Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | P2ry4 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of P2RY4 mRNA | CTD | PMID:36331819 | P2ry4 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | P2ry4 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | P2ry4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | P2ry4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of P2RY4 mRNA | CTD | PMID:26377647 | P2ry4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of P2RY4 mRNA | CTD | PMID:33387578 | P2ry4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | P2ry4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of P2RY4 mRNA | CTD | PMID:25975270 and PMID:26290441 | P2ry4 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of P2RY4 mRNA | CTD | PMID:21346803 | P2ry4 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of P2RY4 mRNA | CTD | PMID:31881176 | P2ry4 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of P2RY4 mRNA | CTD | PMID:28959563 | P2ry4 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of P2RY4 mRNA | CTD | PMID:16483693 | P2ry4 | Rat | ATP | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium more ... | CTD | PMID:12694404 | P2ry4 | Rat | benzo[a]pyrene | decreases expression | ISO | P2RY4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of P2RY4 mRNA | CTD | PMID:22316170 | P2ry4 | Rat | benzo[a]pyrene | affects methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of P2RY4 promoter | CTD | PMID:27901495 | P2ry4 | Rat | benzo[a]pyrene | decreases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of P2RY4 exon | CTD | PMID:27901495 | P2ry4 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of P2RY4 mRNA | CTD | PMID:25181051 | P2ry4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of P2RY4 mRNA | CTD | PMID:30816183 more ... | P2ry4 | Rat | calcium atom | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium and Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] | CTD | PMID:12694404 | P2ry4 | Rat | calcium(0) | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium and Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] | CTD | PMID:12694404 | P2ry4 | Rat | CGP 52608 | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to P2RY4 gene] | CTD | PMID:28238834 | P2ry4 | Rat | dextran sulfate | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of P2RY4 mRNA | CTD | PMID:29950665 | P2ry4 | Rat | disodium selenite | decreases expression | ISO | P2RY4 (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of P2RY4 mRNA | CTD | PMID:18175754 | P2ry4 | Rat | epoxiconazole | decreases expression | ISO | P2ry4 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of P2RY4 mRNA | CTD | PMID:35436446 | P2ry4 | Rat | ethanol | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of P2RY4 mRNA | CTD | PMID:30517762 | P2ry4 | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of P2RY4 mRNA | CTD | PMID:30307764 | P2ry4 | Rat | fonofos | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of P2RY4 promoter | CTD | PMID:22847954 | P2ry4 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of P2RY4 mRNA | CTD | PMID:33387578 | P2ry4 | Rat | GTP | multiple interactions | EXP | | 6480464 | Guanosine Triphosphate binds to and results in increased activity of P2RY4 protein | CTD | PMID:15654852 | P2ry4 | Rat | lithium atom | increases expression | EXP | | 6480464 | Lithium results in increased expression of P2RY4 mRNA | CTD | PMID:19244398 | P2ry4 | Rat | lithium hydride | increases expression | EXP | | 6480464 | Lithium results in increased expression of P2RY4 mRNA | CTD | PMID:19244398 | P2ry4 | Rat | maneb | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA and Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] | CTD | PMID:23963992 | P2ry4 | Rat | melatonin | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] | CTD | PMID:23963992 | P2ry4 | Rat | N-(3-oxododecanoyl)homoserine lactone | decreases expression | ISO | P2RY4 (Homo sapiens) | 6480464 | N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA | CTD | PMID:10496880 | P2ry4 | Rat | paracetamol | affects expression | ISO | P2ry4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of P2RY4 mRNA | CTD | PMID:17562736 | P2ry4 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of P2RY4 mRNA | CTD | PMID:33387578 | P2ry4 | Rat | paraquat | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA and Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] | CTD | PMID:23963992 | P2ry4 | Rat | parathion | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Parathion results in increased methylation of P2RY4 promoter | CTD | PMID:22847954 | P2ry4 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of P2RY4 mRNA | CTD | PMID:36331819 | P2ry4 | Rat | pirinixic acid | decreases expression | ISO | P2ry4 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of P2RY4 mRNA | CTD | PMID:17950772 | P2ry4 | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | P2ry4 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of P2RY4 mRNA | CTD | PMID:28903501 | P2ry4 | Rat | tamoxifen | decreases expression | ISO | P2ry4 (Mus musculus) | 6480464 | Tamoxifen results in decreased expression of P2RY4 mRNA | CTD | PMID:25123088 | P2ry4 | Rat | terbufos | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | terbufos results in increased methylation of P2RY4 promoter | CTD | PMID:22847954 | P2ry4 | Rat | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of P2RY4 mRNA | CTD | PMID:12734012 | P2ry4 | Rat | tetrachloromethane | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of P2RY4 mRNA | CTD | PMID:30517762 | P2ry4 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of P2RY4 mRNA | CTD | PMID:31150632 | P2ry4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of P2RY4 mRNA | CTD | PMID:23411599 | P2ry4 | Rat | titanium dioxide | increases expression | ISO | P2ry4 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of P2RY4 mRNA | CTD | PMID:29264374 | P2ry4 | Rat | titanium dioxide | multiple interactions | ISO | P2ry4 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of P2RY4 mRNA | CTD | PMID:29950665 | P2ry4 | Rat | trichloroethene | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] | CTD | PMID:12694404 | P2ry4 | Rat | trichloroethene | decreases activity | ISO | P2RY4 (Homo sapiens) | 6480464 | Trichloroethylene results in decreased activity of P2RY4 protein | CTD | PMID:12694404 | P2ry4 | Rat | triptonide | increases expression | ISO | P2ry4 (Mus musculus) | 6480464 | triptonide results in increased expression of P2RY4 mRNA | CTD | PMID:33045310 | P2ry4 | Rat | UTP | multiple interactions | EXP | | 6480464 | Uridine Triphosphate binds to and results in increased activity of P2RY4 protein | CTD | PMID:15654852 | P2ry4 | Rat | valproic acid | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of P2RY4 gene | CTD | PMID:29154799 | |