Faah (fatty acid amide hydrolase) - Rat Genome Database

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Gene: Faah (fatty acid amide hydrolase) Rattus norvegicus
Analyze
Symbol: Faah
Name: fatty acid amide hydrolase
RGD ID: 61808
Description: Enables several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; identical protein binding activity; and monoacylglycerol lipase activity. Involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Located in organelle membrane. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anandamide amidase; anandamide amidohydrolase 1; fatty acid ester hydrolase; fatty-acid amide hydrolase 1; oleamide hydrolase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: This locus corresponds to the rat Faah gene and shares synteny with Faah in mouse and human. Rat Faah was previously associated with GeneID: 29347, which may correspond to a duplication of this locus in the rat assembly. [19 Mar 2019]; Note: This locus was previously annotated as the rat Faah gene, which is now associated with GeneID: 100911581. GeneID: 100911581 shares synteny with Faah in mouse and human. This locus corresponds to a duplication of Faah in the rat assembly. [06 Jul 2022]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,716,545 - 134,735,396 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5134,716,545 - 134,735,396 (-)EnsemblGRCr8
mRatBN7.25129,479,774 - 129,499,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5132,096,062 - 132,114,937 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,850,947 - 133,869,822 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,873,084 - 133,891,959 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,852,899 - 134,872,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,331,929 - 134,348,995 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl5134,852,875 - 134,871,775 (-)Ensemblrn6Rnor6.0
Rnor_5.05138,636,638 - 138,655,831 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45136,310,965 - 136,329,817 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5128,010,075 - 128,029,275 (-)NCBICelera
RGSC_v3.15136,316,189 - 136,333,987 (+)NCBI
Cytogenetic Map5q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
anandamide  (EXP,ISO)
antalarmin  (EXP)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
Benzyl parahydroxybenzoate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP,ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cocaine hydrochloride  (EXP)
corticosterone  (EXP)
Cuprizon  (EXP)
Cyclopamine  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dichlorine  (EXP)
diuron  (EXP)
dizocilpine maleate  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenitrothion  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
flurbiprofen  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
heptachlor  (EXP)
Heptachlor epoxide  (ISO)
ibuprofen  (EXP)
indometacin  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
mechlorethamine  (ISO)
methamidophos  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
Methylazoxymethanol acetate  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
Niflumic acid  (EXP)
nimesulide  (EXP,ISO)
nitroglycerin  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (EXP,ISO)
parathion  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylmethanesulfonyl fluoride  (EXP,ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
profenofos  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
rimonabant  (EXP,ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
serotonin  (ISO)
silibinin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tribufos  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
WIN 55212-2  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Bracey MH, etal., Science 2002 Nov 29;298(5599):1793-6.
2. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Cravatt BF, etal., Nature 1996 Nov 7;384(6604):83-7.
3. The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. Flanagan JM, etal., Hum Genet. 2006 Nov;120(4):581-8. Epub 2006 Sep 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Molecular characterization of human and mouse fatty acid amide hydrolases. Giang DK and Cravatt BF, Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2238-42.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Gulyas AI, etal., Eur J Neurosci. 2004 Jul;20(2):441-58. doi: 10.1111/j.1460-9568.2004.03428.x.
8. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Ho WS and Randall MD, Br J Pharmacol. 2007 Mar;150(5):641-51. Epub 2007 Jan 22.
9. Endocannabinoid Enhancement Protects Against Kainic Acid-Induced Seizures and Associated Brain Damage. Karanian DA, etal., J Pharmacol Exp Ther. 2007 Jun 1;.
10. The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. Marcos A, etal., Neuropharmacology. 2022 Mar 15;206:108937. doi: 10.1016/j.neuropharm.2021.108937. Epub 2021 Dec 26.
11. Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase. McKinney MK and Cravatt BF, J Biol Chem. 2003 Sep 26;278(39):37393-9. Epub 2003 May 6.
12. Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase. Mei G, etal., J Biol Chem. 2007 Feb 9;282(6):3829-36. Epub 2006 Dec 7.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Mileni M, etal., Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12820-4. doi: 10.1073/pnas.0806121105. Epub 2008 Aug 27.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. Sanchez-Marin L, etal., Eur Neuropsychopharmacol. 2020 Apr;33:126-138. doi: 10.1016/j.euroneuro.2020.01.012. Epub 2020 Feb 10.
21. Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). Sipe JC, etal., Int J Obes (Lond). 2005 Jul;29(7):755-9.
22. A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Sipe JC, etal., Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8394-9.
23. Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake. Stopponi S, etal., Addict Biol. 2018 Nov;23(6):1223-1232. doi: 10.1111/adb.12573. Epub 2017 Oct 26.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
27. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Vila A, etal., Biochemistry. 2007 Aug 21;46(33):9578-85. doi: 10.1021/bi7005898. Epub 2007 Jul 25.
Additional References at PubMed
PMID:9452020   PMID:12678501   PMID:14506913   PMID:15233754   PMID:15632090   PMID:16418162   PMID:16866346   PMID:17543306   PMID:17555521   PMID:19095868   PMID:19321773   PMID:20493882  
PMID:20657592   PMID:20665820   PMID:21241462   PMID:21867744   PMID:21930339   PMID:22606285   PMID:22776900   PMID:23455058   PMID:24788435   PMID:24861565   PMID:25041240   PMID:25456842  
PMID:25608877   PMID:26238495   PMID:28148494   PMID:28726298   PMID:29038048   PMID:29197803   PMID:29953903   PMID:30159798   PMID:30578649   PMID:32041998   PMID:32488870   PMID:32682844  
PMID:33359656   PMID:36154489   PMID:38368587  


Genomics

Comparative Map Data
Faah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,716,545 - 134,735,396 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5134,716,545 - 134,735,396 (-)EnsemblGRCr8
mRatBN7.25129,479,774 - 129,499,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5132,096,062 - 132,114,937 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,850,947 - 133,869,822 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,873,084 - 133,891,959 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,852,899 - 134,872,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,331,929 - 134,348,995 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl5134,852,875 - 134,871,775 (-)Ensemblrn6Rnor6.0
Rnor_5.05138,636,638 - 138,655,831 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45136,310,965 - 136,329,817 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5128,010,075 - 128,029,275 (-)NCBICelera
RGSC_v3.15136,316,189 - 136,333,987 (+)NCBI
Cytogenetic Map5q35NCBI
FAAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,394,317 - 46,413,845 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,394,317 - 46,413,848 (+)Ensemblhg38GRCh38
GRCh37146,859,989 - 46,879,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,632,575 - 46,652,104 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34146,572,011 - 46,591,536NCBI
Celera145,147,299 - 45,166,880 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef144,975,524 - 44,995,057 (+)NCBIHuRef
CHM1_1146,976,965 - 46,996,516 (+)NCBICHM1_1
T2T-CHM13v2.0146,271,530 - 46,291,059 (+)NCBIT2T-CHM13v2.0
Faah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,853,866 - 115,876,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,824,342 - 115,875,123 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384115,996,668 - 116,018,837 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,967,145 - 116,017,926 (-)Ensemblmm10GRCm38
MGSCv374115,669,261 - 115,690,507 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364115,494,600 - 115,515,834 (-)NCBIMGSCv36mm8
Celera4114,735,873 - 114,757,118 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.08NCBI
Faah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,873,368 - 11,885,369 (-)Ensembl
ChiLan1.0NW_00495546411,873,368 - 11,885,366 (-)NCBIChiLan1.0ChiLan1.0
FAAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,394,843 - 180,414,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,536,454 - 179,555,961 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,697,173 - 45,716,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,053,436 - 47,072,283 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,053,436 - 47,072,283 (+)EnsemblpanPan2panpan1.1
FAAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,023,111 - 14,040,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,023,299 - 14,040,212 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1514,143,619 - 14,160,572 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01514,173,706 - 14,190,680 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,171,285 - 14,190,759 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,974,934 - 13,991,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,043,437 - 14,060,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,112,894 - 14,129,901 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Faah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,594,374 - 61,616,279 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,419,078 - 27,441,039 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,419,211 - 27,441,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,060,285 - 165,079,767 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16165,060,279 - 165,079,340 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,539,044 - 152,558,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Faah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,287,985 - 2,313,172 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249062,288,251 - 2,313,172 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Faah
