_I29 UniProtKB/Swiss-Prot
  Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
TIGR TC229248
UniProt A0ABK0KXP3_RAT UniProtKB/TrEMBL
  A0ABK0M314_RAT UniProtKB/TrEMBL
  A6K2Z5_RAT UniProtKB/TrEMBL
  A6K2Z6 ENTREZGENE, UniProtKB/TrEMBL
  CATK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ctsk  cathepsin K      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in human homolog are associated with pycnodysostosis 704405
gene_function human homolog displays endoprotease activity against fibrinogen 704405