66 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:492
Count of miRNA genes:234
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000015667, ENSRNOT00000015961
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH131970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,480,995 - 129,481,177 (+)MAPPERmRatBN7.2
Rnor_6.05134,854,071 - 134,854,252NCBIRnor6.0
Rnor_6.05134,331,376 - 134,331,557NCBIRnor6.0
Rnor_5.05138,637,810 - 138,637,991UniSTSRnor5.0
Rnor_5.05138,121,847 - 138,122,028UniSTSRnor5.0
RGSC_v3.45136,328,464 - 136,328,645UniSTSRGSC3.4
Celera5128,011,247 - 128,011,428UniSTS
RH 3.4 Map5836.5UniSTS
Cytogenetic Map5q36UniSTS
RH133581  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,480,048 - 129,480,250 (+)MAPPERmRatBN7.2
Rnor_6.05134,853,124 - 134,853,325NCBIRnor6.0
Rnor_6.05134,330,429 - 134,330,630NCBIRnor6.0
Rnor_5.05138,636,863 - 138,637,064UniSTSRnor5.0
Rnor_5.05138,120,900 - 138,121,101UniSTSRnor5.0
RGSC_v3.45136,329,391 - 136,329,592UniSTSRGSC3.4
Celera5128,010,300 - 128,010,501UniSTS
RH 3.4 Map5837.7UniSTS
Cytogenetic Map5q36UniSTS
MARC_7381-7382:996687840:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,484,171 - 129,485,414 (+)MAPPERmRatBN7.2
Rnor_6.05134,857,247 - 134,858,489NCBIRnor6.0
Rnor_6.05134,334,552 - 134,335,794NCBIRnor6.0
Rnor_5.05138,125,023 - 138,126,265UniSTSRnor5.0
Rnor_5.05138,640,986 - 138,642,228UniSTSRnor5.0
RGSC_v3.45136,324,227 - 136,325,469UniSTSRGSC3.4
Celera5128,014,423 - 128,015,665UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 1 30 111 65 57 33 79 33 12 250 143 11 86 55 70 24 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015667   ⟹   ENSRNOP00000015667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,716,545 - 134,735,396 (-)Ensembl
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)Ensembl
Rnor_6.0 Ensembl5134,852,875 - 134,871,775 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000015961   ⟹   ENSRNOP00000015961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,716,545 - 134,735,396 (-)Ensembl
mRatBN7.2 Ensembl5129,479,824 - 129,498,677 (-)Ensembl
Rnor_6.0 Ensembl5134,331,929 - 134,348,995 (-)Ensembl
RefSeq Acc Id: NM_001369126   ⟹   NP_001356055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,716,545 - 134,735,396 (-)NCBI
mRatBN7.25129,479,824 - 129,498,677 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001356055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91148 (Get FASTA)   NCBI Sequence Viewer  
  EDL90296 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015667
  ENSRNOP00000015667.6
GenBank Protein P97612 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000015667   ⟸   ENSRNOT00000015667
RefSeq Acc Id: NP_001356055   ⟸   NM_001369126
- UniProtKB: P97612 (UniProtKB/Swiss-Prot),   Q5BKA3 (UniProtKB/Swiss-Prot),   A6JZ57 (UniProtKB/TrEMBL),   A0A8L2Q8I2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000015961   ⟸   ENSRNOT00000015961
Protein Domains
Amidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97612-F1-model_v2 AlphaFold P97612 1-579 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61808 AgrOrtholog
BioCyc Gene G2FUF-40269 BioCyc
BioCyc Pathway PWY6666-1 [anandamide degradation] BioCyc
BioCyc Pathway Image PWY6666-1 BioCyc
Ensembl Genes ENSRNOG00000011019 Ensembl
  ENSRNOG00000045949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015667 ENTREZGENE
  ENSRNOT00000015667.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.1300.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370226 IMAGE-MGC_LOAD
InterPro Amidase_CS UniProtKB/Swiss-Prot
  Amidase_dom UniProtKB/Swiss-Prot
  AS_sf UniProtKB/Swiss-Prot
  Endocannabinoid_amidase UniProtKB/Swiss-Prot
MGC_CLONE MGC:108682 IMAGE-MGC_LOAD
NCBI Gene 100911581 ENTREZGENE
PANTHER FATTY ACID AMIDE HYDROLASE UniProtKB/Swiss-Prot
  PTHR45847:SF3 UniProtKB/Swiss-Prot
Pfam Amidase UniProtKB/Swiss-Prot
PhenoGen Faah PhenoGen
PIRSF Amidase_fungi UniProtKB/Swiss-Prot
PROSITE AMIDASES UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011019 RatGTEx
  ENSRNOG00000045949 RatGTEx
Superfamily-SCOP SSF75304 UniProtKB/Swiss-Prot
TIGR TC236093
UniProt A0A8L2Q8I2 ENTREZGENE, UniProtKB/TrEMBL
  A6JZ57 ENTREZGENE, UniProtKB/TrEMBL
  FAAH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKA3 ENTREZGENE
UniProt Secondary Q5BKA3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Faah  fatty acid amide hydrolase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference